An approach to design potent anti-Alzheimer's agents by 3D-QSAR studies on fused 5,6-bicyclic heterocycles as γ-secretase modulators using kNN-MFA methodology

Arabian Journal of Chemistry

Volumn 7, Issue 6, 2014, Pages 924-935

  Bhadoriya, Kamlendra Singh ^a   Sharma, Mukesh C ^b   Sharma, Smita ^c   Jain, Shailesh V ^d   Avchar, Mandar H ^a  

^a RC Patel Institute of Pharmaceutical Education and Research   (India)

^b DEVI AHILYA UNIVERSITY   (India)

^c Chodhary Dilip Singh Kanya Mahavidyalya   (India)

^d NIRMA UNIVERSITY   (India)

Author keywords

3D QSAR; Alzheimer's disease; Fused 5,6 bicyclic heterocycles; Hydrophobic and steric descriptors; KNN MFA; Secretase modulators

Indexed keywords

3D MODELING; BINDING ENERGY; COMPUTATIONAL CHEMISTRY; DISEASE CONTROL; HYDROPHOBICITY; MOLECULAR GRAPHICS; STRUCTURAL DESIGN; STRUCTURES (BUILT OBJECTS);

3D-QSAR; ALZHEIMER'S DISEASE; DESCRIPTORS; HETEROCYCLES; KNN-MFA; SECRETASES;

NEURODEGENERATIVE DISEASES;

EID: 84920197868     PISSN: 18785352     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arabjc.2013.02.002     Document Type: Article

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