Soluble CD14 enhances membrane CD14-mediated responses to peptidoglycan: Structural requirements differ from those for responses to lipopolysaccharide

Infection and Immunity

Volumn 68, Issue 9, 2000, Pages 5254-5260

  Dziarski, R ^a   Viriyakosol, S ^a   Kirkland, T N ^a   Gupta, D ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE NORTHWEST   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CD14 ANTIGEN; PEPTIDOGLYCAN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTIGEN BINDING; ARTICLE; BACTERIAL CELL WALL; BACTERIUM ADHERENCE; GRAM POSITIVE BACTERIUM; MEMBRANE BINDING; NONHUMAN; PRIORITY JOURNAL;

ACUTE-PHASE PROTEINS; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD14; CARRIER PROTEINS; HUMANS; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS; MICE; MOLECULAR SEQUENCE DATA; PEPTIDOGLYCAN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033861895     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.9.5254-5260.2000     Document Type: Article

References (26)

1. CD14 employs hydrophilic regions to 'capture' lipopolysaccharide
2. Heparin, sulfated heparinoids, and lipoteichoic acid bind to the 70 kDa peptidoglycan/lipopolysaccharide receptor protein on lymphocytes
3. 2-terminal kinase mitogen-activated protein kinases by bacterial peptidoglycan
4. Binding of bacterial peptidoglycan to CD14
5. Interactions of bacterial lipopolysaccharide and peptidoglycan with mammalian CD14
6. Interactions of CD14 with components of Gram-positive bacteria
7. CD14 is a cell-activating receptor for bacterial peptidoglycan
8. Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14
9. Stimulation of macrophages and neutrophils by complexes of lipopolysaccharide and soluble CD14
10. Endothelial and epithelial cells do not respond to complexes of peptidoglycan with soluble CD14, but are activated indirectly by peptidoglycan-induced tumor necrosis factor-α and interleukin-1 from monocytes
11. Identification of a lipopolysaccharide binding domain in CD14 between amino acids 57 and 64
12. Isolation of peptidoglycan and soluble peptidoglycan fragments
13. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by Toll-like receptor 2
14. Mutation of amino acids 39-34 of human CD14 abrogates binding of lipopolysaccharide and Escherichia coli
15. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components
16. Cellular binding of soluble CD14 requires lipopolysaccharide (LPS) and LPS-binding protein
17. Lipopolysaccharide binding protein-mediated complexation of lipopolysaccharide with soluble CD14
18. Cross-linking of lipopolysaccharide (LPS) to CD14 on THP-1 cells mediated by LPS-binding protein
19. A region of human CD14 required for lipopolysaccharide binding
20. Structure-function analysis of CD14 as a soluble receptor for lipopolysaccharide
21. Chemokines are the main pro-inflammatory mediators in human monocytes activated by Staphylococcus aureus, peptidoglycan, and endotoxin
22. Soluble peptidoglycan-induced monokine production can be blocked by anti-CD14 monoclonal antibodies and by lipid A partial structures
23. Specific binding of soluble peptidoglycan and muramyldipeptide to CD14 on human monocytes
24. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
25. Recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2
26. Catalytic properties of lipopolysaccharide (LPS) binding protein. Transfer of LPS to soluble CD14