Utilization of a one-dimensional score for surveying chemical-induced changes in expression levels of multiple biomarker gene sets using a large-scale toxicogenomics database

Journal of Toxicological Sciences

Volumn 31, Issue 5, 2006, Pages 433-448

  Kiyosawa, Naoki ^a   Shiwaku, Kouji ^a   Hirode, Mitsuhiro ^a   Omura, Ko ^a   Uehara, Takeki ^a   Shimizu, Toshinobu ^a   Mizukawa, Yumiko ^b   Miyagishima, Toshikazu ^a   Ono, Atsushi ^a   Nagao, Taku ^c   Urushidani, Tetsuro ^a,b  

^a NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

^b DOSHISHA WOMEN'S COLLEGE OF LIBERAL ARTS   (Japan)

^c NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

Database; Liver; Rat; Scoring system; Toxicogenomics

Indexed keywords

1 NAPHTHYL ISOTHIOCYANATE; ACETYLSALICYLIC ACID; ALLYL ALCOHOL; BENZBROMARONE; BROMOBENZENE; CARBAMAZEPINE; CARBON TETRACHLORIDE; CHLORPROMAZINE; CLOFIBRATE; COUMARIN; CYTOCHROME P450 1A1; DICLOFENAC; ETHIONINE; GEMFIBROZIL; GLUTATHIONE; HEXACHLOROBENZENE; INDOMETACIN; ISONIAZID; METHOTREXATE; OMEPRAZOLE; PARACETAMOL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PHENOBARBITAL; PHENYLBUTAZONE; PIRINIXIC ACID; RIFAMPICIN; SALAZOSULFAPYRIDINE; THIOACETAMIDE; UNINDEXED DRUG; VALPROIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DATA BASE; DOSE RESPONSE; DRUG MEGADOSE; DRUG SAFETY; GENE EXPRESSION; GENE PROBE; GENOMICS; LIVER CELL; MALE; MICROARRAY ANALYSIS; NONHUMAN; RAT; SCORING SYSTEM; STATISTICAL ANALYSIS; TOXICOLOGY;

EID: 33845979137     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.31.433     Document Type: Article

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