메뉴 건너뛰기




Volumn 175, Issue 5, 2011, Pages 588-598

Protein-protein interactions occur between p53 phosphoforms and ATM and 53BP1 at sites of exogenous DNA damage

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; CARBOXYL GROUP; HYBRID PROTEIN; PROTEIN P53; SERINE;

EID: 79955413060     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR2084.1     Document Type: Article
Times cited : (16)

References (43)
  • 1
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • DOI 10.1038/nature01368
    • C. J. Bakkenist and M. B. Kastan, DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421, 499-506 (2003). (Pubitemid 36168436)
    • (2003) Nature , vol.421 , Issue.6922 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 2
    • 34247871501 scopus 로고    scopus 로고
    • P53: A two-faced cancer gene
    • M. B. Kastan and E. Berkovich, p53: a two-faced cancer gene. Nat. Cell Biol. 9, 489-491 (2007).
    • (2007) Nat. Cell Biol. , vol.9 , pp. 489-491
    • Kastan, M.B.1    Berkovich, E.2
  • 3
    • 34447551681 scopus 로고    scopus 로고
    • Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair
    • DOI 10.1038/ncb1599, PII NCB1599
    • E. Berkovich, R. J. Monnat, Jr. and M. B. Kastan, Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nat. Cell Biol. 9, 683-690 (2007). (Pubitemid 47214731)
    • (2007) Nature Cell Biology , vol.9 , Issue.6 , pp. 683-690
    • Berkovich, E.1    Monnat Jr., R.J.2    Kastan, M.B.3
  • 5
    • 33646757232 scopus 로고    scopus 로고
    • The complexity of p53 stabilization and activation
    • M. F. Lavin and N. Gueven, The complexity of p53 stabilization and activation. Cell Death Differ. 13, 941-950 (2006).
    • (2006) Cell Death Differ. , vol.13 , pp. 941-950
    • Lavin, M.F.1    Gueven, N.2
  • 6
    • 33646807832 scopus 로고    scopus 로고
    • The P53 pathway: What questions remain to be explored?
    • A. J. Levine, W. Hu and Z. Feng, The P53 pathway: what questions remain to be explored? Cell Death Differ. 13, 1027-1036 (2006).
    • (2006) Cell Death Differ. , vol.13 , pp. 1027-1036
    • Levine, A.J.1    Hu, W.2    Feng, Z.3
  • 8
    • 0842278331 scopus 로고    scopus 로고
    • Direct Activation of Bax by p53 Mediates Mitochondrial Membrane Permeabilization and Apoptosis
    • DOI 10.1126/science.1092734
    • J. E. Chipuk, T. Kuwana, L. Bouchier-Hayes, N. M. Droin, D. D. Newmeyer, M. Schuler and D. R. Green, Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303, 1010-1014 (2004). (Pubitemid 38209704)
    • (2004) Science , vol.303 , Issue.5660 , pp. 1010-1014
    • Chipuk, J.E.1    Kuwana, T.2    Bouchier-Hayes, L.3    Droin, N.M.4    Newmeyer, D.D.5    Schuler, M.6    Green, D.R.7
  • 10
    • 33644927601 scopus 로고    scopus 로고
    • P53 in recombination and repair
    • S. A. Gatz and L. Wiesmuller, p53 in recombination and repair. Cell Death Differ. 13, 1003-1016 (2006).
    • (2006) Cell Death Differ. , vol.13 , pp. 1003-1016
    • Gatz, S.A.1    Wiesmuller, L.2
  • 11
    • 14944342130 scopus 로고    scopus 로고
    • Nonhomologous end-joining of site-specific but not of radiation-induced DNA double-strand breaks is reduced in the presence of wild-type p53
    • DOI 10.1038/sj.onc.1208396
    • J. Dahm-Daphi, P. Hubbe, F. Horvath, R. A. El-Awady, K. E. Bouffard, S. N. Powell and H. Willers, Nonhomologous endjoining of site-specific but not of radiation-induced DNA doublestrand breaks is reduced in the presence of wild-type p53. Oncogene 24, 1663-1672 (2005). (Pubitemid 40461123)
    • (2005) Oncogene , vol.24 , Issue.10 , pp. 1663-1672
    • Dahm-Daphi, J.1    Hubbe, P.2    Horvath, F.3    El-Awady, R.A.4    Bouffard, K.E.5    Powell, S.N.6    Willers, H.7
  • 12
    • 0032499298 scopus 로고    scopus 로고
    • Radioresistant MTp53-expressing rat embryo cell transformants exhibit increased DNA-dsb rejoining during exposure to ionizing radiation
    • R. G. Bristow, Q. Hu, A. Jang, S. Chung, J. Peacock, S. Benchimol and R. Hill, Radioresistant MTp53-expressing rat embryo cell transformants exhibit increased DSB rejoining during exposure to ionizing radiation. Oncogene 16, 1789-1802 (1998). (Pubitemid 28197399)
    • (1998) Oncogene , vol.16 , Issue.14 , pp. 1789-1802
    • Bristow, R.G.1    Hu, Q.2    Jang, A.3    Chung, S.4    Peacock, J.5    Benchimol, S.6    Hill, R.7
  • 13
    • 2442477786 scopus 로고    scopus 로고
    • P53's double life: Transactivation-independent repression of homologous recombination
    • DOI 10.1016/j.tig.2004.04.003, PII S0168952504000964
    • P. Bertrand, Y. Saintigny and B. S. Lopez, p53's double life: transactivation-independent repression of homologous recombination. Trends Genet. 20, 235-243 (2004). (Pubitemid 38625681)
    • (2004) Trends in Genetics , vol.20 , Issue.6 , pp. 235-243
    • Bertrand, P.1    Saintigny, Y.2    Lopez, B.S.3
  • 14
    • 0034255046 scopus 로고    scopus 로고
    • The MRE11-NBS1-RAD50 pathway is perturbed in SV40 large T antigen-immortalized AT-1, AT-2 and HL-1 cardiomyocytes
    • N. A. Lanson, Jr., D. B. Egeland, B. A. Royals and W. C. Claycomb, The MRE11-NBS1-RAD50 pathway is perturbed in SV40 large T antigen-immortalized AT-1, AT-2 and HL-1 cardiomyocytes. Nucleic Acids Res. 28, 2882-2892 (2000). (Pubitemid 30599262)
    • (2000) Nucleic Acids Research , vol.28 , Issue.15 , pp. 2882-2892
    • Lanson Jr., N.A.1    Egeland, D.B.2    Royals, B.A.3    Claycomb, W.C.4
  • 16
    • 0032523932 scopus 로고    scopus 로고
    • Wild-type and mutant forms of p53 activate human topoisomerase i: A possible mechanism for gain of function in mutants
    • A. Albor, S. Kaku and M. Kulesz-Martin, Wild-type and mutant forms of p53 activate human topoisomerase I: a possible mechanism for gain of function in mutants. Cancer Res. 58, 2091-2094 (1998). (Pubitemid 28232891)
    • (1998) Cancer Research , vol.58 , Issue.10 , pp. 2091-2094
    • Albor, A.1    Kaku, S.2    Kulesz-Martin, M.3
  • 17
    • 34247329362 scopus 로고    scopus 로고
    • P53 gain-of-function cancer mutants induce genetic instability by inactivating ATM
    • DOI 10.1038/ncb1571, PII NCB1571
    • H. Song, M. Hollstein and Y. Xu, p53 gain-of-function cancer mutants induce genetic instability by inactivating ATM. Nat. Cell Biol. 9, 573-580 (2007). (Pubitemid 46696539)
    • (2007) Nature Cell Biology , vol.9 , Issue.5 , pp. 573-580
    • Song, H.1    Hollstein, M.2    Xu, Y.3
  • 18
  • 19
    • 56449084007 scopus 로고    scopus 로고
    • NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway
    • K. A. Wilson and D. F. Stern, NFBD1/MDC1, 53BP1 and BRCA1 have both redundant and unique roles in the ATM pathway. Cell Cycle 7, 3584-3594 (2008).
    • (2008) Cell Cycle , vol.7 , pp. 3584-3594
    • Wilson, K.A.1    Stern, D.F.2
  • 20
    • 57049114872 scopus 로고    scopus 로고
    • S1219 residue of 53BP1 is phosphorylated by ATM kinase upon DNA damage and required for proper execution of DNA damage response
    • H. Lee, H. J. Kwak, I. T. Cho, S. H. Park and C. H. Lee, S1219 residue of 53BP1 is phosphorylated by ATM kinase upon DNA damage and required for proper execution of DNA damage response. Biochem. Biophys. Res. Commun. 378, 32-36 (2009).
    • (2009) Biochem. Biophys. Res. Commun. , vol.378 , pp. 32-36
    • Lee, H.1    Kwak, H.J.2    Cho, I.T.3    Park, S.H.4    Lee, C.H.5
  • 22
    • 0037099666 scopus 로고    scopus 로고
    • Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor
    • DOI 10.1093/emboj/cdf383
    • D. J. Derbyshire, B. P. Basu, L. C. Serpell, W. S. Joo, T. Date, K. Iwabuchi and A. J. Doherty, Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor. EMBO J. 21, 3863-3872 (2002). (Pubitemid 34787058)
    • (2002) EMBO Journal , vol.21 , Issue.14 , pp. 3863-3872
    • Derbyshire, D.J.1    Basu, B.P.2    Serpell, L.C.3    Joo, W.S.4    Date, T.5    Iwabuchi, K.6    Doherty, A.J.7
  • 24
    • 33646117239 scopus 로고    scopus 로고
    • Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
    • S. Bekker-Jensen, C. Lukas, R. Kitagawa, F. Melander, M. B. Kastan, J. Bartek and J. Lukas, Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J. Cell Biol. 173, 195-206 (2006).
    • (2006) J. Cell Biol. , vol.173 , pp. 195-206
    • Bekker-Jensen, S.1    Lukas, C.2    Kitagawa, R.3    Melander, F.4    Kastan, M.B.5    Bartek, J.6    Lukas, J.7
  • 27
    • 75949122330 scopus 로고    scopus 로고
    • 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair
    • A. T. Noon, A. Shibata, N. Rief, M. Lobrich, G. S. Stewart, P. A. Jeggo and A. A. Goodarzi, 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair. Nat. Cell Biol. 12, 177-184 (2010).
    • (2010) Nat. Cell Biol. , vol.12 , pp. 177-184
    • Noon, A.T.1    Shibata, A.2    Rief, N.3    Lobrich, M.4    Stewart, G.S.5    Jeggo, P.A.6    Goodarzi, A.A.7
  • 32
    • 28444459974 scopus 로고    scopus 로고
    • Recognition of cisplatin-damaged DNA by p53 protein: Critical role of the p53 C-terminal domain
    • DOI 10.1016/j.bbrc.2005.11.038, PII S0006291X05025362
    • H. Pivonkova, M. Brazdova, J. Kasparkova, V. Brabec and M. Fojta, Recognition of cisplatin-damaged DNA by p53 protein: critical role of the p53 C-terminal domain. Biochem. Biophys. Res. Commun. 339, 477-484 (2006). (Pubitemid 41739692)
    • (2006) Biochemical and Biophysical Research Communications , vol.339 , Issue.2 , pp. 477-484
    • Pivonkova, H.1    Brazdova, M.2    Kasparkova, J.3    Brabec, V.4    Fojta, M.5
  • 33
    • 0033153336 scopus 로고    scopus 로고
    • P53 Directly enhances rejoining of DNA double-strand breaks with cohesive ends in γ-irradiated mouse fibroblasts
    • W. Tang, H. Willers and S. N. Powell, p53 directly enhances rejoining of DNA double-strand breaks with cohesive ends in gamma-irradiated mouse fibroblasts. Cancer Res. 59, 2562-2565 (1999). (Pubitemid 29269098)
    • (1999) Cancer Research , vol.59 , Issue.11 , pp. 2562-2565
    • Tang, W.1    Willers, H.2    Powell, S.N.3
  • 36
    • 10944230682 scopus 로고    scopus 로고
    • The interaction of p53 with replication protein A mediates suppression of homologous recombination
    • DOI 10.1038/sj.onc.1207982
    • L. Y. Romanova, H. Willers, M. V. Blagosklonny and S. N. Powell, The interaction of p53 with replication protein A mediates suppression of homologous recombination. Oncogene 23, 9025-9033 (2004). (Pubitemid 40013069)
    • (2004) Oncogene , vol.23 , Issue.56 , pp. 9025-9033
    • Romanova, L.Y.1    Willers, H.2    Blagosklonny, M.V.3    Powell, S.N.4
  • 37
    • 0038021147 scopus 로고    scopus 로고
    • Resistance to DNA-damaging agents is discordant from experimental metastatic capacity in MEF ras-transformants-expressing gain of function MTp53
    • DOI 10.1038/sj.onc.1206405
    • R. G. Bristow, J. Peacock, A. Jang, J. Kim, R. P. Hill and S. Benchimol, Resistance to DNA-damaging agents is discordant from experimental metastatic capacity in MEF rastransformants- expressing gain of function MTp53. Oncogene 22, 2960-2966 (2003). (Pubitemid 36648923)
    • (2003) Oncogene , vol.22 , Issue.19 , pp. 2960-2966
    • Bristow, R.G.1    Peacock, J.2    Jang, A.3    Kim, J.4    Hill, R.P.5    Benchimol, S.6
  • 38
    • 0021767927 scopus 로고
    • Isolation and characterization of a human p53 cDNA clone: Expression of the human p53 gene
    • G. Matlashewski, P. Lamb, D. Pim, J. Peacock, L. Crawford and S. Benchimol, Isolation and characterization of a human p53 cDNA clone: expression of the human p53 gene. EMBO J. 3, 3257-3262 (1984).
    • (1984) EMBO J. , vol.3 , pp. 3257-3262
    • Matlashewski, G.1    Lamb, P.2    Pim, D.3    Peacock, J.4    Crawford, L.5    Benchimol, S.6
  • 39
    • 39049163047 scopus 로고    scopus 로고
    • Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance
    • DOI 10.1158/0008-5472.CAN-07-5472
    • N. Chan, M. Koritzinsky, H. Zhao, R. Bindra, P. M. Glazer, S. Powell, A. Belmaaza, B. Wouters and R. G. Bristow, Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance. Cancer Res. 68, 605-614 (2008). (Pubitemid 351380090)
    • (2008) Cancer Research , vol.68 , Issue.2 , pp. 605-614
    • Chan, N.1    Koritzinsky, M.2    Zhao, H.3    Bindra, R.4    Glazer, P.M.5    Powell, S.6    Belmaaza, A.7    Wouters, B.8    Bristow, R.G.9
  • 40
    • 0021100690 scopus 로고
    • Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
    • J. D. Dignam, R. M. Lebovitz and R. G. Roeder, Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11, 1475-1489 (1983).
    • (1983) Nucleic Acids Res. , vol.11 , pp. 1475-1489
    • Dignam, J.D.1    Lebovitz, R.M.2    Roeder, R.G.3
  • 41
    • 42249093482 scopus 로고    scopus 로고
    • WTp53 induction does not override MTp53 chemoresistance and radioresistance due to gain-of-function in lung cancer cells
    • DOI 10.1158/1535-7163.MCT-07-0471
    • A. R. Cuddihy, F. Jalali, C. Coackley and R. G. Bristow, WTp53 induction does not override MTp53 chemoresistance and radioresistance due to gain-of-function in lung cancer cells. Mol. Cancer Ther. 7, 980-992 (2008). (Pubitemid 351551052)
    • (2008) Molecular Cancer Therapeutics , vol.7 , Issue.4 , pp. 980-992
    • Cuddihy, A.R.1    Jalali, F.2    Coackley, C.3    Bristow, R.G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.