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Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 17, 2010, Pages 5282-5285

Novel Notch-sparing γ-secretase inhibitors derived from a peroxisome proliferator-activated receptor agonist library

(7) Kurosumi, Motonori a Nishio, Yoshino a Osawa, Satoko b Kobayashi, Hisayoshi b Iwatsubo, Takeshi b,c,d Tomita, Taisuke b,c Miyachi, Hiroyuki a

a OKAYAMA UNIVERSITY (Japan)

b UNIVERSITY OF TOKYO (Japan)

c JAPAN SCIENCE AND TECHNOLOGY AGENCY (Japan)

d UNIVERSITY OF TOKYO (Japan)

Author keywords

Secretase; Secretase inhibitor; Notch sparing secretase inhibitor; PPAR

Indexed keywords

CINNAMIC ACID DERIVATIVE; DIMETHYL SULFOXIDE; ESTER DERIVATIVE; GAMMA SECRETASE INHIBITOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PROPIONIC ACID DERIVATIVE; SULINDAC SULFIDE;

ARTICLE; CRYSTALLIZATION; DRUG SCREENING; HYDROLYSIS; IC 50; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION;

AMYLOID PRECURSOR PROTEIN SECRETASES; ENZYME INHIBITORS; PPAR GAMMA; RECEPTORS, NOTCH; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955662670 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.06.131 Document Type: Article

Times cited : (7)

References (29)

1
- 66349133387
- T. Tomita Expert Rev. Neurother. 9 2009 661
- (2009) Expert Rev. Neurother. , vol.9 , pp. 661
- Tomita, T.¹

2
- 0037468759
- N. Takasugi, T. Tomita, I. Hayashi, M. Tsuruoka, M. Niimura, Y. Takahashi, G. Thinakaran, and T. Iwatsubo Nature 422 2003 438
- (2003) Nature , vol.422 , pp. 438
- Takasugi, N.¹ Tomita, T.² Hayashi, I.³ Tsuruoka, M.⁴ Niimura, M.⁵ Takahashi, Y.⁶ Thinakaran, G.⁷ Iwatsubo, T.⁸

3
- 0027258525
- J.T. Jarrett, E.P. Berger, and P.T. Lansbury Jr. Biochemistry 32 1993 4693
- (1993) Biochemistry , vol.32 , pp. 4693
- Jarrett, J.T.¹ Berger, E.P.² Lansbury Jr., P.T.³

4
- 0027332081
- A.E. Roher, J.D. Lowenson, S. Clarke, A.S. Woods, R.J. Cotter, E. Gowing, and M.J. Ball Proc. Natl. Acad. Sci. U.S.A. 90 1993 10836
- (1993) Proc. Natl. Acad. Sci. U.S.A. , vol.90 , pp. 10836
- Roher, A.E.¹ Lowenson, J.D.² Clarke, S.³ Woods, A.S.⁴ Cotter, R.J.⁵ Gowing, E.⁶ Ball, M.J.⁷

5
- 0028169925
- T. Iwatsubo, A. Odaka, N. Suzuki, H. Mizusawa, N. Nukina, and Y. Ihara Neuron 13 1994 45
- (1994) Neuron , vol.13 , pp. 45
- Iwatsubo, T.¹ Odaka, A.² Suzuki, N.³ Mizusawa, H.⁴ Nukina, N.⁵ Ihara, Y.⁶

6
- 0242412482
- G.H. Searfoss, W.H. Jordan, D.O. Calligaro, E.J. Galbreath, L.M. Schirtzinger, B.R. Berridge, H. Gao, M.A. Higgins, P.C. May, and T.P. Ryan J. Biol. Chem. 278 2003 46107
- (2003) J. Biol. Chem. , vol.278 , pp. 46107
- Searfoss, G.H.¹ Jordan, W.H.² Calligaro, D.O.³ Galbreath, E.J.⁴ Schirtzinger, L.M.⁵ Berridge, B.R.⁶ Gao, H.⁷ Higgins, M.A.⁸ May, P.C.⁹ Ryan, T.P.¹⁰

7
- 11144355129
- G.T. Wong, D. Manfra, F.M. Poulet, Q. Zhang, H. Josien, T. Bara, L. Engstrom, M. Pinzon-Ortiz, J.S. Fine, H.J. Lee, L. Zhang, G.A. Higgins, and E.M. Parker J. Biol. Chem. 279 2004 12876
- (2004) J. Biol. Chem. , vol.279 , pp. 12876
- Wong, G.T.¹ Manfra, D.² Poulet, F.M.³ Zhang, Q.⁴ Josien, H.⁵ Bara, T.⁶ Engstrom, L.⁷ Pinzon-Ortiz, M.⁸ Fine, J.S.⁹ Lee, H.J.¹⁰ Zhang, L.¹¹ Higgins, G.A.¹² Parker, E.M.¹³

8
- 8444247084
- J. Milano, J. McKay, C. Dagenais, L. Foster-Brown, F. Pognan, R. Gadient, R.T. Jacobs, A. Zacco, B. Greenberg, and P.J. Ciaccio Toxicol. Sci. 82 2004 341
- (2004) Toxicol. Sci. , vol.82 , pp. 341
- Milano, J.¹ McKay, J.² Dagenais, C.³ Foster-Brown, L.⁴ Pognan, F.⁵ Gadient, R.⁶ Jacobs, R.T.⁷ Zacco, A.⁸ Greenberg, B.⁹ Ciaccio, P.J.¹⁰

9
- 0035005101
- A. Petit, F. Bihel, C. Alves da Costa, O. Pourquie, F. Checler, and J.L. Kraus Nat. Cell Biol. 3 2001 507
- (2001) Nat. Cell Biol. , vol.3 , pp. 507
- Petit, A.¹ Bihel, F.² Alves Da Costa, C.³ Pourquie, O.⁴ Checler, F.⁵ Kraus, J.L.⁶

10
- 0035829592
- S. Weggen, J.L. Eriksen, P. Das, S.A. Sagi, R. Wang, C.U. Pietrzik, K.A. Findlay, T.E. Smith, M.P. Murphy, T. Bulter, D.E. Kang, N. Marquez-Sterling, T.E. Golde, and E.H. Koo Nature 414 2001 212
- (2001) Nature , vol.414 , pp. 212
- Weggen, S.¹ Eriksen, J.L.² Das, P.³ Sagi, S.A.⁴ Wang, R.⁵ Pietrzik, C.U.⁶ Findlay, K.A.⁷ Smith, T.E.⁸ Murphy, M.P.⁹ Bulter, T.¹⁰ Kang, D.E.¹¹ Marquez-Sterling, N.¹² Golde, T.E.¹³ Koo, E.H.¹⁴

11
- 21044458540
- T. Kukar, M.P. Murphy, J.L. Eriksen, S.A. Sagi, S. Weggen, T.E. Smith, T. Ladd, M.A. Khan, R. Kache, J. Beard, M. Dodson, S. Merit, V.V. Ozols, P.Z. Anastasiadis, P. Das, A. Fauq, E.H. Koo, and T.E. Golde Nat. Med. 11 2005 545
- (2005) Nat. Med. , vol.11 , pp. 545
- Kukar, T.¹ Murphy, M.P.² Eriksen, J.L.³ Sagi, S.A.⁴ Weggen, S.⁵ Smith, T.E.⁶ Ladd, T.⁷ Khan, M.A.⁸ Kache, R.⁹ Beard, J.¹⁰ Dodson, M.¹¹ Merit, S.¹² Ozols, V.V.¹³ Anastasiadis, P.Z.¹⁴ Das, P.¹⁵ Fauq, A.¹⁶ Koo, E.H.¹⁷ Golde, T.E.¹⁸

12
- 45149105232
- T.L. Kukar, T.B. Ladd, M.A. Bann, P.C. Fraering, R. Narlawar, G.M. Maharvi, B. Healy, R. Chapman, A.T. Welzel, R.W. Price, B. Moore, V. Rangachari, B. Cusack, J. Eriksen, K. Jansen-West, C. Verbeeck, D. Yager, C. Eckman, W. Ye, S. Sagi, B.A. Cottrell, J. Torpey, T.L. Rosenberry, A. Fauq, M.S. Wolfe, B. Schmidt, D.M. Walsh, E.H. Koo, and T.E. Golde Nature 453 2008 925
- (2008) Nature , vol.453 , pp. 925
- Kukar, T.L.¹ Ladd, T.B.² Bann, M.A.³ Fraering, P.C.⁴ Narlawar, R.⁵ Maharvi, G.M.⁶ Healy, B.⁷ Chapman, R.⁸ Welzel, A.T.⁹ Price, R.W.¹⁰ Moore, B.¹¹ Rangachari, V.¹² Cusack, B.¹³ Eriksen, J.¹⁴ Jansen-West, K.¹⁵ Verbeeck, C.¹⁶ Yager, D.¹⁷ Eckman, C.¹⁸ Ye, W.¹⁹ Sagi, S.²⁰ more..

13
- 19944430290
- D.M. Barten, V.L. Guss, J.A. Corsa, A. Loo, S.B. Hansel, M. Zheng, B. Munoz, K. Srinivasan, B. Wang, B.J. Robertson, C.T. Polson, J. Wang, S.B. Roberts, J.P. Hendrick, J.J. Anderson, J.K. Loy, R. Denton, T.A. Verdoorn, D.W. Smith, and K.M. Felsenstein J. Pharmacol. Exp. Ther. 312 2005 635
- (2005) J. Pharmacol. Exp. Ther. , vol.312 , pp. 635
- Barten, D.M.¹ Guss, V.L.² Corsa, J.A.³ Loo, A.⁴ Hansel, S.B.⁵ Zheng, M.⁶ Munoz, B.⁷ Srinivasan, K.⁸ Wang, B.⁹ Robertson, B.J.¹⁰ Polson, C.T.¹¹ Wang, J.¹² Roberts, S.B.¹³ Hendrick, J.P.¹⁴ Anderson, J.J.¹⁵ Loy, J.K.¹⁶ Denton, R.¹⁷ Verdoorn, T.A.¹⁸ Smith, D.W.¹⁹ Felsenstein, K.M.²⁰ more..

14
- 47149093140
- A. Kreft, B. Harrison, S. Aschmies, K. Atchison, D. Casebier, D.C. Cole, G. Diamantidis, J. Ellingboe, D. Hauze, Y. Hu, D. Huryn, M. Jin, D. Kubrak, P. Lu, J. Lundquist, C. Mann, R. Martone, W. Moore, A. Oganesian, A. Porte, D.R. Riddell, J. Sonnenberg-Reines, J.R. Stock, S.C. Sun, E. Wagner, K. Woller, Z. Xu, H. Zhou, and J. Steven Jacobsen Bioorg. Med. Chem. Lett. 18 2008 4232
- (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 4232
- Kreft, A.¹ Harrison, B.² Aschmies, S.³ Atchison, K.⁴ Casebier, D.⁵ Cole, D.C.⁶ Diamantidis, G.⁷ Ellingboe, J.⁸ Hauze, D.⁹ Hu, Y.¹⁰ Huryn, D.¹¹ Jin, M.¹² Kubrak, D.¹³ Lu, P.¹⁴ Lundquist, J.¹⁵ Mann, C.¹⁶ Martone, R.¹⁷ Moore, W.¹⁸ Oganesian, A.¹⁹ Porte, A.²⁰ more..

15
- 73949087262
- C.C. Shelton, L. Zhu, D. Chau, L. Yang, R. Wang, H. Djaballah, H. Zheng, and Y.M. Li Proc. Natl. Acad. Sci. U.S.A. 106 2009 20228
- (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 20228
- Shelton, C.C.¹ Zhu, L.² Chau, D.³ Yang, L.⁴ Wang, R.⁵ Djaballah, H.⁶ Zheng, H.⁷ Li, Y.M.⁸

16
- 38849125598
- J. Kasuga, D. Yamasaki, K. Ogura, M. Shimizu, M. Sato, M. Makishima, T. Doi, Y. Hashimoto, and H. Miyachi Bioorg. Med. Chem. Lett. 18 2008 1110
- (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 1110
- Kasuga, J.¹ Yamasaki, D.² Ogura, K.³ Shimizu, M.⁴ Sato, M.⁵ Makishima, M.⁶ Doi, T.⁷ Hashimoto, Y.⁸ Miyachi, H.⁹

17
- 34249977052
- J. Kasuga, I. Nakagome, A. Aoyama, K. Sako, M. Ishizawa, M. Ogura, M. Makishima, S. Hirono, Y. Hashimoto, and H. Miyachi Bioorg. Med. Chem. 15 2007 5177
- (2007) Bioorg. Med. Chem. , vol.15 , pp. 5177
- Kasuga, J.¹ Nakagome, I.² Aoyama, A.³ Sako, K.⁴ Ishizawa, M.⁵ Ogura, M.⁶ Makishima, M.⁷ Hirono, S.⁸ Hashimoto, Y.⁹ Miyachi, H.¹⁰

18
- 30344435617
- J. Kasuga, Y. Hashimoto, and H. Miyachi Bioorg. Med. Chem. Lett. 16 2006 771
- (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 771
- Kasuga, J.¹ Hashimoto, Y.² Miyachi, H.³

19
- 33751065860
- J. Kasuga, D. Yamasaki, Y. Araya, A. Nakagawa, M. Makishima, T. Doi, Y. Hashimoto, and H. Miyachi Bioorg. Med. Chem. 14 2006 8405
- (2006) Bioorg. Med. Chem. , vol.14 , pp. 8405
- Kasuga, J.¹ Yamasaki, D.² Araya, Y.³ Nakagawa, A.⁴ Makishima, M.⁵ Doi, T.⁶ Hashimoto, Y.⁷ Miyachi, H.⁸

20
- 34250336128
- N. Isoo, C. Sato, H. Miyashita, M. Shinohara, N. Takasugi, Y. Morohashi, S. Tsuji, T. Tomita, and T. Iwatsubo J. Biol. Chem. 282 2007 12388
- (2007) J. Biol. Chem. , vol.282 , pp. 12388
- Isoo, N.¹ Sato, C.² Miyashita, H.³ Shinohara, M.⁴ Takasugi, N.⁵ Morohashi, Y.⁶ Tsuji, S.⁷ Tomita, T.⁸ Iwatsubo, T.⁹

21
- 0030003538
- R. Kopan, E.H. Schroeter, H. Weintraub, and J.S. Nye Proc. Natl. Acad. Sci. U.S.A. 93 1996 1683
- (1996) Proc. Natl. Acad. Sci. U.S.A. , vol.93 , pp. 1683
- Kopan, R.¹ Schroeter, E.H.² Weintraub, H.³ Nye, J.S.⁴

22
- 2642594045
- L.J. Strobl, H. Hofelmayr, C. Stein, G. Marschall, M. Brielmeier, G. Laux, G.W. Bornkamm, and U. Zimber-Strobl Immunobiology 198 1997 299
- (1997) Immunobiology , vol.198 , pp. 299
- Strobl, L.J.¹ Hofelmayr, H.² Stein, C.³ Marschall, G.⁴ Brielmeier, M.⁵ Laux, G.⁶ Bornkamm, G.W.⁷ Zimber-Strobl, U.⁸

23
- 67650513893
- Y. Imamura, N. Watanabe, N. Umezawa, T. Iwatsubo, N. Kato, T. Tomita, and T. Higuchi J. Am. Chem. Soc. 131 2009 7353
- (2009) J. Am. Chem. Soc. , vol.131 , pp. 7353
- Imamura, Y.¹ Watanabe, N.² Umezawa, N.³ Iwatsubo, T.⁴ Kato, N.⁵ Tomita, T.⁶ Higuchi, T.⁷

24
- 0035163347
- H.F. Dovey, V. John, J.P. Anderson, L.Z. Chen, A.P. de Saint, L.Y. Fang, S.B. Freedman, B. Folmer, E. Goldbach, E.J. Holsztynska, K.L. Hu, K.L. Johnson-Wood, S.L. Kennedy, D. Kholodenko, J.E. Knops, L.H. Latimer, M.Z. Lee, I.M. Lieberburg, R.N. Motter, L.C. Mutter, J. Nietz, K.P. Quinn, K.L. Sacchi, P.A. Seubert, G.M. Shopp, E.D. Thorsett, J.S. Tung, J. Wu, S. Yang, C.T. Yin, D.B. Schenk, P.C. May, L.D. Altstiel, M.H. Bender, L.N. Boggs, T.C. Britton, J.C. Clemens, D.L. Czilli, D.K. Dieckman-McGinty, J.J. Droste, K.S. Fuson, B.D. Gitter, P.A. Hyslop, E.M. Johnstone, W.Y. Li, S.P. Little, T.E. Mabry, F.D. Miller, and J.E. Audia J. Neurochem. 76 2001 173
- (2001) J. Neurochem. , vol.76 , pp. 173
- Dovey, H.F.¹ John, V.² Anderson, J.P.³ Chen, L.Z.⁴ De Saint, A.P.⁵ Fang, L.Y.⁶ Freedman, S.B.⁷ Folmer, B.⁸ Goldbach, E.⁹ Holsztynska, E.J.¹⁰ Hu, K.L.¹¹ Johnson-Wood, K.L.¹² Kennedy, S.L.¹³ Kholodenko, D.¹⁴ Knops, J.E.¹⁵ Latimer, L.H.¹⁶ Lee, M.Z.¹⁷ Lieberburg, I.M.¹⁸ Motter, R.N.¹⁹ Mutter, L.C.²⁰ more..

25
- 29544431526
- J. Kasuga, M. Makishima, Y. Hashimoto, and H. Miyachi Bioorg. Med. Chem. Lett. 16 2006 554
- (2006) Bioorg. Med. Chem. Lett. , vol.16 , pp. 554
- Kasuga, J.¹ Makishima, M.² Hashimoto, Y.³ Miyachi, H.⁴

26
- 0042732947
- M. Nomura, T. Tanase, T. Ide, M. Tsunoda, M. Suzuki, H. Uchiki, K. Murakami, and H. Miyachi J. Med. Chem. 46 2003 3581
- (2003) J. Med. Chem. , vol.46 , pp. 3581
- Nomura, M.¹ Tanase, T.² Ide, T.³ Tsunoda, M.⁴ Suzuki, M.⁵ Uchiki, H.⁶ Murakami, K.⁷ Miyachi, H.⁸

27
- 0038719688
- Y. Takahashi, I. Hayashi, Y. Tominari, K. Rikimaru, Y. Morohashi, T. Kan, H. Natsugari, T. Fukuyama, T. Tomita, and T. Iwatsubo J. Biol. Chem. 278 2003 18664
- (2003) J. Biol. Chem. , vol.278 , pp. 18664
- Takahashi, Y.¹ Hayashi, I.² Tominari, Y.³ Rikimaru, K.⁴ Morohashi, Y.⁵ Kan, T.⁶ Natsugari, H.⁷ Fukuyama, T.⁸ Tomita, T.⁹ Iwatsubo, T.¹⁰

28
- 76749112922
- S.S. Sikandar, K.T. Pate, S. Anderson, D. Dizon, R.A. Edwards, M.L. Waterman, and S.M. Lipkin Cancer Res. 70 2010 1469
- (2010) Cancer Res. , vol.70 , pp. 1469
- Sikandar, S.S.¹ Pate, K.T.² Anderson, S.³ Dizon, D.⁴ Edwards, R.A.⁵ Waterman, M.L.⁶ Lipkin, S.M.⁷

29
- 70849123789
- J. Tammam, C. Ware, C. Efferson, J. O'Neil, S. Rao, X. Qu, J. Gorenstein, M. Angagaw, H. Kim, C. Kenific, K. Kunii, K.J. Leach, G. Nikov, J. Zhao, X. Dai, J. Hardwick, M. Scott, C. Winter, L. Bristow, C. Elbi, J.F. Reilly, T. Look, G. Draetta, L. Van der Ploeg, N.E. Kohl, P.R. Strack, and P.K. Majumder Br. J. Pharmacol. 58 2009 1183
- (2009) Br. J. Pharmacol. , vol.58 , pp. 1183
- Tammam, J.¹ Ware, C.² Efferson, C.³ O'Neil, J.⁴ Rao, S.⁵ Qu, X.⁶ Gorenstein, J.⁷ Angagaw, M.⁸ Kim, H.⁹ Kenific, C.¹⁰ Kunii, K.¹¹ Leach, K.J.¹² Nikov, G.¹³ Zhao, J.¹⁴ Dai, X.¹⁵ Hardwick, J.¹⁶ Scott, M.¹⁷ Winter, C.¹⁸ Bristow, L.¹⁹ Elbi, C.²⁰ more..

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