Inhibition of AMPK accentuates prolonged caloric restriction-induced change in cardiac contractile function through disruption of compensatory autophagy

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1852, Issue 2, 2015, Pages 332-342

  Zheng, Qijun ^a,b   Zhao, Kun ^a   Han, Xuefeng ^b,c   Huff, Anna F ^b   Cui, Qin ^a   Babcock, Sara A ^b   Yu, Shiqiang ^a   Zhang, Yingmei ^a,b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF WYOMING COLLEGE OF HEALTH SCIENCES   (United States)

^c FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

AMPK; Autophagy; Caloric restriction; MTOR; Myocardial

Indexed keywords

ADAPTOR PROTEIN; ADENYLATE KINASE; AUTOPHAGY PROTEIN 5; BECLIN 1; CALCIUM ION; GLUCOSE; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN P62; REGULATOR PROTEIN; TUBERIN; UNC 51 LIKE KINASE; UNCLASSIFIED DRUG; CALCIUM; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PROTEIN KINASE INHIBITOR;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; BODY COMPOSITION; BODY FAT; BODY WEIGHT; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CALORIC RESTRICTION; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HEART CONTRACTION; HEART FUNCTION; HEART LEFT VENTRICLE MASS; HEART MUSCLE CELL; HEART OUTPUT; HEART RATE; HEART WEIGHT; LIPID COMPOSITION; MALE; MEAN ARTERIAL PRESSURE; MOUSE; NONHUMAN; PHYSICAL ACTIVITY; PROTEIN PHOSPHORYLATION; SYSTOLIC BLOOD PRESSURE; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; C57BL MOUSE; DRUG EFFECTS; ECHOCARDIOGRAPHY; ENZYMOLOGY; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; TRANSPORT AT THE CELLULAR LEVEL;

MUS;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; AUTOPHAGY; BIOLOGICAL TRANSPORT; CALCIUM; CALORIC RESTRICTION; ECHOCARDIOGRAPHY; GLUCOSE; GLUCOSE TOLERANCE TEST; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, BIOLOGICAL; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PROTEIN KINASE INHIBITORS; SIGNAL TRANSDUCTION;

EID: 84919831857     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2014.04.023     Document Type: Article

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