Radiobiology of vestibular schwannomas: Mechanisms of radioresistance and potential targets for therapeutic sensitization

Neurosurgical Focus

Volumn 27, Issue 6, 2009, Pages

  Yeung, Andrea H ^a   Sughrue, Michael E ^b   Kane, Ari J ^b   Tihan, Tarik ^b   Cheung, Steven W ^a   Parsa, Andrew T ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Merlin; Neurofibromatosis type 2; Radiotherapy; Resistance; Vestibular schwannoma

Indexed keywords

BIOLOGICAL MODEL; GENE; GENETICS; HUMAN; LONGITUDINAL STUDY; NEUROFIBROMATOSIS; NEUROMA; PHYSIOLOGY; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RADIATION EXPOSURE; RADIATION RESPONSE; RADIOBIOLOGY; RADIOSURGERY; REVIEW; TREATMENT OUTCOME; TUMOR SUPPRESSOR GENE; VESTIBULOCOCHLEAR NERVE;

DOSE FRACTIONATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; GENES, CDC; GENES, P53; HUMANS; LONGITUDINAL STUDIES; MODELS, BIOLOGICAL; NEUROFIBROMATOSIS 2; NEUROMA, ACOUSTIC; RADIATION DOSAGE; RADIATION TOLERANCE; RADIOBIOLOGY; RADIOSURGERY; RADIOTHERAPY DOSAGE; TREATMENT OUTCOME; VESTIBULOCOCHLEAR NERVE;

EID: 73349110095     PISSN: None     EISSN: 10920684     Source Type: Journal    
DOI: 10.3171/2009.9.FOCUS09185     Document Type: Review

References (36)

1. Anniko M, Arndt J, Norén G: The human acoustic neurinoma in organ culture. II. Tissue changes after gamma irradiation. Acta Otolaryngol 91:223-235, 1981
2. Arvold ND, Guha N, Wang D, Matli M, Deen DF, Warren RS, et al: Hypoxia-induced radioresistance is independent of hypoxia-inducible factor-1A in vitro. Int J Radiat Oncol Biol Phys 62:207-212, 2005
3. Cayé-Thomasen P, Baandrup L, Jacobsen GK, Thomsen J, Stangerup SE: Immunohistochemical demonstration of vascular endothelial growth factor in vestibular schwannomas correlates to tumor growth rate. Laryngoscope 113:2129-2134, 2003
4. Deacon J, Peckham MJ, Steel GG: The radioresponsiveness of human tumours and the initial slope of the cell survival curve. Radiother Oncol 2:317-323, 1984
5. Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S: MAPK pathways in radiation responses. Oncogene 22:5885-5896, 2003
6. Fei P, Bernhard EJ, El-Deiry WS: Tissue-specific induction of p53 targets in vivo. Cancer Res 62:7316-7327, 2002
7. Ferrara N: Vascular endothelial growth factor: molecular and biological aspects. Curr Top Microbiol Immunol 237:1-30, 1999
8. Hansen MR, Clark JJ, Gantz BJ, Goswami PC: Effects of ErbB2 signaling on the response of vestibular schwannoma cells to gamma-irradiation. Laryngoscope 118:1023-1030, 2008
9. Hartley KO, Gell D, Smith GC, Zhang H, Divecha N, Connelly MA, et al: DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product. Cell 82:849-856, 1995
10. Hirato M, Inoue H, Zama A, Ohye C, Shibazaki T, Andou Y: Gamma Knife radiosurgery for acoustic schwannoma: effects of low radiation dose and functional prognosis. Stereotact Funct Neurosurg 66 (1 Suppl):134-141, 1996
11. Irving RM, Moffat DA, Hardy DG, Barton DE, Xuereb JH, Maher ER: Molecular genetic analysis of the mechanism of tumorigenesis in acoustic neuroma. Arch Otolaryngol Head Neck Surg 119:1222-1228, 1993
12. Kaylie DM, Horgan MJ, Delashaw JB, McMenomey SO: A meta-analysis comparing outcomes of microsurgery and gamma knife radiosurgery. Laryngoscope 110:1850-1856, 2000
13. Kim H, Lim JY, Kim YH, Kim H, Park SH, Lee KH, et al: Inhibition of ras-mediated activator protein 1 activity and cell growth by merlin. Mol Cells 14:108-114, 2002
14. Kirchgessner CU, Patil CK, Evans JW, Cuomo CA, Fried LM, Carter T, et al: DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect. Science 267:1178-1183, 1995
15. Kwon Y, Khang SK, Kim CJ, Lee DJ, Lee JK, Kwun BD: Radiologic and histopathologic changes after Gamma Knife radiosurgery for acoustic schwannoma. Stereotact Funct Neurosurg 72 (1 Suppl):2-10, 1999
16. Lanser MJ, Sussman SA, Frazer K: Epidemiology, pathogenesis, and genetics of acoustic tumors. Otolaryngol Clin North Am 25:499-520, 1992
17. Lasak JM, Welling DB, Akhmametyeva EM, Salloum M, Chang LS: Retinoblastoma-cyclin-dependent kinase pathway deregulation in vestibular schwannomas. Laryngoscope 112:1555-1561, 2002
18. Lee DJ, Westra WH, Staecker H, Long D, Niparko JK, Slattery WH III: Clinical and histopathologic features of recurrent vestibular schwannoma (acoustic neuroma) after stereotactic radiosurgery. Otol Neurotol 24:650-660, 2003
19. Lee F, Linthicum F Jr, Hung G: Proliferation potential in recurrent acoustic schwannoma following gamma knife radiosurgery versus microsurgery. Laryngoscope 112:948-950, 2002
20. Linskey ME: Stereotactic radiosurgery versus stereotactic radiotherapy for patients with vestibular schwannoma: a Leksell Gamma Knife Society 2000 debate. J Neurosurg 93 (3 Suppl):90-95, 2000
21. Lutchman M, Rouleau GA: Neurofibromatosis type 2: a new mechanism of tumor suppression. Trends Neurosci 19:373-377, 1996
22. Mawrin C, Kirches E, Dietzmann K, Roessner A, Boltze C: Expression pattern of apoptotic markers in vestibular schwannomas. Pathol Res Pract 198:813-819, 2002
23. Monoh K, Ishikawa K, Yasui N, Mineura K, Andoh H, Togawa K: p53 tumor suppressor gene in acoustic neuromas. Acta Otolaryngol Suppl 537:11-15, 1998
24. Morrison H, Sperka T, Manent J, Giovannini M, Ponta H, Herr lich P: Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac. Cancer Res 67:520-527, 2007
25. O'Reilly B, Murray CD, Hadley DM: The conservative management of acoustic neuroma: a review of forty-four patients with magnetic resonance imaging. Clin Otolaryngol Allied Sci 25:93-97, 2000
26. Pawlik TM, Keyomarsi K: Role of cell cycle in mediating sensitivity to radiotherapy. Int J Radiat Oncol Biol Phys 59:928-942, 2004
27. Peters LJ, Withers HR, Thames HD Jr, Fletcher GH: Tumor radioresistance in clinical radiotherapy. Int J Radiat Oncol Biol Phys 8:101-108, 1982
28. Plotkin SR, Stemmer-Rachamimov AO, Barker FG II, Halpin C, Padera TP, Tyrrell A, et al: Hearing improvement after bevacizumab in patients with neurofibromatosis type 2. N Engl J Med 361:358-367, 2009
29. Samuel T, Weber HO, Funk JO: Linking DNA damage to cell cycle checkpoints. Cell Cycle 1:162-168, 2002
30. Slattery WH III, Brackmann DE: Results of surgery following stereotactic irradiation for acoustic neuromas. Am J Otol 16:315-321, 1995
31. Tikoo A, Varga M, Ramesh V, Gusella J, Maruta H: An antiRas function of neurofibromatosis type 2 gene product (NF2/ Merlin). J Biol Chem 269:23387-23390, 1994
32. Viniegra JG, Martínez N, Modirassari P, Losa JH, Parada Cobo C, Lobo VJ, et al: Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM. J Biol Chem 280:4029-4036, 2005
33. Weichselbaum RR, Beckett MA, Schwartz JL, Dritschilo A: Radioresistant tumor cells are present in head and neck carcinomas that recur after radiotherapy. Int J Radiat Oncol Biol Phys 15:575-579, 1988
34. Xiao GH, Chernoff J, Testa JR: NF2: the wizardry of merlin. Genes Chromosomes Cancer 38:389-399, 2003
35. Yaes RJ: Tumor heterogeneity, tumor size, and radioresistance. Int J Radiat Oncol Biol Phys 17:993-1005, 1989
36. Yomo S, Arkha Y, Delsanti C, Roche PH, Thomassin JM, Régis J: Repeat gamma knife surgery for regrowth of vestibular schwannomas. Neurosurgery 64:48-55, 2009