Mechanism of the beneficial and protective effects of exenatide in diabetic rats

Journal of Endocrinology

Volumn 220, Issue 3, 2014, Pages 291-304

  Lotfy, Mohamed ^a,b,c   Singh, Jaipaul ^b,d   Rashed, Hameed ^e   Tariq, Saeed ^e   Zilahi, Erika ^e   Adeghate, Ernest ^e  

^a UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^b UNIVERSITY OF CENTRAL LANCASHIRE   (United Kingdom)

^c NATIONAL RESEARCH CENTRE   (Egypt)

^d UNIVERSITY OF CENTRAL LANCASHIRE   (United Kingdom)

^e UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

Author keywords

Diabetes; Gene expression; Immunohistochemistry; Insulin; Islet cells

Indexed keywords

DIABETES; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; INSULIN; ISLET CELLS;

ANIMALS; ANTIOXIDANTS; BLOOD GLUCOSE; CATALASE; DIABETES MELLITUS; GLUCAGON-LIKE PEPTIDE 1; GLUTATHIONE PEROXIDASE; HOMEODOMAIN PROTEINS; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; MALE; PANCREAS; PEPTIDES; RATS; RATS, WISTAR; RECEPTORS, GLUCAGON; TRANS-ACTIVATORS; VENOMS;

EID: 84894309436     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1530/JOE-13-0426     Document Type: Article

References (54)

1. Adeghate E 1999 Effect of subcutaneous pancreatic tissue transplants on streptozotocin-induced diabetes in rats. I. Morphological studies on normal, diabetic and transplanted pancreatic tissues. Tissue & Cell 31 66-72. (doi:10.1054/tice.1999.0008)
2. Adeghate E & Ponery AS 2002 Ghrelin stimulates insulin secretion from the pancreas of normal and diabetic rats. Journal of Neuroendocrinology 14 555-560. (doi:10.1046/j.1365-2826.2002.00811.x)
3. Adeghate E & Ponery AS 2004 Diabetes mellitus influences the degree of co-localization of calcitonin-gene-related-peptide with insulin and somatostatin in the rat pancreas. Pancreas 29 311-319. (doi:10.1097/00006676-200411000-00011)
4. Adeghate E, Schattner P & Dunn E 2006 An update on the etiology and epidemiology of diabetes mellitus. Annals of the New York Academy of Sciences 1084 1-29. (doi:10.1196/annals.1372.029)
5. Amin A, Lotfy M, Mahmoud-Ghoneim D, Adeghate E, Al-Akhras MA, Al-Saadi M, Al-Rahmoun S & Hameed R 2011 Pancreas-protective effects of chlorella in STZ-induced diabetic animal model: insights into the mechanism. Journal of Diabetes Mellitus 3 36-45. (doi:10.4236/jdm.2011.13006)
6. Baggio LL & Drucker DJ 2007 Biology of incretins: GLP-1 and GIP. Gastroenterology 132 2131-2157. (doi:10.1053/j.gastro.2007.03.054) Barnett A 2007 Exenatide. Expert Opinion on Pharmacotherapy 8 2593-2608. (doi:10.1517/14656566.8.15.2593)
7. Barnett A 2007 Exenatide. Expert Opinion on Pharmacotherapy 8 2593-2608. (doi:10.1517/14656566.8.15.2593)
8. Brubaker PL & Drucker DJ 2002 Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors. Receptors & Channels 8 179-188. (doi:10.1080/10606820213687)
9. Caluwaerts S, Lambin S, van-Bree R, Peeters H, Vergote I & Verhaeghe J 2007 Diet-induced obesity in gravid rats engenders early hyperadiposity in the offspring. Metabolism 56 1431-1438. (doi:10.1016/j.metabol.2007.06.007)
10. Cernea S & Raz I 2011 Therapy in the early stage: incretins. Diabetes Care 34 S264-S271. (doi:10.2337/dc11-s223)
11. Chen HS, Jia J, Su HF, Lin HD, Chen JW, Lin SJ, Yang JY, Lai HC, Mestril R & Wang PH 2006 Down regulation of the constitutively expressed Hsc70 in diabetic myocardium is mediated by insulin deficiency. Journal of Endocrinology 190 433-440. (doi:10.1677/joe.1.06692)
12. Deavall DG, Martin EA, Horner JM & Roberts R 2012 Drug-induced oxidative stress and toxicity. Journal of Toxicology 2012 645460. (doi:10.1155/2012/645460)
13. Deleon DD, Deng S, Madani R, Ahima RS, Drucker DJ & Stoffers DA 2003 Role of endogenous glucagons-like peptide-1 in islet regeneration after partial pancreatectomy. Diabetes 52 365-371. (doi:10.2337/diabetes.52.2.365)
14. Dorsam RT & Gutkind JS 2007 G-protein-coupled receptors and cancer. Nature Reviews. Cancer 7 79-94. (doi:10.1038/nrc2069)
15. Drucker DJ 2003a Glucagon-like peptide-1 and the islet b-cell: augmentation of cell proliferation and inhibition of apoptosis. Journal of Endocrinology 144 5145-5148. (doi:10.1210/en.2003-1147)
16. Drucker DJ 2003b Enhancing incretin action for the treatment of type 2 diabetes. Diabetes Care 26 2929-2940. (doi:10.2337/diacare.26.10.2929)
17. D'Souza A, Hussain M, Howarth FC, Woods NM, Bidasee K & Singh J 2009 Pathogenesis and pathophysiology of accelerated atherosclerosis in the diabetic heart. Molecular and Cellular Biochemistry 331 89-116. (doi:10.1007/s11010-009-0148-8)
18. Dungan K & Buse JB 2005 Glucagon-like peptide 1-based therapies for type 2 diabetes: a focus on exenatide. Clinical Diabetes 23 56-62. (doi:10.2337/diaclin.23.2.56)
19. Figueroa-Quevedo A & Agil A 2011 Changes in plasma's oxidative stress and antioxidant activity, measured with melatonin levels, and its relationship to newborns from obese and diabetic pregnancies. Journal of Diabetes & Metabolism S4 002. (doi:10.4172/2155-6156.S4-002)
20. Fisher TL & White MF 2004 Signaling pathways: the benefits of good communication. Current Biology 14 R1005-R1007. (doi:10.1016/j.cub.2004.11.024)
21. Fontes G, Hagman DK, Latour MG & SemacheM 2010 Lack of preservation of insulin gene expression by a glucagon-like peptide 1 agonist or a dipeptidyl peptidase 4 inhibitor in an in vivo model of glucolipotoxicity. Diabetes Research and Clinical Practice 87 322-328. (doi:10.1016/j.diabres.2009.12.020)
22. Gautier JF, Choukem SP & Girard J 2008 Physiology of incretins (GIP and GLP-1) and abnormalities in type 2 diabetes. Diabetes & Metabolism 34 S65-S72. (doi:10.1016/S1262-3636(08)73397-4)
23. Gedulin BR, Nikoulina SE, Smith PA, Gedulin G, Nielsen LL, Baron AD, Parkes DG & Young AA 2005 Exenatide (exendin-4) improves insulin sensitivity and b-cell mass in insulin-resistant obese fa/fa Zucker rats independent of glycemia and body weight. Journal of Endocrinology 146 2069-2076. (doi:10.1210/en.2004-1349)
24. Haan MN 2006 Therapy insight: type 2 diabetes mellitus and the risk of late-onset Alzheimer's disease. Nature Clinical Practice. Neurology 2 159-166. (doi:10.1038/ncpneuro0124)
25. Habib AM, Richards P, Rogers GJ, Reimann F & Gribble FM 2013 Co-localisation and secretion of glucagon-like peptide 1 and peptide YY from primary cultured human L cells. Diabetologia 56 1413-1416. (doi:10.1007/s00125-013-2887-z)
26. Hamouchene H, Arlt VM, Giddings I & Phillips DH 2011 Influence of cell cycle on responses of MCF-7 cells to benzo[a]pyrene. BioMed Central Genomics 12 333. (doi:10.1186/1471-2164-12-333)
27. Heller RS, Kieffer TJ & Habener JF 1997 Insulinotropic glucagon-like peptide I receptor expression in glucagon-producing a-cells of the rat endocrine pancreas. Diabetes 46 785-791. (doi:10.2337/diab.46.5.785)
28. Holst JJ 2006 Glucagon-like peptide-1: from extract to agent. The Claude Bernard lecture. Diabetologia 49 253-260. (doi:10.1007/s00125-005-0107-1)
29. Holst JJ 2007 The physiology of glucagon-like peptide 1. Physiological Reviews 87 1409-1439. (doi:10.1152/physrev.00034.2006)
30. Holst JJ 2008 The physiology and pharmacology of incretins in type 2 diabetes mellitus. Diabetes, Obesity & Metabolism 10 14-21. (doi:10.1111/j.1463-1326.2008.00920.x)
31. Holz GG 2004 Epac: a new cAMP-binding protein in support of glucagonlike peptide-1 receptor-mediated signal transduction in the pancreatic b-cell. Diabetes 53 5-13. (doi:10.2337/diabetes.53.1.5)
32. Kaneto H, Miyatsuka T, Fujitani Y, Noguchi H, Song KH, Yoon HK & Matsuoka TA 2007 Role of PDX-1 and MafA as a potential therapeutic target for diabetes. Diabetes Research and Clinical Practice 77 S127-S137. (doi:10.1016/j.diabres.2007.01.046)
33. Kedees MH, Grigoryan M, Guz Y & Teitelman G 2009 Differential expression of glucagon and glucagon-like peptide 1 receptors in mouse pancreatic a and b cells in two models of a cell hyperplasia. Molecular and Cellular Endocrinology 311 69-76. (doi:10.1016/j.mce.2009.07.024)
34. Kim W & Egan JM 2008 The role of incretins in glucose homeostasis and diabetes treatment. Pharmacological Reviews 60 470-512. (doi:10.1124/pr.108.000604)
35. Lenzen S 2008 Oxidative stress: the vulnerable b-cell. Biochemical Society Transactions 36 343-347. (doi:10.1042/BST0360343)
36. Li Y, Cao X, Li L-X, Brubaker PL, Edlund H & Drucker DJ 2005 b-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1. Diabetes 54 482-491. (doi:10.2337/diabetes.54.2.482)
37. Li N, Frigerio F & Maechler P 2008 The sensitivity of pancreatic b-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress. Biochemical Society Transactions 36 930-934. (doi:10.1042/BST0360930)
38. Lotfy M, Singh J, Kalász H, Tekes K & Adeghate E 2011 Medicinal chemistry and applications of incretins and DPP-4 inhibitors in the treatment of type 2 diabetes mellitus. Open Medicinal Chemistry Journal 5 82-92. (doi:10.2174/1874104501105010082)
39. Mayhew TM & Lucocq JM 2011 Multiple-labelling immunoEM using different sizes of colloidal gold: alternative approaches to test for differential distribution and colocalization in subcellular structures. Histochemistry and Cell Biology 135 317-326. (doi:10.1007/s00418-011-0788-0)
40. McCarty MF 2007 Exenatide and biotin in conjunction with a proteinsparing fast for normalization of b cell function in type 2 diabetics. Medical Hypotheses 69 928-932. (doi:10.1016/j.mehy.2005.09.059)
41. Muranyi M, Hea QP, Fongc KSK & Li P 2005 Induction of heat shock proteins by hyperglycemic cerebral ischemia. Brain Research. Molecular Brain Research 139 80-87. (doi:10.1016/j.molbrainres.2005.05.023)
42. Nandi A, Kitamura Y, Kahn CR & Accili D 2004 Mouse models of insulin resistance. Physiological Reviews 84 623-647. (doi:10.1152/physrev. 00032.2003)
43. Nie Y, Nakashima M, Brubaker PL, Li Q-L, Perfetti R, Jansen E, Zambre Y, Pipeleers D & Friedman TC 2000 Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic rats. Journal of Clinical Investigation 105 955-965. (doi:10.1172/JCI7456)
44. Park S, Dong X, Fisher TL, Dunn S, Omer AK, Weir G & White MF 2006 Exendin-4 uses Irs2 signaling to mediate pancreatic b cell growth and function. Journal of Biological Chemistry 281 1159-1168. (doi:10.1074/jbc.M508307200)
45. Robertson RP & Harmon JS 2007 Pancreatic islet b-cell and oxidative stress: the importance of glutathione peroxidase. FEBS Letters 581 3743-3748. (doi:10.1016/j.febslet.2007.03.087)
46. Salehi M, Aulinger BA & D'Alessio DA 2008 Targeting b-cell mass in type 2 diabetes: promise and limitations of new drugs based on incretins. Endocrine Reviews 29 367-379. (doi:10.1210/er.2007-0031)
47. Shetzline MA & Liddle RA 2002 Gastrointestinal hormones and neurotransmitters. In Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathophysiology, Diagnosis, Management, 7th edn, pp 3-20.
48. Eds M Feldman, MH Sleisenger & LS Friedman. Philadelphia: W B Saunders. Suen PM, Zou C, Zhang YA, Lau TK, Chan J, Yao KM & Leung PS 2008 PDZ-domain containing-2 (PDZD2) is a novel factor that affects the growth and differentiation of human fetal pancreatic progenitor cells. International Journal of Biochemistry & Cell Biology 40 789-803. (doi:10.1016/j.biocel.2007.10.020)
49. Teixeira-Lemos E, Nunes S, Teixeira F & Reis F 2011 Regular physical exercise training assists in preventing type 2 diabetes development: focus on its antioxidant and anti-inflammatory properties. Cardiovascular Diabetology 10 12. (doi:10.1186/1475-2840-10-12)
50. Vaghasiya JD, Sheth NR, Bhalodia YS & Jivani NP 2010 Exaggerated liver injury induced by renal ischemia reperfusion in diabetes: effect of exenatide. Saudi Journal of Gastroenterology 16 174-180. (doi:10.4103/1319-3767.65187)
51. VilsbØll T, Christensen M, Junker AE, Knop FK & Gluud LL 2012 Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials. BMJ 344 d7771. (doi:10.1136/bmj.d7771)
52. Wong ML & Medrano JF 2005 Real-time PCR for mRNA quantitation. BioTechniques 39 75-85. (doi:10.2144/05391RV01)
53. Xu Y, Wei Z, Zhang Z, Xing Q, Hu P, Zhang X, Gao G, Wang Y, Gao Q, Yi L et al. 2009 No association of the insulin gene VNTR polymorphism with polycystic ovary syndrome in a Han Chinese population. Reproductive Biology and Endocrinology 7 1-5. (doi:10.1186/1477-7827-7-141)
54. Zimmet PZ & Alberti KG 2006 Globalisation and the non-communicable disease epidemic. Obesity 14 1-3. (doi:10.1038/oby.2006.1)