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Volumn 112, Issue 2, 2015, Pages 229-235

Natural and engineered production of taxadiene with taxadiene synthase

Author keywords

Fungus; Metabolic engineering; Metabolic regulation; Protein engineering; Taxadiene synthase; Taxus

Indexed keywords

BIOCHEMICAL ENGINEERING; BIOCHEMISTRY; BIOSYNTHESIS; CRYSTAL ATOMIC STRUCTURE; ENZYMES; ESCHERICHIA COLI; FUNGI; GENETIC ENGINEERING; HYDROGELS; METABOLISM; OLEFINS;

EID: 84920077579     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.25468     Document Type: Review
Times cited : (39)

References (62)
  • 1
    • 28244479352 scopus 로고    scopus 로고
    • Volatile science? Metabolic engineering of terpenoids in plants
    • Aharoni A, Jongsma MA, Bouwmeester HJ. 2005. Volatile science? Metabolic engineering of terpenoids in plants. Trends Plant Sci 10(12):594-602.
    • (2005) Trends Plant Sci , vol.10 , Issue.12 , pp. 594-602
    • Aharoni, A.1    Jongsma, M.A.2    Bouwmeester, H.J.3
  • 4
    • 69449084289 scopus 로고    scopus 로고
    • Production of taxa-4(5),11(12)-diene by transgenic Physcomitrella patens
    • Anterola A, Shanle E, Perroud P-F, Quatrano R. 2009. Production of taxa-4(5), 11(12)-diene by transgenic Physcomitrella patens. Transgenic Res 18(4):655-660.
    • (2009) Transgenic Res , vol.18 , Issue.4 , pp. 655-660
    • Anterola, A.1    Shanle, E.2    Perroud, P.-F.3    Quatrano, R.4
  • 5
    • 0032790361 scopus 로고    scopus 로고
    • A new semisynthesis of paclitaxel from baccatin III
    • Baloglu E, Kingston DGI. 1999. A new semisynthesis of paclitaxel from baccatin III J Nat Prod 62(7):1068-1071.
    • (1999) J Nat Prod , vol.62 , Issue.7 , pp. 1068-1071
    • Baloglu, E.1    Kingston, D.G.I.2
  • 6
    • 6444235290 scopus 로고    scopus 로고
    • Metabolic engineering of isoprenoid biosynthesis in Arabidopsis for the production of taxadiene, the first committed precursor of Taxol
    • Besumbes Ó, Sauret-Güeto S, Phillips MA, Imperial S, Rodríguez-Concepción M, Boronat A. 2004. Metabolic engineering of isoprenoid biosynthesis in Arabidopsis for the production of taxadiene, the first committed precursor of Taxol. Biotechnol Bioeng 88(2):168-175.
    • (2004) Biotechnol Bioeng , vol.88 , Issue.2 , pp. 168-175
    • Besumbes, O.1    Sauret-Güeto, S.2    Phillips, M.A.3    Imperial, S.4    Rodríguez-Concepción, M.5    Boronat, A.6
  • 8
    • 0032516004 scopus 로고    scopus 로고
    • Plant terpenoid synthases: Molecular biology and phylogenetic analysis
    • Bohlmann J, Meyer-Gauen G, Croteau R. 1998. Plant terpenoid synthases: Molecular biology and phylogenetic analysis. Proc Natl Acad Sci USA 95(8):4126-4133.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.8 , pp. 4126-4133
    • Bohlmann, J.1    Meyer-Gauen, G.2    Croteau, R.3
  • 9
    • 84889985095 scopus 로고    scopus 로고
    • High-level diterpene production by transient expression in Nicotiana benthamiana
    • Bruckner K, Tissier A. 2013. High-level diterpene production by transient expression in Nicotiana benthamiana. Plant Methods 9(1):46.
    • (2013) Plant Methods , vol.9 , Issue.1 , pp. 46
    • Bruckner, K.1    Tissier, A.2
  • 10
    • 84871446061 scopus 로고    scopus 로고
    • Production of taxadiene from cultured ginseng roots transformed with taxadiene synthase gene
    • Cha M, Shim SH, Kim SH, Kim OT, Lee S-W, Kwon S-Y, Baek K-H. 2012. Production of taxadiene from cultured ginseng roots transformed with taxadiene synthase gene. BMB Reports 45(10):589-594.
    • (2012) BMB Reports , vol.45 , Issue.10 , pp. 589-594
    • Cha, M.1    Shim, S.H.2    Kim, S.H.3    Kim, O.T.4    Lee, S.-W.5    Kwon, S.-Y.6    Baek, K.-H.7
  • 11
    • 33751120932 scopus 로고    scopus 로고
    • Production of isoprenoid pharmaceuticals by engineered microbes
    • Chang MCY, Keasling JD. 2006. Production of isoprenoid pharmaceuticals by engineered microbes. Nat Chem Biol 2(12):674-681.
    • (2006) Nat Chem Biol , vol.2 , Issue.12 , pp. 674-681
    • Chang, M.C.Y.1    Keasling, J.D.2
  • 12
    • 33744950176 scopus 로고    scopus 로고
    • Crystal structure of type-III geranylgeranyl pyrophosphate synthase from Saccharomyces cerevisiae and the mechanism of product chain length determination
    • Chang T-H, Guo R-T, Ko T-P, Wang AH-J, Liang P-H. 2006. Crystal structure of type-III geranylgeranyl pyrophosphate synthase from Saccharomyces cerevisiae and the mechanism of product chain length determination. J Biol Chem 281(21):14991-15000.
    • (2006) J Biol Chem , vol.281 , Issue.21 , pp. 14991-15000
    • Chang, T.-H.1    Guo, R.-T.2    Ko, T.-P.3    Wang, A.-J.4    Liang, P.-H.5
  • 13
    • 34249005218 scopus 로고    scopus 로고
    • Studies on taxadiene synthase: Interception of the cyclization cascade at the verticillene stage and rearrangement to phomactatriene
    • Chow SY, Williams HJ, Pennington JD, Nanda S, Reibenspies JH, Scott AI. 2007. Studies on taxadiene synthase: Interception of the cyclization cascade at the verticillene stage and rearrangement to phomactatriene. Tetrahedron 63(27):6204-6209.
    • (2007) Tetrahedron , vol.63 , Issue.27 , pp. 6204-6209
    • Chow, S.Y.1    Williams, H.J.2    Pennington, J.D.3    Nanda, S.4    Reibenspies, J.H.5    Scott, A.I.6
  • 14
    • 43049107992 scopus 로고    scopus 로고
    • Unearthing the roots of the terpenome
    • Christianson DW. 2008. Unearthing the roots of the terpenome. Curr Opin Chem Biol 12(2):141-150.
    • (2008) Curr Opin Chem Biol , vol.12 , Issue.2 , pp. 141-150
    • Christianson, D.W.1
  • 17
    • 70349774561 scopus 로고    scopus 로고
    • Directed evolution: New parts and optimized function
    • Dougherty MJ, Arnold FH. 2009. Directed evolution: New parts and optimized function. Curr Opin Biotechnol 20(4):486-491.
    • (2009) Curr Opin Biotechnol , vol.20 , Issue.4 , pp. 486-491
    • Dougherty, M.J.1    Arnold, F.H.2
  • 18
    • 0002745739 scopus 로고    scopus 로고
    • Regulation by compartmentation
    • Dennis T, Layzell B, Lefebvre D, Turpin H, editors. . England: Longman.
    • Emes J, Dennis T. 1997. Regulation by compartmentation. In: Dennis T, Layzell B, Lefebvre D, Turpin H, editors. Plant metabolism. England: Longman.
    • (1997) Plant metabolism
    • Emes, J.1    Dennis, T.2
  • 19
    • 44749083814 scopus 로고    scopus 로고
    • Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production
    • Engels B, Dahm P, Jennewein S. 2008. Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production. Metab Eng 10(3-4):201-206.
    • (2008) Metab Eng , vol.10 , Issue.3-4 , pp. 201-206
    • Engels, B.1    Dahm, P.2    Jennewein, S.3
  • 20
    • 33846142212 scopus 로고    scopus 로고
    • Taxanes: Perspectives for biotechnological production
    • Frense D. 2007. Taxanes: Perspectives for biotechnological production. Appl Microbiol Biotechnol 73(6):1233-1240.
    • (2007) Appl Microbiol Biotechnol , vol.73 , Issue.6 , pp. 1233-1240
    • Frense, D.1
  • 22
    • 84878932326 scopus 로고    scopus 로고
    • Getting to the bottom of Taxol biosynthesis by fungi
    • Heinig U, Scholz S, Jennewein S. 2013. Getting to the bottom of Taxol biosynthesis by fungi. Fungal Divers 60(1):161-170.
    • (2013) Fungal Divers , vol.60 , Issue.1 , pp. 161-170
    • Heinig, U.1    Scholz, S.2    Jennewein, S.3
  • 23
    • 0029087870 scopus 로고
    • Purification and characterization of taxa-4(5),11(12)-diene synthase from Pacific yew (Taxus Brevifolia) that catalyzes the first committed step of Taxol biosynthesis
    • Hezari M, Lewis NG, Croteau R. 1995. Purification and characterization of taxa-4(5), 11(12)-diene synthase from Pacific yew (Taxus Brevifolia) that catalyzes the first committed step of Taxol biosynthesis. Arch Biochem Biophys 322(2):437-444.
    • (1995) Arch Biochem Biophys , vol.322 , Issue.2 , pp. 437-444
    • Hezari, M.1    Lewis, N.G.2    Croteau, R.3
  • 24
    • 83555163776 scopus 로고    scopus 로고
    • Domain loss has independently occurred multiple times in plant terpene synthase evolution
    • Hillwig ML, Xu M, Toyomasu T, Tiernan MS, Wei G, Cui G, Huang L, Peters RJ. 2011. Domain loss has independently occurred multiple times in plant terpene synthase evolution. Plant J 68(6):1051-1060.
    • (2011) Plant J , vol.68 , Issue.6 , pp. 1051-1060
    • Hillwig, M.L.1    Xu, M.2    Toyomasu, T.3    Tiernan, M.S.4    Wei, G.5    Cui, G.6    Huang, L.7    Peters, R.J.8
  • 25
    • 0032102787 scopus 로고    scopus 로고
    • Overproduction, in Escherichia coli, of soluble taxadiene synthase, a key enzyme in the Taxol biosynthetic pathway
    • Huang E, Huang Q, Wildung M, Croteau R, Scott A. 1998. Overproduction, in Escherichia coli, of soluble taxadiene synthase, a key enzyme in the Taxol biosynthetic pathway. Prot Express Purif 13:90-96.
    • (1998) Prot Express Purif , vol.13 , pp. 90-96
    • Huang, E.1    Huang, Q.2    Wildung, M.3    Croteau, R.4    Scott, A.5
  • 26
    • 0034838359 scopus 로고    scopus 로고
    • Engineering Escherichia coli for the synthesis of taxadiene, a key intermediate in the biosynthesis of Taxol
    • Huang Q, Roessner CA, Croteau R, Scott AI. 2001. Engineering Escherichia coli for the synthesis of taxadiene, a key intermediate in the biosynthesis of Taxol. Bioorg Med Chem 9(9):2237-2242.
    • (2001) Bioorg Med Chem , vol.9 , Issue.9 , pp. 2237-2242
    • Huang, Q.1    Roessner, C.A.2    Croteau, R.3    Scott, A.I.4
  • 27
    • 0034789998 scopus 로고    scopus 로고
    • Taxol: Biosynthesis, molecular genetics, and biotechnological applications
    • Jennewein S, Croteau R. 2001. Taxol: Biosynthesis, molecular genetics, and biotechnological applications. Appl Microbiol Biotechnol 57(1-2):13-19.
    • (2001) Appl Microbiol Biotechnol , vol.57 , Issue.1-2 , pp. 13-19
    • Jennewein, S.1    Croteau, R.2
  • 28
    • 20344394434 scopus 로고    scopus 로고
    • Stereochemistry of the macrocyclization and elimination steps in taxadiene biosynthesis through deuterium labeling
    • Jin Q, Williams DC, Hezari M, Croteau R, Coates RM. 2005. Stereochemistry of the macrocyclization and elimination steps in taxadiene biosynthesis through deuterium labeling. J Org Chem 70(12):4667-4675.
    • (2005) J Org Chem , vol.70 , Issue.12 , pp. 4667-4675
    • Jin, Q.1    Williams, D.C.2    Hezari, M.3    Croteau, R.4    Coates, R.M.5
  • 29
    • 32644437468 scopus 로고    scopus 로고
    • Characterization and expression profile analysis of a new cDNA encoding taxadiene synthase from Taxus media
    • Kai G, Zhao L, Zhang L, Li Z, Guo B, Zhao D, Sun X, Miao Z, Tang K. 2005. Characterization and expression profile analysis of a new cDNA encoding taxadiene synthase from Taxus media. J Biochem Mol Biol 38(6):668-675.
    • (2005) J Biochem Mol Biol , vol.38 , Issue.6 , pp. 668-675
    • Kai, G.1    Zhao, L.2    Zhang, L.3    Li, Z.4    Guo, B.5    Zhao, D.6    Sun, X.7    Miao, Z.8    Tang, K.9
  • 30
    • 0034723356 scopus 로고    scopus 로고
    • Functional analysis of the two interacting cyclase domains in ent-kaurene synthase from the fungus Phaeosphaeria sp. L487 and a comparison with cyclases from higher plants
    • Kawaide H, Sassa T, Kamiya Y. 2000. Functional analysis of the two interacting cyclase domains in ent-kaurene synthase from the fungus Phaeosphaeria sp. L487 and a comparison with cyclases from higher plants. J Biol Chem 275(4):2276-2280.
    • (2000) J Biol Chem , vol.275 , Issue.4 , pp. 2276-2280
    • Kawaide, H.1    Sassa, T.2    Kamiya, Y.3
  • 31
    • 33845457895 scopus 로고    scopus 로고
    • The Taxus metabolome and the elucidation of the Taxol biosynthetic pathway in cell suspension cultures
    • Saito K, Dixon R, Willmitzer L, editors. . Berlin Heidelberg: Springer.
    • Ketchum REB, Croteau RB. 2006. The Taxus metabolome and the elucidation of the Taxol biosynthetic pathway in cell suspension cultures. In: Saito K, Dixon R, Willmitzer L, editors. Plant metabolomics. Berlin Heidelberg: Springer. p 291-309.
    • (2006) Plant metabolomics , pp. 291-309
    • Ketchum, R.E.B.1    Croteau, R.B.2
  • 32
    • 34447107974 scopus 로고    scopus 로고
    • The shape of things to come: structural and synthetic studies of Taxol and related compounds
    • Kingston D. 2007. The shape of things to come: structural and synthetic studies of Taxol and related compounds. Phytochemistry 68(14):1844-1854.
    • (2007) Phytochemistry , vol.68 , Issue.14 , pp. 1844-1854
    • Kingston, D.1
  • 33
    • 0028964563 scopus 로고
    • Cyclization of geranylgeranyl diphosphate to taxa-4 (5), 11 (12)-diene is the committed step of Taxol biosynthesis in Pacific yew
    • Koepp AE, Hezari M, Zajicek J, Vogel BS, LaFever RE, Lewis NG, Croteau R. 1995. Cyclization of geranylgeranyl diphosphate to taxa-4 (5), 11 (12)-diene is the committed step of Taxol biosynthesis in Pacific yew. J Biol Chem 270(15):8686-8690.
    • (1995) J Biol Chem , vol.270 , Issue.15 , pp. 8686-8690
    • Koepp, A.E.1    Hezari, M.2    Zajicek, J.3    Vogel, B.S.4    LaFever, R.E.5    Lewis, N.G.6    Croteau, R.7
  • 34
    • 78650991785 scopus 로고    scopus 로고
    • Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis
    • Koksal M, Jin Y, Coates RM, Croteau R, Christianson DW. 2011. Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis. Nature 469(7328):116-120.
    • (2011) Nature , vol.469 , Issue.7328 , pp. 116-120
    • Koksal, M.1    Jin, Y.2    Coates, R.M.3    Croteau, R.4    Christianson, D.W.5
  • 35
    • 33846058003 scopus 로고    scopus 로고
    • Redirection of carotenoid metabolism for the efficient production of taxadiene [taxa-4(5),11(12)-diene] in transgenic tomato fruit
    • Kovacs K, Zhang L, Linforth RT, Whittaker B, Hayes C, Fray R. 2007. Redirection of carotenoid metabolism for the efficient production of taxadiene [taxa-4(5), 11(12)-diene] in transgenic tomato fruit. Transgenic Res 16(1):121-126.
    • (2007) Transgenic Res , vol.16 , Issue.1 , pp. 121-126
    • Kovacs, K.1    Zhang, L.2    Linforth, R.T.3    Whittaker, B.4    Hayes, C.5    Fray, R.6
  • 36
    • 84877698856 scopus 로고    scopus 로고
    • High-throughput screening for terpene-synthase-cyclization activity and directed evolution of a terpene synthase
    • Lauchli R, Rabe KS, Kalbarczyk KZ, Tata A, Heel T, Kitto RZ, Arnold FH. 2013. High-throughput screening for terpene-synthase-cyclization activity and directed evolution of a terpene synthase. Angew Chem Int Ed Engl 52(21):5571-5574.
    • (2013) Angew Chem Int Ed Engl , vol.52 , Issue.21 , pp. 5571-5574
    • Lauchli, R.1    Rabe, K.S.2    Kalbarczyk, K.Z.3    Tata, A.4    Heel, T.5    Kitto, R.Z.6    Arnold, F.H.7
  • 37
    • 0029979356 scopus 로고    scopus 로고
    • Mechanism of taxadiene synthase, a diterpene cyclase that catalyzes the first step of Taxol biosynthesis in Pacific yew
    • Lin X, Hezari M, Koepp AE, Floss HG, Croteau R. 1996. Mechanism of taxadiene synthase, a diterpene cyclase that catalyzes the first step of Taxol biosynthesis in Pacific yew. Biochemistry 35(9):2968-2977.
    • (1996) Biochemistry , vol.35 , Issue.9 , pp. 2968-2977
    • Lin, X.1    Hezari, M.2    Koepp, A.E.3    Floss, H.G.4    Croteau, R.5
  • 38
    • 83655183058 scopus 로고    scopus 로고
    • Scalable enantioselective total synthesis of taxanes
    • Mendoza A, Ishihara Y, Baran PS. 2012. Scalable enantioselective total synthesis of taxanes. Nat Chem 4(1):21-25.
    • (2012) Nat Chem , vol.4 , Issue.1 , pp. 21-25
    • Mendoza, A.1    Ishihara, Y.2    Baran, P.S.3
  • 40
    • 0037422234 scopus 로고    scopus 로고
    • Inhibition of paclitaxel and baccatin III accumulation by mevinolin and fosmidomycin in suspension cultures of Taxus baccata
    • Palazón J, Cusidó RM, Bonfill M, Morales C, Piñol MT. 2003. Inhibition of paclitaxel and baccatin III accumulation by mevinolin and fosmidomycin in suspension cultures of Taxus baccata. J Biotechnol 101(2):157-163.
    • (2003) J Biotechnol , vol.101 , Issue.2 , pp. 157-163
    • Palazón, J.1    Cusidó, R.M.2    Bonfill, M.3    Morales, C.4    Piñol, M.T.5
  • 41
    • 0034687757 scopus 로고    scopus 로고
    • Abietadiene synthase from grand fir (Abies grandis): Characterization and mechanism of action of the "pseudomature" recombinant enzyme
    • Peters RJ, Flory JE, Jetter R, Ravn MM, Lee H-J, Coates RM, Croteau RB. 2000. Abietadiene synthase from grand fir (Abies grandis): Characterization and mechanism of action of the "pseudomature" recombinant enzyme. Biochemistry 39(50):15592-15602.
    • (2000) Biochemistry , vol.39 , Issue.50 , pp. 15592-15602
    • Peters, R.J.1    Flory, J.E.2    Jetter, R.3    Ravn, M.M.4    Lee, H.-J.5    Coates, R.M.6    Croteau, R.B.7
  • 42
    • 84875818431 scopus 로고    scopus 로고
    • Interactions between co-habitating fungi elicit synthesis of Taxol from an endophytic fungus in host Taxus plants
    • Soliman S, Raizada M. 2013. Interactions between co-habitating fungi elicit synthesis of Taxol from an endophytic fungus in host Taxus plants. Front Microbiol 4(3):1-14.
    • (2013) Front Microbiol , vol.4 , Issue.3 , pp. 1-14
    • Soliman, S.1    Raizada, M.2
  • 43
    • 84879429119 scopus 로고    scopus 로고
    • A fungal endophyte induces transcription of genes encoding a redundant fungicide pathway in its host plant
    • Soliman S, Trobacher C, Tsao R, Greenwood J, Raizada M. 2013. A fungal endophyte induces transcription of genes encoding a redundant fungicide pathway in its host plant. BMC Plant Biol 13(1):93.
    • (2013) BMC Plant Biol , vol.13 , Issue.1 , pp. 93
    • Soliman, S.1    Trobacher, C.2    Tsao, R.3    Greenwood, J.4    Raizada, M.5
  • 44
    • 84855248254 scopus 로고    scopus 로고
    • Chemical inhibitors suggest endophytic fungal paclitaxel is derived from both mevalonate and non-mevalonate-like pathways
    • Soliman SSM, Tsao R, Raizada MN. 2011. Chemical inhibitors suggest endophytic fungal paclitaxel is derived from both mevalonate and non-mevalonate-like pathways. J Nat Prod 74(12):2497-2504.
    • (2011) J Nat Prod , vol.74 , Issue.12 , pp. 2497-2504
    • Soliman, S.S.M.1    Tsao, R.2    Raizada, M.N.3
  • 45
    • 0030198673 scopus 로고    scopus 로고
    • Metabolic inhibitors, elicitors, and precursors as tools for probing yield limitation in taxane production by Taxus chinensis cell cultures
    • Srinivasan V, Ciddi V, Bringi V, Shuler M. 1996. Metabolic inhibitors, elicitors, and precursors as tools for probing yield limitation in taxane production by Taxus chinensis cell cultures. Biotechnol Prog 12(4):457-465.
    • (1996) Biotechnol Prog , vol.12 , Issue.4 , pp. 457-465
    • Srinivasan, V.1    Ciddi, V.2    Bringi, V.3    Shuler, M.4
  • 46
    • 73949148697 scopus 로고    scopus 로고
    • Taxomyces andreanae: A presumed paclitaxel producer demystified
    • Staniek A, Woerdenbag H, Kayser O. 2009. Taxomyces andreanae: A presumed paclitaxel producer demystified? Planta Med 75(15):1561-1566.
    • (2009) Planta Med , vol.75 , Issue.15 , pp. 1561-1566
    • Staniek, A.1    Woerdenbag, H.2    Kayser, O.3
  • 47
    • 0027270462 scopus 로고
    • Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew
    • Stierle A, Strobel G, Stierle D. 1993. Taxol and taxane production by Taxomyces andreanae, an endophytic fungus of Pacific yew. Science 260(5105):214-216.
    • (1993) Science , vol.260 , Issue.5105 , pp. 214-216
    • Stierle, A.1    Strobel, G.2    Stierle, D.3
  • 50
    • 0028145239 scopus 로고
    • Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A° resolution
    • Tarshis LC, Yan M, Poulter CD, Sacchettini JC. 1994. Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A° resolution. Biochemistry 33(36):10871-10877.
    • (1994) Biochemistry , vol.33 , Issue.36 , pp. 10871-10877
    • Tarshis, L.C.1    Yan, M.2    Poulter, C.D.3    Sacchettini, J.C.4
  • 52
    • 23844461941 scopus 로고    scopus 로고
    • Proposed mechanism for diterpene synthases in the formation of phomactatriene and taxadiene
    • Tokiwano T, Endo T, Tsukagoshi T, Goto H, Fukushi E, Oikawa H. 2005. Proposed mechanism for diterpene synthases in the formation of phomactatriene and taxadiene. Org Biomol Chem 3(15):2713-2722.
    • (2005) Org Biomol Chem , vol.3 , Issue.15 , pp. 2713-2722
    • Tokiwano, T.1    Endo, T.2    Tsukagoshi, T.3    Goto, H.4    Fukushi, E.5    Oikawa, H.6
  • 53
    • 0037785189 scopus 로고    scopus 로고
    • Translocation of isopentenyl pyrophosphate for Taxol biosynthesis in suspension cultures of Taxus chinensis var. mairei
    • Wang Y-D, Yuan Y-J, Wu J-C. 2003. Translocation of isopentenyl pyrophosphate for Taxol biosynthesis in suspension cultures of Taxus chinensis var. mairei. Plant Cell TissOrg 74(3):283-288.
    • (2003) Plant Cell TissOrg , vol.74 , Issue.3 , pp. 283-288
    • Wang, Y.-D.1    Yuan, Y.-J.2    Wu, J.-C.3
  • 54
    • 84920064602 scopus 로고    scopus 로고
    • Terpene Biosynthesis and metabolism
    • Dennis T, Layzell B, Lefebvre D, Turpin H, editors. . England: Longman.
    • West A. 1997. Terpene Biosynthesis and metabolism. In: Dennis T, Layzell B, Lefebvre D, Turpin H, editors. Plant metabolism. England: Longman.
    • (1997) Plant metabolism
    • West, A.1
  • 55
    • 0034523479 scopus 로고    scopus 로고
    • Intramolecular proton transfer in the cyclization of geranylgeranyl diphosphate to the taxadiene precursor of Taxol catalyzed by recombinant taxadiene synthase
    • Williams DC, Carroll BJ, Jin Q, Rithner CD, Lenger SR, Floss HG, Coates RM, Williams RM, Croteau R. 2000a. Intramolecular proton transfer in the cyclization of geranylgeranyl diphosphate to the taxadiene precursor of Taxol catalyzed by recombinant taxadiene synthase. Chem Biol 7(12):969-977.
    • (2000) Chem Biol , vol.7 , Issue.12 , pp. 969-977
    • Williams, D.C.1    Carroll, B.J.2    Jin, Q.3    Rithner, C.D.4    Lenger, S.R.5    Floss, H.G.6    Coates, R.M.7    Williams, R.M.8    Croteau, R.9
  • 56
    • 0034234699 scopus 로고    scopus 로고
    • Heterologous expression and characterization of a "pseudomature" form of taxadiene synthase involved in paclitaxel (Taxol) biosynthesis and evaluation of a potential intermediate and inhibitors of the multistep diterpene cyclization reaction
    • Williams DC, Wildung MR, Jin AQ, Dalal D, Oliver JS, Coates RM, Croteau R. 2000b. Heterologous expression and characterization of a "pseudomature" form of taxadiene synthase involved in paclitaxel (Taxol) biosynthesis and evaluation of a potential intermediate and inhibitors of the multistep diterpene cyclization reaction. Arch Biochem Biophys 379(1):137-146.
    • (2000) Arch Biochem Biophys , vol.379 , Issue.1 , pp. 137-146
    • Williams, D.C.1    Wildung, M.R.2    Jin, A.Q.3    Dalal, D.4    Oliver, J.S.5    Coates, R.M.6    Croteau, R.7
  • 57
    • 84876672072 scopus 로고    scopus 로고
    • Diversity of endophytic fungi and screening of fungal paclitaxel producer from Anglojap yew,Taxus x media
    • Xiong Z-Q, Yang Y-Y, Zhao N, Wang Y. 2013. Diversity of endophytic fungi and screening of fungal paclitaxel producer from Anglojap yew, Taxus x media. BMC Microbiol 13:71-81.
    • (2013) BMC Microbiol , vol.13 , pp. 71-81
    • Xiong, Z.-Q.1    Yang, Y.-Y.2    Zhao, N.3    Wang, Y.4
  • 58
    • 34250688380 scopus 로고    scopus 로고
    • Following evolution's lead to a single residue switch for diterpene synthase product outcome
    • Xu M, Wilderman PR, Peters RJ. 2007. Following evolution's lead to a single residue switch for diterpene synthase product outcome. Proc Natl Acad Sci USA 104(18):7397-7401.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.18 , pp. 7397-7401
    • Xu, M.1    Wilderman, P.R.2    Peters, R.J.3
  • 59
    • 84892688705 scopus 로고    scopus 로고
    • Genome sequencing and analysis of the paclitaxel-producing endophytic fungus Penicillium aurantiogriseum NRRL 62431
    • Yang Y, Zhao H, Barrero R, Zhang B, Sun G, Wilson I, Xie F, Walker K, Parks J, Bruce R., et al. 2014. Genome sequencing and analysis of the paclitaxel-producing endophytic fungus Penicillium aurantiogriseum NRRL 62431. BMC Genomics 15(1):69.
    • (2014) BMC Genomics , vol.15 , Issue.1 , pp. 69
    • Yang, Y.1    Zhao, H.2    Barrero, R.3    Zhang, B.4    Sun, G.5    Wilson, I.6    Xie, F.7    Walker, K.8    Parks, J.9    Bruce, R.10
  • 60
    • 33646178621 scopus 로고    scopus 로고
    • Designed divergent evolution of enzyme function
    • Yasuo Y, Thomas EF, Jay DK. 2006. Designed divergent evolution of enzyme function. Nature 440(7087):1078-1082.
    • (2006) Nature , vol.440 , Issue.7087 , pp. 1078-1082
    • Yasuo, Y.1    Thomas, E.F.2    Jay, D.K.3
  • 61
    • 34547168999 scopus 로고    scopus 로고
    • Screening of Taxol-producing endophytic fungi from Taxus chinensis var. mairei
    • Zhou X, Wang Z, Jiang K, Wei Y, Lin J, Sun X, Tang K. 2007. Screening of Taxol-producing endophytic fungi from Taxus chinensis var. mairei. Appl Biochem Microbiol 43(4):439-443.
    • (2007) Appl Biochem Microbiol , vol.43 , Issue.4 , pp. 439-443
    • Zhou, X.1    Wang, Z.2    Jiang, K.3    Wei, Y.4    Lin, J.5    Sun, X.6    Tang, K.7
  • 62
    • 77952837839 scopus 로고    scopus 로고
    • A review: Recent advances and future prospects of Taxol-producing endophytic fungi
    • Zhou X, Zhu H, Liu L, Lin J, Tang K. 2010. A review: Recent advances and future prospects of Taxol-producing endophytic fungi. Appl Microbiol Biotechnol 86(6):1707-1717.
    • (2010) Appl Microbiol Biotechnol , vol.86 , Issue.6 , pp. 1707-1717
    • Zhou, X.1    Zhu, H.2    Liu, L.3    Lin, J.4    Tang, K.5


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