Roundabout 4 regulates blood-tumor barrier permeability through the modulation of ZO-1, occludin, and claudin-5 expression

Journal of Neuropathology and Experimental Neurology

Volumn 74, Issue 1, 2015, Pages 25-37

  Cai, Heng ^a   Liu, Wenjing ^b   Xue, Yixue ^a,c   Shang, Xiuli ^b   Liu, Jing ^a   Li, Zhen ^a   Wang, Ping ^a,c   Liu, Libo ^a,c   Hu, Yi ^a   Liu, Yunhui ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b First University Hospital   (China)

^c Liaoning Institute of Basic Medicine   (China)

Author keywords

BloodYtumor barrier; Glioma; MMP 9; Roundabout 4; Tight junction

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CLAUDIN 5; COMPLEMENTARY DNA; GELATINASE A; GELATINASE B; ILOMASTAT; MATRIX METALLOPROTEINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; OCCLUDIN; PROTEIN ZO1; ROUNDABOUT RECEPTOR; ROUNDABOUT RECEPTOR 4; SHORT HAIRPIN RNA; TIGHT JUNCTION PROTEIN; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; NERVE PROTEIN; PROTEIN TYROSINE KINASE; ROBO4 PROTEIN, HUMAN; SIGNAL PEPTIDE; SLIT HOMOLOG 2 PROTEIN;

ARTICLE; BLOOD BRAIN BARRIER; BLOOD TUMOR BARRIER; BLOOD VESSEL PERMEABILITY; BRAIN BLOOD VESSEL; BRAIN TUMOR; CONTROLLED STUDY; ELECTRIC RESISTANCE; ENDOTHELIUM CELL; GLIOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MICROVASCULATURE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TIGHT JUNCTION; WESTERN BLOTTING; CAPILLARY PERMEABILITY; CELL CULTURE; GENE EXPRESSION REGULATION; GENETICS; IMPEDANCE; METABOLISM; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION;

BLOOD-BRAIN BARRIER; BRAIN NEOPLASMS; CAPILLARY PERMEABILITY; CELLS, CULTURED; CLAUDIN-5; ELECTRIC IMPEDANCE; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLIOMA; GREEN FLUORESCENT PROTEINS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MATRIX METALLOPROTEINASE 9; NERVE TISSUE PROTEINS; OCCLUDIN; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; TIGHT JUNCTION PROTEINS; TRANSENDOTHELIAL AND TRANSEPITHELIAL MIGRATION; ZONULA OCCLUDENS-1 PROTEIN;

EID: 84920270616     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/NEN.0000000000000146     Document Type: Article

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