Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium

Molecular Biology of the Cell

Volumn 26, Issue 1, 2015, Pages 1-14

  Toops, Kimberly A ^a   Tan, Li Xuan ^a,b   Jiang, Zhichun ^c   Radu, Roxana A ^c   Lakkaraju, Aparna ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c JULES STEIN EYE INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIS(MONOACYLGLYCERO)PHOSPHATE; CERAMIDE; CHOLESTEROL; LIPOFUSCIN; LIPOFUSCIN BISRETINOID; RETINOID DERIVATIVE; SPHINGOMYELIN PHOSPHODIESTERASE; TUBULIN; UNCLASSIFIED DRUG; A2-E (N-RETINYLIDENE-N-RETINYLETHANOLAMINE); BIS(MONOACYLGLYCERYL)PHOSPHATE; LYSOPHOSPHOLIPID; MONOACYLGLYCEROL; RETINOID;

ACTIN FILAMENT; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL MIGRATION; CELL MOTILITY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MACULAR DEGENERATION; MICROTUBULE; MOUSE; NONHUMAN; PIGMENT EPITHELIUM; PROTEIN ACETYLATION; UPREGULATION; ANIMAL; KNOCKOUT MOUSE; METABOLISM; PATHOPHYSIOLOGY; PHAGOSOME; ULTRASTRUCTURE;

ANIMALS; AUTOPHAGY; CERAMIDES; CHOLESTEROL; HUMANS; LIPOFUSCIN; LYSOPHOSPHOLIPIDS; MACULAR DEGENERATION; MICE; MICE, KNOCKOUT; MICROTUBULES; MONOGLYCERIDES; PHAGOSOMES; RETINAL PIGMENT EPITHELIUM; RETINOIDS; SPHINGOMYELIN PHOSPHODIESTERASE; TUBULIN;

EID: 84920385628     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E14-05-1028     Document Type: Article

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