NNK, a tobacco-specific carcinogen, inhibits the expression of lysyl oxidase, a tumor suppressor

International Journal of Environmental Research and Public Health

Volumn 12, Issue 1, 2015, Pages 64-82

  Cheng, Guang ^a   Li, Jianmin ^a   Zheng, Maoguen ^a   Zhao, Yinzhi ^b   Zhou, Jing ^b   Li, Wande ^b  

^a HEBEI UNITED UNIVERSITY   (China)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

4 (methylnitrosamino) 1 (3 pyridyl) 1 butanone (NNK); CpG methylation; Histone H3 acetylation; Lysyl oxidase (LOX)

Indexed keywords

4 (METHYLNITROSAMINO) 1 (3 PYRIDYL) 1 BUTANONE; HISTONE H3; MESSENGER RNA; PROTEIN LYSINE 6 OXIDASE; 4-(N-METHYL-N-NITROSAMINO)-1-(3-PYRIDYL)-1-BUTANONE; ANTINEOPLASTIC AGENT; CARCINOGEN; ENZYME INHIBITOR; HISTONE; NITROSAMINE; TUMOR SUPPRESSOR PROTEIN;

CANCER; CARCINOGEN; GENE EXPRESSION; METHYLATION; PROTEIN; RNA; TUMOR;

ANIMAL CELL; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DOSE RESPONSE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME SYNTHESIS; FETUS; GENE; GENE INACTIVATION; HISTONE ACETYLATION; LOX GENE; LUNG FIBROBLAST; NONHUMAN; PROMOTER REGION; PROTEIN PROCESSING; RAT; STEADY STATE; ACETYLATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMICALLY INDUCED; GENETICS; LUNG TUMOR; METABOLISM; REAL TIME POLYMERASE CHAIN REACTION;

NICOTIANA TABACUM; RATTUS;

ACETYLATION; ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOGENS; CELL LINE; CPG ISLANDS; DNA METHYLATION; ENZYME INHIBITORS; HISTONES; LUNG NEOPLASMS; NITROSAMINES; PROTEIN-LYSINE 6-OXIDASE; RATS; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEINS;

EID: 84919822701     PISSN: 16617827     EISSN: 16604601     Source Type: Journal    
DOI: 10.3390/ijerph120100064     Document Type: Article

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