Multiple functions of ergosterol in the fission yeast Schizosaccharomyces pombe

Microbiology

Volumn 154, Issue 3, 2008, Pages 830-841

  Iwaki, Tomoko ^a,b   Iefuji, Haruyuki ^c   Hiraga, Yoshikazu ^d   Hosomi, Akira ^a   Morita, Tomotake ^a,b   Giga Hama, Yuko ^b   Takegawa, Kaoru ^a  

^a KAGAWA UNIVERSITY   (Japan)

^b ASAHI GLASS CO LTD   (Japan)

^c NATIONAL RESEARCH INSTITUTE OF BREWING   (Japan)

^d HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; C 22 STEROL DESATURASE; C 24(28) STEROL REDUCTASE; C 5 STEROL DESATURASE; C 8 STEROL ISOMERASE; ERGOSTEROL; FUNGAL ENZYME; GREEN FLUORESCENT PROTEIN; MEMBRANE PROTEIN; NYSTATIN; PERMEASE; POLYENE ANTIBIOTIC AGENT; PROTEIN PMA1P; STAUROSPORINE; STEROL 24 C METHYLTRANSFERASE; ZYMOSTEROL; AMINO ACID TRANSPORTER; ANTIFUNGAL AGENT; ENZYME; FUNGAL PROTEIN; HYBRID PROTEIN;

ANTIBIOTIC RESISTANCE; ARTICLE; CATALYSIS; CELL FUNCTION; CONTROLLED STUDY; FUNGAL GENE; GENE DISRUPTION; GENE FUNCTION; LIPOGENESIS; MEMBRANE STRUCTURE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE; SEQUENCE HOMOLOGY; ANTIFUNGAL RESISTANCE; CELL FRACTIONATION; CHEMISTRY; DRUG EFFECT; ENZYMOLOGY; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; SCHIZOSACCHAROMYCES;

EUKARYOTA; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE; SCHIZOSACCHAROMYCETACEAE;

AMINO ACID TRANSPORT SYSTEMS; AMPHOTERICIN B; ANTIFUNGAL AGENTS; CELL FRACTIONATION; DRUG RESISTANCE, FUNGAL; ENZYMES; ERGOSTEROL; FUNGAL PROTEINS; GENE DELETION; GREEN FLUORESCENT PROTEINS; MEMBRANE PROTEINS; MUTAGENESIS, INSERTIONAL; NYSTATIN; RECOMBINANT FUSION PROTEINS; SCHIZOSACCHAROMYCES;

EID: 42949144293     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.2007/011155-0     Document Type: Article

References (68)

1. Alcazar-Fuoli, L., Mellado, E., Garcia-Effron, G., Buitrago, M. J., Lopez, J. F., Grimalt, J. O., Cuenca-Estrella, J. M. & Rodriguez-Tudela, J. L. (2006). Aspergillus fumigatus C-5 sterol desaturases Erg3A and Erg3b: role in sterol biosynthesis and antifungal drug susceptibility. Antimicrob Agents Chemother 50, 453-460.
2. Alfa, C., Fantes, P., Hyams, J., McLoed, M. & Warbrick, E. (1993). Experiments with Fission Yeast: a Laboratory Course Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
3. Alonso, M. A. & Millán, J. (2001). The role of lipid rafts in signaling and membrane trafficking in T lymphocytes. J Cell Sci 114, 3957-3965.
4. Arthington, B. A., Bennett, L.G., Skatrud, P. L., Guynn, C. J., Barbuch, R. J., Ulbright, C. E. & Bard, M. (1991). Cloning, disruption and sequence of the gene encoding yeast C-5 sterol desaturase. Gene 102, 39-44.
5. Bagnat, M., Keränen, S., Shevchenko, A., Shevchenko, A. & Simons, K. (2000). Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast. Proc Natl Acad Sci U S A 97, 3254-3259.
6. Bagnat, M., Chang, A. & Simons, K. (2001). Plasma membrane proton ATPase Pma1p requires raft association for surface delivery in yeast. Mol Biol Cell 12, 4129-4138.
7. Bone, N., Millar, J. B. A., Toda, T. & Armstrong, J. (1998). Regulated vacuole fusion and fission in Schizosaccharomyces pombe: an osmotic response dependent on MAP kinases. Curr Biol 8, 135-144.
8. Cheng, H., Sugiura, R., Wu, W., Fujita, M., Lu, Y., Sio, S. O., Kawai, R., Takegawa, K., Shuntoh, H. & Kuno, T. (2002). Role of the Rab GTP-binding protein Ypt3 in the fission yeast exocytic pathway, and its connection to calcineurin function. Mol Biol Cell 13, 2963-2976.
9. Daum, G., Lees, N. D., Bard, M. & Dickson, R. (1998). Biochemistry, cell biology and molecular biology of lipids of Saccharomyces cerevisiae. Yeast 14, 1471-1510.
10. Dupré, S. & Haguenauer-Tsapis, R. (2003). Raft partitioning of the yeast uracil permease during trafficking along the endocytic pathway. Traffic 4, 83-96.
11. Elsenkolb, M., Zenzmaier, C., Leitner, E. & Schneiter, R. (2002). A specific structural requirement for ergosterol in long-chain fatty acid synthesis mutants important for maintaining raft domains in yeast. Mol Biol Cell 13, 4414-4428.
12. Emter, R., Heese-Peck, A. & Kralli, A. (2002). ERG6 and PDR5 regulate small lipophilic drug accumulation in yeast cells via distinct mechanisms. FEBS Lett 521, 57-61.
13. Enyenihi, A. H. & Saunders, W. S. (2003). Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae. Genetics 163, 47-54.
14. Gaigg, B., Timischl, B., Corbino, L. & Schneiter, R. (2005). Synthesis of sphirigolipids with very long chain fatty acids but not ergosterol is required for routing of newly synthesized plasma membrane ATPase to the cell surface of yeast. J Biol Chem 280, 22515-22522.
15. Geber, A., Hitchcock, C. A., Swartz, J. E., Pullen, F. S., Marsden, K. E., Kwon-Chung, K. J. & Bennett, J. E. (1995). Deletion of the yeast Candida glabrata ERG3 and ERG11 genes: effect on cell viability, cell growth, sterol composition, and antifungal susceptibility. Antimicrob Agents Chemother 39, 2708-2717.
16. Grossmann, G., Opekarova, M., Novakova, L., Stolz, J. & Tanner, W. (2006). Lipid raft-based membrane compartmentation of a plant transport protein expressed in Saccharomyces cerevisiae. Eukaryot Cell 5, 945-953.
17. Heese-Peck, A., Pichler, H., Zanolari, B., Watanabe, R., Daum, G. & Riezman, H. (2002). Multiple functions of sterols in yeast endocytosis. Mol Biol Cell 13, 2664-2680.
18. Huber, T. B., Schermer, B., Müller, R. U., Höhne, M., Bertram, M., Calixto, A., Hagmann, H., Reinhardt C., Koos, F. & other authors (2006). Posocin and MEC-2 bind cholesterol to regulate the activity of associated ion channels. Proc Natl Acad Sci U S A 103, 17079-17086.
19. +, a gene required for vacuolar biogenesis and protein sorting in Schizosaccharomyces pornbe. Yeast 20, 845-855.
20. Iwaki, T., Giga-Hama, Y. & Takegawa, K (2006). A survey of all 11 ABC transporters in fission yeast: two novel ABC transporers are required for red pigment accumulation in a Schizosaccharomyces pombe adenine biosynthetic mutant. Microbiology 152, 2309-2321.
21. + antiporter confers sodium and lithium tolerance in fission yeast. EMBO J 11, 1631-1640.
22. Kato, M. & Wickner, W. (2001). Ergosterol is required for the Sec18/ATP-dependent priming step of homotypic vacuole fusion. EMBO J 20, 4035-4040.
23. Kaur, R. & Bachhawat, A. K. (1999). The yeast multidrug resistance pump, Pdr5p, confers reduced drug resistance in erg mutants of Saccharomyces cerevisiae. Microbiology 145, 809-818.
24. Kishimoto, T., Yamamoto, T. & Tanaka, K. (2005). Defects in structural integrity of ergosterol and the Cdc50p-Drsp putative phospholipids translocase cause accumulation endocytic membranes, onto which actin patches are assembled in yeast. Mol Biol Cell 16, 5592-5609.
25. Lauwers, E. & André, B. (2006). Association of yeast transporters with detergent-resistant membranes correlates with their cell-surface location. Traffic 7, 1045-1059.
26. Lees, N. D., Skaggs, B., Kirsch, D. R. & Brad, M. (1995). Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae - a review. Lipids 30, 221-226.
27. Lichtenberg, D., Goñi, F. M. & Heerklotz, H. (2005). Detergent-resistant membranes should not be identified with membrane rafts. Trends Biochem Sci 30, 430-436.
28. Maguy, A., Hebett T. E. & Nattel, S. (2006). Involvement of lipid rafts and caveolae in cardiac ion channel function. Cardiovasc Res 69, 798-807.
29. Malathi, K., Higaki, K., Tinkelenberg, A. H., Balderes, D., Almanzar-Paramio, D., Wilcox, L. J., Erdeniz, N., Redican, F., Padamsee, M. & other authors (2004). Mutagenesis of the putative sterol-sensing domain of yeast Niemann Pick C-related protein reveals a primordial role in subcellular sphingolipid distribution. J Cell Biol 164, 547-556.
30. Malinska, K, Malinsky, J., Prekarova, M. & Tanner, W. (2004). Distribution of Canlp into stable domains reflects lateral protein segregation within the plasma membrane of living S. cerevisiae cells. J Cell Sci 117, 6031-6041.
31. Matsumoto, S., Bandyopadhyay, A., Kwiatkowski, D. J., Maitra, U. & Matsumoto, T. (2002). Role of the Tscl-Tsc2 complex in signaling and transport across the cell membrane in the fission yeast Schizosaccharomyces pombe. Genetics 161, 1053-1063.
32. Miyazaki, Y., Geber, A., Miyazaki, H., Falconer, D., Parkinson, T., Hitchcock C., Grimberg, B, Nyswaner, K & Bennett, J. E. (1999). Cloning, sequencing, expression and allelic sequence diversity of ERG3 (C-5 sterol desaturase gene) in Candida albicans. Gene 236, 43-51.
33. Moreno, S., Klar, A. & Nurse, P. (1991). Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol 194, 795-823.
34. Morita, T. & Takegawa, K. (2004). A simple and efficient procedure for transformation of Schizosaccharomyces pombe. Yeast 21, 613-617.
35. Mukhopadhyay, K., Kohli, A. & Prasad, R. (2002). Drug susceptibilities of yeast cells are affected by membrane lipid composition. Antimicrob Agents Chemother 46, 3695-3705.
36. Munn, A. L., Heese-Peck, A. Stevenson, B. J., Pichler, H. & Riezman, H. (1999). Specific sterols required for the internalization step of endocytosis in yeast. Mol Biol Cell 10, 3943-3957.
37. Munro, S. (2003). Lipid rafts: elusive or illusive? Cell 115, 377-388.
38. Murray, J. M. & Johnson, D. I. (2001). The Cdc42p GTPase and its regulators of Nrflp and Scdlp are involved in endocytic trafficking in the fission yeast Schizosaccharomyces pombe. Biol Chem 276, 3004-3009.
39. +, a novel gene of Schizosaccharomyces pombe which confers brefeldin A resistance, is related to the ATP-binding cassette superfamily. J Bacteriol 177, 1536-1543.
40. +- encoding syntaxin-like protein. Mol Biol Cell 12, 3955-3972.
41. Nishi, K., Yoshida, M., Nishimura, M., Nishikawa, M., Nishiyama, M., Horinouchi, S. & Beppu, T. (1992). A leptomycin B resistance gene of Schizosaccharomyces pombe encodes a protein similar to the mammalian P-glycoproteins. Mol Microbiol 6, 761-769.
42. Parks, L. W., Smith, S. J. & Crowley, J. H. (1995). Biochemical and physiological effects of sterol alterations in yeast - a review. Lipids 30, 227-230.
43. Parks, L. W., Crowley, J. H., Leak, F. W., Smith, S. J. & Tomeo, M. E (1999). Use of sterol mutants as probes for sterol functions in the yeast, Saccharomyces cerevisiae. Crit Rev Biochem Mol Biol 34, 399-404.
44. Pasrija, R., Prasad, T. & Prasad, R. (2005a). Membrane raft lipid constituents affect drug susceptibilities of Candida albicans. Biochem Soc Trans 33, 1219-1223.
45. Pasrija, R., Krishnamurthy, S., Prasad, T., Ernst, J. F. & Prasad, R. (2005b). Squalene epoxidase encoded by ERG1 affects morphologenesis and drug susceptibilities of Candida albicans. J Antimicrob Chemother 55, 905-913.
46. Pelkmans, L. (2005). Secrets of caveolae- and lipid raft-mediated endocytosis revealed by mammalian viruses. Biochim Biophys Acta 1746, 295-304.
47. Pichler, H. & Riezman, H. (2004). Where sterols are required for endocytosis. Biochim Biophys Acta 1666, 51-61.
48. Proszynski, T. J., Klemm, R. W., Gravert, M., Hsu, P. P., Gloor, Y., Wagner, J., Kozak, K., Graner, H., Walzer, K. & other authors (2005). A genome-wide visual screen reveals a role for sphingolipids and ergosterol in cell surface delivery in yeast. Proc Natl Acad Sci U S A 102, 17981-17986.
49. Raymond, C. K., Howald-Stevenson, I., Vater, C. A. & Stevens, T. H. (1992). Morphological classification of the yeast vacuolar protein sorting mutants: evidence for a prevacuolar compartment in class E vps mutants. Mol Biol Cell 3, 1389-1402.
50. Sanglard, D., Ischer, F., Parkinson, T., Falconer, D. & Bille, J. (2003). Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents. Antimicrob Agents Chemother 47, 2404-2412.
51. Sharma, S. C. (2006). Implications of sterol structure for membrane lipid composition, fluidity and phospholipids asymmetry in Saccharomyces cerevisiae. FEMS Yeast Res 6, 1047-1051.
52. + gene encodes a protein similar to the chicken lamin B receptor and is implicated in pleiotropic drug-sensitivity, divalent cation-sensitivity, and osmoregulation. Mol Biol Cell 3, 263-273.
53. Shobayashi, M., Mitsueda, S., Ago, M., Fujii, T., Iwashita, K. & Iefuji, H. (2005). Effects of culture conditions on ergosterol biosynthesis by Saccharomyces cerevisiae. Biosci Biotechnol Biochem 69, 2381-2388.
54. Simons, K. & Ikonen, E. (1997). Functional rafts in cell membranes. Nature 387, 569-572.
55. Simons, K. & van Meer, G. (1988). Lipid sorting in epithelial cells. Biochemistry 27, 6197-6202.
56. Skaggs, B. A., Alexander, J. F., Pierson, C. A., Schweitzer, K. S., Chun, K. T., Koegel, C., Barbuch, R. & Bard, M. (1996). Cloning and characterization of the Saccharomyces cerevisiae C-22 sterol desaturase gene, encoding a second cytochrome P-450 involved in ergosterol biosynthesis. Gene 169, 105-109.
57. Sturley, S. L. (2000). Conservation of eukaryotic sterol homeostasis: new insights from studies in budding yeast. Biochim Biophys Acta 1529, 155-163.
58. Suga, M. & Katakeyama, T. (2001). High efficiency transformation of Schizosaccharomyces pombe pretreated with thiol compounds by electroporation. Yeast 18, 1015-1021.
59. Tabuchi, M., Iwaihara, O., Ohtani, Y., Ohuchi, N., Sakurai, J., Morita, T., Iwahara, S. & Takegawa, K. (1997). Vacuolar protein sorting in fission yeast: cloning, biosynthesis, transport, and processing of carboxypeptidase Y from Schizosaccharomyces pombe. J Bacteriol 179, 4179-4189.
60. Takeda, T., Kawate, T. & Chang, F. (2004). Organization of a sterol-rich membrane domain by cdc15p during cytokinesis in fission yeast. Nat Cell Biol 6, 1142-1144.
61. Takegawa, K., DeWald, D. B. & Emr, S. D. (1995). Schizossacharomyces pombe Vps34p, a phosphatidylinositol-specific PI 3-kinase essential for normal cell growth and vacuole morphology. J Cell Sci 108, 3745-3756.
62. Todd, B. L, Stewart, E. V., Burg, J. S., Hughes, A. L. & Espenshade, P. (2006). Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast. Mol Cell Biol 26, 2817-2831.
63. Turi, T. G. & Rose, J. K. (1995). Characterization of a novel Schizosaccharomyces pombe multidrug resistance transporter conferring brefeldin A resistance. Biochem Biophys Res Commun 213, 410-418.
64. Umebayashi, K. & Nakano, A. (2003). Ergosterol is required for targeting of tryptophan permease to the yeast plasma membrane. J Cell Biol 161, 1117-1131.
65. van den Hazel, H. B., Pichler, H., do Valle Matte, M. A., Leitner, E., Goffeau, A. & Daum, G. (1999). PDR16 and PDR17, two homologous genes of Saccharomyces cerevisiae, affect lipid biosynthesis and resistance to multiple drugs. J Biol Chem 274, 1934-1941.
66. Wachtler, V. & Balasubramanian, M. K (2006). Yeast lipid rafts? - an emerging view. Trends Cell Biol 16, 1-4.
67. Wachtler, V., Rajagopalan, S. & Balasubramanian, M. K. 42003). Sterol-rich plasma membrane domains in the fission yeast Schizosaccharomyces pombe. J Cell Sci 116, 867-874.
68. Young, L. Y., Hull, C. M. & Heitman, J. (2003). Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae. Antimicrob Agents Chemother 47, 2717-2724.