Does genetic heterogeneity account for the divergent risk of type 2 diabetes in South Asian and white European populations?

Diabetologia

Volumn 57, Issue 11, 2014, Pages 2270-2281

  Sohani, Zahra N ^a,b,c   Deng, Wei Q ^a,b,c   Pare, Guillaume ^a,b,c,d   Meyre, David ^a,b,c,d   Gerstein, Hertzel C ^a,c,d   Anand, Sonia S ^a,b,c,d  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c HAMILTON HEALTH SCIENCES   (Canada)

^d MCMASTER UNIVERSITY   (Canada)

Author keywords

Epidemiology; Ethnicity; Genetic risk; Meta analysis; South Asian; Type 2 diabetes; White Europeans

Indexed keywords

INSULIN;

ARTICLE; CINAHL; COCHRANE LIBRARY; EMBASE; ETHNICITY; EUROPEAN; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC PREDISPOSITION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; INSULIN RELEASE; INSULIN SENSITIVITY; MEDLINE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; POPULATION; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SOUTH ASIAN; SYSTEMATIC REVIEW; ASIAN CONTINENTAL ANCESTRY GROUP; CAUCASIAN; DIABETES MELLITUS, TYPE 2; EUROPE; GENETICS; META ANALYSIS;

ASIAN CONTINENTAL ANCESTRY GROUP; DIABETES MELLITUS, TYPE 2; EUROPE; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC HETEROGENEITY; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84919902694     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3354-1     Document Type: Article

References (67)

1. Wild S, Roglic G, Green A et al (2004) Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27:1047–1053
2. International Diabetes Federation (2013) Diabetes Atlas, 6th edn. International Diabetes Federation, Brussels
3. Stumvoll M, Goldstein BJ, van Haeften TW (2005) Type 2 diabetes: principles of pathogenesis and therapy. Lancet 365:1333–1346
4. Razak F, Anand SS, Shannon H et al (2007) Defining obesity cut points in a multiethnic population. Circulation 115:2111–2118
5. McKeigue PM, Shah B, Marmot MG (1991) Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians. Lancet 337:382–386
6. Raji A, Seely EW, Arky RA, Simonson DC (2001) Body fat distribution and insulin resistance in healthy Asian Indians and Caucasians. J Clin Endocrinol Metab 86:5366–5371
7. Radha V, Mohan V (2007) Genetic predisposition to type 2 diabetes among Asian Indians. Indian J Med Res 125:259–274
8. Kanaya AM, Wassel CL, Mathur D et al (2010) Prevalence and correlates of diabetes in South asian indians in the United States: findings from the metabolic syndrome and atherosclerosis in South asians living in america study and the multi-ethnic study of atherosclerosis. Metab Syndr Relat Disord 8:157–164
9. Little J, Higgins JPT, Ioannidis JPA et al (2009) STrengthening the REporting of Genetic Association Studies (STREGA): an extension of the STROBE statement. PLoS Med 6:e22
10. Lewis CM, Knight J (2012) Introduction to genetic association studies. Cold Spring Harb Protoc 2012:297–306
11. Johnson AD, Handsaker RE, Pulit SL et al (2008) SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap. Bioinformatics 24:2938–2939
12. Huedo-Medina TB, Sánchez-Meca J, Marín-Martínez F, Botella J (2006) Assessing heterogeneity in meta-analysis: Q statistic or I2 index? Psychol Methods 11:193–206
13. Morris AP, Voight BF, Teslovich TM et al (2012) Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet 44:981–990
14. Kooner JS, Saleheen D, Sim X et al (2011) Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet 43:984–989
15. Tabassum R, Chauhan G, Dwivedi OP et al (2013) Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21. Diabetes 62:977–986
16. Saxena R, Saleheen D, Been LF et al (2013) Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. Diabetes 62:1746–1755
17. Sim X, Ong RT-H, Suo C et al (2011) Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. PLoS Genet 7:e1001363
18. Haseeb A, Iliyas M, Chakrabarti S et al (2009) Single-nucleotide polymorphisms in peroxisome proliferator-activated receptor gamma and their association with plasma levels of resistin and the metabolic syndrome in a South Indian population. J Biosci 34:405–414
19. Anuradha S, Radha V, Mohan V (2011) Association of novel variants in the hepatocyte nuclear factor 4A gene with maturity onset diabetes of the young and early onset type 2 diabetes. Clin Genet 80:541–549
20. Chandak GR, Janipalli CS, Bhaskar S et al (2007) Common variants in the TCF7L2 gene are strongly associated with type 2 diabetes mellitus in the Indian population. Diabetologia 50:63–67
21. Chidambaram M, Radha V, Mohan V (2010) Replication of recently described type 2 diabetes gene variants in a South Indian population. Metabolism 59:1760–1766
22. Mukhopadhyaya PN, Acharya A, Chavan Y et al (2010) Metagenomic study of single-nucleotide polymorphism within candidate genes associated with type 2 diabetes in an Indian population. Genet Mol Res 9:2060–2068
23. Janipalli CS, Kumar MVK, Vinay DG et al (2012) Analysis of 32 common susceptibility genetic variants and their combined effect in predicting risk of Type 2 diabetes and related traits in Indians. Diabet Med 29:121–127
24. Rees SD, Hydrie MZI, Shera AS et al (2011) Replication of 13 genome-wide association (GWA)-validated risk variants for type 2 diabetes in Pakistani populations. Diabetologia 54:1368–1374
25. Uma Jyothi K, Jayaraj M, Subburaj KS et al (2013) Association of TCF7L2 gene polymorphisms with T2DM in the population of Hyderabad, India. PLoS One 8:e60212
26. Rees SD, Islam M, Hydrie MZI et al (2011) An FTO variant is associated with Type 2 diabetes in South Asian populations after accounting for body mass index and waist circumference. Diabet Med 28:673–680
27. Bodhini D, Radha V, Dhar M et al (2007) The rs12255372(G/T) and rs7903146(C/T) polymorphisms of the TCF7L2 gene are associated with type 2 diabetes mellitus in Asian Indians. Metabolism 56:1174–1178
28. Raza ST, Abbas S, Ahmed F et al (2012) Association of MTHFR and PPARγ2 gene polymorphisms in relation to type 2 diabetes mellitus cases among north Indian population. Gene 511:375–379
29. Tan JT, Ng DPK, Nurbaya S et al (2010) Polymorphisms identified through genome-wide association studies and their associations with type 2 diabetes in Chinese, Malays, and Asian-Indians in Singapore. J Clin Endocrinol Metab 95:390–397
30. Humphries SE, Gable D, Cooper JA et al (2006) Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European Whites, Indian Asians and Afro-Caribbean men and women. J Mol Med (Berl) 84:1005–1014
31. Radha V, Vimaleswaran KS, Babu HNS et al (2006) Role of genetic polymorphism peroxisome proliferator-activated receptor-gamma2 Pro12Ala on ethnic susceptibility to diabetes in South-Asian and Caucasian subjects: Evidence for heterogeneity. Diabetes Care 29:1046–1051
32. Boodram LG, Miyake K, Hayes MG et al (2011) Association of the KCNJ11 variant E23K with type 2 diabetes in Indo-Trinidadians. West Indian Med J 60:604–607
33. Yajnik CS, Janipalli CS, Bhaskar S et al (2009) FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians. Diabetologia 52:247–252
34. Gupta V, Khadgawat R, Ng HKT et al (2010) A validation study of type 2 diabetes-related variants of the TCF7L2, HHEX, KCNJ11, and ADIPOQ genes in one endogamous ethnic group of north India. Ann Hum Genet 74:361–368
35. Chauhan G, Spurgeon CJ, Tabassum R et al (2010) Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians. Diabetes 59:2068–2074
36. Chauhan G, Tabassum R, Mahajan A et al (2011) Common variants of FTO and the risk of obesity and type 2 diabetes in Indians. J Hum Genet 56:720–726
37. Sanghera DK, Ortega L, Han S et al (2008) Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk. BMC Med Genet 9:59
38. Lehtovirta M, Kaprio J, Forsblom C et al (2000) Insulin sensitivity and insulin secretion in monozygotic and dizygotic twins. Diabetologia 43:285–293
39. Perry JRB, Voight BF, Yengo L et al (2012) Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. PLoS Genet 8:e1002741
40. Qi Q, Li H, Loos RJF et al (2009) Common variants in KCNQ1 are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population. Hum Mol Genet 18:3508–3515
41. Unoki H, Takahashi A, Kawaguchi T et al (2008) SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet 40:1098–1102
42. Kraft P (2008) Curses–winner’s and otherwise–in genetic epidemiology. Epidemiology 19:649–651, discussion 657–8
43. Tsai F-J, Yang C-F, Chen C-C et al (2010) A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese. PLoS Genet 6:e1000847
44. Zeggini E, Scott LJ, Saxena R et al (2008) Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 40:638–645
45. Voight BF, Scott LJ, Steinthorsdottir V et al (2010) Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet 42:579–589
46. Li H, Gan W, Lu L et al (2013) A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. Diabetes 62:291–298
47. Dupuis J, Langenberg C, Prokopenko I et al (2010) New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 42:105–116
48. Scott LJ, Mohlke KL, Bonnycastle LL et al (2007) A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316:1341–1345
49. DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium et al (2014) Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet 46:234–244
50. Di Rienzo A, Hudson RR (2005) An evolutionary framework for common diseases: the ancestral-susceptibility model. Trends Genet 21:596–601
51. Mattei J, Parnell LD, Lai C-Q et al (2009) Disparities in allele frequencies and population differentiation for 101 disease-associated single nucleotide polymorphisms between Puerto Ricans and non-Hispanic whites. BMC Genet 10:45
52. Yang IV, Wade CM, Kang HM et al (2009) Identification of novel genes that mediate innate immunity using inbred mice. Genetics 183:1535–1544
53. Moorjani P, Thangaraj K, Patterson N et al (2013) Genetic evidence for recent population mixture in India. Am J Hum Genet 93:422–438
54. Anand SS, Meyre D, Pare G et al (2013) Genetic information and the prediction of incident type 2 diabetes in a high-risk multiethnic population: the EpiDREAM genetic study. Diabetes Care 36:2836–2842
55. Rees SD, Hydrie MZI, O’Hare JP et al (2011) Effects of 16 genetic variants on fasting glucose and type 2 diabetes in South Asians: ADCY5 and GLIS3 variants may predispose to type 2 diabetes. PLoS One 6:e24710
56. De Haan HG, Bezemer ID, Doggen CJM et al (2012) Multiple SNP testing improves risk prediction of first venous thrombosis. Blood 120:656–663
57. Cooke JN, Ng MCY, Palmer ND et al (2012) Genetic risk assessment of type 2 diabetes-associated polymorphisms in African Americans. Diabetes Care 35:287–292
58. Chen H, Poon A, Yeung C et al (2011) A genetic risk score combining ten psoriasis risk loci improves disease prediction. PLoS One 6:e19454
59. Lin X, Song K, Lim N et al (2009) Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score–the CoLaus Study. Diabetologia 52:600–608
60. Maher B (2008) Personal genomes: the case of the missing heritability. Nature 456:18–21
61. Manolio TA, Collins FS, Cox NJ et al (2009) Finding the missing heritability of complex diseases. Nature 461:747–753
62. Cirulli ET, Goldstein DB (2010) Uncovering the roles of rare variants in common disease through whole-genome sequencing. Nat Rev Genet 11:415–425
63. Wray NR, Purcell SM, Visscher PM (2011) Synthetic associations created by rare variants do not explain most GWAS results. PLoS Biol 9:e1000579
64. Hugot JP, Chamaillard M, Zouali H et al (2001) Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease. Nature 411:599–603
65. Bonnefond A, Clément N, Fawcett K et al (2012) Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes. Nat Genet 44:297–301
66. Simmons D, Williams R (2007) Dietary practices among Europeans and different South Asian groups in Coventry. Br J Nutr 78:5
67. Babakus WS, Thompson JL (2012) Physical activity among South Asian women: a systematic, mixed-methods review. Int J Behav Nutr Phys Act 9:150