Triazoles as γ-secretase modulators

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 13, 2011, Pages 4083-4087

  Fischer, Christian ^a   Zultanski, Susan L ^a   Zhou, Hua ^a   Methot, Joey L ^a   Brown, W Colby ^a   Mampreian, Dawn M ^a   Schell, Adam J ^a   Shah, Sanjiv ^a   Nuthall, Hugh ^a   Hughes, Bethany L ^a   Smotrov, Nadja ^a   Kenific, Candia M ^a   Cruz, Jonathan C ^a   Walker, Deborah ^a   Bouthillette, Melanie ^a   Nikov, George N ^a   Savage, Dan F ^a   Jeliazkova Mecheva, Valentina V ^a   Diaz, Damaris ^a   Szewczak, Alexander A ^a   Bays, Nathan ^a   Middleton, Richard E ^a   Munoz, Benito ^a   Shearman, Mark S ^a   more..

^a Merck Research Laboratories Boston   (United States)

Author keywords

Abeta lowering; Alzheimer; GSM; Lead optimization; Secretase

Indexed keywords

ALKENE; AMYLOID BETA PROTEIN[1-42]; GAMMA SECRETASE; TRIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; NONHUMAN; RAT;

AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ENZYME ACTIVATION; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

RATTUS;

EID: 79958701021     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.04.089     Document Type: Article

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