Innate immune receptor NOD2 promotes vascular inflammation and formation of lipid-rich necrotic cores in hypercholesterolemic mice

European Journal of Immunology

Volumn 44, Issue 10, 2014, Pages 3081-3092

  Johansson, Maria E ^a,b   Zhang, Xiao Ying ^a,c   Edfeldt, Kristina ^a   Lundberg, Anna M ^a   Levin, Malin C ^d   Borén, Jan ^d   Li, Wei ^e   Yuan, Xi Ming ^e   Folkersen, Lasse ^a,f   Eriksson, Per ^a   Hedin, Ulf ^a   Low, Hann ^g   Sviridov, Dmitri ^g   Rios, Francisco J ^a,h   Hansson, Göran K ^a   Yan, Zhong Qun ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

^e LINKÖPING UNIVERSITY   (Sweden)

^f NOVO NORDISK A S   (Denmark)

^g BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^h UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Atherosclerosis; Inflammation; Innate immunity; Nucleotide binding oligomerization domain containing protein 2; Pattern recognition receptor

Indexed keywords

ABC TRANSPORTER; ABC TRANSPORTER A1; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CD3 ANTIGEN; CD36 ANTIGEN; CD4 ANTIGEN; GAMMA INTERFERON; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INTERLEUKIN 10; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; OXIDIZED LOW DENSITY LIPOPROTEIN; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE 2; SCAVENGER RECEPTOR A; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1; CARD15 PROTEIN, MOUSE; MESSENGER RNA; NOD2 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA ROOT; ARTICLE; ATHEROSCLEROSIS; CAROTID ARTERY; CAROTID ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CYTOKINE RESPONSE; DISEASE COURSE; DISEASE SEVERITY; ENDOTHELIUM CELL; EX VIVO STUDY; HUMAN; HUMAN TISSUE; HYPERCHOLESTEROLEMIA; IN VITRO STUDY; INNATE IMMUNITY; MACROPHAGE ACTIVATION; MONOCYTE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR DOWN REGULATION; T LYMPHOCYTE; UPREGULATION; VASCULITIS; ANIMAL; ATHEROSCLEROTIC PLAQUE; DISEASE MODEL; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; INFLAMMATION; KNOCKOUT MOUSE; METABOLISM; NECROSIS; NICK END LABELING; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; ATHEROSCLEROSIS; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; HUMANS; HYPERCHOLESTEROLEMIA; IMMUNITY, INNATE; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INFLAMMATION; MICE; MICE, KNOCKOUT; NECROSIS; NOD2 SIGNALING ADAPTOR PROTEIN; PLAQUE, ATHEROSCLEROTIC; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84920403924     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201444755     Document Type: Article

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