메뉴 건너뛰기




Volumn 10, Issue SUPPL. 3, 2008, Pages 14-21

The physiology and pharmacology of incretins in type 2 diabetes mellitus

Author keywords

Incretins; Pharmacology; Physiology; Type 2 diabetes

Indexed keywords

ANTIDIABETIC AGENT; GASTRIC INHIBITORY POLYPEPTIDE; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 AGONIST; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; GLUCAGON LIKE PEPTIDE 1 [7-36] AMIDE; GLUCOSE; INCRETIN; INSULIN; LIRAGLUTIDE; PLACEBO;

EID: 47649086665     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2008.00920.x     Document Type: Review
Times cited : (19)

References (44)
  • 1
    • 0002025725 scopus 로고
    • On the treatment of diabetes mellitus by acid extract of duodenal mucous membrane
    • Moore B. On the treatment of diabetes mellitus by acid extract of duodenal mucous membrane. Biochem J 1906; 1: 28-38.
    • (1906) Biochem J , vol.1 , pp. 28-38
    • Moore, B.1
  • 2
    • 47649131890 scopus 로고    scopus 로고
    • GLP-1 in type 2 diabetes: The β-cell and beyond
    • Nauck MA. GLP-1 in type 2 diabetes: The β-cell and beyond. Diabetes Obes Metab 2008; 10 (Suppl. 3): 2-13.
    • (2008) Diabetes Obes Metab , vol.10 , Issue.SUPPL. 3 , pp. 2-13
    • Nauck, M.A.1
  • 3
    • 0141446228 scopus 로고    scopus 로고
    • Enhancing incretin action for the treatment of type 2 diabetes
    • Drucker DJ. Enhancing incretin action for the treatment of type 2 diabetes. Diabetes Care 2003; 26: 2929-2940.
    • (2003) Diabetes Care , vol.26 , pp. 2929-2940
    • Drucker, D.J.1
  • 4
    • 0022461548 scopus 로고
    • Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses
    • Nauck MA, Homberger E, Siegel EG et al. Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses. J Clin Endocrinol Metab 1986; 63: 492-498.
    • (1986) J Clin Endocrinol Metab , vol.63 , pp. 492-498
    • Nauck, M.A.1    Homberger, E.2    Siegel, E.G.3
  • 5
    • 0022617246 scopus 로고
    • Reduced incretin effect in type 2 (non-insulin-dependent) diabetes
    • Nauck M, Stöckmann F, Ebert R, Creutzfeldt W. Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Diabetologia 1986; 29: 46-52.
    • (1986) Diabetologia , vol.29 , pp. 46-52
    • Nauck, M.1    Stöckmann, F.2    Ebert, R.3    Creutzfeldt, W.4
  • 6
    • 35748957503 scopus 로고    scopus 로고
    • The physiology of glucagon-like peptide 1
    • Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev 2007; 87: 1409-1439.
    • (2007) Physiol Rev , vol.87 , pp. 1409-1439
    • Holst, J.J.1
  • 7
    • 0028281773 scopus 로고
    • Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide 1 in humans
    • Ørskov C, Rabenhøj L, Wettergren A, Kofod H, Holst JJ. Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide 1 in humans. Diabetes 1994; 43: 535-539.
    • (1994) Diabetes , vol.43 , pp. 535-539
    • Ørskov, C.1    Rabenhøj, L.2    Wettergren, A.3    Kofod, H.4    Holst, J.J.5
  • 8
    • 0037784011 scopus 로고    scopus 로고
    • GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine
    • Mortensen K, Christensen LL, Holst JJ, Ørskov C. GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine. Regul Pept 2003; 114: 189-196.
    • (2003) Regul Pept , vol.114 , pp. 189-196
    • Mortensen, K.1    Christensen, L.L.2    Holst, J.J.3    Ørskov, C.4
  • 9
    • 0033766716 scopus 로고    scopus 로고
    • Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide
    • Deacon CF, Nauck MA, Meier J, Hucking K, Holst JJ. Degradation of endogenous and exogenous gastric inhibitory polypeptide in healthy and in type 2 diabetic subjects as revealed using a new assay for the intact peptide. J Clin Endocrinol Metab 2000; 85: 3575-3581.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 3575-3581
    • Deacon, C.F.1    Nauck, M.A.2    Meier, J.3    Hucking, K.4    Holst, J.J.5
  • 10
    • 0027215348 scopus 로고
    • Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1 (7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum
    • Mentlein R, Gallwitz B, Schmidt WE et al. Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1 (7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum. Eur J Biochem 1993; 214: 829-835.
    • (1993) Eur J Biochem , vol.214 , pp. 829-835
    • Mentlein, R.1    Gallwitz, B.2    Schmidt, W.E.3
  • 11
    • 0033303516 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 (7-36)amide is transformed to glucagon-like peptide-1 (9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L-cells of the porcine intestine
    • Hansen L, Deacon CF, Ørskov C, Holst JJ. Glucagon-like peptide-1 (7-36)amide is transformed to glucagon-like peptide-1 (9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L-cells of the porcine intestine. Endocrinology 1999; 140: 5356-5363.
    • (1999) Endocrinology , vol.140 , pp. 5356-5363
    • Hansen, L.1    Deacon, C.F.2    Ørskov, C.3    Holst, J.J.4
  • 12
    • 0029765475 scopus 로고    scopus 로고
    • Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day
    • Ørskov C, Wettergren A, Holst JJ. Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day. Scand J Gastroenterol 1996; 31: 665-670.
    • (1996) Scand J Gastroenterol , vol.31 , pp. 665-670
    • Ørskov, C.1    Wettergren, A.2    Holst, J.J.3
  • 13
    • 0028838030 scopus 로고
    • Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients
    • Herrmann C, Göke R, Richter G, Fehmann HC, Arnold R, Göke B. Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients. Digestion 1995; 56: 117-126.
    • (1995) Digestion , vol.56 , pp. 117-126
    • Herrmann, C.1    Göke, R.2    Richter, G.3    Fehmann, H.C.4    Arnold, R.5    Göke, B.6
  • 14
    • 15044341261 scopus 로고    scopus 로고
    • What do we know about the secretion and degradation of incretin hormones?
    • Deacon CF. What do we know about the secretion and degradation of incretin hormones? Regul Pept 2005; 128: 117-124.
    • (2005) Regul Pept , vol.128 , pp. 117-124
    • Deacon, C.F.1
  • 15
    • 0038310124 scopus 로고    scopus 로고
    • Muscarinic receptors control glucagon-like peptide 1 secretion by human endocrine L cells
    • Anini Y, Brubaker PL. Muscarinic receptors control glucagon-like peptide 1 secretion by human endocrine L cells. Endocrinology 2003; 144: 3244-3250.
    • (2003) Endocrinology , vol.144 , pp. 3244-3250
    • Anini, Y.1    Brubaker, P.L.2
  • 17
    • 0029125052 scopus 로고
    • Regulation of glucagon-like peptide-1 secretion from rat ileum by neurotransmitters and peptides
    • Herrmann-Rinke C, Vöge A, Hess M, Göke B. Regulation of glucagon-like peptide-1 secretion from rat ileum by neurotransmitters and peptides. J Endocrinol 1995; 147: 25-31.
    • (1995) J Endocrinol , vol.147 , pp. 25-31
    • Herrmann-Rinke, C.1    Vöge, A.2    Hess, M.3    Göke, B.4
  • 18
    • 0037207057 scopus 로고    scopus 로고
    • The effects of duodenal peptides on glucagon-like peptide-1 secretion from the ileum. A duodeno-ileal loop?
    • Hansen L, Holst JJ. The effects of duodenal peptides on glucagon-like peptide-1 secretion from the ileum. A duodeno-ileal loop? Regul Pept 2002; 110: 39-45.
    • (2002) Regul Pept , vol.110 , pp. 39-45
    • Hansen, L.1    Holst, J.J.2
  • 19
    • 0027391607 scopus 로고
    • Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
    • Nauck MA, Heimesaat MM, Ørskov C, Holst JJ, Ebert R, Creutzfeldt W. Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest 1993; 91: 301-307.
    • (1993) J Clin Invest , vol.91 , pp. 301-307
    • Nauck, M.A.1    Heimesaat, M.M.2    Ørskov, C.3    Holst, J.J.4    Ebert, R.5    Creutzfeldt, W.6
  • 20
    • 0037373183 scopus 로고    scopus 로고
    • International Union of Pharmacology. XXXV. The glucagon receptor family
    • Mayo KE, Miller JL, Bataille D et al. International Union of Pharmacology. XXXV. The glucagon receptor family. Pharmacol Rev 2003; 55: 167-194.
    • (2003) Pharmacol Rev , vol.55 , pp. 167-194
    • Mayo, K.E.1    Miller, J.L.2    Bataille, D.3
  • 21
    • 0347990624 scopus 로고    scopus 로고
    • Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell
    • Holz GG. Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell. Diabetes 2004; 53: 5-13.
    • (2004) Diabetes , vol.53 , pp. 5-13
    • Holz, G.G.1
  • 22
    • 0023104829 scopus 로고
    • Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut
    • Holst JJ, Ørskov C, Nielsen OV, Schwartz TW. Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut. FEBS Lett 1987; 211: 169-174.
    • (1987) FEBS Lett , vol.211 , pp. 169-174
    • Holst, J.J.1    Ørskov, C.2    Nielsen, O.V.3    Schwartz, T.W.4
  • 23
    • 0023107555 scopus 로고
    • Insulinotropin: Glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas
    • Mojsov S, Weir GC, Habener JF. Insulinotropin: Glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J Clin Invest 1987; 79: 616-619.
    • (1987) J Clin Invest , vol.79 , pp. 616-619
    • Mojsov, S.1    Weir, G.C.2    Habener, J.F.3
  • 24
    • 0023638829 scopus 로고
    • Glucagon-like peptide-1 7-36: A physiological incretin in man
    • Kreymann B, Williams G, Ghatei MA, Bloom SR. Glucagon-like peptide-1 7-36: A physiological incretin in man. Lancet 1987; ii: 1300-1304.
    • (1987) Lancet , vol.2 , pp. 1300-1304
    • Kreymann, B.1    Williams, G.2    Ghatei, M.A.3    Bloom, S.R.4
  • 25
    • 0023758530 scopus 로고
    • Effect of truncated glucagon-like peptide-1 [proglucagon-(78-107) amide] on endocrine secretion from pig pancreas, antrum, and nonantral stomach
    • Ørskov C, Holst JJ, Nielsen OV. Effect of truncated glucagon-like peptide-1 [proglucagon-(78-107) amide] on endocrine secretion from pig pancreas, antrum, and nonantral stomach. Endocrinology 1988; 123: 2009-2013.
    • (1988) Endocrinology , vol.123 , pp. 2009-2013
    • Ørskov, C.1    Holst, J.J.2    Nielsen, O.V.3
  • 26
    • 33847617011 scopus 로고    scopus 로고
    • Mechanisms of action of glucagon-like peptide 1 in the pancreas
    • Doyle ME, Egan JM. Mechanisms of action of glucagon-like peptide 1 in the pancreas. Pharmacol Ther 2007; 113: 546-593.
    • (2007) Pharmacol Ther , vol.113 , pp. 546-593
    • Doyle, M.E.1    Egan, J.M.2
  • 27
    • 33644618433 scopus 로고    scopus 로고
    • The biology of the incretins
    • Drucker DJ. The biology of the incretins. Cell Metab 2006; 3: 153-165.
    • (2006) Cell Metab , vol.3 , pp. 153-165
    • Drucker, D.J.1
  • 28
    • 0030667056 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy volunteers
    • Nauck MA, Niedereichholz U, Etter R et al. Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy volunteers. Am J Physiol 1997; 273: E981-E988.
    • (1997) Am J Physiol , vol.273
    • Nauck, M.A.1    Niedereichholz, U.2    Etter, R.3
  • 29
    • 21344454659 scopus 로고    scopus 로고
    • Erythromycin antagonizes the deceleration of gastric emptying by glucagon-like peptide 1 and unmasks its insulinotropic effect in healthy subjects
    • Meier JJ, Kemmeries G, Holst JJ, Nauck MA. Erythromycin antagonizes the deceleration of gastric emptying by glucagon-like peptide 1 and unmasks its insulinotropic effect in healthy subjects. Diabetes 2005; 54: 2212-2218.
    • (2005) Diabetes , vol.54 , pp. 2212-2218
    • Meier, J.J.1    Kemmeries, G.2    Holst, J.J.3    Nauck, M.A.4
  • 30
    • 0038577144 scopus 로고    scopus 로고
    • Cardiac function in mice lacking the glucagon-like peptide-1 receptor
    • Gros R, You X, Baggio CC et al. Cardiac function in mice lacking the glucagon-like peptide-1 receptor. Endocrinology 2003; 144: 2242-2252.
    • (2003) Endocrinology , vol.144 , pp. 2242-2252
    • Gros, R.1    You, X.2    Baggio, C.C.3
  • 31
    • 4344605042 scopus 로고    scopus 로고
    • Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy
    • Nikolaidis LA, Elahi D, Hentosz T et al. Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy. Circulation 2004; 110: 955-961.
    • (2004) Circulation , vol.110 , pp. 955-961
    • Nikolaidis, L.A.1    Elahi, D.2    Hentosz, T.3
  • 32
    • 12144260853 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 can directly protect the heart against ischemia/ reperfusion injury
    • Bose AK, Mocanu MM, Carr RD, Brand CL, Yellon DM. Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury. Diabetes 2005; 54: 146-151.
    • (2005) Diabetes , vol.54 , pp. 146-151
    • Bose, A.K.1    Mocanu, M.M.2    Carr, R.D.3    Brand, C.L.4    Yellon, D.M.5
  • 33
    • 13344282056 scopus 로고    scopus 로고
    • A role for glucagon-like peptide-1 in the central regulation of feeding
    • Turton MD, O'Shea D, Gunn I et al. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 1996; 379: 69-72.
    • (1996) Nature , vol.379 , pp. 69-72
    • Turton, M.D.1    O'Shea, D.2    Gunn, I.3
  • 34
    • 0029859220 scopus 로고    scopus 로고
    • Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats
    • Tang-Christensen M, Larsen PH, Göke R et al. Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats. Am J Physiol 1996; 271: R848-R856.
    • (1996) Am J Physiol , vol.271
    • Tang-Christensen, M.1    Larsen, P.H.2    Göke, R.3
  • 35
    • 0032940582 scopus 로고    scopus 로고
    • Repeated intracerebroventricular administration of glucagon-like peptide-1-(7-36) amide or exendin-(9-39) alters body weight in the rat
    • Meeran K, O'Shea D, Edwards CM et al. Repeated intracerebroventricular administration of glucagon-like peptide-1-(7-36) amide or exendin-(9-39) alters body weight in the rat. Endocrinology 1999; 140: 244-250.
    • (1999) Endocrinology , vol.140 , pp. 244-250
    • Meeran, K.1    O'Shea, D.2    Edwards, C.M.3
  • 36
    • 48449093468 scopus 로고    scopus 로고
    • Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients
    • Muscelli E, Mari A, Casolaro A et al. Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients. Diabetes 2008; 57: 1340-1348.
    • (2008) Diabetes , vol.57 , pp. 1340-1348
    • Muscelli, E.1    Mari, A.2    Casolaro, A.3
  • 37
    • 0034880655 scopus 로고    scopus 로고
    • Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients
    • Toft-Nielsen MB, Damholt MB, Madsbad S et al. Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients. J Clin Endocrinol Metab 2001; 86: 3717-3723.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 3717-3723
    • Toft-Nielsen, M.B.1    Damholt, M.B.2    Madsbad, S.3
  • 38
    • 0037312821 scopus 로고    scopus 로고
    • The influence of GLP-1 on glucose-stimulated insulin secretion: Effects on beta-cell sensitivity in type 2 and nondiabetic subjects
    • Kjems LL, Holst JJ, Vølund A, Madsbad S. The influence of GLP-1 on glucose-stimulated insulin secretion: Effects on beta-cell sensitivity in type 2 and nondiabetic subjects. Diabetes 2003; 52: 380-386.
    • (2003) Diabetes , vol.52 , pp. 380-386
    • Kjems, L.L.1    Holst, J.J.2    Vølund, A.3    Madsbad, S.4
  • 39
    • 0027248866 scopus 로고
    • Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients
    • Nauck MA, Kleine N, Ørskov C, Holst JJ, Willms B, Creuzfeldt W. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia 1993; 36: 741-744.
    • (1993) Diabetologia , vol.36 , pp. 741-744
    • Nauck, M.A.1    Kleine, N.2    Ørskov, C.3    Holst, J.J.4    Willms, B.5    Creuzfeldt, W.6
  • 40
    • 0036373430 scopus 로고    scopus 로고
    • Defective amplification of the late phase insulin response to glucose by GIP in obese type II diabetic patients
    • Vilsbøll T, Krarup T, Madsbad S, Holst JJ. Defective amplification of the late phase insulin response to glucose by GIP in obese type II diabetic patients. Diabetologia 2002; 45: 1111-1119.
    • (2002) Diabetologia , vol.45 , pp. 1111-1119
    • Vilsbøll, T.1    Krarup, T.2    Madsbad, S.3    Holst, J.J.4
  • 41
    • 34547586659 scopus 로고    scopus 로고
    • Reduced incretin effect in type 2 diabetes: Cause or consequence of the diabetic state?
    • Knop FK, Vilsbøll T, Højberg PV et al. Reduced incretin effect in type 2 diabetes: Cause or consequence of the diabetic state? Diabetes 2007; 56: 1951-1959.
    • (2007) Diabetes , vol.56 , pp. 1951-1959
    • Knop, F.K.1    Vilsbøll, T.2    Højberg, P.V.3
  • 42
    • 0037045845 scopus 로고    scopus 로고
    • Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: A parallel-group study
    • Zander M, Madsbad S, Madsen JL, Holst JJ. Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: A parallel-group study. Lancet 2002; 359: 824-880.
    • (2002) Lancet , vol.359 , pp. 824-880
    • Zander, M.1    Madsbad, S.2    Madsen, J.L.3    Holst, J.J.4
  • 43
    • 0027473729 scopus 로고
    • Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1 (7-37)
    • Holz GG IV, Kühtreiber WM, Habener JF. Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1 (7-37). Nature 1993; 361: 362-365.
    • (1993) Nature , vol.361 , pp. 362-365
    • Holz IV, G.G.1    Kühtreiber, W.M.2    Habener, J.F.3
  • 44
    • 47649096171 scopus 로고    scopus 로고
    • GLP-1-based therapies: New developments and emerging data
    • Garber A. GLP-1-based therapies: New developments and emerging data. Diabetes Obes Metab 2008; 10 (Suppl. 3): 22-35.
    • (2008) Diabetes Obes Metab , vol.10 , Issue.SUPPL. 3 , pp. 22-35
    • Garber, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.