Iminoheterocycles as γ-secretase modulators

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 18, 2010, Pages 5380-5384

  Caldwell, John P ^a   Bennett, Chad E ^a   McCracken, Troy M ^a   Mazzola, Robert D ^a   Bara, Thomas ^a   Buevich, Alexei ^a   Burnett, Duane A ^a   Chu, Inhou ^a   Cohen Williams, Mary ^a   Josein, Hubert ^a   Hyde, Lynn ^a   Lee, Julie ^a   McKittrick, Brian ^a   Song, Lixin ^a   Terracina, Giuseppe ^a   Voigt, Johannes ^a   Zhang, Lili ^a   Zhu, Zhaoning ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Secretase modulators; Alzheimer's disease

Indexed keywords

1 (4 FLUOROPHENYL)ETHANAMINE; AMYLOID BETA PROTEIN[1-42]; EISAI; GAMMA SECRETASE; PROSTAGLANDIN SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; IC 50; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BRAIN; HUMANS; IMINES; MICE; MICE, TRANSGENIC; PEPTIDE FRAGMENTS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 77956176235     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.07.121     Document Type: Article

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