Association between NOD2/CARD15 polymorphisms and coronary artery disease: A case-control study

Human Immunology

Volumn 72, Issue 8, 2011, Pages 636-640

  Galluzzo, Sara ^a   Patti, Giuseppe ^a   Dicuonzo, Giordano ^a   Di Sciascio, Germano ^a   Tonini, Giuseppe ^a   Ferraro, Elisabetta ^a   Spoto, Chiara ^a   Campanale, Roberto ^a   Zoccoli, Alice ^a   Angeletti, Silvia ^a  

^a UNIVERSITY CAMPUS BIO MEDICO   (Italy)

Author keywords

CARD15 polymorphisms; Coronary artery disease; Genetic susceptibility; Innate immunity; NOD2

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; LEUCINE;

ACUTE CORONARY SYNDROME; ADULT; AGE DISTRIBUTION; AGED; AMINO ACID SUBSTITUTION; ANGIOCARDIOGRAPHY; ARTICLE; CARDIOVASCULAR RISK; CAUCASIAN; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY DISEASE; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SEX RATIO; SINGLE NUCLEOTIDE POLYMORPHISM; STABLE ANGINA PECTORIS; UNSTABLE ANGINA PECTORIS;

ACUTE CORONARY SYNDROME; AGED; ANGIOGRAPHY; CASE-CONTROL STUDIES; CORONARY ARTERY DISEASE; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; MUTATION; NOD2 SIGNALING ADAPTOR PROTEIN; ODDS RATIO; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; RESTRICTION MAPPING; RISK;

EID: 79960168145     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2011.04.005     Document Type: Article

References (39)

1. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med 1999, 340:115-126.
2. Mitchell J.A., Ryffel B., Quesniaux V.F.J., Cartwright N., Paul-Clark M. Role of pattern-recognition receptors in cardiovascular health and disease. Biochem Soc Trans 2007, 35:1449-1452.
3. Inohara N., Chamaillard M., McDonald C., Nuñez G. NOD-LRR proteins: role in host-microbial interactions and inflammatory disease. Annu Rev Biochem 2005, 74:355-383.
4. Girardin S.E., Boneca I.G., Viala J., Chamaillard M., Labigne A., Thomas G., et al. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 2003, 278:8869-8872.
5. Inohara N., Ogura Y., Fontalba A., Gutierrez O., Pons F., Crespo J., et al. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J Biol Chem 2003, 278:5509-5512.
6. Inohara N., Koseki T., del Peso L., Hu Y., Yee C., Chen S., et al. Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. J Biol Chem 1999, 274:14560-14567.
7. Inohara N., Nuñez G. A signaling module that regulates apoptosis and host defense against pathogens. Oncogene 2001, 20:6473-6481. The NOD.
8. Inohara N., Koseki T., Lin J., del Peso L., Lucas P.C., Chen F.F., et al. An induced proximity model for NF-kappa B activation in the Nod1/RICK and RIP signaling pathways. J Biol Chem 2000, 275:27823-27831.
9. Collins T., Cybulsky M.I. NF-kappaB: pivotal mediator or innocent bystander in atherogenesis?. J Clin Invest 2001, 107:255-264.
10. Hugot J.P., Chamaillard M., Zouali H., Lesage S., Cézard J.P., Belaiche J., et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001, 411:599-603.
11. Ogura Y., Bonen D.K., Inohara N., Nicolae D.L., Chen F.F., Ramos R., et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001, 411:603-606.
12. Penack O., Holler E., van den Brink M.R.M. Graft-versus-host disease: regulation by microbe-associated molecules and innate immune receptors. Blood 2010, 115:1865-1872.
13. Appenrodt B., Grünhage F., Gentemann M.G., Thyssen L., Sauerbruch T., Lammert F. Nucleotide-binding oligomerization domain containing 2 (NOD2) variants are genetic risk factors for death and spontaneous bacterial peritonitis in liver cirrhosis. Hepatology 2010, 51:1327-1333.
14. Henckaerts L., Nielsen K.R., Steffensen R., Van Steen K., Mathieu C., Giulietti A., et al. Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit. Crit Care Med 2009, 37:192-201.
15. Bonen D.K., Ogura Y., Nicolae D.L., Inohara N., Saab L., Tanabe T., et al. Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan. Gastroenterology 2003, 124:140-146.
16. Rahman P., Bartlett S., Siannis F., Pellett F.J., Farewell V.T., Peddle L., et al. CARD15: a pleiotropic autoimmune gene that confers susceptibility to psoriatic arthritis. Am J Hum Genet 2003, 73:677-681.
17. Cavanaugh J.A., Adams K.E., Quak E.J., Bryce M.E., O'Callaghan N.J., Rodgers H.J., et al. CARD15/NOD2 risk alleles in the development of Crohn's disease in the Australian population. Ann Hum Genet 2003, 67:35-41.
18. Yazdanyar S., Kamstrup P.R., Tybjaerg-Hansen A., Nordestgaard B.G. Penetrance of NOD2/CARD15 genetic variants in the general population. CMAJ 2010, 182:661-665.
19. Angeletti S., Galluzzo S., Santini D., Ruzzo A., Vincenzi B., Ferraro E., et al. NOD2/CARD15 polymorphisms impair innate immunity and increase susceptibility to gastric cancer in an Italian population. Hum Immunol 2009, 70:729-732.
20. Philpott D.J., Girardin S.E. The role of Toll-like receptors and Nod proteins in bacterial infection. Mol Immunol 2004, 41:1099-1108.
21. Pauleau A.L., Murray P.J. Role of NOD2 in the response of macrophages to Toll-like receptor agonists. Mol Cell Biol 2003, 23:7531-7539.
22. Ogura Y., Inohara N., Benito A., Chen F.F., Yamaoka S., Nunez G. NOD2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J Biol Chem 2001, 276:4812-4818.
23. Liuzzo G., Biasucci L.M., Gallimore J.R., Grillo R.L., Rebuzzi A.G., Pepys M.B., et al. The prognostic value of C-reactive protein and serum amyloid A protein in severe unstable angina. N Engl J Med 1994, 331:417-424.
24. Patti G., Di Sciascio G., D'Ambrosio A., Dicuonzo G., Abbate A., Dobrina A. Prognostic value of interleukin-1 receptor antagonist in patients undergoing percutaneous coronary intervention. Am J Cardiol 2002, 89:372-376.
25. Patti G., Di Sciascio G., D'Ambrosio A., Dicuonzo G., Abbate A., Dobrina A. Inflammatory markers and coronary interventions: a potentially useful follow-up modality after stenting. Cathet Cardiovasc Int 2002, 56:341-345.
26. Ray K.K., Cannon C.P. The potential relevance of the multiple lipid-independent (pleiotropic) effects of statins in the management of acute coronary syndromes. J Am Coll Cardiol 2005, 46:1425-1433.
27. Renko J., Lepp P.W., Oksala N., Nikkari S., Nikkari S.T. Bacterial signatures in atherosclerotic lesions represent human commensals and pathogens. Atherosclerosis 2008, 201:192-197.
28. Fong I.W. Emerging relations between infectious diseases and coronary artery disease and atherosclerosis. CMAJ 2000, 163:49-56.
29. Ott S.J., El Mokhtari N.E., Musfeldt M., Hellmig S., Freitag S., et al. Detection of diverse bacterial signatures in atherosclerotic lesions of patients with coronary heart disease. Circulation 2006, 113:929-937.
30. Wagner H. Endogenous TLR ligands and autoimmunity. Adv Immunol 2006, 91:159-173.
31. Mullick A.E., Tobias P.S., Curtiss L.K. Toll-like receptors and atherosclerosis: key contributors in disease and health?. Immunol Res 2006, 34:193-209.
32. Frantz S., Ertl G., Bauersachs J. Mechanisms of disease: Toll-like receptors in cardiovascular disease. Nat Clin Pract Cardiovasc Med 2007, 4:444-454.
33. Mullick A.E., Tobias P.S., Curtiss L.K. Modulation of atherosclerosis in mice by Toll-like receptor 2. J Clin Invest 2005, 115:3149-3156.
34. Michelsen K.S., Wong M.H., Shah P.K., Zhang W., Yano J., Doherty T.M., et al. Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci U S A 2004, 101:10679-10684.
35. Opitz B., Förster S., Hocke A.C., Maass M., Schmeck B., Hippenstiel S., et al. Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae. Circ Res 2005, 96:319-326.
36. Davey M.P., Martin T.M., Planck S.R., Lee J., Zamora D., Rosenbaum J.T. Human endothelial cells express NOD2/CARD15 and increase IL-6 secretion in response to muramyl dipeptide. Microvasc Res 2006, 71:103-107.
37. Fillon S., Soulis K., Rajasekaran S., Benedict-Hamilton H., Radin J.N., Orihuela C.J., et al. Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology. J Immunol 2006, 177:6182-6191.
38. Yazdanyar S., Nordestgaard B.G. NOD2/CARD15 genotype, cardiovascular disease and cancer in 43,600 individuals from the general population. J Intern Med 2010, 268:162-170.
39. El Mokhtari N.E., Ott S.J., Nebel A., Schäfer A., Rosenstiel P., Förster M., et al. Role of NOD2/CARD15 in coronary heart disease. BMC Genet 2007, 8:1-8.