DNA demethylases: A new epigenetic frontier in drug discovery

Drug Discovery Today

Volumn 16, Issue 15-16, 2011, Pages 683-690

  Carey, Nessa ^a   Marques, C Joana ^b,d   Reik, Wolf ^b,c  

^a Chesterford Research Park   (United Kingdom)

^b BABRAHAM INSTITUTE   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^d University of Porto   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; 5 HYDROXYMETHYLCYTOSINE; 5 METHYLCYTOSINE; ACTIVATION INDUCED CYTIDINE DEAMINASE; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 1; ARGIPRESSIN; AZACITIDINE; CORTICOTROPIN RELEASING FACTOR; CYTIDINE DEAMINASE; CYTOSINE; DNA GLYCOSYLTRANSFERASE; DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; ELONGATION FACTOR 1; ELONGATION FACTOR 2; ELONGATION FACTOR 3; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; METHYL CPG BINDING PROTEIN; METHYL CPG BINDING PROTEIN 2; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; RING FINGER PROTEIN; THYMINE DNA GLYCOSYLASE;

APOPTOSIS; BLASTOCYST; CELL CYCLE; CELL DIVISION; CELL MIGRATION; CELL PROLIFERATION; CHROMATIN; CPG ISLAND; DNA METHYLATION; DNA REPLICATION; ENHANCER REGION; ENZYME ACTIVITY; EPIGENETICS; EXCISION REPAIR; FERTILIZATION; GAMETE; GENE CONTROL; GENE OVEREXPRESSION; GENE REPRESSION; GENE SILENCING; GENOME IMPRINTING; HUMAN; HYDROXYLATION; LIFE STRESS; NONHUMAN; PRIMORDIAL GERM CELL; PROMOTER REGION; REVIEW; ZYGOTE;

ANIMALS; ANTINEOPLASTIC AGENTS; DNA METHYLATION; DRUG DELIVERY SYSTEMS; DRUG DESIGN; DRUG DISCOVERY; EPIGENESIS, GENETIC; HUMANS;

EID: 80051665371     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2011.05.004     Document Type: Review

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