-
1
-
-
84872967522
-
Cancer statistics 2013
-
Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J. Clin. 63(1), 11-30 (2013).
-
(2013)
CA Cancer J. Clin.
, vol.63
, Issue.1
, pp. 11-30
-
-
Siegel, R.1
Naishadham, D.2
Jemal, A.3
-
2
-
-
33846405332
-
Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: A randomized controlled trial
-
Oettle H, Post S, Neuhaus P et al. Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer: A randomized controlled trial. JAMA 297(3), 267-277 (2007).
-
(2007)
JAMA
, vol.297
, Issue.3
, pp. 267-277
-
-
Oettle, H.1
Post, S.2
Neuhaus, P.3
-
3
-
-
8244254377
-
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial
-
Burris HA 3rd, Moore MJ, Andersen J et al. Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial. J. Clin. Oncol. 15(6), 2403-2413 (1997).
-
(1997)
J. Clin. Oncol.
, vol.15
, Issue.6
, pp. 2403-2413
-
-
Burris, H.A.1
Moore, M.J.2
Andersen, J.3
-
4
-
-
34249933404
-
Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase iii trial of the national cancer institute of canada clinical trials group
-
Moore MJ, Goldstein D, Hamm J et al. Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A Phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J. Clin. Oncol. 25(15), 1960-1966 (2007).
-
(2007)
J. Clin. Oncol.
, vol.25
, Issue.15
, pp. 1960-1966
-
-
Moore, M.J.1
Goldstein, D.2
Hamm, J.3
-
5
-
-
84892143603
-
Management of advanced pancreatic cancer with gemcitabine plus erlotinib: Efficacy and safety results in clinical practice
-
Diaz Beveridge R, Alcolea V, Aparicio J et al. Management of advanced pancreatic cancer with gemcitabine plus erlotinib: Efficacy and safety results in clinical practice. JOP 15(1), 19-24 (2014).
-
(2014)
JOP
, vol.15
, Issue.1
, pp. 19-24
-
-
Diaz Beveridge, R.1
Alcolea, V.2
Aparicio, J.3
-
6
-
-
79955921754
-
FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer
-
Conroy T, Desseigne F, Ychou M et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N. Engl. J. Med. 364(19), 1817-1825 (2011).
-
(2011)
N. Engl. J. Med.
, vol.364
, Issue.19
, pp. 1817-1825
-
-
Conroy, T.1
Desseigne, F.2
Ychou, M.3
-
7
-
-
0020536951
-
The evaluation of synthetic strategies for oligonucleotides of defined sequence Computer programs in nucleic acid syn thesis: I
-
Lombardi S, Seidell H, Hachmann J. The evaluation of synthetic strategies for oligonucleotides of defined sequence. Computer programs in nucleic acid synthesis: I. Comput. Programs Biomed. 16(1-2), 71-76 (1983).
-
(1983)
Comput. Programs Biomed.
, vol.16
, Issue.1-2
, pp. 71-76
-
-
Lombardi, S.1
Seidell, H.2
Hachmann, J.3
-
8
-
-
77951755278
-
Pancreatic cancer
-
Hidalgo M. Pancreatic cancer. N. Engl. J. Med. 362(17), 1605-1617 (2010).
-
(2010)
N. Engl. J. Med.
, vol.362
, Issue.17
, pp. 1605-1617
-
-
Hidalgo, M.1
-
9
-
-
1042302005
-
The STATs of cancer [mdash] new molecular targets come of age
-
Yu H, Jove R. The STATs of cancer [mdash] new molecular targets come of age. Nat. Rev. Cancer 4(2), 97-105 (2004).
-
(2004)
Nat. Rev. Cancer
, vol.4
, Issue.2
, pp. 97-105
-
-
Yu, H.1
Jove, R.2
-
10
-
-
84860321700
-
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
-
Ying H, Kimmelman AC, Lyssiotis CA et al. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell 149(3), 656-670 (2012).
-
(2012)
Cell
, vol.149
, Issue.3
, pp. 656-670
-
-
Ying, H.1
Kimmelman, A.C.2
Lyssiotis, C.A.3
-
11
-
-
84876155675
-
The utility of vision during action: Multiple visuomotor processes?
-
Tremblay L, Hansen S, Kennedy A, Cheng DT The Utility of Vision during Action: Multiple Visuomotor Processes? J. Motor Behav. 45(2), 91-99 (2013).
-
(2013)
J. Motor Behav.
, vol.45
, Issue.2
, pp. 91-99
-
-
Tremblay, L.1
Hansen, S.2
Kennedy, A.3
Cheng, D.T.4
-
12
-
-
33746820175
-
Epidermal growth factor receptor expression in pancreatic carcinoma using tissue microarray technique
-
Bloomston M, Bhardwaj A, Ellison EC, Frankel WL. Epidermal growth factor receptor expression in pancreatic carcinoma using tissue microarray technique. Digest. Surg. 23(1-2), 74-79 (2006).
-
(2006)
Digest. Surg.
, vol.23
, Issue.1-2
, pp. 74-79
-
-
Bloomston, M.1
Bhardwaj, A.2
Ellison, E.C.3
Frankel, W.L.4
-
13
-
-
53949121341
-
Gemcitabine combined with gefitinib in patients with inoperable or metastatic pancreatic cancer: A phase ii study of the hellenic cooperative oncology group with biomarker evaluation
-
Fountzilas G, Bobos M, Kalogera-Fountzila A et al. Gemcitabine combined with gefitinib in patients with inoperable or metastatic pancreatic cancer: A Phase II Study of the Hellenic Cooperative Oncology Group with biomarker evaluation. Cancer Invest. 26(8), 784-793 (2008).
-
(2008)
Cancer Invest.
, vol.26
, Issue.8
, pp. 784-793
-
-
Fountzilas, G.1
Bobos, M.2
Kalogera-Fountzila, A.3
-
14
-
-
77949314352
-
Combined cetuximab and trastuzumab are superior to gemcitabine in the treatment of human pancreatic carcinoma xenografts
-
Larbouret C, Robert B, Bascoul-Mollevi C et al. Combined cetuximab and trastuzumab are superior to gemcitabine in the treatment of human pancreatic carcinoma xenografts. Ann. Oncol. 21(1), 98-103 (2010).
-
(2010)
Ann. Oncol.
, vol.21
, Issue.1
, pp. 98-103
-
-
Larbouret, C.1
Robert, B.2
Bascoul-Mollevi, C.3
-
15
-
-
62549147841
-
Persistent elimination of ErbB-2/ HER2-overexpressing tumors using combinations of monoclonal antibodies: Relevance of receptor endocytosis
-
Ben-Kasus T, Schechter B, Lavi S, Yarden Y, Sela M. Persistent elimination of ErbB-2/ HER2-overexpressing tumors using combinations of monoclonal antibodies: Relevance of receptor endocytosis. Proc. Natl Acad. Sci. USA 106(9), 3294-3299 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, Issue.9
, pp. 3294-3299
-
-
Ben-Kasus, T.1
Schechter, B.2
Lavi, S.3
Yarden, Y.4
Sela, M.5
-
17
-
-
84861235171
-
Monoclonal antibody therapy of pancreatic cancer with cetuximab: Potential for immune modulation
-
Luedke E, Jaime-Ramirez AC, Bhave N, Carson WE 3rd. Monoclonal antibody therapy of pancreatic cancer with cetuximab: Potential for immune modulation. J. Immunother. 35(5), 367-373 (2012).
-
(2012)
J. Immunother.
, vol.35
, Issue.5
, pp. 367-373
-
-
Luedke, E.1
Jaime-Ramirez, A.C.2
Bhave, N.3
Carson, W.E.4
-
18
-
-
4344590997
-
Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter Phase II Trial
-
Xiong HQ, Rosenberg A, Lobuglio A et al. Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter Phase II Trial. J. Clin. Oncol. 22(13), 2610-2616 (2004).
-
(2004)
J. Clin. Oncol.
, vol.22
, Issue.13
, pp. 2610-2616
-
-
Xiong, H.Q.1
Rosenberg, A.2
Lobuglio, A.3
-
19
-
-
77955914277
-
Phase III study of gemcitabine [G] plus cetuximab [C] versus gemcitabine in patients [pts] with locally advanced or metastatic pancreatic adenocarcinoma [PC]: SWOG S0205 study
-
LBA4509 doi:10.1200/JCO.2009.25.7550 Epub ahead of print)
-
Philip Pa BJ, Fenoglio-Presier C et al. Phase III study of gemcitabine [G] plus cetuximab [C] versus gemcitabine in patients [pts] with locally advanced or metastatic pancreatic adenocarcinoma [PC]: SWOG S0205 study. J. Clin. Oncol. 25(LBA4509), doi:10.1200/JCO.2009.25.7550 (2007) (Epub ahead of print) .
-
(2007)
J. Clin. Oncol.
, vol.25
-
-
Philip Pa, B.J.1
Fenoglio-Presier, C.2
-
20
-
-
79960891009
-
Height and cancer incidence in the million women study: Prospective cohort, and meta-Analysis of prospective studies of height and total cancer risk
-
Green J, Cairns BJ, Casabonne D, Wright FL, Reeves G, Beral V. Height and cancer incidence in the Million Women Study: Prospective cohort, and meta-Analysis of prospective studies of height and total cancer risk. Lancet Oncol. 12(8), 785-794 (2011).
-
(2011)
Lancet Oncol.
, vol.12
, Issue.8
, pp. 785-794
-
-
Green, J.1
Cairns, B.J.2
Casabonne, D.3
Wright, F.L.4
Reeves, G.5
Beral, V.6
-
21
-
-
0030870772
-
Geographic variation in breast cancer incidence rates in a cohort of US women
-
Laden F, Spiegelman D, Neas LM et al. Geographic variation in breast cancer incidence rates in a cohort of U.S. women. J. Natl Cancer Inst. 89(18), 1373-1378 (1997).
-
(1997)
J. Natl Cancer Inst.
, vol.89
, Issue.18
, pp. 1373-1378
-
-
Laden, F.1
Spiegelman, D.2
Neas, L.M.3
-
22
-
-
0032559272
-
Plasma insulin-like growth factor-I and prostate cancer risk: A prospective study
-
Chan JM, Stampfer MJ, Giovannucci E et al. Plasma insulin-like growth factor-I and prostate cancer risk: A prospective study. Science 279(5350), 563-566 (1998).
-
(1998)
Science
, vol.279
, Issue.5350
, pp. 563-566
-
-
Chan, J.M.1
Stampfer, M.J.2
Giovannucci, E.3
-
23
-
-
84887557344
-
Identification of the IGF1/PI3K/NF kappaB/ ERK gene signalling networks associated with chemotherapy resistance and treatment response in high-grade serous epithelial ovarian cancer
-
Koti M, Gooding RJ, Nuin P et al. Identification of the IGF1/PI3K/NF kappaB/ ERK gene signalling networks associated with chemotherapy resistance and treatment response in high-grade serous epithelial ovarian cancer. BMC Cancer 13, 549 (2013).
-
(2013)
BMC Cancer
, vol.13
, Issue.549
-
-
Koti, M.1
Gooding, R.J.2
Nuin, P.3
-
24
-
-
0242403449
-
Coexpression of IGF-1R and c-Src proteins in human pancreatic ductal adenocarcinoma
-
Hakam A, Fang Q, Karl R, Coppola D. Coexpression of IGF-1R and c-Src proteins in human pancreatic ductal adenocarcinoma. Digest. Dis. Sci. 48(10), 1972-1978 (2003).
-
(2003)
Digest. Dis. Sci.
, vol.48
, Issue.10
, pp. 1972-1978
-
-
Hakam, A.1
Fang, Q.2
Karl, R.3
Coppola, D.4
-
25
-
-
66849140937
-
AMG 479, a fully human anti-insulin-like growth factor receptor type i monoclonal antibody, inhibits the growth and survival of pancreatic carcinoma cells
-
Beltran PJ, Mitchell P, Chung YA et al. AMG 479, a fully human anti-insulin-like growth factor receptor type I monoclonal antibody, inhibits the growth and survival of pancreatic carcinoma cells. Mol. Cancer Ther. 8(5), 1095-1105 (2009).
-
(2009)
Mol. Cancer Ther.
, vol.8
, Issue.5
, pp. 1095-1105
-
-
Beltran, P.J.1
Mitchell, P.2
Chung, Y.A.3
-
26
-
-
84862509365
-
Safety and pharmacokinetics of ganitumab (AMG 479) combined with sorafenib, panitumumab, erlotinib, or gemcitabine in patients with advanced solid tumors
-
Rosen LS, Puzanov I, Friberg G et al. Safety and pharmacokinetics of ganitumab (AMG 479) combined with sorafenib, panitumumab, erlotinib, or gemcitabine in patients with advanced solid tumors. Clin. Cancer Res. 18(12), 3414-3427 (2012).
-
(2012)
Clin. Cancer Res.
, vol.18
, Issue.12
, pp. 3414-3427
-
-
Rosen, L.S.1
Puzanov, I.2
Friberg, G.3
-
27
-
-
84862531853
-
A randomized, placebo-controlled Phase 2 study of ganitumab (AMG 479) or conatumumab (AMG 655) in combination with gemcitabine in patients with metastatic pancreatic cancer
-
Kindler HL, Richards DA, Garbo LE et al. A randomized, placebo-controlled Phase 2 study of ganitumab (AMG 479) or conatumumab (AMG 655) in combination with gemcitabine in patients with metastatic pancreatic cancer. Ann. Oncol. 23(11), 2834-2842 (2012).
-
(2012)
Ann. Oncol.
, vol.23
, Issue.11
, pp. 2834-2842
-
-
Kindler, H.L.1
Richards, D.A.2
Garbo, L.E.3
-
28
-
-
84893618105
-
The MEK/ERK pathway promotes NOTCH signalling in pancreatic cancer cells
-
Tremblay I, Pare E, Arsenault D, Douziech M, Boucher MJ. The MEK/ERK pathway promotes NOTCH signalling in pancreatic cancer cells. PLoS ONE 8(12), e85502 (2013).
-
(2013)
PLoS ONE
, vol.8
, Issue.12
, pp. e85502
-
-
Tremblay, I.1
Pare, E.2
Arsenault, D.3
Douziech, M.4
Boucher, M.J.5
-
29
-
-
84863673204
-
Improved survival with MEK inhibition in BRAF-mutated melanoma
-
Flaherty KT, Robert C, Hersey P et al. Improved survival with MEK inhibition in BRAF-mutated melanoma. N. Engl. J. Med. 367(2), 107-114 (2012).
-
(2012)
N. Engl. J. Med.
, vol.367
, Issue.2
, pp. 107-114
-
-
Flaherty, K.T.1
Robert, C.2
Hersey, P.3
-
30
-
-
68049085887
-
In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models
-
Hoeflich KP, O'Brien C, Boyd Z et al. In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basal-like breast cancer models. Clin. Cancer Res. 15(14), 4649-4664 (2009).
-
(2009)
Clin. Cancer Res.
, vol.15
, Issue.14
, pp. 4649-4664
-
-
Hoeflich, K.P.1
O'brien, C.2
Boyd, Z.3
-
31
-
-
84885104348
-
Synergistic effects of concurrent blockade of PI3K and MEK pathways in pancreatic cancer preclinical models
-
Zhong H, Sanchez C, Spitrzer D et al. Synergistic effects of concurrent blockade of PI3K and MEK pathways in pancreatic cancer preclinical models. PLoS ONE 8(10), e77243 (2013).
-
(2013)
PLoS ONE
, vol.8
, Issue.10
, pp. e77243
-
-
Zhong, H.1
Sanchez, C.2
Spitrzer, D.3
-
32
-
-
79956018943
-
Antitumor activities of JTP-74057 (GSK1120212), a novel MEK1/2 inhibitor, on colorectal cancer cell lines in vitro and in vivo
-
Yamaguchi T, Kakefuda R, Tajima N, Sowa Y, Sakai T. Antitumor activities of JTP-74057 (GSK1120212), a novel MEK1/2 inhibitor, on colorectal cancer cell lines in vitro and in vivo. Int. J. Oncol. 39(1), 23-31 (2011).
-
(2011)
Int. J. Oncol.
, vol.39
, Issue.1
, pp. 23-31
-
-
Yamaguchi, T.1
Kakefuda, R.2
Tajima, N.3
Sowa, Y.4
Sakai, T.5
-
33
-
-
84877697707
-
A Phase 1b study of trametinib, an oral Mitogen-Activated protein kinase kinase (MEK) inhibitor, in combination with gemcitabine in advanced solid tumours
-
Infante JR, Papadopoulos KP, Bendell JC et al. A Phase 1b study of trametinib, an oral Mitogen-Activated protein kinase kinase (MEK) inhibitor, in combination with gemcitabine in advanced solid tumours. Eur. J. Cancer 49(9), 2077-2085 (2013).
-
(2013)
Eur. J. Cancer
, vol.49
, Issue.9
, pp. 2077-2085
-
-
Infante, J.R.1
Papadopoulos, K.P.2
Bendell, J.C.3
-
34
-
-
79956298812
-
Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: Updated analysis of overall survival according to tumor KRAS and BRAF mutation status
-
Van Cutsem E, Kohne CH, Lang I et al. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: Updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J. Clin. Oncol. 29(15), 2011-2019 (2011).
-
(2011)
J. Clin. Oncol.
, vol.29
, Issue.15
, pp. 2011-2019
-
-
Van Cutsem, E.1
Kohne, C.H.2
Lang, I.3
-
35
-
-
79960889662
-
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, Phase 3 study
-
Zhou C, Wu YL, Chen G et al. Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, Phase 3 study. Lancet Oncol. 12(8), 735-742 (2011).
-
(2011)
Lancet Oncol.
, vol.12
, Issue.8
, pp. 735-742
-
-
Zhou, C.1
Wu, Y.L.2
Chen, G.3
-
36
-
-
0023735997
-
KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas
-
Smit VT, Boot AJ, Smits AM, Fleuren GJ, Cornelisse CJ, Bos JL. KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas. Nucleic Acids Res. 16(16), 7773-7782 (1988).
-
(1988)
Nucleic Acids Res.
, vol.16
, Issue.16
, pp. 7773-7782
-
-
Smit, V.T.1
Boot, A.J.2
Smits, A.M.3
Fleuren, G.J.4
Cornelisse, C.J.5
Bos, J.L.6
-
37
-
-
40949135397
-
PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab
-
Jhawer M, Goel S, Wilson AJ et al. PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab. Cancer Res. 68(6), 1953-1961 (2008).
-
(2008)
Cancer Res.
, vol.68
, Issue.6
, pp. 1953-1961
-
-
Jhawer, M.1
Goel, S.2
Wilson, A.J.3
-
38
-
-
0037616593
-
Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors
-
Bianco R, Shin I, Ritter CA et al. Loss of PTEN/MMAC1/TEP in EGF receptor-expressing tumor cells counteracts the antitumor action of EGFR tyrosine kinase inhibitors. Oncogene 22(18), 2812-2822 (2003).
-
(2003)
Oncogene
, vol.22
, Issue.18
, pp. 2812-2822
-
-
Bianco, R.1
Shin, I.2
Ritter, C.A.3
-
39
-
-
79953038262
-
PTEN loss in the continuum of common cancers, rare syndromes and mouse models
-
Hollander MC, Blumenthal GM, Dennis PA. PTEN loss in the continuum of common cancers, rare syndromes and mouse models. Nat. Rev. Cancer 11(4), 289-301 (2011).
-
(2011)
Nat. Rev. Cancer
, vol.11
, Issue.4
, pp. 289-301
-
-
Hollander, M.C.1
Blumenthal, G.M.2
Dennis, P.A.3
-
40
-
-
84895499536
-
Stars and stripes in pancreatic cancer: Role of stellate cells and stroma in cancer progression
-
Wilson JS, Pirola RC, Apte MV. Stars and stripes in pancreatic cancer: Role of stellate cells and stroma in cancer progression. Front. Physiol. 5, 52 (2014).
-
(2014)
Front. Physiol.
, vol.5
, Issue.52
-
-
Wilson, J.S.1
Pirola, R.C.2
Apte, M.V.3
-
41
-
-
0034684279
-
Pancreatic carcinoma is characterized by elevated content of hyaluronan and chondroitin sulfate with altered disaccharide composition
-
Theocharis AD, Tsara ME, Papageorgacopoulou N, Karavias DD, Theocharis DA. Pancreatic carcinoma is characterized by elevated content of hyaluronan and chondroitin sulfate with altered disaccharide composition. Biochim. Biophys. Acta 1502(2), 201-206 (2000).
-
(2000)
Biochim. Biophys. Acta
, vol.1502
, Issue.2
, pp. 201-206
-
-
Theocharis, A.D.1
Tsara, M.E.2
Papageorgacopoulou, N.3
Karavias, D.D.4
Theocharis, D.A.5
-
42
-
-
84871157346
-
Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
-
Jacobetz MA, Chan DS, Neesse A et al. Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut 62(1), 112-120 (2013).
-
(2013)
Gut
, vol.62
, Issue.1
, pp. 112-120
-
-
Jacobetz, M.A.1
Chan, D.S.2
Neesse, A.3
-
43
-
-
3042697038
-
Hyaluronan: From extracellular glue to pericellular cue
-
Toole BP. Hyaluronan: From extracellular glue to pericellular cue. Nat. Rev. Cancer 4(7), 528-539 (2004).
-
(2004)
Nat. Rev. Cancer
, vol.4
, Issue.7
, pp. 528-539
-
-
Toole, B.P.1
-
44
-
-
84872611820
-
Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer
-
Provenzano PP, Hingorani SR. Hyaluronan, fluid pressure, and stromal resistance in pancreas cancer. Br. J. Cancer 108(1), 1-8 (2013).
-
(2013)
Br. J. Cancer
, vol.108
, Issue.1
, pp. 1-8
-
-
Provenzano, P.P.1
Hingorani, S.R.2
-
45
-
-
84880072835
-
Update on Phase i studies in advanced pancreatic adenocarcinoma Hunting in darkness?
-
Strimpakos AS, Saif MW. Update on Phase I studies in advanced pancreatic adenocarcinoma. Hunting in darkness? JOP 14(4), 354-358 (2013).
-
(2013)
JOP
, vol.14
, Issue.4
, pp. 354-358
-
-
Strimpakos, A.S.1
Saif, M.W.2
-
46
-
-
84866490065
-
Inhibition of the hedgehog pathway targets the tumor-Associated stroma in pancreatic cancer
-
Hwang RF, Moore TT, Hattersley MM et al. Inhibition of the hedgehog pathway targets the tumor-Associated stroma in pancreatic cancer. Mol. Cancer Res. 10(9), 1147-1157 (2012).
-
(2012)
Mol. Cancer Res.
, vol.10
, Issue.9
, pp. 1147-1157
-
-
Hwang, R.F.1
Moore, T.T.2
Hattersley, M.M.3
-
47
-
-
58149143021
-
Sonic hedgehog promotes desmoplasia in pancreatic cancer
-
Bailey JM, Swanson BJ, Hamada T et al. Sonic hedgehog promotes desmoplasia in pancreatic cancer. Clin. Cancer Res. 14(19), 5995-6004 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, Issue.19
, pp. 5995-6004
-
-
Bailey, J.M.1
Swanson, B.J.2
Hamada, T.3
-
48
-
-
77949719411
-
Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-Associated fibroblasts
-
Walter K, Omura N, Hong SM et al. Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-Associated fibroblasts. Clin. Cancer Res. 16(6), 1781-1789 (2010).
-
(2010)
Clin. Cancer Res.
, vol.16
, Issue.6
, pp. 1781-1789
-
-
Walter, K.1
Omura, N.2
Hong, S.M.3
-
49
-
-
84880071454
-
Final analysis of a Phase IB/randomized Phase II study of gemcitabine (G) plus placebo (P) or vismodegib V), a hedgehog (Hh) pathway inhibitor, in patients (pts) with metastatic pancreatic cancer (PC): A University of Chicago Phase II consortium study
-
Catenacci Dvt BN, Nattam Sr et al. Final analysis of a Phase IB/randomized Phase II study of gemcitabine (G) plus placebo (P) or vismodegib (V), a hedgehog (Hh) pathway inhibitor, in patients (pts) with metastatic pancreatic cancer (PC): A University of Chicago Phase II consortium study. ASCO (31), (2013).
-
(2013)
ASCO
, vol.31
-
-
Catenacci Dvt, B.N.1
Nattam, S.R.2
-
50
-
-
84919798592
-
Infinity Pharma halts pancreatic cancer trial
-
Michelle L. Infinity Pharma halts pancreatic cancer trial. Boston Business J.(2012).
-
(2012)
Boston Business J.
-
-
Michelle, L.1
-
51
-
-
0036512208
-
New functions for the matrix metalloproteinases in cancer progression
-
Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat. Rev. Cancer 2(3), 161-174 (2002).
-
(2002)
Nat. Rev. Cancer
, vol.2
, Issue.3
, pp. 161-174
-
-
Egeblad, M.1
Werb, Z.2
-
52
-
-
0037100983
-
A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer
-
Bramhall SR, Schulz J, Nemunaitis J, Brown PD, Baillet M, Buckels JA. A double-blind placebo-controlled, randomised study comparing gemcitabine and marimastat with gemcitabine and placebo as first line therapy in patients with advanced pancreatic cancer. Br. J. Cancer 87(2), 161-167 (2002).
-
(2002)
Br. J. Cancer
, vol.87
, Issue.2
, pp. 161-167
-
-
Bramhall, S.R.1
Schulz, J.2
Nemunaitis, J.3
Brown, P.D.4
Baillet, M.5
Buckels, J.A.6
-
53
-
-
0141688333
-
Comparison of gemcitabine versus the matrix metalloproteinase inhibitor bay 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: A phase iii trial of the national cancer institute of canada clinical trials group
-
Moore MJ, Hamm J, Dancey J et al. Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: A Phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J. Clin. Oncol. 21(17), 3296-3302 (2003).
-
(2003)
J. Clin. Oncol.
, vol.21
, Issue.17
, pp. 3296-3302
-
-
Moore, M.J.1
Hamm, J.2
Dancey, J.3
-
54
-
-
0031438047
-
TGF-beta signalling from cell membrane to nucleus through SMAD proteins
-
Heldin CH, Miyazono K, Ten Dijke P. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 390(6659), 465-471 (1997).
-
(1997)
Nature
, vol.390
, Issue.6659
, pp. 465-471
-
-
Heldin, C.H.1
Miyazono, K.2
Ten Dijke, P.3
-
55
-
-
0027131252
-
Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival
-
Friess H, Yamanaka Y, Buchler M et al. Enhanced expression of transforming growth factor beta isoforms in pancreatic cancer correlates with decreased survival. Gastroenterol. 105(6), 1846-1856 (1993).
-
(1993)
Gastroenterol.
, vol.105
, Issue.6
, pp. 1846-1856
-
-
Friess, H.1
Yamanaka, Y.2
Buchler, M.3
-
56
-
-
84877095601
-
Molecular pathways: Jak/STAT pathway: Mutations, inhibitors, and resistance
-
Quintas-Cardama A, Verstovsek S. Molecular pathways: Jak/STAT pathway: Mutations, inhibitors, and resistance. Clin. Cancer Res. 19(8), 1933-1940 (2013).
-
(2013)
Clin. Cancer Res.
, vol.19
, Issue.8
, pp. 1933-1940
-
-
Quintas-Cardama, A.1
Verstovsek, S.2
-
57
-
-
84876065503
-
Myelofibrosis: An update on current pharmacotherapy and future directions
-
Cervantes F, Martinez-Trillos A. Myelofibrosis: An update on current pharmacotherapy and future directions. Expert Opin. Pharmacother. 14(7), 873-884 (2013).
-
(2013)
Expert Opin. Pharmacother.
, vol.14
, Issue.7
, pp. 873-884
-
-
Cervantes, F.1
Martinez-Trillos, A.2
-
58
-
-
84878216601
-
Investigational Janus kinase inhibitors
-
Tam CS, Verstovsek S. Investigational Janus kinase inhibitors. Expert Opin. Invest. Drugs 22(6), 687-699 (2013).
-
(2013)
Expert Opin. Invest. Drugs
, vol.22
, Issue.6
, pp. 687-699
-
-
Tam, C.S.1
Verstovsek, S.2
-
59
-
-
84919798591
-
Results from a Phase 2 study of ruxolitinib or placebo with capecitabine as second-line therapy in patients with metastatic pancreatic cancer: The recap trial
-
Hurwitz NU H, Wagner SA, Thaddeus BJ et al. Results from a Phase 2 study of ruxolitinib or placebo with capecitabine as second-line therapy in patients with metastatic pancreatic cancer: The recap trial. In: World GI 2014. Spain (2014).
-
(2014)
World GI 2014. Spain
-
-
Hurwitz, N.U.H.1
Wagner, S.A.2
Thaddeus, B.J.3
-
60
-
-
84901044424
-
Oncolytic immunotherapy: Dying the right way is a key to eliciting potent antitumor immunity
-
Guo ZS, Liu Z, Bartlett DL. Oncolytic immunotherapy: Dying the right way is a key to eliciting potent antitumor immunity. Front. Oncol. 4, 74 (2014).
-
(2014)
Front. Oncol.
, vol.4
, Issue.74
-
-
Guo, Z.S.1
Liu, Z.2
Bartlett, D.L.3
-
61
-
-
84890432985
-
P53 status determines the role of autophagy in pancreatic tumour development
-
Rosenfeldt MT, O'Prey J, Morton JP et al. p53 status determines the role of autophagy in pancreatic tumour development. Nature 504(7479), 296-300 (2013).
-
(2013)
Nature
, vol.504
, Issue.7479
, pp. 296-300
-
-
Rosenfeldt, M.T.1
O'prey, J.2
Morton, J.P.3
-
62
-
-
23844446653
-
Interferon-gamma and cancer immunoediting
-
Dunn GP, Ikeda H, Bruce AT et al. Interferon-gamma and cancer immunoediting. Immunologic. Res. 32(1-3), 231-245 (2005).
-
(2005)
Immunologic. Res.
, vol.32
, Issue.1-3
, pp. 231-245
-
-
Dunn, G.P.1
Ikeda, H.2
Bruce, A.T.3
-
63
-
-
79953151458
-
Cancer immunoediting: Integrating immunity's roles in cancer suppression and promotion
-
Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: Integrating immunity's roles in cancer suppression and promotion. Science 331(6024), 1565-1570 (2011).
-
(2011)
Science
, vol.331
, Issue.6024
, pp. 1565-1570
-
-
Schreiber, R.D.1
Old, L.J.2
Smyth, M.J.3
-
64
-
-
84919798590
-
A Phase 2, randomized trial of GVAX Pancreas and CRS-207 immunotherapy versus GVAX alone in patients with metastatic pancreatic adenocarcinoma
-
San Francisco, CA, USA 16-18 January
-
Le DT, Wang-Gillam A, Picozzi V Jr et al. A Phase 2, randomized trial of GVAX Pancreas and CRS-207 immunotherapy versus GVAX alone in patients with metastatic pancreatic adenocarcinoma. Presented at: ASCO Gastrointestinal Cancers Symposium. San Francisco, CA, USA, 16-18 January 2014.
-
(2014)
Presented At: ASCO Gastrointestinal Cancers Symposium
-
-
Le, D.T.1
Wang-Gillam, A.2
Picozzi, V.3
-
66
-
-
84868499316
-
Oncolytic viruses in the treatment of cancer: A review of current strategies
-
Zeyaullah M, Patro M, Ahmad I et al. Oncolytic viruses in the treatment of cancer: A review of current strategies. Pathol. Oncol. Res. 18(4), 771-781 (2012).
-
(2012)
Pathol. Oncol. Res.
, vol.18
, Issue.4
, pp. 771-781
-
-
Zeyaullah, M.1
Patro, M.2
Ahmad, I.3
-
67
-
-
0037314610
-
A Phase I/II trial of intratumoral endoscopic ultrasound injection of ONYX-015 with intravenous gemcitabine in unresectable pancreatic carcinoma
-
Hecht JR, Bedford R, Abbruzzese JL et al. A Phase I/II trial of intratumoral endoscopic ultrasound injection of ONYX-015 with intravenous gemcitabine in unresectable pancreatic carcinoma. Clin. Cancer Res. 9(2), 555-561 (2003).
-
(2003)
Clin. Cancer Res.
, vol.9
, Issue.2
, pp. 555-561
-
-
Hecht, J.R.1
Bedford, R.2
Abbruzzese, J.L.3
-
68
-
-
0344188096
-
An adenovirus mutant that replicates selectively in p53-deficient human tumor cells
-
Bischoff JR, Kirn DH, Williams A et al. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science 274(5286), 373-376 (1996).
-
(1996)
Science
, vol.274
, Issue.5286
, pp. 373-376
-
-
Bischoff, J.R.1
Kirn, D.H.2
Williams, A.3
-
69
-
-
84885573947
-
Long-Term effect of gemcitabine-combined endoscopic ultrasonography-guided brachytherapy in pancreatic cancer
-
Du Y, Jin Z, Meng H et al. Long-Term effect of gemcitabine-combined endoscopic ultrasonography-guided brachytherapy in pancreatic cancer. J. Interv. Gastroenterol. 3(1), 18-24 (2013).
-
(2013)
J. Interv. Gastroenterol.
, vol.3
, Issue.1
, pp. 18-24
-
-
Du, Y.1
Jin, Z.2
Meng, H.3
-
70
-
-
48249121621
-
Non-engineered, naturally oncolytic herpes simplex virus HSV1 HF-10: Applications for cancer gene therapy
-
Nawa A, Luo C, Zhang L et al. Non-engineered, naturally oncolytic herpes simplex virus HSV1 HF-10: Applications for cancer gene therapy. Curr. Gene Ther. 8(3), 208-221 (2008).
-
(2008)
Curr. Gene Ther.
, vol.8
, Issue.3
, pp. 208-221
-
-
Nawa, A.1
Luo, C.2
Zhang, L.3
-
71
-
-
84900851981
-
Antigen cross-presentation of immune complexes
-
Platzer B, Stout M, Fiebiger E. Antigen cross-presentation of immune complexes. Front. Immunol. 5, 140 (2014).
-
(2014)
Front. Immunol.
, vol.5
, Issue.140
-
-
Platzer, B.1
Stout, M.2
Fiebiger, E.3
-
72
-
-
84883207410
-
Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer
-
Le DT, Lutz E, Uram JN et al. Evaluation of ipilimumab in combination with allogeneic pancreatic tumor cells transfected with a GM-CSF gene in previously treated pancreatic cancer. J. Immunother. 36(7), 382-389 (2013).
-
(2013)
J. Immunother.
, vol.36
, Issue.7
, pp. 382-389
-
-
Le, D.T.1
Lutz, E.2
Uram, J.N.3
-
73
-
-
79953154967
-
CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans
-
Beatty GL, Chiorean EG, Fishman MP et al. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science 331(6024), 1612-1616 (2011).
-
(2011)
Science
, vol.331
, Issue.6024
, pp. 1612-1616
-
-
Beatty, G.L.1
Chiorean, E.G.2
Fishman, M.P.3
|