Deleted in breast cancer 1 limits adipose tissue fat accumulation and plays a key role in the development of metabolic syndrome phenotype

Diabetes

Volumn 64, Issue 1, 2015, Pages 12-22

  Escande, Carlos ^a,b   Nin, Veronica ^a   Pirtskhalava, Tamar ^a   Chini, Claudia C S ^a   Tchkonia, Tamar ^a   Kirkland, James L ^a   Chini, Eduardo N ^a  

^a MAYO CLINIC   (United States)

^b INSTITUT PASTEUR DE MONTEVIDEO   (Uruguay)

Author keywords

[No Author keywords available]

Indexed keywords

DELETED IN BREAST CANCER 1; FATTY ACID; REGULATOR PROTEIN; UNCLASSIFIED DRUG; GLYCEROL; KIAA1967 PROTEIN, HUMAN; KIAA1967 PROTEIN, MOUSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SIRT1 PROTEIN, HUMAN; SIRT1 PROTEIN, MOUSE; SIRTUIN 1;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; BIOACCUMULATION; CALORIC INTAKE; CELL DIFFERENTIATION; CONTROLLED STUDY; FATTY ACID BLOOD LEVEL; FATTY LIVER; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LIPID STORAGE; METABOLIC SYNDROME X; MOUSE; NONHUMAN; OBESITY; PHENOTYPE; ANIMAL; AORTA; BLOOD; CELL CULTURE; CYTOLOGY; ENDOTHELIUM CELL; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGY; STEM CELL; STROMA CELL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADIPOCYTES; ANIMALS; AORTA; ATHEROSCLEROSIS; CELL DIFFERENTIATION; CELLS, CULTURED; ENDOTHELIAL CELLS; FATTY ACIDS, NONESTERIFIED; FATTY LIVER; FEMALE; GLYCEROL; HUMANS; METABOLIC SYNDROME X; MICE, KNOCKOUT; OBESITY; PHENOTYPE; SIRTUIN 1; STEM CELLS; STROMAL CELLS;

EID: 84919967626     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-0192     Document Type: Article

References (41)

1. Flegal KM, Graubard BI, Williamson DF, Gail MH. Cause-specific excess deaths associated with underweight, overweight, and obesity. JAMA 2007;298: 2028-2037
2. National Institutes of Health. Strategic Plan for NIH Obesity Research. Bethesda, MD, National Institutes of Health, 2004
3. Tchkonia T, Morbeck DE, Von Zglinicki T, et al. Fat tissue, aging, and cellular senescence. Aging Cell 2010;9:667-684
4. Unger RH, Scherer PE. Gluttony, sloth and the metabolic syndrome: A roadmap to lipotoxicity. Trends Endocrinol Metab 2010;21:345-352
5. Wang MY, Grayburn P, Chen S, Ravazzola M, Orci L, Unger RH. Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome. Proc Natl Acad Sci U S A 2008;105:6139-6144
6. Listenberger LL, Han X, Lewis SE, et al. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci U S A 2003;100: 3077-3082
7. Almandoz JP, Singh E, Howell LA, et al. Spillover of Fatty acids during dietary fat storage in type 2 diabetes: relationship to body fat depots and effects of weight loss. Diabetes 2013;62:1897-1903
8. Asterholm IW, Halberg N, Scherer PE. Mouse models of lipodystrophy key reagents for the understanding of the metabolic syndrome. Drug Discov Today Dis Models 2007;4:17-24
9. Savage DB. Mouse models of inherited lipodystrophy. Dis Model Mech 2009;2:554-562
10. Kim JY, van de Wall E, Laplante M, et al. Obesity-Associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest 2007;117: 2621-2637
11. Franckhauser S, Muñoz S, Pujol A, et al. Increased fatty acid re-esterification by PEPCK overexpression in adipose tissue leads to obesity without insulin resistance. Diabetes 2002;51:624-630
12. Wildman RP. Healthy obesity. Curr Opin Clin Nutr Metab Care 2009;12: 438-443
13. Naukkarinen J, Heinonen S, Hakkarainen A, et al. Characterising metabolically healthy obesity in weight-discordant monozygotic twins. Diabetologia 2014;57:167-176
14. Kim JE, Chen J, Lou Z. DBC1 is a negative regulator of SIRT1. Nature 2008; 451:583-586
15. Escande C, Chini CC, Nin V, et al. Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. J Clin Invest 2010;120:545-558
16. Zhao W, Kruse JP, Tang Y, Jung SY, Qin J, Gu W. Negative regulation of the deacetylase SIRT1 by DBC1. Nature 2008;451:587-590
17. Chini CC, Escande C, Nin V, Chini EN. HDAC3 is negatively regulated by the nuclear protein DBC1. J Biol Chem 2010;285:40830-40837
18. Chini CC, Escande C, Nin V, Chini EN. DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of the nuclear receptor Rev-erba. Biochem J 2013;451:453-461
19. Trauernicht AM, Kim SJ, Kim NH, Boyer TG. Modulation of estrogen receptor alpha protein level and survival function by DBC-1. Mol Endocrinol 2007;21: 1526-1536
20. Koyama S, Wada-Hiraike O, Nakagawa S, et al. Repression of estrogen receptor beta function by putative tumor suppressor DBC1. Biochem Biophys Res Commun 2010;392:357-362
21. Hiraike H, Wada-Hiraike O, Nakagawa S, et al. Identification of DBC1 as a transcriptional repressor for BRCA1. Br J Cancer 2010;102:1061-1067
22. Li Z, Chen L, Kabra N, Wang C, Fang J, Chen J. Inhibition of SUV39H1 methyltransferase activity by DBC1. J Biol Chem 2009;284:10361-10366
23. Park SH, Riley P 4th, Frisch SM. Regulation of anoikis by deleted in breast cancer-1 (DBC1) through NF-kappaB. Apoptosis 2013;18:649-962
24. Vaughan M. The production and release of glycerol by adipose tissue incubated in vitro. J Biol Chem 1962;237:3354-3358
25. Chalkiadaki A, Guarente L. High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction. Cell Metab 2012;16:180-188
26. Donkor J, Sparks LM, Xie H, Smith SR, Reue K. Adipose tissue lipin-1 expression is correlated with peroxisome proliferator-Activated receptor alpha gene expression and insulin sensitivity in healthy young men. J Clin Endocrinol Metab 2008;93:233-239
27. Reue K. The role of lipin 1 in adipogenesis and lipid metabolism. Novartis Found Symp 2007;286:58-68; discussion 68-71, 162-163, 196-203
28. Ohman MK, Shen Y, Obimba CI, et al. Visceral adipose tissue inflammation accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation 2008; 117:798-805
29. Öhman MK, Luo W, Wang H, et al. Perivascular visceral adipose tissue induces atherosclerosis in apolipoprotein E deficient mice. Atherosclerosis 2011;219:33-39
30. Chiba T, Nakazawa T, Yui K, Kaneko E, Shimokado K. VLDL induces adipocyte differentiation in ApoE-dependent manner. Arterioscler Thromb Vasc Biol 2003;23:1423-1429
31. Nin V, Chini CC, Escande C, Capellini V, Chini EN. Deleted in breast cancer 1 (DBC1) protein regulates hepatic gluconeogenesis. J Biol Chem 2014;289: 5518-5527
32. Stancu CS, Toma L, Sima AV. Dual role of lipoproteins in endothelial cell dysfunction in atherosclerosis. Cell Tissue Res 2012;349:433-446
33. Lu Y, Qian L, Zhang Q, et al. Palmitate induces apoptosis in mouse aortic endothelial cells and endothelial dysfunction in mice fed high-calorie and highcholesterol diets. Life Sci 2013;92:1165-1173
34. Appleton SL, Seaborn CJ, Visvanathan R, et al.; North West Adelaide Health Study Team. Diabetes and cardiovascular disease outcomes in the metabolically healthy obese phenotype: a cohort study. Diabetes Care 2013;36:2388-2394
35. Escande C, Nin V, Pirtskhalava T, et al. Deleted in Breast Cancer 1 regulates cellular senescence during obesity. Aging Cell 2014 July 3 [Epub ahead of print]
36. Bordone L, Cohen D, Robinson A, et al. SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell 2007;6:759-767
37. Pfluger PT, Herranz D, Velasco-Miguel S, Serrano M, Tschöp MH. Sirt1 protects against high-fat diet-induced metabolic damage. Proc Natl Acad Sci U S A 2008;105:9793-9798
38. Caron AZ, He X, Mottawea W, et al. The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome. FASEB J 2014;28:1306-1316.
39. Hallakou S, Doaré L, Foufelle F, et al. Pioglitazone induces in vivo adipocyte differentiation in the obese Zucker fa/fa rat. Diabetes 1997;46:1393-1399
40. Miyazaki Y, Glass L, Triplitt C, et al. Effect of rosiglitazone on glucose and non-esterified fatty acid metabolism in Type II diabetic patients. Diabetologia 2001;44:2210-2219
41. Qiang L, Wang L, Kon N, et al. Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparg. Cell 2012;150:620-632