Jaridonin-induced G2/M phase arrest in human esophageal cancer cells is caused by reactive oxygen species-dependent Cdc2-tyr15 phosphorylation via ATM-Chk1/2-Cdc25C pathway

Toxicology and Applied Pharmacology

Volumn 282, Issue 2, 2015, Pages 227-236

  Ma, Yong Cheng ^a   Su, Nan ^b   Shi, Xiao Jing ^c   Zhao, Wen ^c   Ke, Yu ^c   Zi, Xiaolin ^d   Zhao, Ning Min ^a   Qin, Yu Hua ^a   Zhao, Hong Wei ^a   Liu, Hong Min ^c  

^a HENAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

^b HENAN UNIVERSITY OF ANIMAL HUSBANDRY AND ECONOMY   (China)

^c ZHENGZHOU UNIVERSITY   (China)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

ATM; Cell cycle arrest; Ent kaurene diterpenoid; Rabdosia rubescens; ROS

Indexed keywords

ATM PROTEIN; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CYCLIN DEPENDENT KINASE 1; DITERPENOID; GLUTATHIONE; JARIDONIN; PROTEIN TYROSINE PHOSPHATASE; REACTIVE OXYGEN METABOLITE; SERINE; TYROSINE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CELL CYCLE PROTEIN; KAURANE DERIVATIVE; PROTEIN KINASE;

ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVATION; ESOPHAGUS CANCER; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; CELL CYCLE; CELL DIVISION; DRUG EFFECTS; ESOPHAGEAL NEOPLASMS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE;

RABDOSIA RUBESCENS;

ANTINEOPLASTIC AGENTS; ATAXIA TELANGIECTASIA MUTATED PROTEINS; CDC2 PROTEIN KINASE; CELL CYCLE; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE, TUMOR; CHECKPOINT KINASE 2; DITERPENES, KAURANE; ESOPHAGEAL NEOPLASMS; G2 PHASE; GLUTATHIONE; HUMANS; PHOSPHORYLATION; PROTEIN KINASES; REACTIVE OXYGEN SPECIES;

EID: 84920113245     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2014.11.003     Document Type: Article

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