Rational Design of Small Molecule Inhibitors Targeting the Ras GEF, SOS1

Chemistry and Biology

Volumn 21, Issue 12, 2014, Pages 1618-1628

  Evelyn, Chris R ^a   Duan, Xin ^a   Biesiada, Jacek ^a   Seibel, William L ^a   Meller, Jaroslaw ^a,b   Zheng, Yi ^a  

^a CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; GUANINE NUCLEOTIDE EXCHANGE FACTOR; NSC 658497; NSC 674954; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; RAS PROTEIN; SOS PROTEIN; UNCLASSIFIED DRUG; MOLECULAR LIBRARY;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG BINDING; DRUG DESIGN; DRUG EFFICACY; ENZYME ACTIVITY; MUTAGENESIS; PROTEIN INTERACTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; ENZYME ACTIVE SITE; FIBROBLAST; GENETICS; HUMAN; METABOLISM; MOLECULAR LIBRARY; MOUSE; PHARMACOLOGY; PRECLINICAL STUDY; TUMOR CELL LINE;

ANIMALS; CATALYTIC DOMAIN; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; FIBROBLASTS; HUMANS; MICE; MODELS, MOLECULAR; MUTAGENESIS; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; SOS1 PROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84919918713     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2014.09.018     Document Type: Article

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