A novel transcriptomics based in vitro method to compare and predict hepatotoxicity based on mode of action

Toxicology

Volumn 328, Issue , 2015, Pages 29-39

  De Abrew, K Nadira ^a   Overmann, Gary J ^a   Adams, Rachel L ^a   Tiesman, Jay P ^a   Dunavent, John ^a   Shan, Yuqing K ^a   Carr, Gregory J ^a   Daston, George P ^a   Naciff, Jorge M ^a  

^a PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

21st century Tox; Hepatotoxicity; Toxicity pathways; Toxicogenomics; Transcriptomics

Indexed keywords

BETA NAPHTHOFLAVONE; CHLORPROMAZINE; CLOFIBRATE; DIISONONYL PHTHALATE; METHAPYRILENE; PARACETAMOL; PEROXISOME PROLIFERATOR; PHENOBARBITAL; PHTHALIC ACID; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PIRINIXIC ACID; UNCLASSIFIED DRUG; VALPROIC ACID; GENETIC MARKER; PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLUSTER ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; LIVER FUNCTION; LIVER TOXICITY; MALE; MICROARRAY ANALYSIS; NONHUMAN; RAT; TRANSCRIPTOMICS; UPREGULATION; ANIMAL; CELL CULTURE; DNA MICROARRAY; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC MARKER; GENETICS; LIVER; LIVER CELL; METABOLISM; PROCEDURES; SPRAGUE DAWLEY RAT; TIME; TOXIC HEPATITIS; TOXICOGENETICS;

RATTUS;

ANIMALS; CELLS, CULTURED; CLUSTER ANALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC MARKERS; HEPATOCYTES; LIVER; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEINS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TOXICOGENETICS;

EID: 84919935114     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2014.11.008     Document Type: Article

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