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Volumn 3, Issue , 2012, Pages

The Hedgehog signalling pathway regulates autophagy

Author keywords

[No Author keywords available]

Indexed keywords

INITIATION FACTOR 2ALPHA; PROTEIN PATCHED 1; PROTEIN PATCHED 2; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CI; TRANSCRIPTION FACTOR GLI2; UNCLASSIFIED DRUG;

EID: 84870810698     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms2212     Document Type: Article
Times cited : (102)

References (59)
  • 1
    • 78149475088 scopus 로고    scopus 로고
    • Regulation of mammalian autophagy in physiology and pathophysiology
    • Ravikumar, B. et al. Regulation of mammalian autophagy in physiology and pathophysiology. Physiol. Rev. 90, 1383-1435 (2010).
    • (2010) Physiol. Rev. , vol.90 , pp. 1383-1435
    • Ravikumar, B.1
  • 2
    • 0345166111 scopus 로고    scopus 로고
    • Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
    • Yue, Z., Jin, S., Yang, C., Levine, A. J. & Heintz, N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl Acad. Sci. USA 100, 15077-15082 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 15077-15082
    • Yue, Z.1    Jin, S.2    Yang, C.3    Levine, A.J.4    Heintz, N.5
  • 3
    • 11144245626 scopus 로고    scopus 로고
    • The role of autophagy during the early neonatal starvation period
    • Kuma, A. et al. The role of autophagy during the early neonatal starvation period. Nature 432, 1032-1036 (2004).
    • (2004) Nature , vol.432 , pp. 1032-1036
    • Kuma, A.1
  • 4
    • 51449085299 scopus 로고    scopus 로고
    • The role of autophagy in mammalian development: Cell makeover rather than cell death
    • Cecconi, F. & Levine, B. The role of autophagy in mammalian development: cell makeover rather than cell death. Dev. Cell 15, 344-357 (2008).
    • (2008) Dev. Cell , vol.15 , pp. 344-357
    • Cecconi, F.1    Levine, B.2
  • 5
    • 77955172368 scopus 로고    scopus 로고
    • Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation
    • Gao, C. et al. Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. Nat. Cell Biol. 12, 781-790 (2010).
    • (2010) Nat. Cell Biol. , vol.12 , pp. 781-790
    • Gao, C.1
  • 6
    • 34347344990 scopus 로고    scopus 로고
    • Ambra1 regulates autophagy and development of the nervous system
    • Fimia, G. M. et al. Ambra1 regulates autophagy and development of the nervous system. Nature 447, 1121-1125 (2007).
    • (2007) Nature , vol.447 , pp. 1121-1125
    • Fimia, G.M.1
  • 7
    • 84857345898 scopus 로고    scopus 로고
    • Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells
    • Vázquez, P. et al. Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells. Autophagy 8, 187-199 (2012).
    • (2012) Autophagy , vol.8 , pp. 187-199
    • Vázquez, P.1
  • 8
    • 50649088457 scopus 로고    scopus 로고
    • Pattern formation in the vertebrate neural tube: A sonic hedgehog morphogen-regulated transcriptional network
    • Dessaud, E., McMahon, A. P. & Briscoe, J. Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network. Development 135, 2489-2503 (2008).
    • (2008) Development , vol.135 , pp. 2489-2503
    • Dessaud, E.1    McMahon, A.P.2    Briscoe, J.3
  • 9
    • 51949085076 scopus 로고    scopus 로고
    • Hedgehog: Functions and mechanisms
    • Varjosalo, M. & Taipale, J. Hedgehog: functions and mechanisms. Genes Dev. 22, 2454-2472 (2008).
    • (2008) Genes Dev. , vol.22 , pp. 2454-2472
    • Varjosalo, M.1    Taipale, J.2
  • 10
    • 33645734474 scopus 로고    scopus 로고
    • Hedgehog signalling: How to get from Smo to Ci and Gli
    • Østerlund, T. & Kogerman, P. Hedgehog signalling: how to get from Smo to Ci and Gli. Trends Cell Biol. 16, 176-180 (2006).
    • (2006) Trends Cell Biol. , vol.16 , pp. 176-180
    • Østerlund, T.1    Kogerman, P.2
  • 11
    • 0034329418 scopus 로고    scopus 로고
    • LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    • Kabeya, Y. et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19, 5720-5728 (2000).
    • (2000) EMBO J. , vol.19 , pp. 5720-5728
    • Kabeya, Y.1
  • 12
    • 0030027059 scopus 로고    scopus 로고
    • Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by Hedgehog
    • Goodrich, L. V., Johnson, R. L., Milenkovic, L., McMahon, J. A. & Scott, M. P. Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog. Genes Dev. 10, 301-312 (1996).
    • (1996) Genes Dev. , vol.10 , pp. 301-312
    • Goodrich, L.V.1    Johnson, R.L.2    Milenkovic, L.3    McMahon, J.A.4    Scott, M.P.5
  • 13
    • 0030601955 scopus 로고    scopus 로고
    • Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development
    • Marigo, V., Johnson, R. L., Vortkamp, A. & Tabin, C. J. Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. Dev. Biol. 180, 273-283 (1996).
    • (1996) Dev. Biol. , vol.180 , pp. 273-283
    • Marigo, V.1    Johnson, R.L.2    Vortkamp, A.3    Tabin, C.J.4
  • 14
    • 33645211374 scopus 로고    scopus 로고
    • Purmorphamine activates the Hedgehog pathway by targeting smoothened
    • Sinha, S. & Chen, J. K. Purmorphamine activates the Hedgehog pathway by targeting smoothened. Nat. Chem. Biol. 2, 29-30 (2006).
    • (2006) Nat. Chem. Biol. , vol.2 , pp. 29-30
    • Sinha, S.1    Chen, J.K.2
  • 15
    • 0030891148 scopus 로고    scopus 로고
    • A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro
    • Sasaki, H., Hui, C., Nakafuku, M. & Kondoh, H. A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development 124, 1313-1322 (1997).
    • (1997) Development , vol.124 , pp. 1313-1322
    • Sasaki, H.1    Hui, C.2    Nakafuku, M.3    Kondoh, H.4
  • 16
    • 0036566266 scopus 로고    scopus 로고
    • Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy
    • Ravikumar, B., Duden, R. & Rubinsztein, D. C. Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy. Hum. Mol. Genet. 11, 1107-1117 (2002).
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 1107-1117
    • Ravikumar, B.1    Duden, R.2    Rubinsztein, D.C.3
  • 17
    • 84863338229 scopus 로고    scopus 로고
    • The crosstalk of mTOR/S6K1 and Hedgehog pathways
    • Wang, Y. et al. The crosstalk of mTOR/S6K1 and Hedgehog pathways. Cancer Cell 21, 374-387 (2012).
    • (2012) Cancer Cell , vol.21 , pp. 374-387
    • Wang, Y.1
  • 18
    • 33645220566 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling
    • Riobó, N. A., Lu, K., Ai, X., Haines, G. M. & Emerson, Jr C. P. Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling. Proc. Natl Acad. Sci. USA 103, 4505-4510 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 4505-4510
    • Riobó, N.A.1    Lu, K.2    Ai, X.3    Haines, G.M.4    Emerson Jr., C.P.5
  • 19
    • 34247161367 scopus 로고    scopus 로고
    • Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein
    • Sarkar, S., Davies, J. E., Huang, Z., Tunnacliffe, A. & Rubinsztein, D. C. Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein. J. Biol. Chem. 282, 5641-5652 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 5641-5652
    • Sarkar, S.1    Davies, J.E.2    Huang, Z.3    Tunnacliffe, A.4    Rubinsztein, D.C.5
  • 20
    • 0031593675 scopus 로고    scopus 로고
    • Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells
    • Yamamoto, A. et al. Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells. Cell Struct. Funct. 23, 33-42 (1998).
    • (1998) Cell Struct. Funct. , vol.23 , pp. 33-42
    • Yamamoto, A.1
  • 22
    • 59249105964 scopus 로고    scopus 로고
    • Monitoring autophagic degradation of p62/SQSTM1
    • Bjørkøy, G. et al. Monitoring autophagic degradation of p62/SQSTM1. Meth. Enzymol. 452, 181-197 (2009).
    • (2009) Meth. Enzymol. , vol.452 , pp. 181-197
    • Bjørkøy, G.1
  • 23
    • 79961105298 scopus 로고    scopus 로고
    • A fluorescence-microscopic and cytofluorometric system for monitoring the turnover of the autophagic substrate p62/SQSTM1
    • BenYounès, A. et al. A fluorescence-microscopic and cytofluorometric system for monitoring the turnover of the autophagic substrate p62/SQSTM1. Autophagy 7, 883-891 (2011).
    • (2011) Autophagy , vol.7 , pp. 883-891
    • Benyounès, A.1
  • 24
    • 0035911162 scopus 로고    scopus 로고
    • Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells
    • Mizushima, N. et al. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J. Cell Biol. 152, 657-668 (2001).
    • (2001) J. Cell Biol. , vol.152 , pp. 657-668
    • Mizushima, N.1
  • 25
    • 34548077575 scopus 로고    scopus 로고
    • Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3
    • Kimura, S., Noda, T. & Yoshimori, T. Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3. Autophagy 3, 452-460 (2007).
    • (2007) Autophagy , vol.3 , pp. 452-460
    • Kimura, S.1    Noda, T.2    Yoshimori, T.3
  • 26
    • 0036829397 scopus 로고    scopus 로고
    • Inhibition of Hedgehog signaling by direct binding of cyclopamine to smoothened
    • Chen, J. K., Taipale, J., Cooper, M. K. & Beachy, P. A. Inhibition of Hedgehog signaling by direct binding of cyclopamine to smoothened. Genes Dev. 16, 2743-2748 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 2743-2748
    • Chen, J.K.1    Taipale, J.2    Cooper, M.K.3    Beachy, P.A.4
  • 27
    • 0035691773 scopus 로고    scopus 로고
    • Gli1 can rescue the in vivo function of Gli2
    • Bai, C. B. & Joyner, A. L. Gli1 can rescue the in vivo function of Gli2. Development 128, 5161-5172 (2001).
    • (2001) Development , vol.128 , pp. 5161-5172
    • Bai, C.B.1    Joyner, A.L.2
  • 28
    • 0031679850 scopus 로고    scopus 로고
    • Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system
    • Matise, M. P., Epstein, D. J., Park, H. L., Platt, K. A. & Joyner, A. L. Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development 125, 2759-2770 (1998).
    • (1998) Development , vol.125 , pp. 2759-2770
    • Matise, M.P.1    Epstein, D.J.2    Park, H.L.3    Platt, K.A.4    Joyner, A.L.5
  • 29
    • 0034055649 scopus 로고    scopus 로고
    • Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation
    • Park, H. L. et al. Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development 127, 1593-1605 (2000).
    • (2000) Development , vol.127 , pp. 1593-1605
    • Park, H.L.1
  • 30
    • 0034681266 scopus 로고    scopus 로고
    • Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb
    • Wang, B., Fallon, J. F. & Beachy, P. A. Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell 100, 423-434 (2000).
    • (2000) Cell , vol.100 , pp. 423-434
    • Wang, B.1    Fallon, J.F.2    Beachy, P.A.3
  • 31
    • 33744935032 scopus 로고    scopus 로고
    • Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling
    • Lipinski, R. J., Gipp, J. J., Zhang, J., Doles, J. D. & Bushman, W. Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling. Exp. Cell Res. 312, 1925-1938 (2006).
    • (2006) Exp. Cell Res. , vol.312 , pp. 1925-1938
    • Lipinski, R.J.1    Gipp, J.J.2    Zhang, J.3    Doles, J.D.4    Bushman, W.5
  • 32
    • 61949220840 scopus 로고    scopus 로고
    • Genetic manipulation and monitoring of autophagy in Drosophila
    • Neufeld, T. P. Genetic manipulation and monitoring of autophagy in Drosophila. Meth. Enzymol. 451, 653-667 (2008).
    • (2008) Meth. Enzymol. , vol.451 , pp. 653-667
    • Neufeld, T.P.1
  • 33
    • 4344563878 scopus 로고    scopus 로고
    • Role and regulation of starvation-induced autophagy in the Drosophila fat body
    • Scott, R. C., Schuldiner, O. & Neufeld, T. P. Role and regulation of starvation-induced autophagy in the Drosophila fat body. Dev. Cell 7, 167-178 (2004).
    • (2004) Dev. Cell , vol.7 , pp. 167-178
    • Scott, R.C.1    Schuldiner, O.2    Neufeld, T.P.3
  • 34
    • 0033582908 scopus 로고    scopus 로고
    • Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus
    • Méthot, N. & Basler, K. Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus. Cell 96, 819-831 (1999).
    • (1999) Cell , vol.96 , pp. 819-831
    • Méthot, N.1    Basler, K.2
  • 35
    • 7444247429 scopus 로고    scopus 로고
    • Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2
    • Regl, G. et al. Activation of the BCL2 promoter in response to Hedgehog/GLI signal transduction is predominantly mediated by GLI2. Cancer Res. 64, 7724-7731 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 7724-7731
    • Regl, G.1
  • 36
    • 45549090772 scopus 로고    scopus 로고
    • Gli2 upregulates cFlip and renders basal cell carcinoma cells resistant to death ligand-mediated apoptosis
    • Kump, E., Ji, J., Wernli, M., Häusermann, P. & Erb, P. Gli2 upregulates cFlip and renders basal cell carcinoma cells resistant to death ligand-mediated apoptosis. Oncogene 27, 3856-3864 (2008).
    • (2008) Oncogene , vol.27 , pp. 3856-3864
    • Kump, E.1    Ji, J.2    Wernli, M.3    Häusermann, P.4    Erb, P.5
  • 37
    • 25144457455 scopus 로고    scopus 로고
    • Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
    • Pattingre, S. et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122, 927-939 (2005).
    • (2005) Cell , vol.122 , pp. 927-939
    • Pattingre, S.1
  • 38
    • 70449529788 scopus 로고    scopus 로고
    • FLIP-mediated autophagy regulation in cell death control
    • Lee, J.-S. et al. FLIP-mediated autophagy regulation in cell death control. Nat. Cell Biol. 11, 1355-1362 (2009).
    • (2009) Nat. Cell Biol. , vol.11 , pp. 1355-1362
    • Lee, J.-S.1
  • 39
    • 77953728406 scopus 로고    scopus 로고
    • GABARAPL1 (GEC1) associates with autophagic vesicles
    • Chakrama, F. Z. et al. GABARAPL1 (GEC1) associates with autophagic vesicles. Autophagy 6, 495-505 (2010).
    • (2010) Autophagy , vol.6 , pp. 495-505
    • Chakrama, F.Z.1
  • 40
    • 82255173966 scopus 로고    scopus 로고
    • The unfolded protein response: From stress pathway to homeostatic regulation
    • Walter, P. & Ron, D. The unfolded protein response: from stress pathway to homeostatic regulation. Science 334, 1081-1086 (2011).
    • (2011) Science , vol.334 , pp. 1081-1086
    • Walter, P.1    Ron, D.2
  • 41
    • 33846211417 scopus 로고    scopus 로고
    • ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation
    • Kouroku, Y. et al. ER stress (PERK/eIF2alpha phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation. Cell Death Differ. 14, 230-239 (2007).
    • (2007) Cell Death Differ. , vol.14 , pp. 230-239
    • Kouroku, Y.1
  • 42
    • 74949118681 scopus 로고    scopus 로고
    • The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5
    • Rouschop, K. M. A. et al. The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. J. Clin. Invest. 120, 127-141 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 127-141
    • Rouschop, K.M.A.1
  • 43
    • 0037039442 scopus 로고    scopus 로고
    • Regulation of starvation-and virus-induced autophagy by the eIF2alpha kinase signaling pathway
    • Tallóczy, Z. et al. Regulation of starvation-and virus-induced autophagy by the eIF2alpha kinase signaling pathway. Proc. Natl Acad. Sci. USA 99, 190-195 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 190-195
    • Tallóczy, Z.1
  • 44
    • 0034973982 scopus 로고    scopus 로고
    • Translational control is required for the unfolded protein response and in vivo glucose homeostasis
    • Scheuner, D. et al. Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol. Cell 7, 1165-1176 (2001).
    • (2001) Mol. Cell , vol.7 , pp. 1165-1176
    • Scheuner, D.1
  • 45
    • 62549159642 scopus 로고    scopus 로고
    • Hedgehog signal transduction by smoothened: Pharmacologic evidence for a 2-step activation process
    • Rohatgi, R., Milenkovic, L., Corcoran, R. B. & Scott, M. P. Hedgehog signal transduction by smoothened: pharmacologic evidence for a 2-step activation process. Proc. Natl Acad. Sci. USA 106, 3196-3201 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 3196-3201
    • Rohatgi, R.1    Milenkovic, L.2    Corcoran, R.B.3    Scott, M.P.4
  • 46
    • 1342282946 scopus 로고    scopus 로고
    • The Kinesin-related protein Costal2 associates with membranes in a Hedgehog-sensitive, smoothened-independent manner
    • Stegman, M. A. et al. The Kinesin-related protein Costal2 associates with membranes in a Hedgehog-sensitive, smoothened-independent manner. J. Biol. Chem. 279, 7064-7071 (2004).
    • (2004) J. Biol. Chem. , vol.279 , pp. 7064-7071
    • Stegman, M.A.1
  • 47
    • 77955420936 scopus 로고    scopus 로고
    • Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer
    • Barakat, M. T., Humke, E. W. & Scott, M. P. Learning from Jekyll to control Hyde: Hedgehog signaling in development and cancer. Trends Mol. Med. 16, 337-348 (2010).
    • (2010) Trends Mol. Med. , vol.16 , pp. 337-348
    • Barakat, M.T.1    Humke, E.W.2    Scott, M.P.3
  • 48
    • 69949106925 scopus 로고    scopus 로고
    • The double-edged sword of autophagy modulation in cancer
    • White, E. & DiPaola, R. S. The double-edged sword of autophagy modulation in cancer. Clin. Cancer Res. 15, 5308-5316 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , pp. 5308-5316
    • White, E.1    Dipaola, R.S.2
  • 49
    • 0034738979 scopus 로고    scopus 로고
    • Effects of oncogenic mutations in smoothened and patched can be reversed by cyclopamine
    • Taipale, J. et al. Effects of oncogenic mutations in smoothened and patched can be reversed by cyclopamine. Nature 406, 1005-1009 (2000).
    • (2000) Nature , vol.406 , pp. 1005-1009
    • Taipale, J.1
  • 50
    • 0037200078 scopus 로고    scopus 로고
    • Medulloblastoma growth inhibition by hedgehog pathway blockade
    • Berman, D. M. et al. Medulloblastoma growth inhibition by hedgehog pathway blockade. Science 297, 1559-1561 (2002).
    • (2002) Science , vol.297 , pp. 1559-1561
    • Berman, D.M.1
  • 51
    • 67349224197 scopus 로고    scopus 로고
    • Cyclopamine inhibition of human breast cancer cell growth independent of smoothened (Smo)
    • Zhang, X. et al. Cyclopamine inhibition of human breast cancer cell growth independent of smoothened (Smo). Breast Cancer Res. Treat. 115, 505-521 (2009).
    • (2009) Breast Cancer Res. Treat. , vol.115 , pp. 505-521
    • Zhang, X.1
  • 52
    • 63549116774 scopus 로고    scopus 로고
    • Germ cell migration in zebrafish is cyclopamine-sensitive but smoothened-independent
    • Mich, J. K. et al. Germ cell migration in zebrafish is cyclopamine-sensitive but smoothened-independent. Dev. Biol. 328, 342-354 (2009).
    • (2009) Dev. Biol. , vol.328 , pp. 342-354
    • Mich, J.K.1
  • 53
    • 33646111185 scopus 로고    scopus 로고
    • Overlapping and distinct transcriptional regulator properties of the GLI1 and GLI2 oncogenes
    • Eichberger, T. et al. Overlapping and distinct transcriptional regulator properties of the GLI1 and GLI2 oncogenes. Genomics 87, 616-632 (2006).
    • (2006) Genomics , vol.87 , pp. 616-632
    • Eichberger, T.1
  • 54
    • 33646270662 scopus 로고    scopus 로고
    • Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation
    • Pan, Y., Bai, C. B., Joyner, A. L. & Wang, B. Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation. Mol. Cell Biol. 26, 3365-3377 (2006).
    • (2006) Mol. Cell Biol. , vol.26 , pp. 3365-3377
    • Pan, Y.1    Bai, C.B.2    Joyner, A.L.3    Wang, B.4
  • 55
    • 78049398265 scopus 로고    scopus 로고
    • The antioxidant transcription factor Nrf2 negatively regulates autophagy and growth arrest induced by the anticancer redox agent mitoquinone
    • Rao, V. A. et al. The antioxidant transcription factor Nrf2 negatively regulates autophagy and growth arrest induced by the anticancer redox agent mitoquinone. J. Biol. Chem. 285, 34447-34459 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 34447-34459
    • Rao, V.A.1
  • 56
    • 0141752795 scopus 로고    scopus 로고
    • Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival
    • Cullinan, S. B. et al. Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol. Cell. Biol. 23, 7198-7209 (2003).
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 7198-7209
    • Cullinan, S.B.1
  • 57
    • 65249089754 scopus 로고    scopus 로고
    • Methodological considerations for assessing autophagy modulators: A study with calcium phosphate precipitates
    • Sarkar, S., Korolchuk, V., Renna, M., Winslow, A. & Rubinsztein, D. C. Methodological considerations for assessing autophagy modulators: a study with calcium phosphate precipitates. Autophagy 5, 307-313 (2009).
    • (2009) Autophagy , vol.5 , pp. 307-313
    • Sarkar, S.1    Korolchuk, V.2    Renna, M.3    Winslow, A.4    Rubinsztein, D.C.5
  • 58
    • 0037026603 scopus 로고    scopus 로고
    • Alternative first exons of PTCH1 are differentially regulated in vivo and may confer different functions to the PTCH1 protein
    • Kogerman, P. et al. Alternative first exons of PTCH1 are differentially regulated in vivo and may confer different functions to the PTCH1 protein. Oncogene 21, 6007-6016 (2002).
    • (2002) Oncogene , vol.21 , pp. 6007-6016
    • Kogerman, P.1
  • 59
    • 12144288863 scopus 로고    scopus 로고
    • Distinct roles of PTCH2 splice variants in Hedgehog signalling
    • Rahnama, F., Toftgård, R. & Zaphiropoulos, P. G. Distinct roles of PTCH2 splice variants in Hedgehog signalling. Biochem. J. 378, 325-334 (2004).
    • (2004) Biochem. J. , vol.378 , pp. 325-334
    • Rahnama, F.1    Toftgård, R.2    Zaphiropoulos, P.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.