β-Arrestin-2 knockout prevents development of cellular μ-opioid receptor tolerance but does not affect opioid-withdrawal-related adaptations in single PAG neurons

British Journal of Pharmacology

Volumn 172, Issue 2, 2015, Pages 492-500

  Connor, M ^a   Bagley, E E ^b   Chieng, B C ^b,c   Christie, M J ^b  

^a MACQUARIE UNIVERSITY   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

arrestins; morphine; opioid tolerance; opioid withdrawal; periaqueductal grey; opioid receptor

Indexed keywords

BETA ARRESTIN 2; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; GABA TRANSPORTER 1; MORPHINE; MU OPIATE RECEPTOR; VOLTAGE GATED CALCIUM CHANNEL; 4 AMINOBUTYRIC ACID CARRIER; BETA ARRESTIN; NARCOTIC ANALGESIC AGENT; RETINA S ANTIGEN; SLC6A1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA ARRESTIN 2 GENE; BRAIN CELL; CELLULAR PARAMETERS; CELLULAR TOLERANCE; CONTROLLED STUDY; DRUG RESPONSE; DRUG SENSITIVITY; GENE DELETION; GENE INACTIVATION; MORPHINE ADDICTION; MORPHINE TOLERANCE; MOUSE; NONHUMAN; PERFORATED PATCH CLAMP; PERIAQUEDUCTAL GREY NEURON; PROTEIN FUNCTION; WHOLE CELL PATCH CLAMP; WILD TYPE; ANIMAL; C57BL MOUSE; DRUG TOLERANCE; GENETICS; KNOCKOUT MOUSE; MALE; NERVE CELL; PATHOPHYSIOLOGY; PERIAQUEDUCTAL GRAY MATTER; PHYSIOLOGY; WITHDRAWAL SYNDROME;

ANALGESICS, OPIOID; ANIMALS; ARRESTINS; DRUG TOLERANCE; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MORPHINE; NEURONS; PERIAQUEDUCTAL GRAY; RECEPTORS, OPIOID, MU; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 84920196160     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12673     Document Type: Article

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