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Volumn 42, Issue 6, 2008, Pages 1007-1013

The pathogenesis of the bone disease of multiple myeloma

Author keywords

Dkk1; Multiple myeloma; Osteoblast; Osteoclast; RANKL

Indexed keywords

ANTINEOPLASTIC AGENT; BISPHOSPHONIC ACID DERIVATIVE; BORTEZOMIB; CHEMOKINE RECEPTOR CXCR4; DENOSUMAB; DEXAMETHASONE; INTERLEUKIN 3; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEASOME INHIBITOR; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; SCATTER FACTOR; STROMAL CELL DERIVED FACTOR 1ALPHA; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN; WNT PROTEIN;

EID: 43149089554     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2008.01.027     Document Type: Review
Times cited : (146)

References (84)
  • 1
    • 0032512903 scopus 로고    scopus 로고
    • Myeloma bone disease
    • Mundy G.R. Myeloma bone disease. Eur J Cancer 34 (1998) 246-251
    • (1998) Eur J Cancer , vol.34 , pp. 246-251
    • Mundy, G.R.1
  • 2
    • 0016262579 scopus 로고
    • Evidence for the secretion of an osteoclast stimulating factor in myeloma
    • Mundy G.R., Raisz L.G., Cooper R.A., Schechter G.P., and Salmon S. Evidence for the secretion of an osteoclast stimulating factor in myeloma. N Engl J Med 291 (1974) 1041-1046
    • (1974) N Engl J Med , vol.291 , pp. 1041-1046
    • Mundy, G.R.1    Raisz, L.G.2    Cooper, R.A.3    Schechter, G.P.4    Salmon, S.5
  • 4
    • 0026690115 scopus 로고
    • Abnormal bone remodelling in patients with myelomatosis and normal biochemical indices of bone resorption
    • Taube T., Beneton M.N.C., McCloskey E.V., Rogers S., Greaves M., and Kanis J.A. Abnormal bone remodelling in patients with myelomatosis and normal biochemical indices of bone resorption. Eur J Haematol 49 (1992) 192-198
    • (1992) Eur J Haematol , vol.49 , pp. 192-198
    • Taube, T.1    Beneton, M.N.C.2    McCloskey, E.V.3    Rogers, S.4    Greaves, M.5    Kanis, J.A.6
  • 5
    • 0025783336 scopus 로고
    • Recruitment of new osteoblasts and osteoclasts is the earliest critical event in the pathogenesis of human multiple myeloma
    • Bataille R., Chappard D., Marcelli C., Dessauw P., Balset P., Sany J., et al. Recruitment of new osteoblasts and osteoclasts is the earliest critical event in the pathogenesis of human multiple myeloma. J Clin Invest 88 (1991) 62-66
    • (1991) J Clin Invest , vol.88 , pp. 62-66
    • Bataille, R.1    Chappard, D.2    Marcelli, C.3    Dessauw, P.4    Balset, P.5    Sany, J.6
  • 6
    • 0024593494 scopus 로고
    • Does myeloma secrete an osteoblast inhibiting factor?
    • Evans C.E., Galasko C.S., and Ward C. Does myeloma secrete an osteoblast inhibiting factor?. J Bone Joint Surg Br 71 (1989) 288-290
    • (1989) J Bone Joint Surg Br , vol.71 , pp. 288-290
    • Evans, C.E.1    Galasko, C.S.2    Ward, C.3
  • 7
    • 0025282177 scopus 로고
    • Abnormal serum bone Gla protein levels in multiple myeloma. Crucial role of bone formation and prognostic implications
    • Bataille R., Delmas P.D., Chappard D., and Sany J. Abnormal serum bone Gla protein levels in multiple myeloma. Crucial role of bone formation and prognostic implications. Cancer 66 (1990) 167-172
    • (1990) Cancer , vol.66 , pp. 167-172
    • Bataille, R.1    Delmas, P.D.2    Chappard, D.3    Sany, J.4
  • 8
    • 0031876780 scopus 로고    scopus 로고
    • Long-term oral pamidronate treatment inhibits osteoclastic bone resorption and bone turnover without affecting osteoblastic function in multiple myeloma
    • Abildgaard N., Rungby J., Glerup H., Brixen K., Kassem M., Brincker H., et al. Long-term oral pamidronate treatment inhibits osteoclastic bone resorption and bone turnover without affecting osteoblastic function in multiple myeloma. Eur J Haematol 61 (1998) 128-134
    • (1998) Eur J Haematol , vol.61 , pp. 128-134
    • Abildgaard, N.1    Rungby, J.2    Glerup, H.3    Brixen, K.4    Kassem, M.5    Brincker, H.6
  • 9
    • 0035057590 scopus 로고    scopus 로고
    • Biochemical markers of bone formation in patients with plasma cell dyscrasias and benign osteoporosis
    • Woitge H.W., Horn E., Keck A.V., Auler B., Seibel M.J., and Pecherstorfer M. Biochemical markers of bone formation in patients with plasma cell dyscrasias and benign osteoporosis. Clin Chem 47 (2001) 686-693
    • (2001) Clin Chem , vol.47 , pp. 686-693
    • Woitge, H.W.1    Horn, E.2    Keck, A.V.3    Auler, B.4    Seibel, M.J.5    Pecherstorfer, M.6
  • 10
  • 11
    • 0023849455 scopus 로고
    • Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas
    • Kawano M., Hirano T., Matsuda T., Taga T., Horij Y., Iwato K., et al. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature 332 (1988) 83-85
    • (1988) Nature , vol.332 , pp. 83-85
    • Kawano, M.1    Hirano, T.2    Matsuda, T.3    Taga, T.4    Horij, Y.5    Iwato, K.6
  • 12
    • 1542313900 scopus 로고    scopus 로고
    • IL-3 expression by myeloma cells increases both osteoclast formation and growth of myeloma cells
    • Lee J.W., Chung H.Y., Ehrlich L.A., Jelinek D.F., Callander N.S., Roodman G.D., et al. IL-3 expression by myeloma cells increases both osteoclast formation and growth of myeloma cells. Blood 103 (2004) 2308-2315
    • (2004) Blood , vol.103 , pp. 2308-2315
    • Lee, J.W.1    Chung, H.Y.2    Ehrlich, L.A.3    Jelinek, D.F.4    Callander, N.S.5    Roodman, G.D.6
  • 13
    • 0024419152 scopus 로고
    • Production of cytokines by bone marrow cells obtained from patients with multiple myeloma
    • Lichtenstein A., Berenson J., Norman D., Chang M.P., and Carlile A. Production of cytokines by bone marrow cells obtained from patients with multiple myeloma. Blood 74 (1989) 1266-1273
    • (1989) Blood , vol.74 , pp. 1266-1273
    • Lichtenstein, A.1    Berenson, J.2    Norman, D.3    Chang, M.P.4    Carlile, A.5
  • 14
    • 0030714605 scopus 로고    scopus 로고
    • A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
    • Anderson D.M., Maraskovsky E., Billingsley W.L., Dougall W.C., Tometsko M.E., Roux E.R., et al. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390 (1997) 175-179
    • (1997) Nature , vol.390 , pp. 175-179
    • Anderson, D.M.1    Maraskovsky, E.2    Billingsley, W.L.3    Dougall, W.C.4    Tometsko, M.E.5    Roux, E.R.6
  • 15
    • 0032540319 scopus 로고    scopus 로고
    • Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    • Lacey D.L., Timms E., Tan H.L., Kelley M.J., Dunstan C.R., Butgess T., et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93 (1998) 165-176
    • (1998) Cell , vol.93 , pp. 165-176
    • Lacey, D.L.1    Timms, E.2    Tan, H.L.3    Kelley, M.J.4    Dunstan, C.R.5    Butgess, T.6
  • 16
    • 0031005576 scopus 로고    scopus 로고
    • Osteoprotegerin: a novel secreted protein involved in the regulation of bone density
    • Simonet W.S., Lacey D.L., Dunstan C.R., Kelley M., Chang M.S., Lüthy R., et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89 (1997) 309-319
    • (1997) Cell , vol.89 , pp. 309-319
    • Simonet, W.S.1    Lacey, D.L.2    Dunstan, C.R.3    Kelley, M.4    Chang, M.S.5    Lüthy, R.6
  • 17
    • 0033611467 scopus 로고    scopus 로고
    • OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
    • Kong Y.Y., Yoshida H., Sarosi I., Tan H.L., Timms E., Capparelli C., et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397 (1999) 315-323
    • (1999) Nature , vol.397 , pp. 315-323
    • Kong, Y.Y.1    Yoshida, H.2    Sarosi, I.3    Tan, H.L.4    Timms, E.5    Capparelli, C.6
  • 18
    • 12944262423 scopus 로고    scopus 로고
    • RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism
    • Li J., Sarosi I., Yan X.Q., Morony S., Capparelli C., Tan H.L., et al. RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc Natl Acad Sci U S A 97 (2000) 1566-1571
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 1566-1571
    • Li, J.1    Sarosi, I.2    Yan, X.Q.3    Morony, S.4    Capparelli, C.5    Tan, H.L.6
  • 19
    • 0032577903 scopus 로고    scopus 로고
    • Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin
    • Mizuno A., Amizuka N., Irie K., Murakami A., Fujise N., Kanno T., et al. Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin. Biochem Biophys Res Commun 247 (1998) 610-615
    • (1998) Biochem Biophys Res Commun , vol.247 , pp. 610-615
    • Mizuno, A.1    Amizuka, N.2    Irie, K.3    Murakami, A.4    Fujise, N.5    Kanno, T.6
  • 20
    • 0035949510 scopus 로고    scopus 로고
    • Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression
    • Pearse R.N., Sordillo E.M., Yaccoby S., Wong B.R., Liau D.F., Colman N., et al. Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression. PNAS 98 (2001) 11581-11586
    • (2001) PNAS , vol.98 , pp. 11581-11586
    • Pearse, R.N.1    Sordillo, E.M.2    Yaccoby, S.3    Wong, B.R.4    Liau, D.F.5    Colman, N.6
  • 21
    • 0035895083 scopus 로고    scopus 로고
    • Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment
    • Giuliani N., Bataille R., Mancini C., Lazzaretti M., and Barillé S. Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment. Blood 98 (2001) 3527-3533
    • (2001) Blood , vol.98 , pp. 3527-3533
    • Giuliani, N.1    Bataille, R.2    Mancini, C.3    Lazzaretti, M.4    Barillé, S.5
  • 22
    • 0036329036 scopus 로고    scopus 로고
    • RANK (receptor activator of nuclear factor kappa B) and RANK ligand are expressed in giant cell tumors of bone
    • Roux S., Amazit L., Meduri G., Guiochon-Mantel A., Milgrom E., and Mariette X. RANK (receptor activator of nuclear factor kappa B) and RANK ligand are expressed in giant cell tumors of bone. Am J Clin Pathol 117 (2002) 210-216
    • (2002) Am J Clin Pathol , vol.117 , pp. 210-216
    • Roux, S.1    Amazit, L.2    Meduri, G.3    Guiochon-Mantel, A.4    Milgrom, E.5    Mariette, X.6
  • 23
    • 0035496947 scopus 로고    scopus 로고
    • Serum osteoprotegerin levels are reduced in patients with multiple myeloma with lytic bone disease
    • Seidel C., Hjertner Ø., Abildgaard N., Heickendorff L., Hjorth M., Westin J., et al. Serum osteoprotegerin levels are reduced in patients with multiple myeloma with lytic bone disease. Blood 98 (2001) 2269-2271
    • (2001) Blood , vol.98 , pp. 2269-2271
    • Seidel, C.1    Hjertner, Ø.2    Abildgaard, N.3    Heickendorff, L.4    Hjorth, M.5    Westin, J.6
  • 24
    • 4544360663 scopus 로고    scopus 로고
    • Role of receptor activator of nuclear factor-kappa B ligand (RANKL), osteoprotegerin and macrophage protein 1-alpha (MIP-1a) in monoclonal gammopathy of undetermined significance (MGUS)
    • Politou M., Terpos E., Anagnostopoulos A., Szydlo R., Laffan M., Layton M., et al. Role of receptor activator of nuclear factor-kappa B ligand (RANKL), osteoprotegerin and macrophage protein 1-alpha (MIP-1a) in monoclonal gammopathy of undetermined significance (MGUS). Br J Haematol 126 (2004) 686-689
    • (2004) Br J Haematol , vol.126 , pp. 686-689
    • Politou, M.1    Terpos, E.2    Anagnostopoulos, A.3    Szydlo, R.4    Laffan, M.5    Layton, M.6
  • 25
    • 0043245842 scopus 로고    scopus 로고
    • Soluble receptor activator of nuclear factor kappaB ligand-osteoprotegerin ratio predicts survival in multiple myeloma: proposal for a novel prognostic index
    • Terpos E., Szydlo R., Apperley J.F., Hatjiharissi E., Politou M., Meletis J., et al. Soluble receptor activator of nuclear factor kappaB ligand-osteoprotegerin ratio predicts survival in multiple myeloma: proposal for a novel prognostic index. Blood 102 (2003) 1064-1069
    • (2003) Blood , vol.102 , pp. 1064-1069
    • Terpos, E.1    Szydlo, R.2    Apperley, J.F.3    Hatjiharissi, E.4    Politou, M.5    Meletis, J.6
  • 26
    • 0141482103 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor-kappaB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo
    • Farrugia A.N., Atkins G.J., To L.B., Pan B., Horvath N., Kostakis P., et al. Receptor activator of nuclear factor-kappaB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo. Cancer Res 63 (2003) 5438-5445
    • (2003) Cancer Res , vol.63 , pp. 5438-5445
    • Farrugia, A.N.1    Atkins, G.J.2    To, L.B.3    Pan, B.4    Horvath, N.5    Kostakis, P.6
  • 27
    • 0000236587 scopus 로고    scopus 로고
    • Tumour cells isolated from patients with multiple myeloma express the critical osteoclastogenic factor, RANKL
    • Shipman C.M., Holen I., Lippitt J.M., Vandeberghe E., and Croucher P.I. Tumour cells isolated from patients with multiple myeloma express the critical osteoclastogenic factor, RANKL. Blood 96 (2000) 360a
    • (2000) Blood , vol.96
    • Shipman, C.M.1    Holen, I.2    Lippitt, J.M.3    Vandeberghe, E.4    Croucher, P.I.5
  • 28
    • 0037374460 scopus 로고    scopus 로고
    • Osteoprotegerin is a soluble decoy receptor for tumor necrosis factor-related apoptosis-inducing ligand/Apo2 ligand and can function as a paracrine survival factor for human myeloma cells
    • Shipman C.M., and Croucher P.I. Osteoprotegerin is a soluble decoy receptor for tumor necrosis factor-related apoptosis-inducing ligand/Apo2 ligand and can function as a paracrine survival factor for human myeloma cells. Cancer Res 63 (2003) 912-916
    • (2003) Cancer Res , vol.63 , pp. 912-916
    • Shipman, C.M.1    Croucher, P.I.2
  • 29
    • 0035895055 scopus 로고    scopus 로고
    • Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma
    • Croucher P.I., Shipman C.M., Lippitt J., Perry M., Asosingh K., Hijzen A., et al. Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma. Blood 98 (2001) 3534-3540
    • (2001) Blood , vol.98 , pp. 3534-3540
    • Croucher, P.I.1    Shipman, C.M.2    Lippitt, J.3    Perry, M.4    Asosingh, K.5    Hijzen, A.6
  • 30
    • 0037439916 scopus 로고    scopus 로고
    • Recombinant osteoprotegerin decreases tumor burden and increases survival in a murine model of multiple myeloma
    • Vanderkerken K., De Leenheer E., Shipman C., Asosingh K., Willems A., Van Camp B., et al. Recombinant osteoprotegerin decreases tumor burden and increases survival in a murine model of multiple myeloma. Cancer Res 63 (2003) 287-289
    • (2003) Cancer Res , vol.63 , pp. 287-289
    • Vanderkerken, K.1    De Leenheer, E.2    Shipman, C.3    Asosingh, K.4    Willems, A.5    Van Camp, B.6
  • 31
    • 0037302195 scopus 로고    scopus 로고
    • Receptor activator of NF-kappaB ligand, macrophage inflammatory protein-1alpha, and the proteasome: novel therapeutic targets in myeloma
    • Oyajobi B.O., and Mundy G.R. Receptor activator of NF-kappaB ligand, macrophage inflammatory protein-1alpha, and the proteasome: novel therapeutic targets in myeloma. Cancer 97 (2003) 813-817
    • (2003) Cancer , vol.97 , pp. 813-817
    • Oyajobi, B.O.1    Mundy, G.R.2
  • 32
    • 0036181668 scopus 로고    scopus 로고
    • Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity
    • Yaccoby S., Pearse R.N., Johnson R.N., Johnson C.L., Barologie B., Choi Y., et al. Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity. Br J Haematol 116 (2002) 278-290
    • (2002) Br J Haematol , vol.116 , pp. 278-290
    • Yaccoby, S.1    Pearse, R.N.2    Johnson, R.N.3    Johnson, C.L.4    Barologie, B.5    Choi, Y.6
  • 33
    • 0141707692 scopus 로고    scopus 로고
    • Serum levels of macrophage inflammatory protein-1 alpha (MIP-1alpha) correlate with the extent of bone disease and survival in patients with multiple myeloma
    • Terpos E., Politou M., Szydlo R., Goldman J.M., Apperley J.F., and Rahemtulla A. Serum levels of macrophage inflammatory protein-1 alpha (MIP-1alpha) correlate with the extent of bone disease and survival in patients with multiple myeloma. Br J Haematol 123 (2003) 106-109
    • (2003) Br J Haematol , vol.123 , pp. 106-109
    • Terpos, E.1    Politou, M.2    Szydlo, R.3    Goldman, J.M.4    Apperley, J.F.5    Rahemtulla, A.6
  • 34
    • 0342322717 scopus 로고    scopus 로고
    • Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma
    • Choi S.J., Cruz J.C., Craig F., Chung H., Devlin R.D., Roodman G.D., et al. Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma. Blood 96 (2000) 671-675
    • (2000) Blood , vol.96 , pp. 671-675
    • Choi, S.J.1    Cruz, J.C.2    Craig, F.3    Chung, H.4    Devlin, R.D.5    Roodman, G.D.6
  • 35
    • 13844317079 scopus 로고    scopus 로고
    • MIP-1alpha utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells
    • Oba Y., Lee J.W., Ehrlich L.A., Chung H.Y., Jelinek D.F., Callander N.S., et al. MIP-1alpha utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells. Exp Hematol 33 (2005) 272-278
    • (2005) Exp Hematol , vol.33 , pp. 272-278
    • Oba, Y.1    Lee, J.W.2    Ehrlich, L.A.3    Chung, H.Y.4    Jelinek, D.F.5    Callander, N.S.6
  • 36
    • 0038579121 scopus 로고    scopus 로고
    • Dual effects of macrophage inflammatory protein-1alpha on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease
    • Oyajobi B.O., Franchin G., Williams P.J., Pulkrabek D., Gupta A., Munoz S., et al. Dual effects of macrophage inflammatory protein-1alpha on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease. Blood 102 (2003) 311-319
    • (2003) Blood , vol.102 , pp. 311-319
    • Oyajobi, B.O.1    Franchin, G.2    Williams, P.J.3    Pulkrabek, D.4    Gupta, A.5    Munoz, S.6
  • 37
    • 0035664488 scopus 로고    scopus 로고
    • Antisense inhibition of macrophage inflammatory protein 1-alpha blocks bone destruction in a model of myeloma bone disease
    • Choi S.J., Oba Y., Gazitt Y., Alsina M., Cruz J., Anderson J., et al. Antisense inhibition of macrophage inflammatory protein 1-alpha blocks bone destruction in a model of myeloma bone disease. J Clin Invest 108 (2001) 1833-1841
    • (2001) J Clin Invest , vol.108 , pp. 1833-1841
    • Choi, S.J.1    Oba, Y.2    Gazitt, Y.3    Alsina, M.4    Cruz, J.5    Anderson, J.6
  • 39
    • 0033584243 scopus 로고    scopus 로고
    • Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption
    • Niida S., Kaku M., Amano H., Yoshida H., Kataoka H., Nishikawa S., et al. Vascular endothelial growth factor can substitute for macrophage colony-stimulating factor in the support of osteoclastic bone resorption. J Exp Med 190 (1999) 293-298
    • (1999) J Exp Med , vol.190 , pp. 293-298
    • Niida, S.1    Kaku, M.2    Amano, H.3    Yoshida, H.4    Kataoka, H.5    Nishikawa, S.6
  • 40
    • 33847368961 scopus 로고    scopus 로고
    • Myeloma cell-osteoclast interaction enhances angiogenesis together with bone resorption: a role for vascular endothelial cell growth factor and osteopontin
    • Tanaka Y., Abe M., Hiasa M., Oda A., Amou H., Nakano A., et al. Myeloma cell-osteoclast interaction enhances angiogenesis together with bone resorption: a role for vascular endothelial cell growth factor and osteopontin. Clin Cancer Res 13 (2007) 816-823
    • (2007) Clin Cancer Res , vol.13 , pp. 816-823
    • Tanaka, Y.1    Abe, M.2    Hiasa, M.3    Oda, A.4    Amou, H.5    Nakano, A.6
  • 41
    • 1642433313 scopus 로고    scopus 로고
    • SDF-1 and CXCR4 in normal and malignant hematopoiesis
    • Juarez J., and Bendall L. SDF-1 and CXCR4 in normal and malignant hematopoiesis. Histol Histopathol 19 (2004) 299-309
    • (2004) Histol Histopathol , vol.19 , pp. 299-309
    • Juarez, J.1    Bendall, L.2
  • 42
    • 0347397553 scopus 로고    scopus 로고
    • Stromal cell-derived factor-1 (SDF-1) recruits osteoclast precursors by inducing chemotaxis, matrix metalloproteinase-9 (MMP-9) activity, and collagen transmigration
    • Yu X., Huang Y., Collin-Osdoby P., and Osdoby P. Stromal cell-derived factor-1 (SDF-1) recruits osteoclast precursors by inducing chemotaxis, matrix metalloproteinase-9 (MMP-9) activity, and collagen transmigration. J Bone Miner Res 18 (2003) 1404-1418
    • (2003) J Bone Miner Res , vol.18 , pp. 1404-1418
    • Yu, X.1    Huang, Y.2    Collin-Osdoby, P.3    Osdoby, P.4
  • 44
    • 33947600329 scopus 로고    scopus 로고
    • Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma
    • Alsayed Y., Ngo H., Runnels J., Leleu X., Singha U.K., Pitsillides C.M., et al. Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma. Blood 109 (2007) 2708-2717
    • (2007) Blood , vol.109 , pp. 2708-2717
    • Alsayed, Y.1    Ngo, H.2    Runnels, J.3    Leleu, X.4    Singha, U.K.5    Pitsillides, C.M.6
  • 45
    • 20144388592 scopus 로고    scopus 로고
    • Elevated serum levels of stromal-derived factor-1alpha are associated with increased osteoclast activity and osteolytic bone disease in multiple myeloma patients
    • Zannettino A.C., Farrugia A.N., Kortesidis A., Manavis J., To L.B., Martin S.K., et al. Elevated serum levels of stromal-derived factor-1alpha are associated with increased osteoclast activity and osteolytic bone disease in multiple myeloma patients. Cancer Res 65 (2005) 1700-1709
    • (2005) Cancer Res , vol.65 , pp. 1700-1709
    • Zannettino, A.C.1    Farrugia, A.N.2    Kortesidis, A.3    Manavis, J.4    To, L.B.5    Martin, S.K.6
  • 46
    • 0034284054 scopus 로고    scopus 로고
    • Cell-cell contact between marrow stromal cells and myeloma cells via VCAM-1 and a4b1-integrin enhances production of osteoclast-stimulating activity
    • Michigami T., Shimizu N., Williams P.J., Niewolna M., Dallas S.L., Mundy G.R., et al. Cell-cell contact between marrow stromal cells and myeloma cells via VCAM-1 and a4b1-integrin enhances production of osteoclast-stimulating activity. Blood 96 (2000) 1953-1960
    • (2000) Blood , vol.96 , pp. 1953-1960
    • Michigami, T.1    Shimizu, N.2    Williams, P.J.3    Niewolna, M.4    Dallas, S.L.5    Mundy, G.R.6
  • 47
    • 4644357296 scopus 로고    scopus 로고
    • Anti-alpha4 integrin antibody suppresses the development of multiple myeloma and associated osteoclastic osteolysis
    • Mori Y., Shimizu N., Dallas M., Niewolna M., Story B., Williams P.J., et al. Anti-alpha4 integrin antibody suppresses the development of multiple myeloma and associated osteoclastic osteolysis. Blood 104 (2004) 2149-2154
    • (2004) Blood , vol.104 , pp. 2149-2154
    • Mori, Y.1    Shimizu, N.2    Dallas, M.3    Niewolna, M.4    Story, B.5    Williams, P.J.6
  • 48
    • 0001562249 scopus 로고    scopus 로고
    • Expression of RANK ligand (RANKL) by myeloma cells requires binding to bone marrow stromal cells via an a4b1-VCAM-1 interaction
    • Oyayobi B.O., Ytaianedes K., Yoneda T., and Mundy G.R. Expression of RANK ligand (RANKL) by myeloma cells requires binding to bone marrow stromal cells via an a4b1-VCAM-1 interaction. Bone 23 (1998) S180
    • (1998) Bone , vol.23
    • Oyayobi, B.O.1    Ytaianedes, K.2    Yoneda, T.3    Mundy, G.R.4
  • 50
    • 4944230728 scopus 로고    scopus 로고
    • Osteoclasts enhance myeloma cell growth and survival via cell-cell contact: a vicious cycle between bone destruction and myeloma expansion
    • Abe M., Hiura K., Wilde J., Shioyasono A., Moriyama K., Hashimoto T., et al. Osteoclasts enhance myeloma cell growth and survival via cell-cell contact: a vicious cycle between bone destruction and myeloma expansion. Blood 104 (2004) 2484-2491
    • (2004) Blood , vol.104 , pp. 2484-2491
    • Abe, M.1    Hiura, K.2    Wilde, J.3    Shioyasono, A.4    Moriyama, K.5    Hashimoto, T.6
  • 51
    • 18044386744 scopus 로고    scopus 로고
    • LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    • Gong Y., Slee R.B., Fukai N., Rawadi G., Roman-Roman S., Reginato A.M., et al. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 107 (2001) 513-523
    • (2001) Cell , vol.107 , pp. 513-523
    • Gong, Y.1    Slee, R.B.2    Fukai, N.3    Rawadi, G.4    Roman-Roman, S.5    Reginato, A.M.6
  • 52
    • 0037118285 scopus 로고    scopus 로고
    • High bone density due to a mutation in LDL-receptor-related protein 5
    • Boyden L.M., Mao J., Belsky J., Mitzner L., Farhi A., Mitnick M.A., et al. High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med 346 (2002) 1513-1521
    • (2002) N Engl J Med , vol.346 , pp. 1513-1521
    • Boyden, L.M.1    Mao, J.2    Belsky, J.3    Mitzner, L.4    Farhi, A.5    Mitnick, M.A.6
  • 53
    • 0037092049 scopus 로고    scopus 로고
    • Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistant embryonic eye vascularization in mice deficient in LRP5, a Wnt coreceptor
    • Kato M., Patel M., Levasseur R., Lobov I., Chang B.H., Glass D.A., et al. Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistant embryonic eye vascularization in mice deficient in LRP5, a Wnt coreceptor. J Cell Biol 157 (2002) 303-314
    • (2002) J Cell Biol , vol.157 , pp. 303-314
    • Kato, M.1    Patel, M.2    Levasseur, R.3    Lobov, I.4    Chang, B.H.5    Glass, D.A.6
  • 54
    • 28444438846 scopus 로고    scopus 로고
    • Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice
    • Clement-Lacroix P., Ai M., Morvan F., Roman-Roman S., Vayssiere B., Belleville C., et al. Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice. Proc Natl Acad Sci U S A 102 (2005) 17406-17411
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 17406-17411
    • Clement-Lacroix, P.1    Ai, M.2    Morvan, F.3    Roman-Roman, S.4    Vayssiere, B.5    Belleville, C.6
  • 56
    • 0346363760 scopus 로고    scopus 로고
    • The role of the Wnt-signaling antagonist in the development of osteolytic lesions in multiple myeloma
    • Tian E., Zhan F., Walker R., Rasmussen E., Ma Y., Barlogie B., et al. The role of the Wnt-signaling antagonist in the development of osteolytic lesions in multiple myeloma. N Engl J Med 349 (2003) 2483-2494
    • (2003) N Engl J Med , vol.349 , pp. 2483-2494
    • Tian, E.1    Zhan, F.2    Walker, R.3    Rasmussen, E.4    Ma, Y.5    Barlogie, B.6
  • 57
    • 0142241118 scopus 로고    scopus 로고
    • BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop
    • Rawadi G., Vayssiere B., Dunn F., Baron R., and Roman-Roman S. BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop. J Bone Miner Res 18 (2003) 1842-1853
    • (2003) J Bone Miner Res , vol.18 , pp. 1842-1853
    • Rawadi, G.1    Vayssiere, B.2    Dunn, F.3    Baron, R.4    Roman-Roman, S.5
  • 58
    • 33748156090 scopus 로고    scopus 로고
    • Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia
    • Li J., Sarosi I., Cattley R.C., Pretorius J., Asuncion F., Grisanti M., et al. Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia. Bone 39 (2006) 754-766
    • (2006) Bone , vol.39 , pp. 754-766
    • Li, J.1    Sarosi, I.2    Cattley, R.C.3    Pretorius, J.4    Asuncion, F.5    Grisanti, M.6
  • 60
    • 20844450840 scopus 로고    scopus 로고
    • Role of Dickkopf 1(Dkk) in myeloma bone disease and modulation by the proteasome inhibitor velcade
    • Oyajobi B.O., Garrett I.R., Gupta A., Banerjee M., Esparza X., Flores A., et al. Role of Dickkopf 1(Dkk) in myeloma bone disease and modulation by the proteasome inhibitor velcade. J Bone Miner Res 19 (2004) 1011
    • (2004) J Bone Miner Res , vol.19 , pp. 1011
    • Oyajobi, B.O.1    Garrett, I.R.2    Gupta, A.3    Banerjee, M.4    Esparza, X.5    Flores, A.6
  • 61
    • 33745494534 scopus 로고    scopus 로고
    • A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: a potential role in the development of lytic bone disease and tumor progression in multiple myeloma
    • Gunn W.G., Conley A., Deininger L., Olson S.D., Prockop D.J., and Gregory C.A. A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: a potential role in the development of lytic bone disease and tumor progression in multiple myeloma. Stem Cells 24 (2006) 986-991
    • (2006) Stem Cells , vol.24 , pp. 986-991
    • Gunn, W.G.1    Conley, A.2    Deininger, L.3    Olson, S.D.4    Prockop, D.J.5    Gregory, C.A.6
  • 62
    • 33847397091 scopus 로고    scopus 로고
    • Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo
    • Yaccoby S., Ling W., Zhan F., Walker R., Barlogie B., and Shaughnessy Jr. J.D. Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo. Blood 109 (2007) 2106-2111
    • (2007) Blood , vol.109 , pp. 2106-2111
    • Yaccoby, S.1    Ling, W.2    Zhan, F.3    Walker, R.4    Barlogie, B.5    Shaughnessy Jr., J.D.6
  • 63
    • 27644473781 scopus 로고    scopus 로고
    • Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2
    • Oshima T., Abe M., Asano J., Hara T., Kitazoe K., Sekimoto E., et al. Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2. Blood 106 (2005) 160-165
    • (2005) Blood , vol.106 , pp. 160-165
    • Oshima, T.1    Abe, M.2    Asano, J.3    Hara, T.4    Kitazoe, K.5    Sekimoto, E.6
  • 64
    • 43149106760 scopus 로고    scopus 로고
    • Enhancement of osteoblast differentiation by inhibition of TGF-beta signaling suppresses myeloma cell growth and protects from destructive bone lesions
    • Takeuchi K., Abe M., Oda A., Amou H., Hiasa M., Asano J., et al. Enhancement of osteoblast differentiation by inhibition of TGF-beta signaling suppresses myeloma cell growth and protects from destructive bone lesions. J Bone Miner Res 21 (2006) 1101
    • (2006) J Bone Miner Res , vol.21 , pp. 1101
    • Takeuchi, K.1    Abe, M.2    Oda, A.3    Amou, H.4    Hiasa, M.5    Asano, J.6
  • 65
    • 23744498205 scopus 로고    scopus 로고
    • Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation
    • Giuliani N., Colla S., Morandi F., Lazzaretti M., Sala R., Bonomini S., et al. Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation. Blood 106 (2005) 2472-2483
    • (2005) Blood , vol.106 , pp. 2472-2483
    • Giuliani, N.1    Colla, S.2    Morandi, F.3    Lazzaretti, M.4    Sala, R.5    Bonomini, S.6
  • 66
    • 23744507989 scopus 로고    scopus 로고
    • IL-3 is a potential inhibitor of osteoblast differentiation in multiple myeloma
    • Ehrlich L.A., Chung H.Y., Ghobrial I., Choi S.J., Morandi F., Colla S., et al. IL-3 is a potential inhibitor of osteoblast differentiation in multiple myeloma. Blood 106 (2005) 1407-1414
    • (2005) Blood , vol.106 , pp. 1407-1414
    • Ehrlich, L.A.1    Chung, H.Y.2    Ghobrial, I.3    Choi, S.J.4    Morandi, F.5    Colla, S.6
  • 67
    • 0032006829 scopus 로고    scopus 로고
    • Elevated serum concentrations of hepatocyte growth factor in patients with multiple myeloma
    • Seidel C., Berset M., Turesson I., Abildgaard N., Sundan A., and Waage A. Elevated serum concentrations of hepatocyte growth factor in patients with multiple myeloma. Blood 91 (1998) 806-812
    • (1998) Blood , vol.91 , pp. 806-812
    • Seidel, C.1    Berset, M.2    Turesson, I.3    Abildgaard, N.4    Sundan, A.5    Waage, A.6
  • 68
    • 12744279346 scopus 로고    scopus 로고
    • Syndecan-1 and angiogenic cytokines in multiple myeloma: correlation with bone marrow angiogenesis and survival
    • Andersen N.F., Standal T., Nielsen J.L., Heickendorff L., Borset M., Sorensen F.B., et al. Syndecan-1 and angiogenic cytokines in multiple myeloma: correlation with bone marrow angiogenesis and survival. Br J Haematol 128 (2005) 210-217
    • (2005) Br J Haematol , vol.128 , pp. 210-217
    • Andersen, N.F.1    Standal, T.2    Nielsen, J.L.3    Heickendorff, L.4    Borset, M.5    Sorensen, F.B.6
  • 69
    • 33947605189 scopus 로고    scopus 로고
    • HGF inhibits BMP-induced osteoblastogenesis: possible implications for the bone disease of multiple myeloma
    • Standal T., Abildgaard N., Fagerli U.M., Stordal B., Hjertner O., Borset M., et al. HGF inhibits BMP-induced osteoblastogenesis: possible implications for the bone disease of multiple myeloma. Blood 109 (2007) 3024-3030
    • (2007) Blood , vol.109 , pp. 3024-3030
    • Standal, T.1    Abildgaard, N.2    Fagerli, U.M.3    Stordal, B.4    Hjertner, O.5    Borset, M.6
  • 70
    • 27644476353 scopus 로고    scopus 로고
    • Clinical factors predictive of outcome with bortezomib in patients with relapsed, refractory multiple myeloma
    • Richardson P.G., Barlogie B., Berenson J., Singhal S., Jagannath S., Irwin D., et al. Clinical factors predictive of outcome with bortezomib in patients with relapsed, refractory multiple myeloma. Blood 106 (2005) 2977-2981
    • (2005) Blood , vol.106 , pp. 2977-2981
    • Richardson, P.G.1    Barlogie, B.2    Berenson, J.3    Singhal, S.4    Jagannath, S.5    Irwin, D.6
  • 71
    • 0142186217 scopus 로고    scopus 로고
    • A prospective, open-label safety and efficacy study of combination treatment with bortezomib (PS-341, velcade and melphalan in patients with relapsed or refractory multiple myeloma
    • Yang H.H., Vescio R., Schenkein D., and Berenson J.R. A prospective, open-label safety and efficacy study of combination treatment with bortezomib (PS-341, velcade and melphalan in patients with relapsed or refractory multiple myeloma. Clin Lymphoma 4 (2003) 119-122
    • (2003) Clin Lymphoma , vol.4 , pp. 119-122
    • Yang, H.H.1    Vescio, R.2    Schenkein, D.3    Berenson, J.R.4
  • 72
    • 20044381304 scopus 로고    scopus 로고
    • Bortezomib in recurrent and/or refractory multiple myeloma. Initial clinical experience in patients with impared renal function
    • Jagannath S., Barlogie B., Berenson J.R., Singhal S., Alexanian R., Srkalovic G., et al. Bortezomib in recurrent and/or refractory multiple myeloma. Initial clinical experience in patients with impared renal function. Cancer 103 (2005) 1195-1200
    • (2005) Cancer , vol.103 , pp. 1195-1200
    • Jagannath, S.1    Barlogie, B.2    Berenson, J.R.3    Singhal, S.4    Alexanian, R.5    Srkalovic, G.6
  • 73
    • 21344469223 scopus 로고    scopus 로고
    • Bortezomib therapy alone and in combination with dexamethasone for previously untreated symptomatic multiple myeloma
    • Jagannath S., Durie B.G., Wolf J., Camacho E., Irwin D., Lutzky J., et al. Bortezomib therapy alone and in combination with dexamethasone for previously untreated symptomatic multiple myeloma. Br J Haematol 129 (2005) 776-783
    • (2005) Br J Haematol , vol.129 , pp. 776-783
    • Jagannath, S.1    Durie, B.G.2    Wolf, J.3    Camacho, E.4    Irwin, D.5    Lutzky, J.6
  • 75
    • 0038819051 scopus 로고    scopus 로고
    • Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro
    • Garrett I.R., Chen D., Gutierrez G., Zhao M., Escobedo A., Rossini G., et al. Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro. J Clin Invest 111 (2003) 1771-1782
    • (2003) J Clin Invest , vol.111 , pp. 1771-1782
    • Garrett, I.R.1    Chen, D.2    Gutierrez, G.3    Zhao, M.4    Escobedo, A.5    Rossini, G.6
  • 77
    • 34548041260 scopus 로고    scopus 로고
    • PTH and bortezomib suppresses growth of primary human myeloma through increased bone formation in vivo
    • Pennisi A., Ling W., Perkins P., Saha R., Barlogie B., Tricot G., et al. PTH and bortezomib suppresses growth of primary human myeloma through increased bone formation in vivo. Blood 108 (2006) 154a
    • (2006) Blood , vol.108
    • Pennisi, A.1    Ling, W.2    Perkins, P.3    Saha, R.4    Barlogie, B.5    Tricot, G.6
  • 78
    • 27744557499 scopus 로고    scopus 로고
    • Response to bortezomib is associated to osteoblastic activation in patients with multiple myeloma
    • Zangari M., Esseltine D., Lee C.K., Barlogie B., Elice F., Burns M.J., et al. Response to bortezomib is associated to osteoblastic activation in patients with multiple myeloma. Br J Haematol 131 (2005) 71-73
    • (2005) Br J Haematol , vol.131 , pp. 71-73
    • Zangari, M.1    Esseltine, D.2    Lee, C.K.3    Barlogie, B.4    Elice, F.5    Burns, M.J.6
  • 79
    • 20844451019 scopus 로고    scopus 로고
    • High serum bone-specific alkaline phosphatase level after bortezomib-combined therapy in refractory multiple myeloma: possible role of bortezomib on osteoblast differentiation
    • Shimazaki C., Uchida R., Nakano S., Namura K., Fuchida S.I., Okano A., et al. High serum bone-specific alkaline phosphatase level after bortezomib-combined therapy in refractory multiple myeloma: possible role of bortezomib on osteoblast differentiation. Leukemia 19 (2005) 1102-1103
    • (2005) Leukemia , vol.19 , pp. 1102-1103
    • Shimazaki, C.1    Uchida, R.2    Nakano, S.3    Namura, K.4    Fuchida, S.I.5    Okano, A.6
  • 81
    • 36649020813 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib affects osteoblastogenesis and bone formation in vitro and in vivo in multiple myeloma patients
    • Giuliani N., Morandi F., Tagliaferri S., Lazzaretti M., Bonomini S., Crugnola M., et al. The proteasome inhibitor bortezomib affects osteoblastogenesis and bone formation in vitro and in vivo in multiple myeloma patients. Blood 108 (2006) 508
    • (2006) Blood , vol.108 , pp. 508
    • Giuliani, N.1    Morandi, F.2    Tagliaferri, S.3    Lazzaretti, M.4    Bonomini, S.5    Crugnola, M.6
  • 82
    • 33750566914 scopus 로고    scopus 로고
    • Bortezomib reduces serum dickkopf-1 and receptor activator of nuclear factor-kappaB ligand concentrations and normalises indices of bone remodelling in patients with relapsed multiple myeloma
    • Terpos E., Heath D.J., Rahemtulla A., Zervas K., Chantry A., Anagnostopoulos A., et al. Bortezomib reduces serum dickkopf-1 and receptor activator of nuclear factor-kappaB ligand concentrations and normalises indices of bone remodelling in patients with relapsed multiple myeloma. Br J Haematol 135 (2006) 688-692
    • (2006) Br J Haematol , vol.135 , pp. 688-692
    • Terpos, E.1    Heath, D.J.2    Rahemtulla, A.3    Zervas, K.4    Chantry, A.5    Anagnostopoulos, A.6
  • 83
    • 0346837985 scopus 로고    scopus 로고
    • A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases
    • Body J.J., Greipp P., Coleman R.E., Facon T., Geurs F., Fermand J.P., et al. A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases. Cancer 97 (2003) 887-892
    • (2003) Cancer , vol.97 , pp. 887-892
    • Body, J.J.1    Greipp, P.2    Coleman, R.E.3    Facon, T.4    Geurs, F.5    Fermand, J.P.6
  • 84
    • 33644760436 scopus 로고    scopus 로고
    • A study of the biological receptor activator of nuclear factor-kappaB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer
    • Body J.J., Facon T., Coleman R.E., Lipton A., Geurs F., Fan M., et al. A study of the biological receptor activator of nuclear factor-kappaB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer. Clin Cancer Res 12 (2006) 1221-1228
    • (2006) Clin Cancer Res , vol.12 , pp. 1221-1228
    • Body, J.J.1    Facon, T.2    Coleman, R.E.3    Lipton, A.4    Geurs, F.5    Fan, M.6


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