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Volumn 8, Issue 6, 2009, Pages 1613-1624

Inflexinol inhibits colon cancer cell growth through inhibition of nuclear factor-κB activity via direct interaction with p50

Author keywords

[No Author keywords available]

Indexed keywords

DITHIOTHREITOL; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLEXINOL; KAURANE DERIVATIVE; MUTANT PROTEIN; PROTEIN P50; UNCLASSIFIED DRUG;

EID: 67649360284     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-08-0694     Document Type: Article
Times cited : (29)

References (48)
  • 1
    • 0024759789 scopus 로고
    • 65-κD subunit of active NF-κB is required for inhibition of NF-κB by I κB
    • Baeuerle PA, Baltimore DA. 65-κD subunit of active NF-κB is required for inhibition of NF-κB by I κB. Genes Dev 1989;3:1689-1698
    • (1989) Genes Dev , vol.3 , pp. 1689-1698
    • Baeuerle, P.A.1    Baltimore, D.A.2
  • 2
    • 0026527184 scopus 로고
    • The 65-kDa subunit of human NFκB functions as a potent transcriptional activator and a target for v-rel-mediated repression
    • Ballard DW, Dixon EP, Peffer NJ, et al. The 65-kDa subunit of human NFκB functions as a potent transcriptional activator and a target for v-rel-mediated repression. Proc Natl Acad Sci U S A 1992;89:1875-1879
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 1875-1879
    • Ballard, D.W.1    Dixon, E.P.2    Peffer, N.J.3
  • 3
    • 0025943986 scopus 로고
    • The p65 subunit is responsible for the strong transcription activating potential of IMF-κB
    • Schmitz ML, Baeuerle PA. The p65 subunit is responsible for the strong transcription activating potential of NF-κB. EMBO J 1991;10:3805-3817 (Pubitemid 21905409)
    • (1991) EMBO Journal , vol.10 , Issue.12 , pp. 3805-3817
    • Lienhard Schmitz, M.1    Baeuerle, P.A.2
  • 4
    • 0029874138 scopus 로고    scopus 로고
    • The NF-κB and IκB proteins: New discoveries and insights
    • Baldwin AS, Jr.. The NF-κB and IκB proteins: new discoveries and insights. Annu Rev Immunol 1996;14:649-683
    • (1996) Annu Rev Immunol , vol.14 , pp. 649-683
    • Baldwin Jr., A.S.1
  • 5
    • 33749051213 scopus 로고    scopus 로고
    • Can NF-κB be a target for novel and efficient anti-cancer agents?
    • review
    • Olivier S, Robe P, Bours V. Can NF-κB be a target for novel and efficient anti-cancer agents? [review]. Biochem Pharmacol 2006;72:1054-1068
    • (2006) Biochem Pharmacol , vol.72 , pp. 1054-1068
    • Olivier, S.1    Robe, P.2    Bours, V.3
  • 6
    • 0034896686 scopus 로고    scopus 로고
    • NF-κB is upregulated in colorectal cancer
    • Lind DS. NF-κB is upregulated in colorectal cancer. Surgey 2001;130:363-369
    • (2001) Surgey , vol.130 , pp. 363-369
    • Lind, D.S.1
  • 7
    • 0035864733 scopus 로고    scopus 로고
    • NF-kappaB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps
    • DOI 10.1038/sj.onc.1204162
    • Hardwick JC, Van den Brink GR, Offerhaus GJ, Van Deventer SJ, Peppelenbosch MP. NF-κB, p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps. Oncogene 2001;20:819-827 (Pubitemid 32198175)
    • (2001) Oncogene , vol.20 , Issue.7 , pp. 819-827
    • Hardwick, J.C.H.1    Van Den Brink, G.R.2    Offerhaus, G.J.3    Van Deventer, S.J.H.4    Peppelenbosch, M.P.5
  • 8
    • 0036546501 scopus 로고    scopus 로고
    • NF-κB in cancer: From innocent bystander to major culprit
    • Karin M, Cao Y, Greten FR, Li ZW. NF-κB in cancer: from innocent by stander to major culprit. Nat Rev Drug Discov 2002;2:301-310 (Pubitemid 37328783)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.4 , pp. 301-310
    • Karin, M.1    Cao, Y.2    Greten, F.R.3    Li, Z.-W.4
  • 9
    • 0033596127 scopus 로고    scopus 로고
    • Control of apoptosis by Rel/NF-κB transcription factors
    • Barket M, Gilmore TD. Control of apoptosis by Rel/NF-κB transcription factors. Oncogene 1999;18:6910-6924
    • (1999) Oncogene , vol.18 , pp. 6910-6924
    • Barket, M.1    Gilmore, T.D.2
  • 10
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/ NF-κB transcription factors
    • Phal HL. Activators and target genes of Rel/ NF-κB transcription factors. Oncogene 1999;18:6853-6866
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Phal, H.L.1
  • 11
    • 0032032469 scopus 로고    scopus 로고
    • Sulfasalazine: A potent and specific inhibitor of nuclear factor kappa B
    • Wahl C, Liptay S, Adler G, Schmid RM. Sulfasalazine: a potent and specific inhibitor of nuclear factor κB. J Clin Invest 1998;101:1163-1174 (Pubitemid 28125296)
    • (1998) Journal of Clinical Investigation , vol.101 , Issue.5 , pp. 1163-1174
    • Wahl, C.1    Liptay, S.2    Adler, G.3    Schmid, R.M.4
  • 12
    • 3843138492 scopus 로고    scopus 로고
    • Evidence for colorectal cancer cell specificity of aspirin effects on NFκB signalling and apoptosis
    • Din FV, Dunlop MG, Stark LA. Evidence for colorectal cancer cell specificity of aspirin effects on NF-κB signaling and apoptosis. Br J Cancer 2004;91:381-388 (Pubitemid 39037087)
    • (2004) British Journal of Cancer , vol.91 , Issue.2 , pp. 381-388
    • Din, F.V.N.1    Dunlop, M.G.2    Stark, L.A.3
  • 14
    • 11244334168 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-κB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation
    • DOI 10.1038/sj.onc.1208169
    • Takada Y, Bhardwaj A, Potdar P, Aggarwal BB. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-κB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene 2004;23:9247-9258 (Pubitemid 40069695)
    • (2004) Oncogene , vol.23 , Issue.57 , pp. 9247-9258
    • Takada, Y.1    Bhardwaj, A.2    Potdar, P.3    Aggarwal, B.B.4
  • 16
    • 22144452570 scopus 로고    scopus 로고
    • Indole-3-carbinol suppresses NF-κB and IκBα kinase activation, causing inhibition of expression of NF-κB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells
    • DOI 10.1182/blood-2004-12-4589
    • Takada Y, Andreeff M, Aggarwal BB. Indole-3-carbinol suppresses NF-κB and IκBα kinase activation, causing inhibition of expression of NF-κB-regulated anti-apoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells. Blood 2005;106:641-649 (Pubitemid 40981262)
    • (2005) Blood , vol.106 , Issue.2 , pp. 641-649
    • Takada, Y.1    Andreeff, M.2    Aggarwal, B.B.3
  • 18
    • 33749026355 scopus 로고    scopus 로고
    • Diterpenoids from Isodon species and their biological activities
    • Sun HD, Huang SX, Han QB. Diterpenoids from Isodon species and their biological activities. Nat Prod Rep 2006;23:673-698
    • (2006) Nat Prod Rep , vol.23 , pp. 673-698
    • Sun, H.D.1    Huang, S.X.2    Han, Q.B.3
  • 19
    • 0037166268 scopus 로고    scopus 로고
    • Kaurane diterpene, kamebakaurin, inhibits NF-κB by directly targeting the DNA-binding activity of p50 and blocks the expression of antiapoptotic NF-κB target genes
    • DOI 10.1074/jbc.M201368200
    • Lee JH, Koo TH, Hwang BY, Lee JJ. Kaurane diterpene, kamebakaurin, inhibits NF-κB by directly targeting the DNA-binding activity of p50 and blocks the expression of anti-apoptotic NF-κB target genes. J Biol Chem 2002;277:18411-18420 (Pubitemid 34952387)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.21 , pp. 18411-18420
    • Lee, J.-H.1    Koo, T.H.2    Hwang, B.Y.3    Lee, J.J.4
  • 22
    • 34250896179 scopus 로고    scopus 로고
    • Inhibitory effect of inflexinol on nitric oxide generation and iNOS expression via inhibition of NF-κB activation
    • DOI 10.1155/2007/93148, PII S0962935107931488
    • Lee JW, Kim TH, Hong SS, Hwang BY, Ro JW, Hong JT. Inhibitory effect of inflexinol on nitric oxide generation and iNOS expression via inhibition of NF-κB activation. Mediators Inflamm 2007;2007:93148. (Pubitemid 46987647)
    • (2007) Mediators of Inflammation , vol.2007 , pp. 93148
    • Lee, J.W.1    Lee, M.S.2    Kim, T.H.3    Lee, H.J.4    Hong, S.S.5    Noh, Y.H.6    Hwang, B.Y.7    Ro, J.S.8    Hong, J.T.9
  • 23
    • 0034031401 scopus 로고    scopus 로고
    • Protein kinase C-θ Participates in NF-κB activation induced by CD3- CD28 costimulation through selective activation of IκB kinase β
    • DOI 10.1128/MCB.20.8.2933-2940.2000
    • Lin X, O'Mahony A, Mu Y, Geleziunas R, Greene WC. Protein kinase Cθ participates in NF-κB activation induced by CD3-28 costimulation through selective activation of IκB kinase β. Mol Cell Biol 2000;20:2933-2940 (Pubitemid 30183513)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.8 , pp. 2933-2940
    • Lin, X.1    O'Mahony, A.2    Mu, Y.3    Geleziunas, R.4    Greene, W.C.5
  • 24
    • 33847368594 scopus 로고    scopus 로고
    • Inhibitory effect of snake venom toxin from Vipera lebetina turanica on hormone-refractory human prostate cancer cell growth: Induction of apoptosis through inactivation of nuclear factor κB
    • DOI 10.1158/1535-7163.MCT-06-0328
    • Son DJ, Park MH, Chae SJ, et al. Inhibitory effect of snake venom toxin from Vipera lebetina turanica on hormone-refractory human prostate cancer cell growth: induction of apoptosis through inactivation of nuclear factor κB. Mol Cancer Ther 2007;6:675-683 (Pubitemid 46332468)
    • (2007) Molecular Cancer Therapeutics , vol.6 , Issue.2 , pp. 675-683
    • Son, D.J.1    Park, M.H.2    Chae, S.J.3    Moon, S.O.4    Lee, J.W.5    Song, H.S.6    Moon, D.C.7    Kang, S.S.8    Kwon, Y.E.9    Hong, J.T.10
  • 25
    • 34248200600 scopus 로고    scopus 로고
    • Chip-based detection of hepatitis C virus using RNA aptamers that specifically bind to HCV core antigen
    • DOI 10.1016/j.bbrc.2007.04.057, PII S0006291X0700736X
    • Lee S, Kim YS, Jo M, Jin M, Lee DK, Kim S. Chip-based detection of hepatitis C virus using RNA aptamers that specifically bind to HCV core antigen. Biochem Biophys Res Commun 2007;358:47-52. (Pubitemid 46719079)
    • (2007) Biochemical and Biophysical Research Communications , vol.358 , Issue.1 , pp. 47-52
    • Lee, S.1    Kim, Y.S.2    Jo, M.3    Jin, M.4    Lee, D.-K.5    Kim, S.6
  • 26
    • 8444239358 scopus 로고    scopus 로고
    • Antiarthritic effect of bee venom: Inhibition of inflammation mediator generation by suppression of NF-κB through interaction with the p50 subunit
    • DOI 10.1002/art.20626
    • Park HJ, Lee SH, Son DJ, et al. Antiarthritic effect of bee venom: inhibition of inflammation mediator generation by suppression of NF-κB through interaction with the p50 subunit. Arthritis Rheum 2004;50:3504-3515 (Pubitemid 39488675)
    • (2004) Arthritis and Rheumatism , vol.50 , Issue.11 , pp. 3504-3515
    • Hye, J.P.1    Seong, H.L.2    Dong, J.S.3    Ki, W.O.4    Ki, H.K.5    Ho, S.S.6    Goon, J.K.7    Goo, T.O.8    Do, Y.Y.9    Jin, T.H.10
  • 27
    • 0030927167 scopus 로고    scopus 로고
    • Constitutive activation of NF-κB during progression of breast cancer to hormone-independent growth
    • Nakshatri H, Bhat-Nakshatri P, Martin DA, Goulet RJ, Jr., Sledge GW, Jr. Constitutive activation of NF-κB during progression of breast cancer to hormone-independent growth. Mol Cell Biol 1997;17:3629-3639
    • (1997) Mol Cell Biol , vol.17 , pp. 3629-3639
    • Nakshatri, H.1    Bhat-Nakshatri, P.2    Martin, D.A.3    Goulet Jr., R.J.4    Sledge Jr., G.W.5
  • 28
    • 11844269840 scopus 로고    scopus 로고
    • Phosphorylation of NF-κB and IκB proteins: Implications in cancer and inflammation
    • DOI 10.1016/j.tibs.2004.11.009, PII S0968000404002993
    • Viatour P, Merville MP, Bours V, Chariot A. Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammation. Trends Biochem Sci 2005;30:43-52. (Pubitemid 40093740)
    • (2005) Trends in Biochemical Sciences , vol.30 , Issue.1 , pp. 43-52
    • Viatour, P.1    Merville, M.-P.2    Bours, V.3    Chariot, A.4
  • 29
    • 9744263165 scopus 로고    scopus 로고
    • Nuclear factor-κB p65 (RelA) transcription factor is constitutively activated in human colorectal carcinoma tissue
    • Yu LL, Yu HG, Yu JP. Nuclear factor-κB p65 (RelA) transcription factor is constitutively activated in human colorectal carcinoma tissue. World J Gastroenterol 2004;10:55-60.
    • (2004) World J Gastroenterol , vol.10 , pp. 55-60
    • Yu, L.L.1    Yu, H.G.2    Yu, J.P.3
  • 30
    • 44949101395 scopus 로고    scopus 로고
    • Cytokines: From gut inflammation to colorectal cancer
    • DOI 10.2174/138945008784221206
    • Fantini MC, Pallone F. Cytokines: from gut inflammation to colorectal cancer. Curr Drug Targets 2008;9:375-380 (Pubitemid 352025211)
    • (2008) Current Drug Targets , vol.9 , Issue.5 , pp. 375-380
    • Fantini, M.C.1    Pallone, F.2
  • 31
    • 2642575023 scopus 로고    scopus 로고
    • A comparison of apoptosis and necrosis induced by ent-kaurene-type diterpenoids in HL-60 cells
    • DOI 10.1055/s-2004-818966
    • Suzuki I, Kondoh M, Nagashima F, Fujii M, Asakawa Y, Watanabe Y. A comparison of apoptosis and necrosis induced by ent-kaurene type diterpenoids in HL-60 cells. Planta Med 2004;70:401-406 (Pubitemid 38716471)
    • (2004) Planta Medica , vol.70 , Issue.5 , pp. 401-406
    • Suzuki, I.1    Kondoh, M.2    Nagashima, F.3    Fujii, M.4    Asakawa, Y.5    Watanabe, Y.6
  • 32
    • 25844511169 scopus 로고    scopus 로고
    • Differential control of growth, cell cycle progression, and expression of NF-κB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the Chinese herb Rabdosia rubescens
    • DOI 10.1016/j.bbrc.2005.09.040, PII S0006291X05020413
    • Hsieh TC, Wijeratne EK, Liang JY, Gunatilaka AL, Wu JM. Differential control of growth, cell cycle progression, and expression of NF-κB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the Chinese herb Rabdosia rubescens. Biochem Biophys Res Commun 2005;337:224-231 (Pubitemid 41393783)
    • (2005) Biochemical and Biophysical Research Communications , vol.337 , Issue.1 , pp. 224-231
    • Hsieh, T.-C.1    Wijeratne, E.K.2    Liang, J.-Y.3    Gunatilaka, A.L.4    Wu, J.M.5
  • 34
    • 30044446136 scopus 로고    scopus 로고
    • Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IκBα kinase and Akt activation
    • DOI 10.1124/mol.105.017400
    • Aggarwal S, Ichikawa H, Takada Y, Sandur SK, Shishodia S, Aggarwal BB. Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and anti-apoptotic and metastatic gene products through suppression of IκBα kinase and Akt activation. Mol Pharmacol 2006;69:195-206. (Pubitemid 43048906)
    • (2006) Molecular Pharmacology , vol.69 , Issue.1 , pp. 195-206
    • Aggarwal, S.1    Ichikawa, H.2    Takada, Y.3    Sandur, S.K.4    Shishodia, S.5    Aggarwal, B.B.6
  • 35
    • 1942532874 scopus 로고    scopus 로고
    • Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear factor kappaB and induction of apoptosis
    • DOI 10.1038/sj.onc.1207353
    • Gupta S, Hastak K, Afaq F, Ahmad N, Mukhtar H. Essential role of caspases in epigallocatechin-3-gallate-mediated inhibition of nuclear factor κB and induction of apoptosis. Oncogene 2004;23:2507-2522 (Pubitemid 38520748)
    • (2004) Oncogene , vol.23 , Issue.14 , pp. 2507-2522
    • Gupta, S.1    Hastak, K.2    Afaq, F.3    Ahmad, N.4    Mukhtar, H.5
  • 36
    • 5644283296 scopus 로고    scopus 로고
    • Role of chemopreventive agents in cancer therapy
    • DOI 10.1016/j.canlet.2004.07.013, PII S0304383504005464
    • Dorai T, Aggarwal BB. Role of chemopreventive agents in cancer therapy. Cancer Lett 2004;215:129-140 (Pubitemid 39370030)
    • (2004) Cancer Letters , vol.215 , Issue.2 , pp. 129-140
    • Dorai, T.1    Aggarwal, B.B.2
  • 39
    • 39149104633 scopus 로고    scopus 로고
    • Growth inhibitory effects of obovatol through induction of apoptotic cell death in prostate and colon cancer by blocking of NF-κB
    • Lee SY, Yuk DY, Song HS, et al. Growth inhibitory effects of obovatol through induction of apoptotic cell death in prostate and colon cancer by blocking of NF-κB. Eur J Pharmacol 2008;582:17-25.
    • (2008) Eur J Pharmacol , vol.582 , pp. 17-25
    • Lee, S.Y.1    Yuk, D.Y.2    Song, H.S.3
  • 40
    • 33749026355 scopus 로고    scopus 로고
    • Diterpenoids from Isodon species and their biological activities
    • Sun HD, Huang SX, Han QB. Diterpenoids from Isodon species and their biological activities. Nat Prod Rep 2006;23:673-698
    • (2006) Nat Prod Rep , vol.23 , pp. 673-698
    • Sun, H.D.1    Huang, S.X.2    Han, Q.B.3
  • 41
    • 23044504665 scopus 로고    scopus 로고
    • Novel mechanism of inhibition of nuclear factor-κB DNA-binding activity by diterpenoids isolated from Isodon rubescens
    • DOI 10.1124/mol.105.012765
    • Leung CH, Grill SP, Lam W, Han QB, Sun HD, Cheng YC. Novel mechanism of inhibition of nuclear factor-κB DNA-binding activity by diterpenoids isolated from Isodon rubescens. Mol Pharmacol 2005;68:286-297 (Pubitemid 41058292)
    • (2005) Molecular Pharmacology , vol.68 , Issue.2 , pp. 286-297
    • Leung, C.-H.1    Grill, S.P.2    Lam, W.3    Han, Q.-B.4    Sun, H.-D.5    Cheng, Y.-C.6
  • 42
    • 0035929592 scopus 로고    scopus 로고
    • 15-Deoxy-Δ 12,14-prostaglandin J2 inhibition of NF-κB-DNA binding through covalent modification of the p50 subunit
    • Cernuda-Morollon E, Pineda-Molina E, Canada FJ, Perez-Sala D. 15-Deoxy-Δ 12,14-prostaglandin J2 inhibition of NF-κB-DNA binding through covalent modification of the p50 subunit. J Biol Chem 2001;276:35530-35536
    • (2001) J Biol Chem , vol.276 , pp. 35530-35536
    • Cernuda-Morollon, E.1    Pineda-Molina, E.2    Canada, F.J.3    Perez-Sala, D.4
  • 43
    • 0034680928 scopus 로고    scopus 로고
    • Inhibition of NF-κB activation by arsenite through reaction with a critical cysteine in the activation loop of IκB kinase
    • Kapahi P, Takahashi T, Natoli G, et al. Inhibition of NF-κB activation by arsenite through reaction with a critical cysteine in the activation loop of IκB kinase. J Biol Chem 2002;275:36062-36066
    • (2002) J Biol Chem , vol.275 , pp. 36062-36066
    • Kapahi, P.1    Takahashi, T.2    Natoli, G.3
  • 44
    • 0038147060 scopus 로고    scopus 로고
    • Gold compound auranofin inhibits IκB kinase (IKK) by modifying Cys-179 of IKKβ subunit
    • Jeon KI, Byun MS, Jue DM. Gold compound auranofin inhibits IκB kinase (IKK) by modifying Cys-179 of IKKβ subunit. Exp Mol Med 2003;35:61-66 (Pubitemid 36626935)
    • (2003) Experimental and Molecular Medicine , vol.35 , Issue.2 , pp. 61-66
    • Jeon, K.-I.1    Byun, M.-S.2    Jue, D.-M.3
  • 45
    • 33751161701 scopus 로고    scopus 로고
    • Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: Role of the IκB kinase/nuclear factor-κB pathway
    • DOI 10.1124/mol.106.025759
    • Ciucci A, Gianferretti P, Piva R, et al. Induction of apoptosis in estrogen receptor-negative breast cancer cells by natural and synthetic cyclopentenones: role of the IκB kinase/nuclear factor-κB pathway. Mol Pharmacol 2006;70:1812-1821 (Pubitemid 44776441)
    • (2006) Molecular Pharmacology , vol.70 , Issue.5 , pp. 1812-1821
    • Ciucci, A.1    Gianferretti, P.2    Piva, R.3    Guyot, T.4    Snape, T.J.5    Roberts, S.M.6    Santoro, M.G.7
  • 46
    • 34948888792 scopus 로고    scopus 로고
    • 13-Hydroxy-15-oxo-zoapatlin, an ent-kaurane diterpene, induces apoptosis in human leukemia cells, affecting thiol-mediated redox regulation
    • DOI 10.1016/j.freeradbiomed.2007.07.022, PII S0891584907005035
    • Dal Piaz F, Nigro P, Braca A, De Tommasi N, Belisario MA. 13-Hydroxy- 15-oxo-zoapatlin, an ent-kaurane diterpene, induces apoptosis in human leukemia cells, affecting thiol-mediated redox regulation. Free Radic Biol Med 2007;43:1409-1422 (Pubitemid 47532364)
    • (2007) Free Radical Biology and Medicine , vol.43 , Issue.10 , pp. 1409-1422
    • Dal Piaz, F.1    Nigro, P.2    Braca, A.3    De Tommasi, N.4    Belisario, M.A.5
  • 48
    • 18044387257 scopus 로고    scopus 로고
    • Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-κB signal pathways
    • DOI 10.1158/1535-7163.MCT-04-0277
    • Ikezoe T, Yang Y, Bandobashi K, et al. Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-κB signal pathways. Mol Cancer Ther 2005;4:578-586 (Pubitemid 40601839)
    • (2005) Molecular Cancer Therapeutics , vol.4 , Issue.4 , pp. 578-586
    • Ikezoe, T.1    Yang, Y.2    Bandobashi, K.3    Saito, T.4    Takemoto, S.5    Machida, H.6    Togitani, K.7    Koeffler, H.P.8    Taguchi, H.9


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