Two-step mechanism involving active-site conformational changes regulates human telomerase DNA binding

Biochemical Journal

Volumn 465, Issue , 2015, Pages 347-357

  Tomlinson, Christopher G ^a,b   Moye, Aaron L ^a,b   Holien, Jessica K ^c   Parker, Michael W ^c,d   Cohen, Scott B ^a,b   Bryan, Tracy M ^a,b  

^a CHILDREN'S MEDICAL RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Dyskeratosis congenita; Enzymology; Idiopathic pulmonary fibrosis; Telomerase

Indexed keywords

HISTIDINE; PROLINE; SERINE; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; DNA; PROTEIN BINDING; TERT PROTEIN, HUMAN;

ARTICLE; BINDING KINETICS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DNA BINDING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PROTEIN INTERACTION; STATIC ELECTRICITY; AMINO ACID SUBSTITUTION; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HEK293 CELL LINE; METABOLISM; MISSENSE MUTATION; TELOMERE;

AMINO ACID SUBSTITUTION; CATALYTIC DOMAIN; DNA; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; MUTATION, MISSENSE; PROTEIN BINDING; TELOMERASE; TELOMERE;

EID: 84920613230     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20140922     Document Type: Article

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