Inhibition of the expression of lysyl oxidase and its substrates in cadmium-resistant rat Fetal lung fibroblasts

Toxicological Sciences

Volumn 90, Issue 2, 2006, Pages 478-489

  Zhao, Yinzhi ^a   Gao, Song ^a   Chou, Iih Nan ^a   Toselli, Paul ^a   Stone, Phillip ^a   Li, Wande ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cadmium; Cellular thiols; Collagen; Copper; Elastin; Lysyl oxidase

Indexed keywords

CADMIUM CHLORIDE; CELL EXTRACT; COLLAGEN; COPPER; ELASTIN; ENZYME PRECURSOR; GLUTATHIONE; MESSENGER RNA; METALLOTHIONEIN; PROTEIN LYSINE 6 OXIDASE; THIOL;

ANIMAL CELL; ARTICLE; CATALYSIS; CELLULAR DISTRIBUTION; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CULTURE MEDIUM; DOWN REGULATION; EMPHYSEMA; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME SUBSTRATE; EXPOSURE; EXTRACELLULAR MATRIX; FETUS LUNG; LUNG FIBROBLAST; LUNG INJURY; NONHUMAN; PATHOGENESIS; PHENOTYPE; PROTEIN CROSS LINKING; PROTEIN EXPRESSION; RAT;

ANIMALS; CADMIUM; CELLS, CULTURED; COLLAGEN TYPE I; COPPER; DRUG TOLERANCE; ELASTIN; FIBROBLASTS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTATHIONE; LUNG; METALLOTHIONEIN; PROTEIN-LYSINE 6-OXIDASE; RATS; RNA, MESSENGER;

ANIMALIA;

EID: 33645123841     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfj112     Document Type: Article

References (49)

1. Absher, M. (1989). Fibroblasts. In Lung Cell Biology (Massaro, D., Ed.), pp. 401-439, Marcel Dekker, Inc., New York.
2. Campagnone, R., Regan, J., Rich, C. B., Miller, M., Keene, D. R., Sakai, L., and Foster, J. A. (1987). Methods in laboratory investigation. Pulmonary fibroblasts: A model system for studying elastin synthesis. Lab. Invest. 56, 224-230.
3. Carnevali, S., Petruzzelli, S., Longoni, B., Vanacore, R., Barale, R., Cipollini, M., Scatena, F., Paggiaro, P., Celi, A., and Giuntini, C. (2003). Cigarette smoke extract induces oxidative stress and apoptosis in human lung fibroblasts. Am. J. Physiol. Lung Cell. Mol. Physiol. 284, L955-L963.
4. Chambers, R. C., McAnulty, R. J., Shock, A., Campa, J. S., Taylor, A. J. N., and Laurent, G. J. (1994). Cadmium selectively inhibits fibroblast procollagen production and proliferation. Am. J. Physiol. Lung Cell. Mol. Physiol. 267, L300-L308.
5. Chen, L.-J., Zhao, Y., Gao, S., Chou, I.-N., Toselli, P., Stone, P., and Li, W. (2005). Downregulation of lysyl oxidase and upregulation of cellular thiols in rat fetal lung fibroblasts treated with cigarette smoke condensate. Toxicol. Sci. 83, 372-379.
6. Chun, Y.-S., Choi, E., Kim, G.-T., Choi, H., Kim, C.-H., Lee, M.-J., Kim, M.-S., and Park, J.-W. (2000). Cadmium blocks hypoxia-inducible factor (HIF)-1-mediated response to hypoxia by stimulating the proteasome-dependent degradation of HIF-1α. Eur. J. Biochem. 267, 4198-4204.
7. Coultas, D. B., and Samet, J. M. (1989). Cigarette smoking. In Clinical Epidemiology of Cronic Obstractive Pulmonary Disease (Hensley, M. J., and Saunders, N. A., Eds.), pp.109-138, Marcel Dekker, New York.
8. Davision, A. G., Newman Taylor, A. J., Darbyshire, J., Chettle, D. R., Guthrie, C. J. G., O'Malley, D., Mason, H. J., Fayers, P. M., Venables, K. M., Pickering, C. A. C., et al. (1988). Cadmium fume inhalation and emphysema. Lancet 1, 663-667.
9. - lung fibroblast subpopulations. Am. J. Physiol. Lung Cell. Mol. Physiol. 263, L283-L290.
10. Diegelmann, R. F., and Peterkofsky, B. (1972). Collagen biosynthesis during connective tissue development in chick embryo. Dev. Biol. 28, 443-453.
11. Dubic, M. A., Keen, C. L., and Rucker, R. B. (1985). Elastin metabolism during prenatal lung development in the copper-deficient rat. Exp. Lung Res. 8, 227-241.
12. Eaton, D. L., and Toal, B. F. (1982). Evaluation of the Cd-hemoglobin affinity assay for rapid determination of metallothionein in biological tissue. Toxicol. Appl. Pharmacol. 66, 134-142.
13. Fisk, D. E., and Kuhn, C. (1976). Emphysema-like changes in the lungs of blotchy mouse. Am. Rev. Respir. Dis. 113, 787-797.
14. Foster, J. A. Rich, C. B., and Miller, M. F. (1990). Pulmonary fibroblasts: An in vitro model of emphysema. J. Biol. Chem. 265, 15544-15549.
15. Gao, S., Chen, K., Zhao, Y., Rich, C. B., Chen, L., Li, S. J., Toselli, P., Stone, P., and Li, W. (2005). Transcriptional and posttranscriptional inhibition of lysyl oxidase expression by cigarette smoke condensate in cultured rat fetal lung fibroblasts. Toxicol. Sci. 87, 197-203.
16. Giampuzzi, M., Botti, G., Duca, M. D., Arata, L., Ghiggeri, G., Gusmano, R., Ravazzolo, R., and Donato A. D. (2000). Lysyl oxidase activates the transcription activity of human collagene III promoter. J. Biol. Chem. 275, 36341-36349.
17. Gong, P., Ogra, Y., and Koizumi, S. (2000). Inhibitory effects of heavy metals on transcription factor Sp1. Ind. Health 38, 224-227.
18. Harris, E. D. (1986). Biochemical defect in chick lung resulting from copper deficiency. J. Nutr. 116, 252-258.
19. Harris, E. D. (1993). Menkes' disease: Perspective and update on a fatal copper disorder. Nutr. Rev. 51, 235-245.
20. Hill, C. G., Matrone, G., Payne, W. L., and Barber, C. W. (1963). In vivo interactions of cadmium with copper, zinc and ion. J. Nutr. 80, 227-235.
21. IARC (1993). Beryllium, cadmium, mercury and exposures in the glass manufacturing industry. Monographs on the evaluation of carcinogenic risk to humans. IARC, Lyon, France, 58, 119-236.
22. Ivarsson, M., McWhirter, A. Black, C. M., and Rubin, K. (1993). Impaired regulation of collagen pro-α1 (I) mRNA and change in pattern of collagen-binding integrins on scleroderma fibroblasts. J. Invest. Dermatol. 101, 216-221.
23. Jackson, L. E., Faris, B., Martin, B. M., Jones, H. V., Rich, C. B, Foster, J. A., and Franzblau, C. (1991). The effect of β-aminopropionitrile on elastin gene expression in smooth muscle cell cultures. Biochem. Biophys. Res. Commun. 179, 939-944.
24. Kagan, H. M., and Li, W. (2003). Lysyl oxidase: Properties, specificity and biological roles inside of the cell. J. Cell. Biochem. 88, 660-672.
25. Kagi, J. H. R., and Schaffer, A. (1988). Biochemistry of metallothioncin. Biochem. 27, 8509-8515.
26. Kazantzis, G., and Blacks, R. G. (1992). A mortality study of cadmium exposed workers. In Proceedings of the Seventh International Cadmium Conference (M. E. Cook, S. A. Hiscock, H. Morrow, and R. A. Volpe, Eds.), pp. 150-157, New Orleans, LA, 6-8 April 1992, Cadmium Association/ Cadmium Council, London/Reston, Virginia.
27. Kosonen, T., Uriu-Hare, J. Y., Clegg, M. S., Keen, C. L., and Rucker, R. B. (1997). Incorporation of copper into lysyl oxidase. Biochem. J. 327, 283-289.
28. Kuhn, C., III, and Starcher, B. C. (1980). The effects of lathyrogens on the evolution of elastase-induced emphysema. Am. Rev. Respir. Dis. 122, 453-460.
29. Lane, R. E., and Campbell, A. C. P. (1954). Fatal emphysema in two men making a copper cadmium alloy. Br. J. Ind. Med. 11, 118-122.
30. Li, W., Chou, I. N., Boak, A., and Kagan, H. M. (1995). Downregulation of lysyl oxidase in cadmium-resistant fibroblasts. Am. J. Respir. Cell Mol. Biol. 13, 418-425.
31. Li, W., Kagan, H. M., and Chou, I. N. (1994). Alteration in cytoskeletal organization and homeostasis of cellular thiols in cadmium-resistant cells. Toxicol. Appl. Pharmacol. 126, 114-123.
32. Li, W., Nellaiappan, K., Strassmaier, T., Graham, L., Thomas, K. M., and Kagan, H. M. (1997). Localization and activity of lysyl oxidase within nuclei of fibrogenic cells. Proc. Natl. Acad. Sci. U.S.A. 94, 12817-12822.
33. Lim, A., Greenspan, D. S., and Smith, B. D. (1994). Expression of α2 type I collagen in W8 cells increases cell adhesion and decreases colony formation in soft agar. Matrix Biol. 14, 21-30.
34. Mattie, M. D., and Freedman, J. H. (2004). Copper-inducible transcription: Regulation by metal- and oxidative stress responsive pathways. Am. J. Physiol. Cell. Physiol. 286, C293-C301.
35. Meister, A. (1984). New aspects of glutathione biochemistry and transport: Selective alteration of glutathione metabolism. Federation Proc. 43, 3031-3042.
36. Nellaiappan, K., Risitano, A., Liu, G., Nicklas, G., and Kagan, H. M. (2000). Fully processed lysyl oxidase catalyst translocates from the extracellular space into nuclei of aortic smooth muscle cells. J. Cell. Biochem. 79, 576-582.
37. Niewoehner, D. E., and Hoidal, J. R. (1982). Lung fibrosis and emphysema: Divergent responses to a common injury. Science 217, 359-360.
38. Paakko, P., Kokkonen, P., Anttila, S., and Kalliomaki, P.-L. (1989). Cadmium and chromium as markers of smoking in human lung tissue. Environ. Res. 49, 197-207.
39. Parent, A., Benzaghou, I., Bougie, I., and Bisaillon, M. (2004). Transcription and mRNA processing events: The importance of coordination. J. Biol. Sci. 4, 624-627.
40. Post, C., Johansson, B., and Allenmark, S. (1984). Organ distribution and protein binding of cadmium in autopsy material from heavy smokers. Environ. Res. 34, 29-37.
41. Riikonen, T., Westermarck, J., Koivisto, L., Kahari, V. M., and Heino, J. (1995). Integrin α2β1 is a positive regulator of collagenase (MMP-1) and collagen α1 (I) gene expression. J. Biol. Chem. 270, 13548-13552.
42. Sampson, C. E., Chichester, C. O., Hayes, J. A., and Kagan, H. M. (1984). Alteration in collagen biosynthesis and in metallothionein in lungs of rats acutely or repeatedly exposed to cadmium chloride aerosol. Am. Rev. Respir. Dis. 129, 619-624.
43. Snider, G. L., Lucey, E. C., and Stone, P. J. (1986). Animal models of emphysema. Am. Rev. Respir. Dis. 133, 149-169.
44. Stone, P. J., Morris, S. M., Thomas, K. M., Schuhwerk, K., and Mitchelson, A. (1997). Repair of elastase-digested elastic fibers in acellular matrices by replating with neonatal rat-lung lipid interstitial fibroblasts or other elastogenic cell types. Am. J. Respir. Cell Mol. Biol. 17, 289-301.
45. Tietze, F. (1969). Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione. Application to mammalian blood and other tissues. Anal. Chem. 27, 502-522.
46. Trackman, P. C., Pratt, A. M., Wolanski, A., Tang, S.-S., Offner, G. D., Troxler, R. F., and Kagan, H. M. (1990). Cloning of rat aorta lysyl oxidase cDNA: Complete codons and predicted amino acid sequence. Biochemistry 29, 4863-4870.
47. Trackman, P. C., Pratt, A. M., Wolanski, A., Tang, S.-S., Offner, G. D., Troxler, R. F., and Kagan, H. M. (1990). Cloning of rat aorta lysyl oxidase cDNA: Complete codons and predicted amino acid sequence. Biochemistry 30, 8282.
48. Tremblay, G. M., Sarnstrand, B., Jordana, M., and Gauldie, J. (1995). Fibroblasts as effector cells in fibrosis. In Pulmonary Fibrosis (S. H. Phan and R. S. Thrall, Eds.), pp. 541-577, Marcel Dekker, Inc., New York.
49. Yang, L., Guan, T., and Gerace, L. (1997). Integral membrane proteins of the nuclear envelope are dispersed throughout the endoplasmic reticulum during mitosis. J. Cell Biol. 137, 1199-1210.