메뉴 건너뛰기




Volumn 35, Issue 9, 2014, Pages 9035-9043

Aberrant promoter methylation of p15 INK4b and p16 INK4a genes may contribute to the pathogenesis of multiple myeloma: a meta-analysis

Author keywords

Meta analysis; Methylation; Multiple myeloma; p15INK4b; p16INK4a

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B;

EID: 84919873860     PISSN: 10104283     EISSN: None     Source Type: Journal    
DOI: 10.1007/s13277-014-2054-2     Document Type: Article
Times cited : (16)

References (36)
  • 1
    • 43149089554 scopus 로고    scopus 로고
    • The pathogenesis of the bone disease of multiple myeloma
    • PID: 18406675, COI: 1:CAS:528:DC%2BD1cXmtValtbk%3D
    • Edwards CM, Zhuang J, Mundy GR. The pathogenesis of the bone disease of multiple myeloma. Bone. 2008;42(6):1007–13.
    • (2008) Bone , vol.42 , Issue.6 , pp. 1007-1013
    • Edwards, C.M.1    Zhuang, J.2    Mundy, G.R.3
  • 2
    • 56149086629 scopus 로고    scopus 로고
    • Multiple myeloma: diagnosis and treatment
    • PID: 18841734
    • Nau KC, Lewis WD. Multiple myeloma: diagnosis and treatment. Am Fam Physician. 2008;78(7):853–9.
    • (2008) Am Fam Physician , vol.78 , Issue.7 , pp. 853-859
    • Nau, K.C.1    Lewis, W.D.2
  • 3
    • 79955595041 scopus 로고    scopus 로고
    • Epidemiology of multiple myeloma
    • PID: 21509679
    • Becker N. Epidemiology of multiple myeloma. Recent Results Cancer Res. 2011;183:25–35.
    • (2011) Recent Results Cancer Res , vol.183 , pp. 25-35
    • Becker, N.1
  • 4
    • 79952713257 scopus 로고    scopus 로고
    • Genomics in multiple myeloma
    • PID: 21411439, COI: 1:CAS:528:DC%2BC3MXjtFCiurc%3D
    • Munshi NC, Avet-Loiseau H. Genomics in multiple myeloma. Clin Cancer Res. 2011;17(6):1234–42.
    • (2011) Clin Cancer Res , vol.17 , Issue.6 , pp. 1234-1242
    • Munshi, N.C.1    Avet-Loiseau, H.2
  • 5
    • 55849114062 scopus 로고    scopus 로고
    • Occupation, exposure to chemicals, sensitizing agents, and risk of multiple myeloma in Sweden
    • PID: 18990753, COI: 1:CAS:528:DC%2BD1cXhtlCkur%2FL
    • Lope V, Perez-Gomez B, Aragones N, Lopez-Abente G, Gustavsson P, Plato N, et al. Occupation, exposure to chemicals, sensitizing agents, and risk of multiple myeloma in Sweden. Cancer Epidemiol Biomarkers Prev. 2008;17(11):3123–7.
    • (2008) Cancer Epidemiol Biomarkers Prev , vol.17 , Issue.11 , pp. 3123-3127
    • Lope, V.1    Perez-Gomez, B.2    Aragones, N.3    Lopez-Abente, G.4    Gustavsson, P.5    Plato, N.6
  • 6
    • 79959918457 scopus 로고    scopus 로고
    • Body mass index and risk of multiple myeloma: a meta-analysis of prospective studies
    • PID: 21354783
    • Wallin A, Larsson SC. Body mass index and risk of multiple myeloma: a meta-analysis of prospective studies. Eur J Cancer. 2011;47(11):1606–15.
    • (2011) Eur J Cancer , vol.47 , Issue.11 , pp. 1606-1615
    • Wallin, A.1    Larsson, S.C.2
  • 7
    • 45849122775 scopus 로고    scopus 로고
    • Aberrant gene promoter methylation in plasma cell dyscrasias
    • PID: 18410922, COI: 1:CAS:528:DC%2BD1cXotlCnuro%3D
    • Martin P, Garcia-Cosio M, Santon A, Bellas C. Aberrant gene promoter methylation in plasma cell dyscrasias. Exp Mol Pathol. 2008;84(3):256–61.
    • (2008) Exp Mol Pathol , vol.84 , Issue.3 , pp. 256-261
    • Martin, P.1    Garcia-Cosio, M.2    Santon, A.3    Bellas, C.4
  • 8
    • 85027921379 scopus 로고    scopus 로고
    • Concurrent p16 methylation pattern as an adverse prognostic factor in multiple myeloma: a methylation-specific polymerase chain reaction study using two different primer sets
    • PID: 20721556
    • Park G, Kang SH, Lee JH, Suh C, Kim M, Park SM, et al. Concurrent p16 methylation pattern as an adverse prognostic factor in multiple myeloma: a methylation-specific polymerase chain reaction study using two different primer sets. Ann Hematol. 2011;90(1):73–9.
    • (2011) Ann Hematol , vol.90 , Issue.1 , pp. 73-79
    • Park, G.1    Kang, S.H.2    Lee, J.H.3    Suh, C.4    Kim, M.5    Park, S.M.6
  • 9
    • 46849102610 scopus 로고    scopus 로고
    • Loss of 9p leads to p16INK4A down-regulation and enables RB/E2F1-dependent cell cycle promotion in gastrointestinal stromal tumours (GISTs)
    • PID: 18438954, COI: 1:CAS:528:DC%2BD1cXptVKjtbo%3D
    • Haller F, Lobke C, Ruschhaupt M, Cameron S, Schulten HJ, Schwager S, et al. Loss of 9p leads to p16INK4A down-regulation and enables RB/E2F1-dependent cell cycle promotion in gastrointestinal stromal tumours (GISTs). J Pathol. 2008;215(3):253–62.
    • (2008) J Pathol , vol.215 , Issue.3 , pp. 253-262
    • Haller, F.1    Lobke, C.2    Ruschhaupt, M.3    Cameron, S.4    Schulten, H.J.5    Schwager, S.6
  • 10
    • 1042289347 scopus 로고    scopus 로고
    • Methylation profiling in multiple myeloma
    • PID: 15109538, COI: 1:CAS:528:DC%2BD2cXhtFWitb4%3D
    • Chim CS, Kwong YL, Fung TK, Liang R. Methylation profiling in multiple myeloma. Leuk Res. 2004;28(4):379–85.
    • (2004) Leuk Res , vol.28 , Issue.4 , pp. 379-385
    • Chim, C.S.1    Kwong, Y.L.2    Fung, T.K.3    Liang, R.4
  • 11
    • 0032589744 scopus 로고    scopus 로고
    • Mechanisms of inactivation of p14ARF, p15INK4b, and p16INK4a genes in human esophageal squamous cell carcinoma
    • PID: 10537333, COI: 1:CAS:528:DyaK1MXntlGltLk%3D
    • Xing EP, Nie Y, Song Y, Yang GY, Cai YC, Wang LD, et al. Mechanisms of inactivation of p14ARF, p15INK4b, and p16INK4a genes in human esophageal squamous cell carcinoma. Clin Cancer Res. 1999;5(10):2704–13.
    • (1999) Clin Cancer Res , vol.5 , Issue.10 , pp. 2704-2713
    • Xing, E.P.1    Nie, Y.2    Song, Y.3    Yang, G.Y.4    Cai, Y.C.5    Wang, L.D.6
  • 12
    • 42649116089 scopus 로고    scopus 로고
    • Genomic instability, mutations and expression analysis of the tumour suppressor genes p14(ARF), p15(INK4b), p16(INK4a) and p53 in actinic keratosis
    • PID: 18331779, COI: 1:CAS:528:DC%2BD1cXls12ju7s%3D
    • Kanellou P, Zaravinos A, Zioga M, Stratigos A, Baritaki S, Soufla G, et al. Genomic instability, mutations and expression analysis of the tumour suppressor genes p14(ARF), p15(INK4b), p16(INK4a) and p53 in actinic keratosis. Cancer Lett. 2008;264(1):145–61.
    • (2008) Cancer Lett , vol.264 , Issue.1 , pp. 145-161
    • Kanellou, P.1    Zaravinos, A.2    Zioga, M.3    Stratigos, A.4    Baritaki, S.5    Soufla, G.6
  • 15
    • 84865832157 scopus 로고    scopus 로고
    • Nucleosomes correlate with in vivo progression pattern of de novo methylation of p16 CpG islands in human gastric carcinogenesis
    • PID: 22558275, COI: 1:CAS:528:DC%2BC38XmvFSnu7o%3D
    • Lu ZM, Zhou J, Wang X, Guan Z, Bai H, Liu ZJ, et al. Nucleosomes correlate with in vivo progression pattern of de novo methylation of p16 CpG islands in human gastric carcinogenesis. PLoS One. 2012;7(4):e35928.
    • (2012) PLoS One , vol.7 , Issue.4 , pp. e35928
    • Lu, Z.M.1    Zhou, J.2    Wang, X.3    Guan, Z.4    Bai, H.5    Liu, Z.J.6
  • 16
    • 84865339004 scopus 로고    scopus 로고
    • Characterization of CDKN2A(p16) methylation and impact in colorectal cancer: systematic analysis using pyrosequencing
    • PID: 22925370, COI: 1:CAS:528:DC%2BC38XhvVShsr7O
    • Bihl MP, Foerster A, Lugli A, Zlobec I. Characterization of CDKN2A(p16) methylation and impact in colorectal cancer: systematic analysis using pyrosequencing. J Transl Med. 2012;10:173.
    • (2012) J Transl Med , vol.10 , pp. 173
    • Bihl, M.P.1    Foerster, A.2    Lugli, A.3    Zlobec, I.4
  • 17
    • 72249095248 scopus 로고    scopus 로고
    • Correlation of aberrant methylation of MGMT gene to MTHFR C677T genetic polymorphisms in esophageal squamous cell carcinoma]
    • PID: 19079989, COI: 1:CAS:528:DC%2BD1MXhtVGmurrN
    • Xue HC, Wang JM, Xu B, Guo GP, Hua ZL, Zhou Q, et al. Correlation of aberrant methylation of MGMT gene to MTHFR C677T genetic polymorphisms in esophageal squamous cell carcinoma]. Ai Zheng. 2008;27(12):1256–62.
    • (2008) Ai Zheng , vol.27 , Issue.12 , pp. 1256-1262
    • Xue, H.C.1    Wang, J.M.2    Xu, B.3    Guo, G.P.4    Hua, Z.L.5    Zhou, Q.6
  • 18
    • 67649442519 scopus 로고    scopus 로고
    • p15 promoter methylation—a novel prognostic marker in glioblastoma patients
    • PID: 19424593, COI: 1:CAS:528:DC%2BD1MXmsVCiu7k%3D
    • Wemmert S, Bettscheider M, Alt S, Ketter R, Kammers K, Feiden W, et al. p15 promoter methylation—a novel prognostic marker in glioblastoma patients. Int J Oncol. 2009;34(6):1743–8.
    • (2009) Int J Oncol , vol.34 , Issue.6 , pp. 1743-1748
    • Wemmert, S.1    Bettscheider, M.2    Alt, S.3    Ketter, R.4    Kammers, K.5    Feiden, W.6
  • 19
    • 84860455640 scopus 로고    scopus 로고
    • The clinical implications of methylated p15 and p73 genes in adult acute lymphoblastic leukemia
    • Abd El-Hamid TM, Mossallam GI, Sherisher MA. The clinical implications of methylated p15 and p73 genes in adult acute lymphoblastic leukemia. J Egypt Natl Cancer Inst. 2010;22(3):175–84.
    • (2010) J Egypt Natl Cancer Inst , vol.22 , Issue.3 , pp. 175-184
    • Abd El-Hamid, T.M.1    Mossallam, G.I.2    Sherisher, M.A.3
  • 20
    • 84871603787 scopus 로고    scopus 로고
    • Prognostic significance of epigenetic inactivation of p16, p15, MGMT and DAPK genes in follicular lymphoma
    • PID: 23275143
    • Krajnovic M, Radojkovic M, Davidovic R, Dimitrijevic B, Krtolica K. Prognostic significance of epigenetic inactivation of p16, p15, MGMT and DAPK genes in follicular lymphoma. Med Oncol. 2013;30(1):441.
    • (2013) Med Oncol , vol.30 , Issue.1 , pp. 441
    • Krajnovic, M.1    Radojkovic, M.2    Davidovic, R.3    Dimitrijevic, B.4    Krtolica, K.5
  • 21
    • 75049085509 scopus 로고    scopus 로고
    • Methylation status of nine tumor suppressor genes in multiple myeloma
    • PID: 20037750, COI: 1:CAS:528:DC%2BC3cXnt1yruw%3D%3D
    • Braggio E, Maiolino A, Gouveia ME, Magalhaes R, Souto Filho JT, Garnica M, et al. Methylation status of nine tumor suppressor genes in multiple myeloma. Int J Hematol. 2010;91(1):87–96.
    • (2010) Int J Hematol , vol.91 , Issue.1 , pp. 87-96
    • Braggio, E.1    Maiolino, A.2    Gouveia, M.E.3    Magalhaes, R.4    Souto Filho, J.T.5    Garnica, M.6
  • 22
    • 67549142103 scopus 로고    scopus 로고
    • Absence of methylation-dependent transcriptional silencing in TP73 irrespective of the methylation status of the CDKN2A CpG island in plasma cell neoplasia
    • PID: 19423161, COI: 1:CAS:528:DC%2BD1MXnvVakt74%3D
    • Hatzimichael E, Benetatos L, Dasoula A, Dranitsaris G, Tsiara S, Georgiou I, et al. Absence of methylation-dependent transcriptional silencing in TP73 irrespective of the methylation status of the CDKN2A CpG island in plasma cell neoplasia. Leuk Res. 2009;33(9):1272–5.
    • (2009) Leuk Res , vol.33 , Issue.9 , pp. 1272-1275
    • Hatzimichael, E.1    Benetatos, L.2    Dasoula, A.3    Dranitsaris, G.4    Tsiara, S.5    Georgiou, I.6
  • 23
    • 84919860662 scopus 로고    scopus 로고
    • Study on hypermethylation of p15INK4B gene in multiple myeloma
    • Guo XZ, Fan HT, Tan GX, Wu Q, Zhou T, Chen P, et al. Study on hypermethylation of p15INK4B gene in multiple myeloma. Chin J Pathophysiol. 2001;17(7):679–82.
    • (2001) Chin J Pathophysiol , vol.17 , Issue.7 , pp. 679-682
    • Guo, X.Z.1    Fan, H.T.2    Tan, G.X.3    Wu, Q.4    Zhou, T.5    Chen, P.6
  • 24
    • 74049122570 scopus 로고    scopus 로고
    • DNA methylation analysis of tumor suppressor genes in monoclonal gammopathy of undetermined significance
    • PID: 19727727, COI: 1:CAS:528:DC%2BC3cXjt1yluw%3D%3D
    • Stanganelli C, Arbelbide J, Fantl DB, Corrado C, Slavutsky I. DNA methylation analysis of tumor suppressor genes in monoclonal gammopathy of undetermined significance. Ann Hematol. 2010;89(2):191–9.
    • (2010) Ann Hematol , vol.89 , Issue.2 , pp. 191-199
    • Stanganelli, C.1    Arbelbide, J.2    Fantl, D.B.3    Corrado, C.4    Slavutsky, I.5
  • 25
    • 77957661914 scopus 로고    scopus 로고
    • Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses
    • PID: 20652370
    • Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25(9):603–5.
    • (2010) Eur J Epidemiol , vol.25 , Issue.9 , pp. 603-605
    • Stang, A.1
  • 26
    • 24644511654 scopus 로고    scopus 로고
    • HEGESMA: genome search meta-analysis and heterogeneity testing
    • PID: 15955784, COI: 1:CAS:528:DC%2BD2MXpvFGqsb4%3D
    • Zintzaras E, Ioannidis JP. HEGESMA: genome search meta-analysis and heterogeneity testing. Bioinformatics. 2005;21(18):3672–3.
    • (2005) Bioinformatics , vol.21 , Issue.18 , pp. 3672-3673
    • Zintzaras, E.1    Ioannidis, J.P.2
  • 27
    • 32144440794 scopus 로고    scopus 로고
    • Comparison of two methods to detect publication bias in meta-analysis
    • PID: 16467236, COI: 1:CAS:528:DC%2BD28XhtF2qsrw%3D
    • Peters JL, Sutton AJ, Jones DR, Abrams KR, Rushton L. Comparison of two methods to detect publication bias in meta-analysis. JAMA. 2006;295(6):676–80.
    • (2006) JAMA , vol.295 , Issue.6 , pp. 676-680
    • Peters, J.L.1    Sutton, A.J.2    Jones, D.R.3    Abrams, K.R.4    Rushton, L.5
  • 28
    • 0035412365 scopus 로고    scopus 로고
    • INK4b gene methylations in plasma cells from monoclonal gammopathy of undetermined significance
    • PID: 11418489, COI: 1:CAS:528:DC%2BD3MXkvFSls7o%3D
    • INK4b gene methylations in plasma cells from monoclonal gammopathy of undetermined significance. Blood. 2001;98(1):244–6.
    • (2001) Blood , vol.98 , Issue.1 , pp. 244-246
    • Guillerm, G.1    Gyan, E.2    Wolowiec, D.3    Facon, T.4    Avet-Loiseau, H.5    Kuliczkowski, K.6
  • 29
    • 0036736587 scopus 로고    scopus 로고
    • Alterations of the cyclin D1/pRb/p16(INK4A) pathway in multiple myeloma
    • PID: 12200702, COI: 1:STN:280:DC%2BD38vkt1yhsw%3D%3D
    • Kramer A, Schultheis B, Bergmann J, Willer A, Hegenbart U, Ho AD, et al. Alterations of the cyclin D1/pRb/p16(INK4A) pathway in multiple myeloma. Leukemia. 2002;16(9):1844–51.
    • (2002) Leukemia , vol.16 , Issue.9 , pp. 1844-1851
    • Kramer, A.1    Schultheis, B.2    Bergmann, J.3    Willer, A.4    Hegenbart, U.5    Ho, A.D.6
  • 30
    • 70449564372 scopus 로고    scopus 로고
    • Relationship between methylation of p15/p16 genes and prognosis of multiple myeloma
    • COI: 1:CAS:528:DC%2BC3cXht1Grs7s%3D
    • Fu HY, Shen JZ, Shen SF, Zhou HR, Fan LP. Relationship between methylation of p15/p16 genes and prognosis of multiple myeloma. J Leuk Lymphoma. 2009;18(9):535–7,40.
    • (2009) J Leuk Lymphoma , vol.18 , Issue.9 , pp. 535-7,40
    • Fu, H.Y.1    Shen, J.Z.2    Shen, S.F.3    Zhou, H.R.4    Fan, L.P.5
  • 31
  • 32
    • 84977546364 scopus 로고    scopus 로고
    • The significance of p15 gene methylation in multiple myeloma
    • Jiang JH, Lin SX, Chen GY, Yan J. The significance of p15 gene methylation in multiple myeloma. J Clin Hematol. 2007;20(2):104–5,8.
    • (2007) J Clin Hematol , vol.20 , Issue.2 , pp. 104-158
    • Jiang, J.H.1    Lin, S.X.2    Chen, G.Y.3    Yan, J.4
  • 33
    • 84919842222 scopus 로고    scopus 로고
    • Hypermethylation of CPG island of p15 and p16 genes in multiple myeloma
    • Li LH, Dai H, Chen SL, Zhu JZ, Chen WM, Liu JZ, et al. Hypermethylation of CPG island of p15 and p16 genes in multiple myeloma. Chin J Hematol. 2000;21(11):604–5.
    • (2000) Chin J Hematol , vol.21 , Issue.11 , pp. 604-605
    • Li, L.H.1    Dai, H.2    Chen, S.L.3    Zhu, J.Z.4    Chen, W.M.5    Liu, J.Z.6
  • 34
    • 84919875904 scopus 로고    scopus 로고
    • Study on hypermethylation and mRNA expression of p16 and p15 gene in multiple myeloma
    • COI: 1:CAS:528:DC%2BD2sXksFKjtLo%3D
    • Liang XY, Jiang YZ, Xu W, Liu JH. Study on hypermethylation and mRNA expression of p16 and p15 gene in multiple myeloma. Clin Focus. 2006;21(1):10–3.
    • (2006) Clin Focus , vol.21 , Issue.1 , pp. 10-13
    • Liang, X.Y.1    Jiang, Y.Z.2    Xu, W.3    Liu, J.H.4
  • 35
    • 77953464931 scopus 로고    scopus 로고
    • Relationship between methylation of p16 gene and prognosis of multiple myeloma
    • COI: 1:CAS:528:DC%2BD1MXovVSjug%3D%3D
    • Xu W, Lu AP, Jia JY, Liang XY, Zhang W, Zhu XY, et al. Relationship between methylation of p16 gene and prognosis of multiple myeloma. Chin J Biol. 2007;20(12):897–9,906.
    • (2007) Chin J Biol , vol.20 , Issue.12 , pp. 897-9,906
    • Xu, W.1    Lu, A.P.2    Jia, J.Y.3    Liang, X.Y.4    Zhang, W.5    Zhu, X.Y.6
  • 36
    • 74049141478 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • PID: 19752007, COI: 1:CAS:528:DC%2BC3cXktlCntw%3D%3D
    • Sharma S, Kelly TK, Jones PA. Epigenetics in cancer. Carcinogenesis. 2010;31(1):27–36.
    • (2010) Carcinogenesis , vol.31 , Issue.1 , pp. 27-36
    • Sharma, S.1    Kelly, T.K.2    Jones, P.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.