27-Hydroxycholesterol up-regulates CD14 and predisposes monocytic cells to superproduction of CCL2 in response to lipopolysaccharide

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1852, Issue 3, 2015, Pages 442-450

  Kim, Sun Mi ^a   Kim, Bo Young ^a   Eo, Seong Kug ^b   Kim, Chi Dae ^a   Kim, Koanhoi ^a  

^a Pusan National University School of Medicine   (South Korea)

^b Chonbuk National University   (South Korea)

Author keywords

Atherosclerosis; CCL2; CD14; Cholesterol oxides (oxysterols); Lipopolysaccharide; Macrophages

Indexed keywords

26 HYDROXYCHOLESTEROL; APOLIPOPROTEIN E; CD14 ANTIGEN; GELATINASE B; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; 27-HYDROXYCHOLESTEROL; CCL2 PROTEIN, HUMAN; CCL2 PROTEIN, MOUSE; CHOLESTEROL DERIVATIVE;

ANIMAL CELL; ARTICLE; ATHEROSCLEROSIS; BACTERIAL INFECTION; CELL ISOLATION; CELL MIGRATION; CHOLESTEROL DIET; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE PRODUCTION; ENZYME INHIBITION; GENE PRODUCT; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INFLAMMATION; MONOCYTE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SECRETION; SMOOTH MUSCLE FIBER; UPREGULATION; VASCULAR SMOOTH MUSCLE; ANIMAL; BIOSYNTHESIS; DRUG EFFECTS; GENETICS; GRAM NEGATIVE INFECTION; JURKAT CELL LINE; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; MOUSE; PATHOLOGY; SECRETION (PROCESS);

BACTERIA (MICROORGANISMS); MUS; NEGIBACTERIA;

ANIMALS; ANTIGENS, CD14; CHEMOKINE CCL2; GRAM-NEGATIVE BACTERIAL INFECTIONS; HUMANS; HYDROXYCHOLESTEROLS; JURKAT CELLS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, KNOCKOUT; MONOCYTES; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 84919934705     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2014.12.003     Document Type: Article

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