메뉴 건너뛰기




Volumn 9, Issue 12, 2014, Pages

T-Cell populations and cytokine expression are impaired in thymus and spleen of protein malnourished balb/c mice infected with leishmania infantum

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA; CYTOKINE;

EID: 84919784890     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0114584     Document Type: Article
Times cited : (29)

References (66)
  • 1
    • 84861665791 scopus 로고    scopus 로고
    • Leishmaniasis worldwide and global estimates of its incidence
    • Alvar J, Velez ID, Bern C, Herrero M, Desjeux P, et al. (2012) Leishmaniasis worldwide and global estimates of its incidence. PLoS One 7: e35671.
    • (2012) PLoS One , vol.7 , pp. e35671
    • Alvar, J.1    Velez, I.D.2    Bern, C.3    Herrero, M.4    Desjeux, P.5
  • 2
    • 35548987998 scopus 로고    scopus 로고
    • Visceral leishmaniasis: What are the needs for diagnosis, treatment and control?
    • Chappuis F, Sundar S, Hailu A, Ghalib H, Rijal S, et al. (2007) Visceral leishmaniasis: What are the needs for diagnosis, treatment and control? Nat Rev Microbiol 5: 873-882.
    • (2007) Nat Rev Microbiol , vol.5 , pp. 873-882
    • Chappuis, F.1    Sundar, S.2    Hailu, A.3    Ghalib, H.4    Rijal, S.5
  • 3
    • 0346217977 scopus 로고    scopus 로고
    • Natural history of leishmania (leishmania) Chagasi infection in northeastern Brazil: Long-term follow-up
    • Jeronimo SM, Teixeira MJ, Sousa A, Thielking P, Pearson RD, et al. (2000) Natural history of Leishmania (Leishmania) chagasi infection in Northeastern Brazil: long-term follow-up. Clin Infect Dis 30: 608-609.
    • (2000) Clin Infect Dis , vol.30 , pp. 608-609
    • Jeronimo, S.M.1    Teixeira, M.J.2    Sousa, A.3    Thielking, P.4    Pearson, R.D.5
  • 4
    • 0030114502 scopus 로고    scopus 로고
    • The reemergence of visceral leishmaniasis in Brazil
    • Arias JR, Monteiro PS, Zicker F (1996) The reemergence of visceral leishmaniasis in Brazil. Emerg Infect Dis 2: 145-146.
    • (1996) Emerg Infect Dis , vol.2 , pp. 145-146
    • Arias, J.R.1    Monteiro, P.S.2    Zicker, F.3
  • 5
    • 0036068163 scopus 로고    scopus 로고
    • Trends in the temporal and spatial distribution of visceral and Cutaneous leishmaniasis in the state of bahia, Brazil, from 1985 to 1999
    • Franke CR, Staubach C, Ziller M, Schluter H (2002) Trends in the temporal and spatial distribution of visceral and cutaneous leishmaniasis in the state of Bahia, Brazil, from 1985 to 1999. Trans R Soc Trop Med Hyg 96: 236-241.
    • (2002) Trans R Soc Trop Med Hyg , vol.96 , pp. 236-241
    • Franke, C.R.1    Staubach, C.2    Ziller, M.3    Schluter, H.4
  • 6
    • 0035315864 scopus 로고    scopus 로고
    • Visceral leishmaniasis in the metropolitan region of belo horizonte, state of minas gerais, Brazil
    • Silva ES, Gontijo CM, Pacheco RS, Fiuza VO, Brazil RP (2001) Visceral leishmaniasis in the Metropolitan Region of Belo Horizonte, State of Minas Gerais, Brazil. Mem Inst Oswaldo Cruz 96: 285- 291.
    • (2001) Mem Inst Oswaldo Cruz , vol.96 , pp. 285-291
    • Silva, E.S.1    Gontijo, C.M.2    Pacheco, R.S.3    Fiuza, V.O.4    Brazil, R.P.5
  • 7
    • 4143129899 scopus 로고    scopus 로고
    • An emerging peri-urban pattern of infection with leishmania chagasi, the protozoan causing visceral leishmaniasis in northeast Brazil
    • Jeronimo SM, Duggal P, Braz RF, Cheng C, Monteiro GR, et al. (2004) An emerging peri-urban pattern of infection with Leishmania chagasi, the protozoan causing visceral leishmaniasis in northeast Brazil. Scand J Infect Dis 36: 443-449.
    • (2004) Scand J Infect Dis , vol.36 , pp. 443-449
    • Jeronimo, S.M.1    Duggal, P.2    Braz, R.F.3    Cheng, C.4    Monteiro, G.R.5
  • 8
    • 84863396241 scopus 로고    scopus 로고
    • Leishmania infantum chagasi in northeastern Brazil: Asymptomatic infection at the urban perimeter
    • Lima ID, Queiroz JW, Lacerda HG, Queiroz PV, Pontes NN, et al. (2012) Leishmania infantum chagasi in northeastern Brazil: Asymptomatic infection at the urban perimeter. Am J Trop Med Hyg 86: 99-107.
    • (2012) Am J Trop Med Hyg , vol.86 , pp. 99-107
    • Lima, I.D.1    Queiroz, J.W.2    Lacerda, H.G.3    Queiroz, P.V.4    Pontes, N.N.5
  • 9
    • 0023571607 scopus 로고
    • Malnutrition as a risk factor for severe visceral leishmaniasis
    • Cerf BJ, Jones TC, Badaro R, Sampaio D, Teixeira R, et al. (1987) Malnutrition as a risk factor for severe visceral leishmaniasis. J Infect Dis 156: 1030-1033.
    • (1987) J Infect Dis , vol.156 , pp. 1030-1033
    • Cerf, B.J.1    Jones, T.C.2    Badaro, R.3    Sampaio, D.4    Teixeira, R.5
  • 10
    • 38349061342 scopus 로고    scopus 로고
    • Maternal and child under nutrition: Global and regional exposures and health consequences
    • Black RE, Allen LH, Bhutta ZA, Caulfield LE, de Onis M, et al. (2008) Maternal and child under nutrition: global and regional exposures and health consequences. Lancet 371: 243-260.
    • (2008) Lancet , vol.371 , pp. 243-260
    • Black, R.E.1    Allen, L.H.2    Bhutta, Z.A.3    Caulfield, L.E.4    De Onis, M.5
  • 13
    • 0022447028 scopus 로고
    • A prospective study of visceral leishmaniasis in an endemic area of Brazil
    • Badaro R, Jones TC, Lorenco R, Cerf BJ, Sampaio D, et al. (1986) A prospective study of visceral leishmaniasis in an endemic area of Brazil. J Infect Dis 154: 639-649.
    • (1986) J Infect Dis , vol.154 , pp. 639-649
    • Badaro, R.1    Jones, T.C.2    Lorenco, R.3    Cerf, B.J.4    Sampaio, D.5
  • 14
    • 3042555141 scopus 로고    scopus 로고
    • Leishmaniasis: Current situation and new perspectives
    • Desjeux P (2004) Leishmaniasis: current situation and new perspectives. Comp Immunol Micro biol Infect Dis 27: 305-318.
    • (2004) Comp Immunol Micro Biol Infect Dis , vol.27 , pp. 305-318
    • Desjeux, P.1
  • 15
    • 53749100761 scopus 로고    scopus 로고
    • Association of nutritional status with the response to infection with leishmania chagasi
    • Maciel BL, Lacerda HG, Queiroz JW, Galvao J, Pontes NN, et al. (2008) Association of nutritional status with the response to infection with Leishmania chagasi. Am J Trop Med Hyg 79: 591-598.
    • (2008) Am J Trop Med Hyg , vol.79 , pp. 591-598
    • Maciel, B.L.1    Lacerda, H.G.2    Queiroz, J.W.3    Galvao, J.4    Pontes, N.N.5
  • 16
    • 84919811009 scopus 로고    scopus 로고
    • World Health Organization, Leishmaniasis Control Ginebra: World Health organization
    • World Health Organization (2010) Leishmaniasis in the human being. Leishmaniasis Control Ginebra: World Health organization. 10-14.
    • (2010) Leishmaniasis in the Human Being , pp. 10-14
  • 17
    • 0027922449 scopus 로고
    • Malnutrition, age and the risk of parasitic disease: Visceral leishmaniasis revisited
    • Dye C, Williams BG (1993) Malnutrition, age and the risk of parasitic disease: visceral leishmaniasis revisited. Proc Biol Sci 254: 33-39.
    • (1993) Proc Biol Sci , vol.254 , pp. 33-39
    • Dye, C.1    Williams, B.G.2
  • 18
    • 0348047539 scopus 로고    scopus 로고
    • Multi nutrient under nutrition dysregulates the resident macrophage pro inflammatory cytokine network, nuclear factor-kappa b activation, and nitric oxide production
    • Anstead GM, Chandrasekar B, Zhang Q, Melby PC (2003) Multi nutrient under nutrition dysregulates the resident macrophage pro inflammatory cytokine network, nuclear factor-kappa B activation, and nitric oxide production. J Leukoc Biol 74: 982-991.
    • (2003) J Leukoc Biol , vol.74 , pp. 982-991
    • Anstead, G.M.1    Chandrasekar, B.2    Zhang, Q.3    Melby, P.C.4
  • 19
    • 0034923317 scopus 로고    scopus 로고
    • Malnutrition alters the innate immune response and increases early visceralization following leishmania donovani infection
    • Anstead GM, Chandrasekar B, Zhao W, Yang J, Perez LE, et al. (2001) Malnutrition alters the innate immune response and increases early visceralization following Leishmania donovani infection. Infect Immun 69: 4709-4718.
    • (2001) Infect Immun , vol.69 , pp. 4709-4718
    • Anstead, G.M.1    Chandrasekar, B.2    Zhao, W.3    Yang, J.4    Perez, L.E.5
  • 20
    • 84883336770 scopus 로고    scopus 로고
    • The malnutrition-related increase in early visceralization of leishmania donovani is associated with a reduced number of lymph node phagocytes and altered conduit system flow
    • Ibrahim MK, Barnes JL, Anstead GM, Jimenez F, Travi BL, et al. (2013) The malnutrition-related increase in early visceralization of Leishmania donovani is associated with a reduced number of lymph node phagocytes and altered conduit system flow. PLoS Negl Trop Dis 7: e2329.
    • (2013) PLoS Negl Trop Dis , vol.7 , pp. e2329
    • Ibrahim, M.K.1    Barnes, J.L.2    Anstead, G.M.3    Jimenez, F.4    Travi, B.L.5
  • 21
    • 67649424628 scopus 로고    scopus 로고
    • Malnutrition promotes prostaglandin over leukotriene production and dysregulates eicosanoid-cytokine crosstalk in activated resident macrophages
    • Anstead GM, Zhang Q, Melby PC (2009) Malnutrition promotes prostaglandin over leukotriene production and dysregulates eicosanoid-cytokine crosstalk in activated resident macrophages. Pro staglandins Leukot Essent Fatty Acids 81: 41-51.
    • (2009) Pro Staglandins Leukot Essent Fatty Acids , vol.81 , pp. 41-51
    • Anstead, G.M.1    Zhang, Q.2    Melby, P.C.3
  • 22
    • 77957973985 scopus 로고    scopus 로고
    • Immune response to leishmania (leishmania) chagasi infection is reduced in malnourished BALB/C mice
    • Serafim TD, Malafaia G, Silva ME, Pedrosa ML, Rezende SA (2010) Immune response to Leishmania (Leishmania) chagasi infection is reduced in malnourished BALB/c mice. Mem Inst Oswaldo Cruz 105: 811-817.
    • (2010) Mem Inst Oswaldo Cruz , vol.105 , pp. 811-817
    • Serafim, T.D.1    Malafaia, G.2    Silva, M.E.3    Pedrosa, M.L.4    Rezende, S.A.5
  • 23
    • 0036046261 scopus 로고    scopus 로고
    • The thymus gland is a target in malnutrition
    • Savino W (2002) The thymus gland is a target in malnutrition. Eur J Clin Nutr 56 Suppl 3: S46-S49.
    • (2002) Eur J Clin Nutr , vol.56 , pp. S46-S49
    • Savino, W.1
  • 24
    • 79951954004 scopus 로고    scopus 로고
    • Nutritional imbalances and infections affect the thymus: Consequences on T-cell-mediated immune responses
    • Savino W, Dardenne M (2010) Nutritional imbalances and infections affect the thymus: consequences on T-cell-mediated immune responses. Proc Nutr Soc 69: 636-643.
    • (2010) Proc Nutr Soc , vol.69 , pp. 636-643
    • Savino, W.1    Dardenne, M.2
  • 26
    • 84858806759 scopus 로고    scopus 로고
    • Tnf-alpha is involved in the abnormal thymocyte migration during experimental trypanosoma cruzi infection and favors the export of immature cells
    • Perez AR, Berbert LR, Lepletier A, Revelli S, Bottasso O, et al. (2012) TNF-alpha is involved in the abnormal thymocyte migration during experimental Trypanosoma cruzi infection and favors the export of immature cells. PLoS One 7: e34360.
    • (2012) PLoS One , vol.7 , pp. e34360
    • Perez, A.R.1    Berbert, L.R.2    Lepletier, A.3    Revelli, S.4    Bottasso, O.5
  • 27
    • 33745712576 scopus 로고    scopus 로고
    • The thymus is a common target organ in infectious diseases
    • Savino W (2006) The thymus is a common target organ in infectious diseases. PLoS Pathog 2: e62.
    • (2006) PLoS Pathog , vol.2 , pp. e62
    • Savino, W.1
  • 28
    • 57749089638 scopus 로고    scopus 로고
    • Protein-energy malnutrition decreases immune response to leishmania chagasi vaccine in BALB/C mice
    • Malafaia G, Serafim TD, Silva ME, Pedrosa ML, Rezende SA (2009) Protein-energy malnutrition decreases immune response to Leishmania chagasi vaccine in BALB/c mice. Parasite Immunol 31: 41- 49.
    • (2009) Parasite Immunol , vol.31 , pp. 41-49
    • Malafaia, G.1    Serafim, T.D.2    Silva, M.E.3    Pedrosa, M.L.4    Rezende, S.A.5
  • 29
    • 7244219925 scopus 로고    scopus 로고
    • Emergence or re-emergence of visceral leishmaniasis in areas of Somalia, north-eastern Kenya, and south-eastern Ethiopia in 2000-01
    • Marlet MV, Sang DK, Ritmeijer K, Muga RO, Onsongo J, et al. (2003) Emergence or re-emergence of visceral leishmaniasis in areas of Somalia, north-eastern Kenya, and south-eastern Ethiopia in 2000-01. Trans R Soc Trop Med Hyg 97: 515-518.
    • (2003) Trans R Soc Trop Med Hyg , vol.97 , pp. 515-518
    • Marlet, M.V.1    Sang, D.K.2    Ritmeijer, K.3    Muga, R.O.4    Onsongo, J.5
  • 30
    • 28344454353 scopus 로고    scopus 로고
    • American visceral leishmaniasis (Kala-Azar) in hospitalized children from an endemic area
    • Rey LC, Martins CV, Ribeiro HB, Lima AA (2005) American visceral leishmaniasis (kala-azar) in hospitalized children from an endemic area. J Pediatr (Rio J) 81: 73-78.
    • (2005) J Pediatr (Rio J) , vol.81 , pp. 73-78
    • Rey, L.C.1    Martins, C.V.2    Ribeiro, H.B.3    Lima, A.A.4
  • 31
    • 0032908871 scopus 로고    scopus 로고
    • Insulin-like growth factor-I, but not growth hormone, is dependent on a high protein intake to increase nitrogen balance in the rat
    • Sanchez-Gomez M, Malmlof K, Mejia W, Bermudez A, Ochoa MT, et al. (1999) Insulin-like growth factor-I, but not growth hormone, is dependent on a high protein intake to increase nitrogen balance in the rat. Br J Nutr 81: 145-152.
    • (1999) Br J Nutr , vol.81 , pp. 145-152
    • Sanchez-Gomez, M.1    Malmlof, K.2    Mejia, W.3    Bermudez, A.4    Ochoa, M.T.5
  • 32
    • 0036090389 scopus 로고    scopus 로고
    • Protein calorie restriction affects nonhepatic IGF-I production and the lymphoid system: Studies using the liver-specific IGF-I genedeleted mouse model
    • Naranjo WM, Yakar S, Sanchez-Gomez M, Perez AU, Setser J, et al. (2002) Protein calorie restriction affects nonhepatic IGF-I production and the lymphoid system: Studies using the liver-specific IGF-I genedeleted mouse model. Endocrinology 143: 2233-2241.
    • (2002) Endocrinology , vol.143 , pp. 2233-2241
    • Naranjo, W.M.1    Yakar, S.2    Sanchez-Gomez, M.3    Perez, A.U.4    Setser, J.5
  • 34
    • 51349140469 scopus 로고    scopus 로고
    • Inflammation and structural changes of splenic lymphoid tissue in visceral leishmaniasis: A study on naturally infected dogs
    • Santana CC, Vassallo J, de Freitas LA, Oliveira GG, Pontes-de-Carvalho LC, et al. (2008) Inflammation and structural changes of splenic lymphoid tissue in visceral leishmaniasis: A study on naturally infected dogs. Parasite Immunol 30: 515-524.
    • (2008) Parasite Immunol , vol.30 , pp. 515-524
    • Santana, C.C.1    Vassallo, J.2    De Freitas, L.A.3    Oliveira, G.G.4    Pontes-De-Carvalho, L.C.5
  • 35
    • 84857209026 scopus 로고    scopus 로고
    • Evaluation of immunohistochemistry for the diagnosis of sporotrichosis in dogs
    • Miranda LH, Quintella LP, Menezes RC, dos Santos IB, Oliveira RV, et al. (2011) Evaluation of immunohistochemistry for the diagnosis of sporotrichosis in dogs. Vet J 190: 408-411.
    • (2011) Vet J , vol.190 , pp. 408-411
    • Miranda, L.H.1    Quintella, L.P.2    Menezes, R.C.3    Dos, S.I.B.4    Oliveira, R.V.5
  • 36
    • 45049087047 scopus 로고    scopus 로고
    • Standardization of real-time PCR gene expression data from independent biological replicates
    • Willems E, Leyns L, Vandesompele J (2008) Standardization of real-time PCR gene expression data from independent biological replicates. Anal Bio chem 379: 127-129.
    • (2008) Anal Bio Chem. , vol.379 , pp. 127-129
    • Willems, E.1    Leyns, L.2    Van De Sompele, J.3
  • 37
    • 64149097786 scopus 로고    scopus 로고
    • The miqe guidelines: Minimum information for publication of quantitative real-time PCR experiments
    • Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, et al. (2009) The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem 55: 611-622.
    • (2009) Clin Chem , vol.55 , pp. 611-622
    • Bustin, S.A.1    Benes, V.2    Garson, J.A.3    Hellemans, J.4    Huggett, J.5
  • 38
    • 45449120029 scopus 로고    scopus 로고
    • Multiplexed cytokine detection of interstitial fluid collected from polymeric hollow tube implants-A feasibility study
    • Wang X, Lennartz MR, Loegering DJ, Stenken JA (2008) Multiplexed cytokine detection of interstitial fluid collected from polymeric hollow tube implants-a feasibility study. Cytokine 43: 15-19.
    • (2008) Cytokine , vol.43 , pp. 15-19
    • Wang, X.1    Lennartz, M.R.2    Loegering, D.J.3    Stenken, J.A.4
  • 40
  • 41
    • 77956640046 scopus 로고    scopus 로고
    • Malnutrition and host defense
    • Inc BD, editor. Duggan C, Watkins J, Walker WA, eds, 4th ed ed. Hamilton, Ontario, Canada
    • Cunningham-Rundles S, Moon A, McNeeley DF (2008) Malnutrition and Host Defense. In: Inc BD, editor. Duggan C, Watkins J, Walker WA, eds Nutrition in Pediatrics. 4th ed ed. Hamilton, Ontario, Canada. 262-271.
    • (2008) Nutrition in Pediatrics , pp. 262-271
    • Cunningham-Rundles, S.1    Moon, A.2    McNeeley, D.F.3
  • 42
    • 80052422547 scopus 로고    scopus 로고
    • Chagasic thymic atrophy does not affect negative selection but results in the export of activated CD4+CD8+ T cells in severe forms of human disease
    • Morrot A, Terra-Granado E, Perez AR, Silva-Barbosa SD, Milicevic NM, et al. (2011) Chagasic thymic atrophy does not affect negative selection but results in the export of activated CD4+CD8+ T cells in severe forms of human disease. PLoS Negl Trop Dis 5: e1268.
    • (2011) PLoS Negl Trop Dis , vol.5 , pp. e1268
    • Morrot, A.1    Terra-Granado, E.2    Perez, A.R.3    Silva-Barbosa, S.D.4    Milicevic, N.M.5
  • 43
    • 0027253614 scopus 로고
    • Characterization and mechanisms of thymic atrophy in protein-malnourished mice: Role of corticosterone
    • Barone KS, O'Brien PC, Stevenson JR (1993) Characterization and mechanisms of thymic atrophy in protein-malnourished mice: role of corticosterone. Cell Immunol 148: 226-233.
    • (1993) Cell Immunol , vol.148 , pp. 226-233
    • Barone, K.S.1    O'Brien, P.C.2    Stevenson, J.R.3
  • 44
    • 34247466504 scopus 로고    scopus 로고
    • Protein-energy malnutrition alters histological and ultra structural characteristics of the bone marrow and decreases haematopoiesis in adult mice
    • Xavier JG, Favero ME, Vinolo MA, Rogero MM, Dagli ML, et al. (2007) Protein-energy malnutrition alters histological and ultra structural characteristics of the bone marrow and decreases haematopoiesis in adult mice. Histol Histopathol 22: 651-660.
    • (2007) Histol Histopathol , vol.22 , pp. 651-660
    • Xavier, J.G.1    Favero, M.E.2    Vinolo, M.A.3    Rogero, M.M.4    Dagli, M.L.5
  • 45
    • 34247648002 scopus 로고    scopus 로고
    • Reduction of erythroid progenitors in protein-energy malnutrition
    • Borelli P, Blatt S, Pereira J, de Maurino BB, Tsujita M, et al. (2007) Reduction of erythroid progenitors in protein-energy malnutrition. Br J Nutr 97: 307-314.
    • (2007) Br J Nutr , vol.97 , pp. 307-314
    • Borelli, P.1    Blatt, S.2    Pereira, J.3    De Maurino, B.B.4    Tsujita, M.5
  • 46
    • 84875048070 scopus 로고    scopus 로고
    • Protein malnutrition induces bone marrow mesenchymal stem cells commitment to adipogenic differentiation leading to hematopoietic failure
    • Cunha MC, Lima Fda S, Vinolo MA, Hastreiter A, Curi R, et al. (2013) Protein malnutrition induces bone marrow mesenchymal stem cells commitment to adipogenic differentiation leading to hematopoietic failure. PLoS One 8: e58872.
    • (2013) PLoS One , vol.8 , pp. e58872
    • Cunha, M.C.1    Lima, F.S.2    Vinolo, M.A.3    Hastreiter, A.4    Curi, R.5
  • 47
    • 84905026285 scopus 로고    scopus 로고
    • Itga6 gene silencing by RNA interference modulates the expression of a large number of cell migration-related genes in human thymic epithelial cells
    • Golbert DC, Correa-de-Santana E, Ribeiro-Alves M, de Vasconcelos AT, Savino W (2013) ITGA6 gene silencing by RNA interference modulates the expression of a large number of cell migration-related genes in human thymic epithelial cells. BMC Genomics 14 Suppl 6: S3.
    • (2013) BMC Genomics , vol.14 , pp. S3
    • Golbert, D.C.1    Correa-De-santana, E.2    Ribeiro-Alves, M.3    De Vasconcelos, A.T.4    Savino, W.5
  • 50
    • 1442276985 scopus 로고    scopus 로고
    • Cytokines in the thymus: Production and biological effects
    • Yarilin AA, Belyakov IM (2004) Cytokines in the thymus: production and biological effects. Curr Med Chem 11: 447-464.
    • (2004) Curr Med Chem. , vol.11 , pp. 447-464
    • Yarilin, A.A.1    Belyakov, I.M.2
  • 51
    • 14044276321 scopus 로고    scopus 로고
    • Synergistic effect of Il-2, Il-12, and Il-18 on thymocyte apoptosis and Th1/Th2 cytokine expression
    • Rodriguez-Galan MC, Bream JH, Farr A, Young HA (2005) Synergistic effect of IL-2, IL-12, and IL-18 on thymocyte apoptosis and Th1/Th2 cytokine expression. J Immunol 174: 2796-2804.
    • (2005) J Immunol , vol.174 , pp. 2796-2804
    • Rodriguez-Galan, M.C.1    Bream, J.H.2    Farr, A.3    Young, H.A.4
  • 52
    • 84867203977 scopus 로고    scopus 로고
    • MCP-1/CCR2 interactions direct migration of peripheral b and t lymphocytes to the thymus during acute infectious/inflammatory processes
    • Hodge DL, Reynolds D, Cerban FM, Correa SG, Baez NS, et al. (2012) MCP-1/CCR2 interactions direct migration of peripheral B and T lymphocytes to the thymus during acute infectious/inflammatory processes. Eur J Immunol 42: 2644-2654.
    • (2012) Eur J Immunol , vol.42 , pp. 2644-2654
    • Hodge, D.L.1    Reynolds, D.2    Cerban, F.M.3    Correa, S.G.4    Baez, N.S.5
  • 53
    • 84855414428 scopus 로고    scopus 로고
    • Protein energy malnutrition impairs homeostatic proliferation of memory CD8 T cells
    • Iyer SS, Chatraw JH, Tan WG, Wherry EJ, Becker TC, et al. (2012) Protein energy malnutrition impairs homeostatic proliferation of memory CD8 T cells. J Immunol 188: 77-84.
    • (2012) J Immunol , vol.188 , pp. 77-84
    • Iyer, S.S.1    Chatraw, J.H.2    Tan, W.G.3    Wherry, E.J.4    Becker, T.C.5
  • 54
    • 33645852563 scopus 로고    scopus 로고
    • Immunohistological features of visceral leishmaniasis in BALB/C mice
    • Carrion J, Nieto A, Iborra S, Iniesta V, Soto M, et al. (2006) Immunohistological features of visceral leishmaniasis in BALB/c mice. Parasite Immunol 28: 173-183.
    • (2006) Parasite Immunol , vol.28 , pp. 173-183
    • Carrion, J.1    Nieto, A.2    Iborra, S.3    Iniesta, V.4    Soto, M.5
  • 55
    • 4744342557 scopus 로고    scopus 로고
    • Macrophages, pathology and parasite persistence in experimental visceral leishmaniasis
    • Engwerda CR, Ato M, Kaye PM (2004) Macrophages, pathology and parasite persistence in experimental visceral leishmaniasis. Trends Parasitol 20: 524-530.
    • (2004) Trends Parasitol , vol.20 , pp. 524-530
    • Engwerda, C.R.1    Ato, M.2    Kaye, P.M.3
  • 56
    • 15744396294 scopus 로고    scopus 로고
    • Immunopathogenesis of infection with the visceralizing leishmania species
    • Wilson ME, Jeronimo SM, Pearson RD (2005) Immunopathogenesis of infection with the visceralizing Leishmania species. Microb Pathog 38: 147-160.
    • (2005) Microb Pathog , vol.38 , pp. 147-160
    • Wilson, M.E.1    Jeronimo, S.M.2    Pearson, R.D.3
  • 57
    • 80052017606 scopus 로고    scopus 로고
    • Mechanisms of resistance and susceptibility to experimental visceral leishmaniosis: BALB/C mouse versus syrian hamster model
    • Nieto A, Dominguez-Bernal G, Orden JA, De La Fuente R, Madrid-Elena N, et al. (2011) Mechanisms of resistance and susceptibility to experimental visceral leishmaniosis: BALB/c mouse versus Syrian hamster model. Vet Res 42: 39.
    • (2011) Vet Res , vol.42 , pp. 39
    • Nieto, A.1    Dominguez-Bernal, G.2    Orden, J.A.3    De La Fuente, R.4    Madrid-Elena, N.5
  • 58
    • 84937555280 scopus 로고    scopus 로고
    • Protein malnutrition alters spleen cell proliferation and Il-2 and Il-10 production by affecting the stat-1 and stat-3 balance
    • Mello AS, de Oliveira DC, Bizzarro B, Sa-Nunes A, Hastreiter AA, et al. (2014) Protein Malnutrition Alters Spleen Cell Proliferation and IL-2 and IL-10 Production by Affecting the STAT-1 and STAT-3 Balance. Inflammation.
    • (2014) Inflammation
    • Mello, A.S.1    De Oliveira, D.C.2    Bizzarro, B.3    Sa-Nunes, A.4    Hastreiter, A.A.5
  • 59
    • 0023903734 scopus 로고
    • Role of L3t4+ and lyt-2+ cells in experimental visceral leishmaniasis
    • Stern JJ, Oca MJ, Rubin BY, Anderson SL, Murray HW (1988) Role of L3T4+ and LyT-2+ cells in experimental visceral leishmaniasis. J Immunol 140: 3971-3977.
    • (1988) J Immunol , vol.140 , pp. 3971-3977
    • Stern, J.J.1    Oca, M.J.2    Rubin, B.Y.3    Anderson, S.L.4    Murray, H.W.5
  • 60
    • 0026733615 scopus 로고
    • Leishmania donovani infection in scid mice: Lack of tissue response and in vivo macrophage activation correlates with failure to trigger natural killer cell-derived gamma interferon production in vitro
    • Kaye PM, Bancroft GJ (1992) Leishmania donovani infection in scid mice: lack of tissue response and in vivo macrophage activation correlates with failure to trigger natural killer cell-derived gamma interferon production in vitro. Infect Immun 60: 4335-4342.
    • (1992) Infect Immun , vol.60 , pp. 4335-4342
    • Kaye, P.M.1    Bancroft, G.J.2
  • 61
    • 0030822043 scopus 로고    scopus 로고
    • Vaccination with DNA encoding the immuno dominant lack parasite antigen confers protective immunity to mice infected with leishmania major
    • Gurunathan S, Sacks DL, Brown DR, Reiner SL, Charest H, et al. (1997) Vaccination with DNA encoding the immuno dominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major. J Exp Med 186: 1137-1147.
    • (1997) J Exp Med , vol.186 , pp. 1137-1147
    • Gurunathan, S.1    Sacks, D.L.2    Brown, D.R.3    Reiner, S.L.4    Charest, H.5
  • 62
    • 0037090268 scopus 로고    scopus 로고
    • Cd8+ t cells are required for primary immunity in C57bl/6 mice following low-dose, intra dermal challenge with leishmania major
    • Belkaid Y, Von Stebut E, Mendez S, Lira R, Caler E, et al. (2002) CD8+ T cells are required for primary immunity in C57BL/6 mice following low-dose, intra dermal challenge with Leishmania major. J Immunol 168: 3992-4000.
    • (2002) J Immunol , vol.168 , pp. 3992-4000
    • Belkaid, Y.1    Von Stebut, E.2    Mendez, S.3    Lira, R.4    Caler, E.5
  • 63
    • 10744222524 scopus 로고    scopus 로고
    • Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T-cell responses
    • Stager S, Alexander J, Kirby AC, Botto M, Rooijen NV, et al. (2003) Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T-cell responses. Nat Med 9: 1287- 1292.
    • (2003) Nat Med , vol.9 , pp. 1287-1292
    • Stager, S.1    Alexander, J.2    Kirby, A.C.3    Botto, M.4    Rooijen, N.V.5
  • 64
    • 36749091065 scopus 로고    scopus 로고
    • Hybrid cell vaccination resolves leishmania donovani infection by eliciting a strong CD8+ cytotoxic T-lymphocyte response with concomitant suppression of interleukin-10 (Il-10) but not il-4 or il-13
    • Basu R, Bhaumik S, Haldar AK, Naskar K, De T, et al. (2007) Hybrid cell vaccination resolves Leishmania donovani infection by eliciting a strong CD8+ cytotoxic T-lymphocyte response with concomitant suppression of interleukin-10 (IL-10) but not IL-4 or IL-13. Infect Immun 75: 5956-5966.
    • (2007) Infect Immun , vol.75 , pp. 5956-5966
    • Basu, R.1    Bhaumik, S.2    Haldar, A.K.3    Naskar, K.4    De, T.5
  • 65
    • 0037767300 scopus 로고    scopus 로고
    • Perforin and gamma interferon are critical CD8+ T-cell-mediated responses in vaccine-induced immunity against Leishmania Amazonensis infection
    • Colmenares M, Kima PE, Samoff E, Soong L, McMahon-Pratt D (2003) Perforin and gamma interferon are critical CD8+ T-cell-mediated responses in vaccine-induced immunity against Leishmania amazonensis infection. Infect Immun 71: 3172-3182.
    • (2003) Infect Immun , vol.71 , pp. 3172-3182
    • Colmenares, M.1    Kima, P.E.2    Samoff, E.3    Soong, L.4    McMahon-Pratt, D.5
  • 66
    • 0026501981 scopus 로고
    • Translational status of the insulin-like growth factor-I MRNAS in liver of protein-restricted rats
    • Thissen JP, Underwood LE (1992) Translational status of the insulin-like growth factor-I mRNAs in liver of protein-restricted rats. J Endocrinol 132: 141-147.
    • (1992) J Endocrinol , vol.132 , pp. 141-147
    • Thissen, J.P.1    Underwood, L.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.