Investigation of human telomerase holoenzyme assembly, activity, and processivity using disease-linked subunit variants

Journal of Biological Chemistry

Volumn 285, Issue 7, 2010, Pages 4375-4386

  Robart, Aaron R ^a   Collins, Kathleen ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVITY ASSAYS; BIOCHEMICAL MECHANISMS; BONE MARROW; CATALYTIC ACTIVITY; CATALYTIC CORE; CATALYTIC CYCLES; GENES ENCODING; HUMAN TELOMERASE; IN-VITRO; IN-VIVO; PRIMER EXTENSION; PROCESSIVITY; PULMONARY FIBROSIS; RIBONUCLEOPROTEINS; STRUCTURAL REQUIREMENTS; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; WIDE SPECTRUM;

ASSAYS; ELECTROCHEMICAL SENSORS; RNA;

CATALYST ACTIVITY;

HOLOENZYME; RIBONUCLEOPROTEIN; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBUNIT; HUMAN; HUMAN CELL; LUNG FIBROSIS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEFECT; PROTEIN DEPLETION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN VARIANT; TELOMERE;

BLOTTING, NORTHERN; BONE MARROW DISEASES; CELL LINE; CHILD; CHILD, PRESCHOOL; DYSKERATOSIS CONGENITA; FEMALE; HOLOENZYMES; HUMANS; MALE; MUTATION; NUCLEIC ACID CONFORMATION; POLYMERASE CHAIN REACTION; RIBONUCLEOPROTEINS; RNA; TELOMERASE;

EID: 77951178977     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.088575     Document Type: Article

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