Enhanced expression of natural resistance-associated macrophage protein 1 in atherosclerotic lesions may be associated with oxidized lipid-induced apoptosis

Annals of the New York Academy of Sciences

Volumn 1030, Issue , 2004, Pages 202-207

  Li, Wei ^a   Hellsten, Anna ^a   Nyhalah, Jerome Dinga ^a   Yuan, Xi Ming ^a,b  

^a LINKÖPING UNIVERSITY   (Sweden)

^b LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Apoptosis; Atherosclerosis; Natural resistance associated macrophage proteins; Oxysterols; Redox active iron

Indexed keywords

1,10 PHENANTHROLINE; 7BETA HYDROXYCHOLESTEROL; DEFEROXAMINE; FERROUS ION; LIPID; LIPOCORTIN 5; MESSENGER RNA; METAL; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 1;

ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; APOPTOSIS; ATHEROGENESIS; ATHEROSCLEROSIS; CELL DEATH; CELL STRAIN U937; CONFERENCE PAPER; CONTROLLED STUDY; HUMAN; HUMAN CELL; HYPERLIPIDEMIA; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MACROPHAGE; NICK END LABELING; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RABBIT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ORYCTOLAGUS CUNICULUS;

EID: 15044361883     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1329.026     Document Type: Article

References (8)

1. SULLIVAN, J.L. 1981. Iron and the sex difference in heart disease risk. Lancet 1: 1293-1294.
2. SALONEN, J.T., K. NYYSSÖNEN, H. LORAL, et al. 1992. High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men. Circulation 86: 803-811.
3. YUAN, X.M. & W. LI. 2003. The iron hypothesis of atherosclerosis and its clinical impact. Ann. Med. 35: 1-15.
4. YUAN, X.M. 1999. Apoptotic macrophage-derived foam cells of human atheromas are rich in iron and ferritin, suggesting iron-catalysed reactions to be involved in apoptosis. Free Radic. Res. 30: 221-231.
5. WYLLIE, S., P. SEU & J.A. Goss. 2002. The natural resistance-associated macrophage protein 1 S1c11a1 (formerly Nramp1) and iron metabolism in macrophages. Microbes Infect. 4: 351-359.
6. LI, W., H. DALEN, J.W. EATON, et al. 2001. Apoptotic death of inflammatory cells in human atheroma. Arterioscler. Thromb. Vasc. Biol. 21: 1124-1130.
7. MIGUET-ALFONSI, C., C. PRUNET, S. MONIER, et al. 2002. Analysis of oxidative processes and of myelin figures formation before and after the loss of mitochondrial transmembrane potential during 7β-hydroxycholesterol and 7-ketocholesterol-induced apoptosis: comparison with various pro-apoptotic chemicals. Biochem. Pharmacol. 64: 527-541.
8. MINQIN, R., F. WATT, B.T. HUAT, et al. 2003. Correlation of iron and zinc levels with lesion depth in newly formed atherosclerotic lesions. Free Radic. Biol. Med. 15: 746-752.