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Volumn 4, Issue 1, 2007, Pages 17-24

Mouse models of lipodystrophy: Key reagents for the understanding of the metabolic syndrome

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; CYTOKINE; DIPHTHERIA TOXIN; HORMONE RECEPTOR STIMULATING AGENT; INDINAVIR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 3; LEPTIN; LEUCINE ZIPPER PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; PROTEINASE INHIBITOR; RITONAVIR; S6 KINASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; UNCLASSIFIED DRUG;

EID: 37349063135     PISSN: 17406757     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddmod.2007.10.003     Document Type: Review
Times cited : (45)

References (39)
  • 1
    • 34548148047 scopus 로고    scopus 로고
    • Thematic review series: adipocyte biology. Lipodystrophies: windows on adipose biology and metabolism
    • Hegele R.A., et al. Thematic review series: adipocyte biology. Lipodystrophies: windows on adipose biology and metabolism. J. Lipid Res. 48 (2007) 1433-1444
    • (2007) J. Lipid Res. , vol.48 , pp. 1433-1444
    • Hegele, R.A.1
  • 2
    • 33845921647 scopus 로고    scopus 로고
    • Adipose tissue dysfunction in obesity and lipodystrophy
    • Garg A. Adipose tissue dysfunction in obesity and lipodystrophy. Clin. Cornerstone 8 Suppl. 4 (2006) S7-S13
    • (2006) Clin. Cornerstone , vol.8 , Issue.SUPPL. 4
    • Garg, A.1
  • 3
    • 33846950833 scopus 로고    scopus 로고
    • Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy
    • Ebihara K., et al. Efficacy and safety of leptin-replacement therapy and possible mechanisms of leptin actions in patients with generalized lipodystrophy. J. Clin. Endocrinol. Metab. 92 (2007) 532-541
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , pp. 532-541
    • Ebihara, K.1
  • 4
    • 21344447493 scopus 로고    scopus 로고
    • Long-term efficacy of leptin replacement in patients with generalized lipodystrophy
    • Javor E.D., et al. Long-term efficacy of leptin replacement in patients with generalized lipodystrophy. Diabetes 54 (2005) 1994-2002
    • (2005) Diabetes , vol.54 , pp. 1994-2002
    • Javor, E.D.1
  • 5
    • 0032532152 scopus 로고    scopus 로고
    • Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy
    • Shimomura I., et al. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev. 12 (1998) 3182-3194
    • (1998) Genes Dev. , vol.12 , pp. 3182-3194
    • Shimomura, I.1
  • 6
    • 11144357287 scopus 로고    scopus 로고
    • Site and mechanism of leptin action in a rodent form of congenital lipodystrophy
    • Asilmaz E., et al. Site and mechanism of leptin action in a rodent form of congenital lipodystrophy. J. Clin. Invest. 113 (2004) 414-424
    • (2004) J. Clin. Invest. , vol.113 , pp. 414-424
    • Asilmaz, E.1
  • 7
    • 0033517284 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
    • Shimomura I., et al. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy. Nature 401 (1999) 73-76
    • (1999) Nature , vol.401 , pp. 73-76
    • Shimomura, I.1
  • 8
    • 33847350685 scopus 로고    scopus 로고
    • Hypotension, lipodystrophy, and insulin resistance in generalized PPARgamma-deficient mice rescued from embryonic lethality
    • Duan S.Z., et al. Hypotension, lipodystrophy, and insulin resistance in generalized PPARgamma-deficient mice rescued from embryonic lethality. J. Clin. Invest. 117 (2007) 812-822
    • (2007) J. Clin. Invest. , vol.117 , pp. 812-822
    • Duan, S.Z.1
  • 9
    • 0141446024 scopus 로고    scopus 로고
    • Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass
    • Gavrilova O., et al. Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass. J. Biol. Chem. 278 (2003) 34268-34276
    • (2003) J. Biol. Chem. , vol.278 , pp. 34268-34276
    • Gavrilova, O.1
  • 10
    • 0037373008 scopus 로고    scopus 로고
    • Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes
    • Matsusue K., et al. Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. J. Clin. Invest. 111 (2003) 737-747
    • (2003) J. Clin. Invest. , vol.111 , pp. 737-747
    • Matsusue, K.1
  • 11
    • 9144229185 scopus 로고    scopus 로고
    • Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle
    • He W., et al. Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 15712-15717
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 15712-15717
    • He, W.1
  • 12
    • 20944439189 scopus 로고    scopus 로고
    • Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance
    • Jones J.R., et al. Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 6207-6212
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 6207-6212
    • Jones, J.R.1
  • 13
    • 3242720242 scopus 로고    scopus 로고
    • Selective disruption of PPARgamma 2 impairs the development of adipose tissue and insulin sensitivity
    • Zhang J., et al. Selective disruption of PPARgamma 2 impairs the development of adipose tissue and insulin sensitivity. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 10703-10708
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 10703-10708
    • Zhang, J.1
  • 14
    • 0344630205 scopus 로고    scopus 로고
    • Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice
    • Koutnikova H., et al. Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPAR gamma hypomorphic mice. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 14457-14462
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 14457-14462
    • Koutnikova, H.1
  • 15
    • 0033599038 scopus 로고    scopus 로고
    • Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension
    • Barroso I., et al. Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension. Nature 402 (1999) 880-883
    • (1999) Nature , vol.402 , pp. 880-883
    • Barroso, I.1
  • 16
    • 4043151601 scopus 로고    scopus 로고
    • Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma
    • Tsai Y.S., et al. Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma. J. Clin. Invest. 114 (2004) 240-249
    • (2004) J. Clin. Invest. , vol.114 , pp. 240-249
    • Tsai, Y.S.1
  • 17
    • 33750856072 scopus 로고    scopus 로고
    • Leptin deficiency unmasks the deleterious effects of impaired peroxisome proliferator-activated receptor gamma function (P465L PPARgamma) in mice
    • Gray S.L., et al. Leptin deficiency unmasks the deleterious effects of impaired peroxisome proliferator-activated receptor gamma function (P465L PPARgamma) in mice. Diabetes 55 (2006) 2669-2677
    • (2006) Diabetes , vol.55 , pp. 2669-2677
    • Gray, S.L.1
  • 18
    • 0035163850 scopus 로고    scopus 로고
    • Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin
    • Peterfy M., et al. Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. Nat. Genet. 27 (2001) 121-124
    • (2001) Nat. Genet. , vol.27 , pp. 121-124
    • Peterfy, M.1
  • 19
    • 3142685480 scopus 로고    scopus 로고
    • Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro
    • Phan J., et al. Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro. J. Biol. Chem. 279 (2004) 29558-29564
    • (2004) J. Biol. Chem. , vol.279 , pp. 29558-29564
    • Phan, J.1
  • 20
    • 0033942169 scopus 로고    scopus 로고
    • Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene
    • Reue K., et al. Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene. J. Lipid Res. 41 (2000) 1067-1076
    • (2000) J. Lipid Res. , vol.41 , pp. 1067-1076
    • Reue, K.1
  • 21
    • 15944375261 scopus 로고    scopus 로고
    • Lipin, a lipodystrophy and obesity gene
    • Phan J., and Reue K. Lipin, a lipodystrophy and obesity gene. Cell Metab. 1 (2005) 73-83
    • (2005) Cell Metab. , vol.1 , pp. 73-83
    • Phan, J.1    Reue, K.2
  • 22
    • 0032532753 scopus 로고    scopus 로고
    • Life without white fat: a transgenic mouse
    • Moitra J., et al. Life without white fat: a transgenic mouse. Genes Dev. 12 (1998) 3168-3181
    • (1998) Genes Dev. , vol.12 , pp. 3168-3181
    • Moitra, J.1
  • 23
    • 33846456616 scopus 로고    scopus 로고
    • Elevated blood pressure in transgenic lipoatrophic mice and altered vascular function
    • Takemori K., et al. Elevated blood pressure in transgenic lipoatrophic mice and altered vascular function. Hypertension 49 (2007) 365-372
    • (2007) Hypertension , vol.49 , pp. 365-372
    • Takemori, K.1
  • 24
    • 0033965557 scopus 로고    scopus 로고
    • Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice
    • Gavrilova O., et al. Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. J. Clin. Invest. 105 (2000) 271-278
    • (2000) J. Clin. Invest. , vol.105 , pp. 271-278
    • Gavrilova, O.1
  • 25
    • 0036724616 scopus 로고    scopus 로고
    • Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy
    • Colombo C., et al. Transplantation of adipose tissue lacking leptin is unable to reverse the metabolic abnormalities associated with lipoatrophy. Diabetes 51 (2002) 2727-2733
    • (2002) Diabetes , vol.51 , pp. 2727-2733
    • Colombo, C.1
  • 26
    • 0037115464 scopus 로고    scopus 로고
    • Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice
    • Laustsen P.G., et al. Lipoatrophic diabetes in Irs1(-/-)/Irs3(-/-) double knockout mice. Genes Dev. 16 (2002) 3213-3222
    • (2002) Genes Dev. , vol.16 , pp. 3213-3222
    • Laustsen, P.G.1
  • 27
    • 0027268308 scopus 로고
    • Targeted expression of a toxin gene to adipose tissue: transgenic mice resistant to obesity
    • Ross S.R., et al. Targeted expression of a toxin gene to adipose tissue: transgenic mice resistant to obesity. Genes Dev. 7 (1993) 1318-1324
    • (1993) Genes Dev. , vol.7 , pp. 1318-1324
    • Ross, S.R.1
  • 28
    • 0031441286 scopus 로고    scopus 로고
    • Troglitazone action is independent of adipose tissue
    • Burant C.F., et al. Troglitazone action is independent of adipose tissue. J. Clin. Invest. 100 (1997) 2900-2908
    • (1997) J. Clin. Invest. , vol.100 , pp. 2900-2908
    • Burant, C.F.1
  • 29
    • 0038660080 scopus 로고    scopus 로고
    • Insulin resistance and lipodystrophy in mice lacking ribosomal S6 kinase 2
    • El-Haschimi K., et al. Insulin resistance and lipodystrophy in mice lacking ribosomal S6 kinase 2. Diabetes 52 (2003) 1340-1346
    • (2003) Diabetes , vol.52 , pp. 1340-1346
    • El-Haschimi, K.1
  • 30
    • 22544456545 scopus 로고    scopus 로고
    • Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy
    • Pajvani U.B., et al. Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy. Nat. Med. 11 (2005) 797-803
    • (2005) Nat. Med. , vol.11 , pp. 797-803
    • Pajvani, U.B.1
  • 31
    • 0345151837 scopus 로고    scopus 로고
    • Atherogenic dyslipidemia in HIV-infected individuals treated with protease inhibitors. The Swiss HIV Cohort Study
    • Periard D., et al. Atherogenic dyslipidemia in HIV-infected individuals treated with protease inhibitors. The Swiss HIV Cohort Study. Circulation 100 (1999) 700-705
    • (1999) Circulation , vol.100 , pp. 700-705
    • Periard, D.1
  • 32
    • 0842291596 scopus 로고    scopus 로고
    • Adiponectin ameliorates dyslipidemia induced by the human immunodeficiency virus protease inhibitor ritonavir in mice
    • Xu A., et al. Adiponectin ameliorates dyslipidemia induced by the human immunodeficiency virus protease inhibitor ritonavir in mice. Endocrinology 145 (2004) 487-494
    • (2004) Endocrinology , vol.145 , pp. 487-494
    • Xu, A.1
  • 33
    • 33845243670 scopus 로고    scopus 로고
    • Long-term treatment with lopinavir-ritonavir induces a reduction in peripheral adipose depots in mice
    • Prot M., et al. Long-term treatment with lopinavir-ritonavir induces a reduction in peripheral adipose depots in mice. Antimicrob. Agents Chemother. 50 (2006) 3998-4004
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 3998-4004
    • Prot, M.1
  • 34
    • 0042627770 scopus 로고    scopus 로고
    • Leptin replacement therapy but not dietary polyunsaturated fatty acid alleviates HIV protease inhibitor-induced dyslipidemia and lipodystrophy in mice
    • Riddle T.M., et al. Leptin replacement therapy but not dietary polyunsaturated fatty acid alleviates HIV protease inhibitor-induced dyslipidemia and lipodystrophy in mice. J. Acquir. Immune Defic. Syndr. 33 (2003) 564-570
    • (2003) J. Acquir. Immune Defic. Syndr. , vol.33 , pp. 564-570
    • Riddle, T.M.1
  • 35
    • 0035813195 scopus 로고    scopus 로고
    • HIV protease inhibitor induces fatty acid and sterol biosynthesis in liver and adipose tissues due to the accumulation of activated sterol regulatory element-binding proteins in the nucleus
    • Riddle T.M., et al. HIV protease inhibitor induces fatty acid and sterol biosynthesis in liver and adipose tissues due to the accumulation of activated sterol regulatory element-binding proteins in the nucleus. J. Biol. Chem. 276 (2001) 37514-37519
    • (2001) J. Biol. Chem. , vol.276 , pp. 37514-37519
    • Riddle, T.M.1
  • 36
    • 0036230647 scopus 로고    scopus 로고
    • Indinavir induces acute and reversible peripheral insulin resistance in rats
    • Hruz P.W., et al. Indinavir induces acute and reversible peripheral insulin resistance in rats. Diabetes 51 (2002) 937-942
    • (2002) Diabetes , vol.51 , pp. 937-942
    • Hruz, P.W.1
  • 37
    • 0034005969 scopus 로고    scopus 로고
    • Hyperlipidemia and insulin resistance are induced by protease inhibitors independent of changes in body composition in patients with HIV infection
    • Mulligan K., et al. Hyperlipidemia and insulin resistance are induced by protease inhibitors independent of changes in body composition in patients with HIV infection. J. Acquir. Immune Defic. Syndr. 23 (2000) 35-43
    • (2000) J. Acquir. Immune Defic. Syndr. , vol.23 , pp. 35-43
    • Mulligan, K.1
  • 38
    • 0037103097 scopus 로고    scopus 로고
    • Prospective, intensive study of metabolic changes associated with 48 weeks of amprenavir-based antiretroviral therapy
    • Dube M.P., et al. Prospective, intensive study of metabolic changes associated with 48 weeks of amprenavir-based antiretroviral therapy. Clin. Infect. Dis. 35 (2002) 475-481
    • (2002) Clin. Infect. Dis. , vol.35 , pp. 475-481
    • Dube, M.P.1
  • 39
    • 0034617191 scopus 로고    scopus 로고
    • The mechanism of insulin resistance caused by HIV protease inhibitor therapy
    • Murata H., et al. The mechanism of insulin resistance caused by HIV protease inhibitor therapy. J. Biol. Chem. 275 (2000) 20251-20254
    • (2000) J. Biol. Chem. , vol.275 , pp. 20251-20254
    • Murata, H.1


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