Alterations of p16 and p14ARF genes and their 9p21 locus in oral squamous cell carcinoma

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology

Volumn 107, Issue 1, 2009, Pages 81-91

  Ohta, Shinsuke ^a   Uemura, Hiroji ^a   Matsui, Yoshiro ^a   Ishiguro, Hitoshi ^a   Fujinami, Kiyoshi ^a   Kondo, Keiichi ^a   Miyamoto, Hiroshi ^a   Yazawa, Takuya ^a   Danenberg, Kathleen ^b   Danenberg, Peter V ^b   Tohnai, Iwai ^a   Kubota, Yoshinobu ^a  

^a YOKOHAMA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; MESSENGER RNA; P16 PROTEIN, HUMAN; TUMOR PROTEIN;

ARTICLE; BIOSYNTHESIS; CHROMOSOME 9; DNA METHYLATION; GENE DELETION; GENE SILENCING; GENETICS; HETEROZYGOSITY LOSS; HUMAN; MOUTH TUMOR; NUCLEOTIDE SEQUENCE; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE STRAND CONFORMATION POLYMORPHISM; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE;

CARCINOMA, SQUAMOUS CELL; CHROMOSOMES, HUMAN, PAIR 9; DNA METHYLATION; DNA MUTATIONAL ANALYSIS; GENE DELETION; GENE SILENCING; GENES, P16; HUMANS; LOSS OF HETEROZYGOSITY; MOUTH NEOPLASMS; NEOPLASM PROTEINS; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEIN P14ARF;

EID: 57649230131     PISSN: 10792104     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tripleo.2008.08.027     Document Type: Article

References (37)

1. Jin X., Ngyuen D., Zhang W.W., Kyritsis A.P., and Roth J.A. Cell cycle arrest and inhibition of tumor cell proliferation by the p16INK4 gene mediated by an adenovirus vector. Cancer Res 55 (1995) 3250-3253
2. Serrano M., Lee H.W., Chin L., Cordon-Cardo C., Beach D., and DePinho R.A. Role of the INK4a locus in tumor suppression and cell mortality. Cell 85 (1996) 27-37
3. Paradiso A., Ranieri G., Stea B., Zito A., Zehbe I., Tommasino M., et al. Altered p16INK4a and Fhit expression in carcinogenesis and progression of human oral cancer. Int J Oncol 24 (2004) 249-255
4. Mao L., Merlo A., Bedi G., Shapiro G.I., Edwards C.D., Rollins B.J., et al. A novel p16INK4A transcript. Cancer Res 55 (1995) 2995-2997
5. Stone S., Jiang P., Dayananth P., Tavigian S.V., Katcher H., Parry D., et al. Complex structure and regulation of the p16 (MTS1) locus. Cancer Res 55 (1995) 2988-2994
6. Zhang Y., Xiong Y., and Yarbrough W.G. ARF promotes MDM2 degradation and stabilizes p53:ARF-INK4a locus deletion impairs both the RB and p53 tumor suppression pathways. Cell 92 (1998) 725-734
7. Pomerantz J., Schreiber-Agus N., Silverman A., Alland L., Chin L., Potes J., et al. The INK4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell 92 (1998) 713-723
8. Sakai E., and Tsuchida N. Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumor-suppressor genes. Oncogene 7 (1992) 927-933
9. van de Riet P., Nawroz H., Hruban H.R., Corio R., Tokino K., Koch W., et al. Frequent loss of chromosome 9p21-22 early in head and neck cancer progression. Cancer Res 54 (1994) 1156-1158
10. Reed A.L., Califano J., Cairns P., Westra W.H., Jones R.M., Koch W., et al. High frequency of p16 (CDKN2/MTS-1/INK4A) inactivation in head and neck squamous cell carcinoma. Cancer Res 56 (1996) 3630-3633
11. Zhang Y., Klein-Szanto A.J.P., Sauter E.R., Shafarenko M., Mitsunaga S., Nobori T., et al. Higher frequency of alterations in the p16/CDKN2 gene in squamous cell carcinoma cell lines than in primary tumors of head and neck. Cancer Res 54 (1994) 5050-5053
12. Nawroz H., van der Riet P., Hruban R., Koch W., and Ruppert M. Sidransky D. Allelotype of head and neck squamous cell carcinoma. Cancer Res 54 (1994) 1152-1155
13. Cairns P., Polascik T.J., Eby Y., Tokino K., Califano J., Merlo A., et al. Frequency of homozygous deletion at p16/CDKN2 in primary human tumors. Nat Genet 13 (1995) 210-212
14. Cairns P., Mao L., Merlo A., Lee D.J., Schwab D., Eby Y., et al. Rates of p16 (MTS1) mutations in primary tumors with 9p loss. Science 265 (1994) 415-416
15. Chomczynski P. A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. BioTechniques 15 (1993) 532-535
16. Gibson U.E.M., Heid C.A., and Williams P.M. A novel method for real time quantitative RT-PCR. Genome Res 6 (1996) 995-1001
17. Heid C.A., Stevens J., Livik K.J., and Williams P.M. Real time quantitative PCR. Genome Res 6 (1996) 986-994
18. Orita M., Suzuki Y., Sekiya T., and Hayashi K. Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. Genomics 5 (1989) 874-879
19. Herman J.G., Graff J.R., Myohanen S., Nelkin B.D., and Baylin S.B. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A 93 (1996) 9821-9826
20. Gonzalez-Zulueta M., Bender C.M., Yang A.S., Nguyen T., Beart R.W., Tornout J.M.V., et al. Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res 55 (1995) 4531-4535
21. Robertson K.D., and Jones P.A. The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53. Mol Cell Biol 18 (1998) 6457-6473
22. Baylin S.B., Herman J.G., Graff J.R., and Vertino PM Issa J.P. Alteration in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res 72 (1998) 141-196
23. Merlo A., Herman J.G., Mao L., Lee D.J., Gabreilson E., Burger P.C., et al. 5'CpG island methylation is associated with transcriptional silencing of the tumor suppressor p16/CDKN2/MTS1 in human cancers. Nat Med 1 (1995) 686-692
24. Herman J.G., Merlo A., Mao L., Lapidus R.G., Issa J.P., Davidson N.E., et al. Inactivation of a CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 55 (1995) 4525-4530
25. Gonzalez M.V., Pello M.F., Lopez-Larrea C., Suarez C., Menendez M., and Coto E. Deletion and methylation of the tumour suppressor gene p16/CDKN2 in primary head and neck squamous cell carcinoma. J Clin Pathol 50 (1997) 509-512
26. Tran T.N., Liu Y., Takagi M., Yamaguchi A., and Fujii H. Frequent promoter hypermethylation of RAFFSIA and p16INK4a and infrequent allelic loss other than 9p21 in betel-associated oral carcinoma in a Vietnamese non-smoking/non-drinking female population. J Oral Pathol Med 34 (2005) 150-156
27. Loughran O., Malliri A., Owens D., Gallimore P.H., Stanley M.A., Ozanne B., et al. Association of CDKN2A/p16INK4A with human head and neck keratinocyte replicative senescence:relationship of dysfunction to immortality and neoplasia. Oncogene 13 (1996) 561-568
28. Hayashi K., Metzger R., Salonga D., Danenberg K., Groshen S., Lenz H.-J., et al. High frequency of simultaneous loss of p16 and p16b gene expression in squamous cell carcinoma of the esophagus but not in adenocarcinoma of the esophagus or stomach. Oncogene 15 (1997) 1481-1488
29. Worsham M.J., Chen K.M., Tiwari N., Pals G., Schouten J.P., Sethi S., et al. Fine-mapping loss of gene architecture at the CDKN2B (p15INK4b), CDKN2A (p14ARF, p16INK4a), and MTAP genes in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 132 (2006) 409-415
30. Jares P., Fernandez P.L., Nadal A., Cazorla M., Hernandez L., Pinyol M., et al. p16MTS1/CDK4I mutations and concomitant loss of heterozygosity at 9p21-23 are frequent events in squamous cell carcinoma of the larynx. Oncogene 15 (1997) 1445-1453
31. Waber P., Dlugosz S., Cheng Q.C., Truelson J., and Nisen P.D. Genetic alterations of chromosome band 9p21-23 in head and neck cancer are not restricted to p16INK4a. Oncogene 15 (1997) 1699-1704
32. Lydiatt W.M., Murty V.V.V.S., Davidson B.J., Xu L., Dyomina K., Sacks P.G., et al. Homozygous deletions and loss of expression of the CDKN2 gene occur frequently in head and neck squamous cell carcinoma cell lines but infrequently in primary tumors. Genes Chromosomes Cancer 13 (1995) 94-98
33. Serrano M., Hannon G.J., and Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D1/CDK4. Nature 366 (1993) 704-707
34. Medema R.H., Herrera R.E., Lam F., and Weinberg R.A. Growth suppression by p16Ink4 requires functional retinoblastoma protein. Proc Natl Acad Sci U S A 92 (1995) 6289-6293
35. Weinberg R.A. The retinoblastoma protein and cell cycle control. Cell 81 (1995) 323-330
36. Brown V.L., Harwood C.A., Crook T., Cronin J.G., Kelsell D.P., and Proby C.M. p16INK4a and p14ARF tumor suppressor genes are commonly inactivated in cutaneous squamous cell carcinoma. J Invest Dermatol 122 (2004) 1284-1292
37. Kwong R.A., Kalish L.H., Nguyen T.V., Kench J.G., Bova R.J., Cole I.E., et al. p14ARF protein expression is a predictor of both relapse and survival in squamous cell carcinoma of the anterior tongue. Clin Cancer Res 11 (2005) 4107-4116