Ascochlorin suppresses oxLDL-induced MMP-9 expression by inhibiting the MEK/ERK signaling pathway in human THP-1 macrophages

Journal of Cellular Biochemistry

Volumn 102, Issue 2, 2007, Pages 506-514

  Jeong, Han Kang ^a,b   Kim, June Ki ^b   Park, Won Hwan ^b   Park, Kwan Kyu ^a   Lee, Tae Sung ^a   Magae, Junji ^c   Nakajima, Hiroo ^d   Kim, Cheorl Ho ^e   Chang, Young Chae ^a  

^a The Catholic University of Korea   (South Korea)

^b Dongguk University   (South Korea)

^c INSTITUTE OF RESEARCH AND INNOVATION   (Japan)

^d KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^e Sungkyunkwan University   (South Korea)

Author keywords

Activator protein 1; Ascochlorin; Atherosclerosis; Matrix metalloproteinase 9; Oxidized low density lipoprotein; THP 1

Indexed keywords

ANTIVIRUS AGENT; ASCOCHLORIN; GELATINASE B; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE; OXIDIZED LOW DENSITY LIPOPROTEIN; UNCLASSIFIED DRUG;

ARTICLE; ASCOCHYTA VICIAE; ATHEROGENESIS; CELL VIABILITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; FUNGUS; HUMAN; HUMAN CELL; MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ALKENES; BUTADIENES; CELL LINE; FLAVONOIDS; GENE EXPRESSION REGULATION; HUMANS; LIPOPROTEINS, LDL; MACROPHAGES; MATRIX METALLOPROTEINASE 9; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NITRILES; PHENOLS; SIGNAL TRANSDUCTION;

ASCOCHYTA; FUNGI;

EID: 34948814544     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21312     Document Type: Article

References (27)

1. Burdon RH, Kinppenberg PH. 1984. A guide book to lipoprotein techiniques. Amsterdam: Elsevier Science.
2. Corcoran ML, Kibbey MC, Kleinman HK, Wahl LM. 1995. Laminin SIKVAV peptide induction of monocyte/macrophage prostaglandin E2 and matrix metalloproteinases. J Biol Chem 270:10365-10368.
3. Galis ZS, Sukhova GK, Kranzhofer R, Clark S, Libby P. 1995a. Macrophage foam cells from experimental atheroma constitutively produce matrix-degrading proteinases. Proc Natl Acad Sci U S A 92:402-406.
4. Galis ZS, Sukhova GK, Libby P. 1995b. Microscopic localization of active proteases by in situ zymography: Detection of matrix metalloproteinase activity in vascular tissue. FASEB J 9:974-980.
5. Heinecke JW, Rosen H, Chait A. 1984. Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture. J Clin Invest 74:1890-1894.
6. Hong S, Park KK, Magae J, Ando K, Lee TS, Kwon TK, Kwak JY, Kim CH, Chang YC. 2005. Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated gene expression through the ERK1/2 signaling pathway: Inhibitory effects of ascochlorin on the invasion of renal carcinoma cells. J Biol Chem 280:25202-25209.
7. Hosokawa T, Ando K, Tamura G. 1985. An ascochlorin derivative, AS-6, reduces insulin resistance in the genetically obese diabetic mouse, db/db. Diabetes 34:267-274.
8. Hosokawa T, Sawada M, Ando K, Tamura G. 1981. Alteration of cholesterol metabolism by 4-O-methylascochlorin in rats. Lipids 16:433-438.
9. Kang JH, Park KK, Lee IS, Magae J, Ando K, Kim CH, Chang YC. 2006. Proteome analysis of responses to ascochlorin in a human osteosarcoma cell line by 2-D gel electrophoresis and MALDI-TOF MS. J Proteome Res 5:2620-2631.
10. Magae J, Hayasaki J, Matsuda Y, Hotta M, Hosokawa T, Suzuki S, Nagai K, Ando K, Tamura G. 1988. Antitumor and antimetastatic activity of an antibiotic, ascofuranone, and activation of phagocytes. J Antibiot (Tokyo) 41:959-965.
11. Magae J, Munemura K, Ichikawa C, Osada K, Hanada T, Tsuji RF, Yamashita M, Hino A, Horiuchi T, Uramoto M. et al. 1993. Effects of microbial products on glucose consumption and morphology of macrophages. Biosci Biotechnol Biochem 57:1628-1631.
12. Magae J, Suzuki S, Nagai K, Yamasaki M, Ando K, Tamura G. 1986. In vitro effects of an antitumor antibiotic, ascofuranone, on the murine immune system. Cancer Res 46:1073-1078.
13. Murphy G, Docherty AJ, Hembry RM, Reynolds JJ. 1991. Metalloproteinases and tissue damage. Br J Rheumatol 30: (Suppl 1):25-31.
14. Nabeshima K, Inoue T, Shimao Y, Sameshima T. 2002. Matrix metalloproteinases in tumor invasion: Role for cell migration. Pathol Int 52:255-264.
15. Nagase H, Barrett AJ, Woessner JF Jr. 1992. Nomenclature and glossary of the matrix metalloproteinases. Matrix (Suppl 1):421-424.
16. Palinski W, Rosenfeld ME, Yla-Herttuala S, Gurtner GC, Socher SS, Butler SW, Parthasarathy S, Carew TE, Steinberg D, Witztum JL. 1989. Low density lipoprotein undergoes oxidative modification in vivo. Proc Natl Acad Sci U S A 86:1372-1376.
17. Rajagopalan S, Meng XP, Ramasamy S, Harrison DG, Galis ZS. 1996. Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability. J Clin Invest 98:2572-2579.
18. Roh DD, Kamanna VS, Kirschenbaum MA. 1998. Oxidative modification of low-density lipoprotein enhances mesangial cell protein synthesis and gene expression of extracellular matrix proteins. Am J Nephrol 18:344-350.
19. Sato H, Seiki M. 1993. Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells. Oncogene 8:395-405.
20. Shah PK, Falk E, Badimon JJ, Fernandez-Ortiz A, Mailhac A, Villareal-Levy G, Fallon JT, Regnstrom J, Fuster V. 1995. Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques. Potential role of matrix-degrading metalloproteinases and implications for plaque rupture. Circulation 92:1565-1569.
21. Steinberg D. 1997. Low density lipoprotein oxidation and its pathobiological significance. J Biol Chem 272:20963-20966.
22. Stetler-Stevenson WG, Brown PD, Onisto M, Levy AT, Liotta LA. 1990. Tissue inhibitor of metalloproteinases-2 (TIMP-2) mRNA expression in tumor cell lines and human tumor tissues. J Biol Chem 265:13933-13938.
23. Tamura G, Suzuki S, Takatsuki A, Ando K, Arima K. 1968. Ascochlorin, a new antibiotic, found by the paper-disc agar-diffusion method. I. Isolation, biological and chemical properties of ascochlorin. (Studies on antiviral and antitumor antibiotics. I). J Antibiot (Tokyo) 21:539-544.
24. Togashi M, Ozawa S, Abe S, Nishimura T, Tsuruga M, Ando K, Tamura G, Kuwahara S, Ubukata M, Magae J. 2003. Ascochlorin derivatives as ligands for nuclear hormone receptors. J Med Chem 46:4113-4123.
25. Williams KJ, Tabas I. 1995. The response-to-retention hypothesis of early atherogenesis. Arterioscler Thromb Vasc Biol 15:551-561.
26. Woessner JF, Jr. 1991. Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 5:2145-2154.
27. Xu XP, Meisel SR, Ong JM, Kaul S, Cercek B, Rajavashisth TB, Sharifi B, Shah PK. 1999. Oxidized low-density lipoprotein regulates matrix metalloproteinase-9 and its tissue inhibitor in human monocyte-derived macrophages. Circulation 99:993-998.