Insights into the role of the microbiome in obesity and type 2 diabetes

Diabetes Care

Volumn 38, Issue 1, 2015, Pages 159-165

  Hartstra, Annick V ^a   Bouter, Kristien E C ^a   Bäckhed, Fredrik ^b,c   Nieuwdorp, Max ^a,b  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c University of Copenhagen   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BUTYRIC ACID;

BACTERIAL STRAIN; CLINICAL RESEARCH; DIET; DISEASE ASSOCIATION; DISEASE MARKER; ENDOTOXEMIA; ENERGY METABOLISM; FECAL MICROBIOTA TRANSPLANTATION; GENE EXPRESSION; GLUCONEOGENESIS; HIGH RISK PATIENT; HORMONAL REGULATION; HUMAN; INSULIN SENSITIVITY; INTESTINE FLORA; METABOLIC SYNDROME X; MICROBIAL DIVERSITY; MICROBIOME; MITOCHONDRIAL RESPIRATION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PREVALENCE; REVIEW; TRANSPLANTATION; FECES; FEEDING BEHAVIOR; FEMALE; INSULIN RESISTANCE; INTESTINE; MALE; METABOLISM; MICROBIOLOGY; MICROFLORA; RANDOMIZED CONTROLLED TRIAL (TOPIC);

DIABETES MELLITUS, TYPE 2; DIET; ENDOTOXEMIA; FECES; FEMALE; FOOD HABITS; HUMANS; INSULIN RESISTANCE; INTESTINES; MALE; METABOLIC SYNDROME X; MICROBIOTA; OBESITY; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 84920025561     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc14-0769     Document Type: Review

References (74)

1. Danaei G, Finucane MM, Lu Y, et al.; Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Blood Glucose). National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: Systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2z7 million participants. Lancet 2011;378:31-40
2. Palermo A, Maggi D, Maurizi AR, Pozzilli P, Buzzetti R. Prevention of type 2 diabetes mellitus: Is it feasible? Diabetes Metab Res Rev 2014; 30(Suppl. 1):4-12
3. Tilg H, Kaser A. Gut microbiome, obesity, and metabolic dysfunction. J Clin Invest 2011;121: 2126-2132
4. Friedman JM. Modern science versus the stigma of obesity. Nat Med 2004;10:563-569
5. Zhu B, Wang X, Li L. Human gut microbiome: The second genome of human body. Protein Cell 2010;1:718-725
6. Simrén M, Barbara G, Flint HJ, et al.; Rome Foundation Committee. Intestinal microbiota in functional bowel disorders: A Rome foundation report. Gut 2013;62:159-176
7. Claesson MJ, O'Toole PW. Evaluating the latest high-throughput molecular techniques for the exploration of microbial gut communities. Gut Microbes 2010;1:277-278
8. Lee YK, Mazmanian SK. Has the microbiota played a critical role in the evolution of the adaptive immune system? Science 2010;330: 1768-1773
9. Flint HJ, Bayer EA, Rincon MT, Lamed R, White BA. Polysaccharide utilization by gut bacteria: Potential for new insights from genomic analysis. Nat Rev Microbiol 2008;6:121-131
10. Ley RE, Bäckhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI. Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A 2005; 102:11070-11075
11. Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesityassociated gut microbiome with increased capacity for energy harvest. Nature 2006;444: 1027-1031
12. Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: Human gut microbes associated with obesity. Nature 2006;444:1022-1023
13. Turnbaugh PJ, Bäckhed F, Fulton L, Gordon JI. Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe 2008;3:213-223
14. Turnbaugh PJ, Ridaura VK, Faith JJ, Rey FE, Knight R, Gordon JI. The effect of diet on the human gut microbiome: A metagenomic analysis in humanized gnotobiotic mice. Sci Transl Med 2009;1:6ra14
15. Fleissner CK, Huebel N, Abd El-Bary MM, Loh G, Klaus S, Blaut M. Absence of intestinal microbiota does not protect mice from dietinduced obesity. Br J Nutr 2010;104:919-929
16. Hildebrandt MA, Hoffmann C, Sherrill-Mix SA, et al. High-fat diet determines the composition of the murine gut microbiome independently of obesity. Gastroenterology 2009;137: 1716-1724.e1-2
17. Schwiertz A, Taras D, Schäfer K, et al. Microbiota and SCFA in lean and overweight healthy subjects. Obesity (Silver Spring) 2010;18:190-195
18. Arumugam M, Raes J, Pelletier E, et al.; MetaHIT Consortium. Enterotypes of the human gut microbiome. Nature 2011;473:174-180
19. Duncan SH, Belenguer A, Holtrop G, Johnstone AM, Flint HJ, Lobley GE. Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces. Appl Environ Microbiol 2007;73:1073-1078
20. Bäckhed F, Ding H, Wang T, et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A 2004; 101:15718-15723
21. Smits LP, Bouter KEC, de Vos WM, Borody TJ, Nieuwdorp M. Therapeutic potential of fecal microbiota transplantation. Gastroenterology 2013;145:946-953
22. van Nood E, Vrieze A, Nieuwdorp M, et al. Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med 2013;368: 407-415
23. Kootte RS, Vrieze A, Holleman F, et al. The therapeutic potential of manipulating gut microbiota in obesity and type 2 diabetes mellitus. Diabetes Obes Metab 2012;14:112-120
24. Vrieze A, Van Nood E, Holleman F, et al. Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome. Gastroenterology 2012;143:913-916.e7
25. Karlsson FH, Tremaroli V, Nookaew I, et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature 2013;498:99-103
26. Qin J, Li Y, Cai Z, et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 2012;490:55-60
27. de VosWM, Nieuwdorp M. Genomics: A gut prediction. Nature 2013;498:48-49
28. Olle B. Medicines from microbiota. Nat Biotechnol 2013;31:309-315
29. Cummings JH. Short chain fatty acids in the human colon. Gut 1981;22:763-779
30. Scheppach W. Effects of short chain fatty acids on gut morphology and function. Gut 1994;35(Suppl.):S35-S38
31. Vernia P, Gnaedinger A, Hauck W, Breuer RI. Organic anions and the diarrhea of inflammatory bowel disease. Dig Dis Sci 1988;33:1353-1358
32. Scheppach W, Sommer H, Kirchner T, et al. Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis. Gastroenterology 1992;103:51-56
33. Vernia P, Monteleone G, Grandinetti G, et al. Combined oral sodium butyrate and mesalazine treatment compared to oral mesalazine alone in ulcerative colitis: Randomized, double-blind, placebo-controlled pilot study. Dig Dis Sci 2000;45:976-981
34. Di Sabatino A, Morera R, Ciccocioppo R, et al. Oral butyrate for mildly to moderately active Crohn's disease. Aliment Pharmacol Ther 2005;22:789-794
35. Gao Z, Yin J, Zhang J, et al. Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes 2009;58:1509-1517
36. Davie JR. Inhibition of histone deacetylase activity by butyrate. J Nutr 2003;133(Suppl.): 2485S-2493S
37. Donohoe DR, Garge N, Zhang X, et al. The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon. Cell Metab 2011;13:517-526
38. Tazoe H, Otomo Y, Kaji I, Tanaka R, Karaki S-I, Kuwahara A. Roles of short-chain fatty acids receptors, GPR41 and GPR43 on colonic functions. J Physiol Pharmacol 2008;59(Suppl. 2):251-262
39. Samuel BS, Shaito A, Motoike T, et al. Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41. Proc Natl Acad Sci U S A 2008;105:16767-16772
40. Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest 2005;115: 1111-1119
41. Tremaroli V, Bäckhed F. Functional interactions between the gut microbiota and host metabolism. Nature 2012;489:242-249
42. Cani PD, Amar J, Iglesias MA, et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 2007;56:1761-1772
43. Delaere F, Duchampt A,Mounien L, et al. The role of sodium-coupled glucose co-transporter 3 in the satiety effect of portal glucose sensing.Mol Metab 2012;2:47-53
44. De Vadder F, Kovatcheva-Datchary P, Goncalves D, et al. Microbiota-generated metabolites promote metabolic benefits via gutbrain neural circuits. Cell 2014;156:84-96
45. Gill RK, Kumar A, Malhotra P, et al. Regulation of intestinal serotonin transporter expression via epigenetic mechanisms: Role of HDAC2. Am J Physiol Cell Physiol 2013;304:C334-C341
46. Zhu H, Huang Q, Xu H, Niu L, Zhou J-N. Antidepressant-like effects of sodium butyrate in combination with estrogen in rat forced swimming test: Involvement of 5-HT(1A) receptors. Behav Brain Res 2009;196:200-206
47. Won Y-J, Lu VB, Puhl HL 3rd, Ikeda SR. β-Hydroxybutyrate modulates N-type calcium channels in rat sympathetic neurons by acting as an agonist for the G-protein-coupled receptor FFA3. J Neurosci 2013;33:19314-19325
48. Basterfield L, Mathers JC. Intestinal tumours, colonic butyrate and sleep in exercised Min mice. Br J Nutr 2010;104:355-363
49. Yamada T, Inui A, Hayashi N, Fujimura M, Fujimiya M. Serotonin stimulates endotoxin translocation via 5-HT3 receptors in the rat ileum. Am J Physiol Gastrointest Liver Physiol 2003;284:G782-G788
50. Simansky KJ. Serotonergic control of the organization of feeding and satiety. Behav Brain Res 1996;73:37-42
51. Ratner C, Ettrup A, Bueter M, et al. Cerebral markers of the serotonergic system in rat models of obesity and after Roux-en-Y gastric bypass. Obesity (Silver Spring) 2012;20:2133-2141
52. Koopman KE, Booij J, Fliers E, Serlie MJ, la Fleur SE. Diet-induced changes in the lean brain: Hypercaloric high-fat-high-sugar snacking decreases serotonin transporters in the human hypothalamic region. Mol Metab 2013;2:417-422
53. Haub S, Kanuri G, Volynets V, Brune T, Bischoff SC, Bergheim I. Serotonin reuptake transporter (SERT) plays a critical role in the onset of fructose-induced hepatic steatosis in mice. Am J Physiol Gastrointest Liver Physiol 2010;298:G335-G344
54. Wikoff WR, Anfora AT, Liu J, et al. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci U S A 2009;106:3698-3703
55. Romanova IV, Ramos EJB, Xu Y, et al. Neurobiologic changes in the hypothalamus associated with weight loss after gastric bypass. J Am Coll Surg 2004;199:887-895
56. DefrancescoM, Liebaert J, Kemmler G, et al. Psychosocial state after bariatric surgery is associated with the serotonin-transporter promoter polymorphism. Eat Weight Disord 2013;18:311-316
57. Sjöström L, Narbro K, Sjöström CD, et al.; Swedish Obese Subjects Study. Effects of bariatric surgery on mortality in Swedish obese subjects. N Engl J Med 2007;357:741-752
58. Sjöström L, Lindroos A-K, Peltonen M, et al.; Swedish Obese Subjects Study Scientific Group. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med 2004;351:2683-2693
59. Liou AP, Paziuk M, Luevano J-M, Machineni S, Turnbaugh PJ, Kaplan LM. Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity. Sci Transl Med 2013; 5:178ra41
60. Furet J-P, Kong L-C, Tap J, et al. Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: Links with metabolic and low-grade inflammation markers. Diabetes 2010;59:3049-3057
61. Zhang H, DiBaise JK, Zuccolo A, et al. Human gut microbiota in obesity and after gastric bypass. Proc Natl Acad Sci U S A 2009;106:2365-2370
62. Meyer D, Stasse-Wolthuis M. The bifidogenic effect of inulin and oligofructose and its consequences for gut health. Eur J Clin Nutr 2009;63:1277-1289
63. Cani PD, Neyrinck AM, Fava F, et al. Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia. Diabetologia 2007;50:2374-2383
64. Rastall RA, Gibson GR, Gill HS, et al. Modulation of the microbial ecology of the human colon by probiotics, prebiotics and synbiotics to enhance human health: An overview of enabling science and potential applications. FEMS Microbiol Ecol 2005;52:145-152
65. Yadav H, Jain S, Sinha PR. Antidiabetic effect of probiotic dahi containing Lactobacillus acidophilus and Lactobacillus casei in high fructose fed rats. Nutrition 2007;23:62-68
66. Naito E, Yoshida Y, Makino K, et al. Beneficial effect of oral administration of Lactobacillus casei strain Shirota on insulin resistance in dietinduced obesity mice. J Appl Microbiol 2011; 110:650-657
67. Blaser M. Antibiotic overuse: Stop the killing of beneficial bacteria. Nature 2011;476:393-394
68. Thuny F, Richet H, Casalta J-P, Angelakis E, Habib G, Raoult D. Vancomycin treatment of infective endocarditis is linked with recently acquired obesity. PLoS ONE 2010;5:e9074
69. Vrieze A, Out C, Fuentes S, et al. Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity. J Hepatol 2014;60:824-831
70. Dethlefsen L, Relman DA. Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. Proc Natl Acad Sci U S A 2011;108 (Suppl. 1):4554-4561
71. Ajslev TA, Andersen CS, Gamborg M, Sørensen TIA, Jess T. Childhood overweight after establishment of the gut microbiota: The role of delivery mode, pre-pregnancy weight and early administration of antibiotics. Int J Obes (Lond) 2011;35:522-529
72. Cho I, Yamanishi S, Cox L, et al. Antibiotics in early life alter the murine colonic microbiome and adiposity. Nature 2012;488:621-626
73. Wu GD, Chen J, Hoffmann C, et al. Linking long-term dietary patterns with gut microbial enterotypes. Science 2011;334:105-108
74. Cotillard A, Kennedy SP, Kong LC, et al.; ANR MicroObes consortium. Dietary intervention impact on gut microbial gene richness. Nature 2013;500:585-588