Discovery of potent anticonvulsant ligands as dual NMDA and AMPA receptors antagonists by molecular modelling studies

Medicinal Chemistry Research

Volumn 21, Issue 11, 2012, Pages 3465-3484

  Jain, Shailesh V ^a   Bhadoriya, Kamlendra S ^b   Bari, Sanjaykumar B ^b   Sahu, Nitendra K ^c   Ghate, Manjunath ^a  

^a NIRMA UNIVERSITY   (India)

^b R C PATEL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH   (India)

^c DR H S GOUR UNIVERSITY   (India)

Author keywords

2D and 3D QSAR; Aminobenzothiazole; AMPA receptor; Gly NMDA receptor; Pharmacophore; Virtual screening

Indexed keywords

2 [5 (4 DIMETHYLSULFAMOYLPHENYL) 6,7,8,9 TETRAHYDRO 8 METHYL 2 OXO 1H PYRROLO[3,2 H]ISOQUINOLIN 3 YLIMINOXY] 4 HYDROXYBUTYRIC ACID; AC 12; AC 18; AC 22; AC 23; AC 24; AC 31; AC 4; AC 40; AC 45; AC 51; AC 52; AC 58; AC 61; AC 99; AMPA RECEPTOR ANTAGONIST; ANTICONVULSIVE AGENT; CGP 395551; D AP 5; FELBAMATE; IFENPRODIL; LIGAND; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHENOBARBITAL; REMACEMIDE; TALAMPANEL; UNCLASSIFIED DRUG;

ANTICONVULSANT ACTIVITY; ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; HYDROGEN BOND; MOLECULAR DOCKING; PHARMACOPHORE; PREDICTION; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

EID: 84871450508     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-011-9889-5     Document Type: Article

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