VLDL induces adipocyte differentiation in ApoE-dependent manner

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 23, Issue 8, 2003, Pages 1423-1429

  Chiba, Tsuyoshi ^b   Nakazawa, Toru ^b   Yui, Katsumasa ^b   Kaneko, Eiji ^b   Shimokado, Kentaro ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b NONE

Author keywords

Adipogenesis; Apolipoprotein E; Lipoprotein lipase; Obesity; VLDL

Indexed keywords

APOLIPOPROTEIN E; FATTY ACID; LIPOPROTEIN LIPASE; TETRAHYDROLIPSTATIN; VERY LOW DENSITY LIPOPROTEIN;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BONE MARROW CELL; CELL DIFFERENTIATION; CHOLESTEROL DIET; CLINICAL PATHWAY; CONTROLLED STUDY; HUMAN; HYDROLYSIS; HYPERLIPIDEMIA; LIPOGENESIS; LIPOPROTEIN BLOOD LEVEL; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; STROMA CELL;

ADIPOCYTES; ANIMALS; APOLIPOPROTEINS E; FATTY ACIDS, NONESTERIFIED; HUMANS; HYPERLIPIDEMIAS; LIPOPROTEINS, VLDL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MICE, OBESE; OBESITY;

EID: 0042734439     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000085040.58340.36     Document Type: Article

References (43)

1. Olefsky JM. The effects of spontaneous obesity on insulin binding, glucose transport, and glucose oxidation of isolated rat adipocytes. J Clin Invest. 1976;57:842-851.
2. Abbott WG, Foley JE. Comparison of body composition, adipocyte size, and glucose and insulin concentrations in Pima Indian and Caucasian children. Metabolism. 1987;36:576-579.
3. de la Llera M. Glick JM, Rothblat G. Mechanism of triglyceride accumulation in rat preadipocyte cultures exposed to very low density lipoprotein. J Lipid Res. 1981:22:245-253.
4. Santamarina-Fojo S, Brewer HB Jr. Lipoprotein lipase: structure, function and mechanism of action. Int J Clin Lab Res. 1994;24:143-147.
5. Saxena U, Klein MG, Goldberg IJ. Identification and characterization of the endothelial cell surface lipoprotein lipase receptor. J Biol Chem. 1991;266:17516-17521.
6. Takahashi S, Suzuki J, Kohno M, Oida K, Tamai T, Miyabo S, Yamamoto T, Nakai T. Enhancement of the binding of triglyceride-rich lipoproteins to the very low density lipoprotein receptor by apolipoprotein E and lipoprotein lipase. J Biol Chem. 1995:270:15747-15754.
7. Obunike JC, Lutz EP, Li Z, Paka L, Katopodis T, Strickland DK, Kozarsky KF, Pillarisetti S, Goldberg IJ. Transcytosis of lipoprotein lipase across cultured endothelial cells requires both heparan sulfate proteoglycans and the very low density lipoprotein receptor. J Biol Chem. 2001:276:8934-8941.
8. Weinstock PH, Bisgaier CL, Aalto-Setala K, Radner H, Ramakrishnan R, Levak-Frank S, Essenburg AD, Zechner R, Breslow JL. Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice: mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes. J Clin Invest. 1995;96:2555-2568.
9. Ullrich NF, Purnell JQ, Brunzell JD. Adipose tissue fatty acid composition in humans with lipoprotein lipase deficiency. J Investig Med. 2001;49:273-275.
10. Weinstock PH, Levak-Frank S, Hudgins LC, Radner H, Friedman JM, Zechner R, Breslow JL. Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase. Proc Natl Acad Sci U S A. 1997;94:10261-10266.
11. Yamauchi T, Oike Y, Kamon J, Waki H, Komeda K, Tsuchida A, Date Y, Li MX, Miki H, Akanuma Y, Nagai R, Kimura S, Saheki T, Nakazato M, Naitoh T, Yamamura K, Kadowaki T. Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice. Nat Genet. 2002;30:221-226.
12. Rolland V, Dugail I, Le Liepvre X, Lavau M. Evidence of increased glyceraldehyde-3-phosphate dehydrogenase and fatty acid synthetase promoter activities in transiently transfected adipocytes from genetically obese rats. J Biol Chem. 1995;270:1102-1106.
13. Brun LD, Gagne C, Julien P, Tremblay A, Moorjani S, Bouchard C, Lupien PJ. Familial lipoprotein lipase-activity deficiency: study of total body fatness and subcutaneous fat tissue distribution. Metabolism. 1989;38:1005-1009.
14. de Graaf J, Hoffer MJ, Stuyt PM, Frants RR, Stalenhoef AF. Familial chylomicronemia caused by a novel type of mutation in the APOE-CI-CIV-CII gene cluster encompassing both the APOCII gene and the first APOCIV gene mutation: APOCII-CIV (Nijmegen). Biochem Biophys Res Commun. 2000;273:1084-1087.
15. Watson RT, Pessin JE. Subcellular compartmentalization and trafficking of the insulin-responsive glucose transporter, GLUT4. Exp Cell Res. 2001;271:75-83.
16. Shachter NS. Apolipoproteins C-I and C-III as important modulators of lipoprotein metabolism. Curr Opin Lipidol. 2001:12:297-304,
17. Jong MC, van Dijk KW, Dahlmans VE, Van der Boom H, Kobayashi K, Oka K, Siest G, Chan L, Hofker MH, Havekes LM. Reversal of hyperlipidaemia in apolipoprotein C1transgenic mice by adenovirus-mediated gene delivery of the low-density-lipoprotein receptor, but not by the very-low-density-lipoprotein receptor. Biochem J. 1999;338:281-287.
18. Jong MC, Voshol PJ, Muurling M, Dahlmans VE, Romijn JA, Pijl H, Havekes LM. Protection from obesity and insulin resistance in mice overexpressing human apolipoprotein C1. Diabetes. 2001;50:2779-2785.
19. Goudriaan JR, Tacken PJ, Dahlmans VE, Gijbels MJ, van Dijk KW, Havekes LM, Jong MC. Protection from obesity in mice lacking the VLDL receptor. Arterioscler Thromb Vasc Biol. 2001;21:1488-1493.
20. Hofker MH, van Vlijmen BJ, Havekes LM. Transgenic mouse models to study the role of APOE in hyperlipidemia and atherosclerosis. Atherosclerosis. 1998;137:1-11.
21. Plump AS, Smith JD, Hayek T, Aalto-Setala K, Walsh A, Verstuyft JG, Rubin EM, Breslow JL. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell. 1992;71:343-353.
22. Zhang SH, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science. 1992;258:468-471.
23. Coleman DL. Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia. 1978;14:141-148.
24. Paigen B, Morrow A, Brandon C, Mitchell D, Holmes P. Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis. 1985;57:65-73.
25. Green H, Meuth M. An established pre-adipose cell line and its differentiation in culture. Cell. 1974;3:127-133.
26. Marko O, Cascieri MA, Ayad N, Strader CD, Candelore MR. Isolation of a preadipocyte cell line from rat bone marrow and differentiation to adipocytes. Endocrinology. 1995;136:4582-4588.
27. Jong MC, Dahlmans VE, Hofker MH, Havekes LM. Nascent very-low-density lipoprotein triacylglycerol hydrolysis by lipoprotein lipase is inhibited by apolipoprotein E in a dose-dependent manner. Biochem J. 1997;328:745-750.
28. Descamps O, Bilheimer D, Herz J. Insulin stimulates receptor-mediated uptake of apoE-enriched lipoproteins and activated alpha 2-macroglobulin in adipocytes. J Biol Chem. 1993;268:974-981.
29. Gianturco SH, Gotto AM Jr, Hwang SL, Karlin JB, Lin AH, Prasad SC, Bradley WA. Apolipoprotein E mediates uptake of Sf 100-400 hypertriglyceridemic very low density lipoproteins by the low density lipoprotein receptor pathway in normal human fibroblasts. J Biol Chem. 1983;258:4526-4533.
30. Nawa T, Nawa MT, Cai Y, Zhang C, Uchimura I, Narumi S, Numano F, Kitajima S. Repression of TNF-alpha-induced E-selectin expression by PPAR activators: involvement of transcriptional repressor LRF-1/ATF3. Biochem Biophys Res Commun. 2000;275:406-411.
31. Nilsson-Ehle P, Schotz MC. A stable, radioactive substrate emulsion for assay of lipoprotein lipase. J Lipid Res. 1976;17:536-541.
32. Lookene A, Skottova N, Olivecrona G. Interactions of lipoprotein lipase with the active-site inhibitor tetrahydrolipstatin (Orlistat). Eur J Biochem. 1994;222:395-403.
33. Medh JD, Fry GL, Bowen SL, Ruben S, Wong H, Chappell DA. Lipoprotein lipase- and hepatic triglyceride lipase-promoted very low density lipoprotein degradation proceeds via an apolipoprotein E-dependent mechanism. J Lipid Res. 2000;41:1858-1871.
34. Zsigmond E, Fuke Y, Li L, Kobayashi K, Chan L. Resistance of chylomicron and VLDL remnants to post-heparin lipolysis in apoE-deficient mice: the role of apoE in lipoprotein lipase-mediated lipolysis in vivo and in vitro. J Lipid Res. 1998;39:1852-1861.
35. Merkel M, Kako Y, Radner H, Cho IS, Ramasamy R, Brunzell JD, Goldberg IJ, Breslow JL. Catalytically inactive lipoprotein lipase expression in muscle of transgenic mice increases very low density lipoprotein uptake: direct evidence that lipoprotein lipase bridging occurs in vivo. Proc Natl Acad Sci USA. 1998;95:13841-13846.
36. Takahashi S, Kawarabayasi Y, Nakai T, Sakai J, Yamamoto T. Rabbit very low density lipoprotein receptor: a low density lipoprotein receptor-like protein with distinct ligand specificity. Proc Natl Acad Sci U S A. 1992;89:9252-9256.
37. Oka K, Ishimura-Oka K, Chu MJ, Sullivan M, Krushkal J, Li WH, Chan L. Mouse very-low-density-lipoprotein receptor (VLDLR) cDNA cloning, tissue-specific expression and evolutionary relationship with the low-density-lipoprotein receptor. Eur J Biochem. 1994;224:975-982.
38. Le Lay S, Krief S, Farnier C, Lefrere I, Le Liepvre X, Bazin R, Ferre P, Dugail I. Cholesterol, a cell size-dependent signal that regulates glucose metabolism and gene expression in adipocytes. J Biol Chem. 2001:276:16904-16910.
39. Yagyu H, Lutz EP, Kako Y, Marks S, Hu Y, Choi SY, Bensadoun A, Goldberg IJ. VLDL receptor deficient mice have reduced lipoprotein lipase activity: possible causes of hypertriglyceridemia and reduced body mass with VLDL receptor deficiency. J Biol Chem. 2002;277:10037-10043.
40. Ko KW, Avramoglu RK, McLeod RS, Vukmirica J, Yao Z. The insulin-stimulated cell surface presentation of low density lipoprotein receptor-related protein in 3T3-L1 adipocytes is sensitive to phosphatidylinositide 3-kinase inhibition. Biochemistry. 2001;40:752-759.
41. Salinelli S, Lo JY, Mims MP, Zsigmond E, Smith LC, Chan L. Structure-function relationship of lipoprotein lipase-mediated enhancement of very low density lipoprotein binding and catabolism by the low density lipoprotein receptor: functional importance of a properly folded surface loop covering the catalytic center. J Biol Chem. 1996;271:21906-21913.
42. Ferre P. Regulation of gene expression by glucose. Proc Nutr Soc. 1999;58:621-623.
43. Kopecky J, Flachs P, Bardova K, Brauner P, Prazak T, Sponarova J. Modulation of lipid metabolism by energy status of adipocytes: implications for insulin sensitivity. Ann N Y Acad Sci. 2002;967:88-101.