Balance between exocytosis and endocytosis determines the efficacy of sterol-targeting antibiotics

Chemistry and Biology

Volumn 21, Issue 12, 2014, Pages 1690-1699

  Nishimura, Shinichi ^a   Tokukura, Masato ^a   Ochi, Junko ^a   Yoshida, Minoru ^b   Kakeya, Hideaki ^a  

^a KYOTO UNIVERSITY   (Japan)

^b RIKEN Center for Sustainable Resource Science   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; PROTEIN CDC42; STEROL; AMIDE; ANTIFUNGAL AGENT; MANUMYCIN; POLYENE;

ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DRUG BINDING; DRUG EFFICACY; DRUG TARGETING; ENDOCYTOSIS; EXOCYTOSIS; HEAT SHOCK; LIPID MEMBRANE; PROTEIN DOMAIN; ANTIBIOTIC RESISTANCE; CYTOLOGY; DRUG EFFECTS; HEAT SHOCK RESPONSE; METABOLISM; SCHIZOSACCHAROMYCES;

SCHIZOSACCHAROMYCETACEAE;

ANTIFUNGAL AGENTS; CDC42 GTP-BINDING PROTEIN; DRUG RESISTANCE, BACTERIAL; ENDOCYTOSIS; EXOCYTOSIS; HEAT-SHOCK RESPONSE; MEMBRANE MICRODOMAINS; POLYENES; POLYUNSATURATED ALKAMIDES; SCHIZOSACCHAROMYCES; STEROLS;

EID: 84919882317     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2014.10.014     Document Type: Article

References (47)

1. C. Arenz, M. Thutewohl, O. Block, H. Waldmann, H.J. Altenbach, and A. Giannis Manumycin A and its analogues are irreversible inhibitors of neutral sphingomyelinase ChemBioChem 2 2001 141 143
2. M.S. Bhuiyan, Y. Ito, A. Nakamura, N. Tanaka, K. Fujita, H. Fukui, and K. Takegawa Nystatin effects on vacuolar function in Saccharomyces cerevisiae Biosci. Biotechnol. Biochem. 63 1999 1075 1082
3. J. Bolard How do the polyene macrolide antibiotics affect the cellular membrane properties? Biochim. Biophys. Acta 864 1986 257 304
4. D.K. Breslow, D.M. Cameron, S.R. Collins, M. Schuldiner, J. Stewart-Ornstein, H.W. Newman, S. Braun, H.D. Madhani, N.J. Krogan, and J.S. Weissman A comprehensive strategy enabling high-resolution functional analysis of the yeast genome Nat. Methods 5 2008 711 718
5. C.S. Chou, T.I. Moore, S.D. Chang, Q. Nie, and T.M. Yi Signaling regulated endocytosis and exocytosis lead to mating pheromone concentration dependent morphologies in yeast FEBS Lett. 586 2012 4208 4214
6. S. Codlin, R.L. Haines, and S.E. Mole btn1 affects endocytosis, polarization of sterol-rich membrane domains and polarized growth in Schizosaccharomyces pombe Traffic 9 2008 936 950
7. W. Drabikowski, E. Lagwińska, and M.G. Sarzala Filipin as a fluorescent probe for the location of cholesterol in the membranes of fragmented sarcoplasmic reticulum Biochim. Biophys. Acta 291 1973 61 70
8. R.A. Espiritu, N. Matsumori, M. Murata, S. Nishimura, H. Kakeya, S. Matsunaga, and M. Yoshida Interaction between the marine sponge cyclic peptide theonellamide A and sterols in lipid bilayers as viewed by surface plasmon resonance and solid state H NMR Biochemistry 52 2013 2410 2418
9. M. Estravís, S.A. Rincón, B. Santos, and P. Pérez Cdc42 regulates multiple membrane traffic events in fission yeast Traffic 12 2011 1744 1758
10. Y. Fang, L. Hu, X. Zhou, W. Jaiseng, B. Zhang, T. Takami, and T. Kuno A genomewide screen in Schizosaccharomyces pombe for genes affecting the sensitivity of antifungal drugs that target ergosterol biosynthesis Antimicrob. Agents Chemother. 56 2012 1949 1959
11. Y. Gachet, and J.S. Hyams Endocytosis in fission yeast is spatially associated with the actin cytoskeleton during polarised cell growth and cytokinesis J. Cell Sci. 118 2005 4231 4242
12. T.R. Graham, P.A. Scott, and S.D. Emr Brefeldin A reversibly blocks early but not late protein transport steps in the yeast secretory pathway EMBO J. 12 1993 869 877
13. K.C. Gray, D.S. Palacios, I. Dailey, M.M. Endo, B.E. Uno, B.C. Wilcock, and M.D. Burke Amphotericin primarily kills yeast by simply binding ergosterol Proc. Natl. Acad. Sci. USA 109 2012 2234 2239
14. M. Hara, K. Akasaka, S. Akinaga, M. Okabe, H. Nakano, R. Gomez, D. Wood, M. Uh, and F. Tamanoi Identification of Ras farnesyltransferase inhibitors by microbial screening Proc. Natl. Acad. Sci. USA 90 1993 2281 2285
15. J. Hayles, and P. Nurse A journey into space Nat. Rev. Mol. Cell Biol. 2 2001 647 656
16. C.H. Ho, L. Magtanong, S.L. Barker, D. Gresham, S. Nishimura, P. Natarajan, J.L. Koh, J. Porter, C.A. Gray, and R.J. Andersen A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds Nat. Biotechnol. 27 2009 369 377
17. T. Iwaki, H. Iefuji, Y. Hiraga, A. Hosomi, T. Morita, Y. Giga-Hama, and K. Takegawa Multiple functions of ergosterol in the fission yeast Schizosaccharomyces pombe Microbiology 154 2008 830 841
18. R.W. Klemm, C.S. Ejsing, M.A. Surma, H.J. Kaiser, M.J. Gerl, J.L. Sampaio, Q. de Robillard, C. Ferguson, T.J. Proszynski, A. Shevchenko, and K. Simons Segregation of sphingolipids and sterols during formation of secretory vesicles at the trans-Golgi network J. Cell Biol. 185 2009 601 612
19. D.R. Kovar, V. Sirotkin, and M. Lord Three's company: the fission yeast actin cytoskeleton Trends Cell Biol. 21 2011 177 187
20. Y. Ma, T. Kuno, A. Kita, Y. Asayama, and R. Sugiura Rho2 is a target of the farnesyltransferase Cpp1 and acts upstream of Pmk1 mitogen-activated protein kinase signaling in fission yeast Mol. Biol. Cell 17 2006 5028 5037
21. S.G. Martin, S.A. Rincón, R. Basu, P. Pérez, and F. Chang Regulation of the formin for3p by cdc42p and bud6p Mol. Biol. Cell 18 2007 4155 4167
22. S. Matsunaga, and N. Fusetani Theonellamides A-E, cytotoxic bicyclic peptides, from a marine sponge Theonella sp J. Org. Chem. 60 1995 1177 1181
23. S. Matsunaga, N. Fusetani, K. Hashimoto, and M. Walchli Bioactive marine metabolites 0.26. Theonellamide F - a novel antifungal bicyclic peptide from a marine sponge Theonella sp J. Am. Chem. Soc. 111 1989 2582 2588
24. A. Matsuyama, R. Arai, Y. Yashiroda, A. Shirai, A. Kamata, S. Sekido, Y. Kobayashi, A. Hashimoto, M. Hamamoto, and Y. Hiraoka ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe Nat. Biotechnol. 24 2006 841 847
25. A. Mogilner, J. Allard, and R. Wollman Cell polarity: quantitative modeling as a tool in cell biology Science 336 2012 175 179
26. D. Muhlrad, and R. Parker Aberrant mRNAs with extended 3′ UTRs are substrates for rapid degradation by mRNA surveillance RNA 5 1999 1299 1307
27. K. Nakano, M. Toya, A. Yoneda, Y. Asami, A. Yamashita, N. Kamasawa, M. Osumi, and M. Yamamoto Pob1 ensures cylindrical cell shape by coupling two distinct rho signaling events during secretory vesicle targeting Traffic 12 2011 726 739
28. S. Nishimura, Y. Arita, M. Honda, K. Iwamoto, A. Matsuyama, A. Shirai, H. Kawasaki, H. Kakeya, T. Kobayashi, S. Matsunaga, and M. Yoshida Marine antifungal theonellamides target 3β-hydroxysterol to activate Rho1 signaling Nat. Chem. Biol. 6 2010 519 526
29. S. Nishimura, K. Ishii, K. Iwamoto, Y. Arita, S. Matsunaga, Y. Ohno-Iwashita, S.B. Sato, H. Kakeya, T. Kobayashi, and M. Yoshida Visualization of sterol-rich membrane domains with fluorescently-labeled theonellamides PLoS ONE 8 2013 e83716
30. H.O. Park, and E. Bi Central roles of small GTPases in the development of cell polarity in yeast and beyond Microbiol. Mol. Biol. Rev. 71 2007 48 96
31. P. Perez, and S.A. Rincón Rho GTPases: regulation of cell polarity and growth in yeasts Biochem. J. 426 2010 243 253
32. S.A. Rincón, Y. Ye, M.A. Villar-Tajadura, B. Santos, S.G. Martin, and P. Pérez Pob1 participates in the Cdc42 regulation of fission yeast actin cytoskeleton Mol. Biol. Cell 20 2009 4390 4399
33. K. Simons, and E. Ikonen Functional rafts in cell membranes Nature 387 1997 569 572
34. T. Takeda, and F. Chang Role of fission yeast myosin I in organization of sterol-rich membrane domains Curr. Biol. 15 2005 1331 1336
35. T. Takeda, T. Kawate, and F. Chang Organization of a sterol-rich membrane domain by cdc15p during cytokinesis in fission yeast Nat. Cell Biol. 6 2004 1142 1144
36. T. Tanaka, E. Tsukuda, Y. Uosaki, and Y. Matsuda EI-1511-3, -5 and EI-1625-2, novel interleukin-1 beta converting enzyme inhibitors produced by Streptomyces sp. E-1511 and E-1625. III. Biochemical properties of EI-1511-3, -5 and EI-1625-2 J. Antibiot. (Tokyo) 49 1996 1085 1090
37. H. Tatebe, K. Nakano, R. Maximo, and K. Shiozaki Pom1 DYRK regulates localization of the Rga4 GAP to ensure bipolar activation of Cdc42 in fission yeast Curr. Biol. 18 2008 322 330
38. K. Trajkovic, C. Hsu, S. Chiantia, L. Rajendran, D. Wenzel, F. Wieland, P. Schwille, B. Brügger, and M. Simons Ceramide triggers budding of exosome vesicles into multivesicular endosomes Science 319 2008 1244 1247
39. G. van Meer, D.R. Voelker, and G.W. Feigenson Membrane lipids: where they are and how they behave Nat. Rev. Mol. Cell Biol. 9 2008 112 124
40. J. Verghese, J. Abrams, Y. Wang, and K.A. Morano Biology of the heat shock response and protein chaperones: budding yeast (Saccharomyces cerevisiae) as a model system Microbiol. Mol. Biol. Rev. 76 2012 115 158
41. A.A. Volmer, A.M. Szpilman, and E.M. Carreira Synthesis and biological evaluation of amphotericin B derivatives Nat. Prod. Rep. 27 2010 1329 1349
42. V. Wachtler, S. Rajagopalan, and M.K. Balasubramanian Sterol-rich plasma membrane domains in the fission yeast Schizosaccharomyces pombe J. Cell Sci. 116 2003 867 874
43. H. Wang, X. Tang, J. Liu, S. Trautmann, D. Balasundaram, D. McCollum, and M.K. Balasubramanian The multiprotein exocyst complex is essential for cell separation in Schizosaccharomyces pombe Mol. Biol. Cell 13 2002 515 529
44. H. Wang, X. Tang, and M.K. Balasubramanian Rho3p regulates cell separation by modulating exocyst function in Schizosaccharomyces pombe Genetics 164 2003 1323 1331
45. Z. Yan, M. Costanzo, L.E. Heisler, J. Paw, F. Kaper, B.J. Andrews, C. Boone, G. Giaever, and C. Nislow Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers Nat. Methods 5 2008 719 725
46. W. Yang, J. Urano, and F. Tamanoi Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe J. Biol. Chem. 275 2000 429 438
47. A. Zeeck, K. Schröder, K. Frobel, R. Grote, and R. Thiericke The structure of manumycin. I. Characterization, structure elucidation and biological activity J. Antibiot. 40 1987 1530 1540