메뉴 건너뛰기




Volumn 174, Issue 5, 2005, Pages 2796-2804

Synergistic effect of IL-2, IL-12, and IL-18 on thymocyte apoptosis and Th1/Th2 cytokine expression

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 18; INTERLEUKIN 2; STAT4 PROTEIN; STAT6 PROTEIN; TRANSCRIPTION FACTOR NFAT;

EID: 14044276321     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.5.2796     Document Type: Article
Times cited : (55)

References (48)
  • 1
    • 0024306622 scopus 로고
    • Effects of cytokines on human thymic epithelial cells in culture: IL1 induces thymic epithelial cell proliferation and change in morphology
    • Galy, A. H., E. M. Hadden, J. L. Touraine, and J. W. Hadden. 1989. Effects of cytokines on human thymic epithelial cells in culture: IL1 induces thymic epithelial cell proliferation and change in morphology. Cell. Immunol. 124:13.
    • (1989) Cell. Immunol. , vol.124 , pp. 13
    • Galy, A.H.1    Hadden, E.M.2    Touraine, J.L.3    Hadden, J.W.4
  • 2
    • 0026438966 scopus 로고
    • Expression of cytokines and their receptors by human thymocytes and thymic stromal cells
    • Wolf, S. S., and A. Cohen. 1992. Expression of cytokines and their receptors by human thymocytes and thymic stromal cells. Immunology 77:362.
    • (1992) Immunology , vol.77 , pp. 362
    • Wolf, S.S.1    Cohen, A.2
  • 3
    • 1442276985 scopus 로고    scopus 로고
    • Cytokines in the thymus: Production and biological effects
    • Yarilin, A. A., and I. M. Belyakov. 2004. Cytokines in the thymus: production and biological effects. Curr. Med. Chem. 11:447.
    • (2004) Curr. Med. Chem. , vol.11 , pp. 447
    • Yarilin, A.A.1    Belyakov, I.M.2
  • 4
    • 0035083020 scopus 로고    scopus 로고
    • Bacterially induced activation of interleukin-18 in porcine intestinal mucosa
    • Foss, D. L., M. J. Zilliox, and M. P. Murtaugh. 2001. Bacterially induced activation of interleukin-18 in porcine intestinal mucosa. Vet. Immunol Immunopathol. 78:263.
    • (2001) Vet. Immunol Immunopathol. , vol.78 , pp. 263
    • Foss, D.L.1    Zilliox, M.J.2    Murtaugh, M.P.3
  • 6
    • 1342282246 scopus 로고    scopus 로고
    • IL-12 inhibits thymic involution by enhancing IL-7- and IL-2-induced thymocyte proliferation
    • Li, L., H. C. Hsu, C. R. Stockard, P. Yang, J. Zhou, Q. Wu, W. E. Grizzle, and J. D. Mountz. 2004. IL-12 inhibits thymic involution by enhancing IL-7- and IL-2-induced thymocyte proliferation. J. Immunol. 172:2909.
    • (2004) J. Immunol. , vol.172 , pp. 2909
    • Li, L.1    Hsu, H.C.2    Stockard, C.R.3    Yang, P.4    Zhou, J.5    Wu, Q.6    Grizzle, W.E.7    Mountz, J.D.8
  • 7
    • 0344631673 scopus 로고    scopus 로고
    • Role of IL-12 in intrathymic negative selection
    • Ludviksson, B. R., R. O. Ehrhardt, and W. Strober. 1999. Role of IL-12 in intrathymic negative selection. J. Immunol. 163:4349.
    • (1999) J. Immunol. , vol.163 , pp. 4349
    • Ludviksson, B.R.1    Ehrhardt, R.O.2    Strober, W.3
  • 8
    • 0037320335 scopus 로고    scopus 로고
    • Type 1 cytokines polarize thymocytes during T cell development in adult thymus organ cultures
    • Whalen, B. J., J. Marounek, J. P. Mordes, A. A. Rossini, and D. L. Greiner. 2003. Type 1 cytokines polarize thymocytes during T cell development in adult thymus organ cultures. J. Autoimmun. 20:27.
    • (2003) J. Autoimmun. , vol.20 , pp. 27
    • Whalen, B.J.1    Marounek, J.2    Mordes, J.P.3    Rossini, A.A.4    Greiner, D.L.5
  • 10
    • 0032909720 scopus 로고    scopus 로고
    • IL-13 production by NK cells: IL-13-producing NK and T cells are present in vivo in the absence of IFN-γ
    • Hoshino, T., R. T. Winkler-Pickett, A. T. Mason, J. R. Ortaldo, and H. A. Young. 1999. IL-13 production by NK cells: IL-13-producing NK and T cells are present in vivo in the absence of IFN-γ. J. Immunol. 162:51.
    • (1999) J. Immunol. , vol.162 , pp. 51
    • Hoshino, T.1    Winkler-Pickett, R.T.2    Mason, A.T.3    Ortaldo, J.R.4    Young, H.A.5
  • 11
    • 0035071329 scopus 로고    scopus 로고
    • Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu
    • Nakanishi, K., T. Yoshimoto, H. Tsutsui, and H. Okamura. 2001. Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu. Cytokine Growth Factor Rev. 12:53.
    • (2001) Cytokine Growth Factor Rev. , vol.12 , pp. 53
    • Nakanishi, K.1    Yoshimoto, T.2    Tsutsui, H.3    Okamura, H.4
  • 12
    • 0037313578 scopus 로고    scopus 로고
    • Interleukin-12 and the regulation of innate resistance and adaptive immunity
    • Trinchieri, G. 2003. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3:133.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 133
    • Trinchieri, G.1
  • 15
    • 0034054496 scopus 로고    scopus 로고
    • Chemokines in tissue-specific and microenvironment-specific lymphocyte homing
    • Campbell, J. J., and E. C. Butcher. 2000. Chemokines in tissue-specific and microenvironment-specific lymphocyte homing. Curr. Opin. Immunol. 12:336.
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 336
    • Campbell, J.J.1    Butcher, E.C.2
  • 17
    • 0031000838 scopus 로고    scopus 로고
    • Regulation of local host-mediated anti-tumor mechanisms by cytokines: Direct and indirect effects on leukocyte recruitment and angiogenesis
    • Watanabe, M., K. L. McCormick, K. Volker, J. R. Ortaldo, J. M. Wigginton, M. J. Brunda, R. H. Wiltrout, and W. E. Fogler. 1997. Regulation of local host-mediated anti-tumor mechanisms by cytokines: direct and indirect effects on leukocyte recruitment and angiogenesis. Am. J. Pathol. 150:1869.
    • (1997) Am. J. Pathol. , vol.150 , pp. 1869
    • Watanabe, M.1    McCormick, K.L.2    Volker, K.3    Ortaldo, J.R.4    Wigginton, J.M.5    Brunda, M.J.6    Wiltrout, R.H.7    Fogler, W.E.8
  • 18
    • 0033120060 scopus 로고    scopus 로고
    • Recapitulation of normal and abnormal BioBreeding rat T cell development in adult thymus organ culture
    • Whalen, B. J., P. Weiser, J. Marounek, A. A. Rossini, J. P. Mordes, and D. L. Greiner. 1999. Recapitulation of normal and abnormal BioBreeding rat T cell development in adult thymus organ culture. J. Immunol. 162:4003.
    • (1999) J. Immunol. , vol.162 , pp. 4003
    • Whalen, B.J.1    Weiser, P.2    Marounek, J.3    Rossini, A.A.4    Mordes, J.P.5    Greiner, D.L.6
  • 19
    • 0024563012 scopus 로고
    • Medullary epithelial cell lines from murine thymus constitutively secrete IL-1 and hematopoietic growth factors and express class II antigens in response to recombinant interferon-γ
    • Farr, A. G., S. Hosier, S. C. Braddy, S. K. Anderson, D. J. Eisenhardt, Z. J. Yan, and C. P. Robles. 1989. Medullary epithelial cell lines from murine thymus constitutively secrete IL-1 and hematopoietic growth factors and express class II antigens in response to recombinant interferon-γ. Cell. Immunol. 119:427.
    • (1989) Cell. Immunol. , vol.119 , pp. 427
    • Farr, A.G.1    Hosier, S.2    Braddy, S.C.3    Anderson, S.K.4    Eisenhardt, D.J.5    Yan, Z.J.6    Robles, C.P.7
  • 20
    • 0032584069 scopus 로고    scopus 로고
    • The role of peptides in thymic positive selection of class II major histocompatibility complex-restricted T cells
    • Wang, R., A. Nelson, K. Kimachi, H. M. Grey, and A. G. Farr. 1998. The role of peptides in thymic positive selection of class II major histocompatibility complex-restricted T cells. Proc. Natl. Acad. Sci. USA 95:3804.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 3804
    • Wang, R.1    Nelson, A.2    Kimachi, K.3    Grey, H.M.4    Farr, A.G.5
  • 21
    • 0037097674 scopus 로고    scopus 로고
    • IL-2 and IL-12 alter NK cell responsiveness to IFN-γ-inducible protein 10 by down-regulating CXCR3 expression
    • Hodge, D. L., W. B. Schill, J. M. Wang, I. Blanca, D. A. Reynolds, J. R. Ortaldo, and H. A. Young. 2002. IL-2 and IL-12 alter NK cell responsiveness to IFN-γ-inducible protein 10 by down-regulating CXCR3 expression. J. Immunol. 168:6090.
    • (2002) J. Immunol. , vol.168 , pp. 6090
    • Hodge, D.L.1    Schill, W.B.2    Wang, J.M.3    Blanca, I.4    Reynolds, D.A.5    Ortaldo, J.R.6    Young, H.A.7
  • 25
    • 0027220179 scopus 로고
    • CD3-mediated apoptosis of human medullary thymocytes and activated peripheral T cells: Respective roles of interleukin-1, interleukin-2, interferon-γ and accessory cells
    • Groux, H., D. Monte, B. Plouvier, A. Capron, and J. C. Ameisen. 1993. CD3-mediated apoptosis of human medullary thymocytes and activated peripheral T cells: respective roles of interleukin-1, interleukin-2, interferon-γ and accessory cells. Eur. J. Immunol. 23:1623.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 1623
    • Groux, H.1    Monte, D.2    Plouvier, B.3    Capron, A.4    Ameisen, J.C.5
  • 26
    • 0022358987 scopus 로고
    • Interferon-γ modulates HLA class II antigen expression on cultured human thymic epithelial cells
    • Berrih, S., F. Arenzana-Seisdedos, S. Cohen, R. Devos, D. Charron, and J. L. Virelizier. 1985. Interferon-γ modulates HLA class II antigen expression on cultured human thymic epithelial cells. J. Immunol. 135:1165.
    • (1985) J. Immunol. , vol.135 , pp. 1165
    • Berrih, S.1    Arenzana-Seisdedos, F.2    Cohen, S.3    Devos, R.4    Charron, D.5    Virelizier, J.L.6
  • 28
    • 0242416575 scopus 로고    scopus 로고
    • Cytokines and transcription factors that regulate T helper cell differentiation: New players and new insights
    • Agnello, D., C. S. Lankford, J. Bream, A. Morinobu, M. Gadina, J. J. O'Shea, and D. M. Frucht. 2003. Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights. J. Clin. Immunol. 23:147.
    • (2003) J. Clin. Immunol. , vol.23 , pp. 147
    • Agnello, D.1    Lankford, C.S.2    Bream, J.3    Morinobu, A.4    Gadina, M.5    O'Shea, J.J.6    Frucht, D.M.7
  • 29
    • 0033800077 scopus 로고    scopus 로고
    • Regulation of Th2 cytokine gene transcription
    • Lavender, P., D. Cousins, and T. Lee. 2000. Regulation of Th2 cytokine gene transcription. Chem. Immunol. 78:16.
    • (2000) Chem. Immunol. , vol.78 , pp. 16
    • Lavender, P.1    Cousins, D.2    Lee, T.3
  • 31
    • 0034283018 scopus 로고    scopus 로고
    • Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun
    • Macian, F., C. Garcia-Rodriguez, and A. Rao. 2000. Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun. EMBO J. 19:4783.
    • (2000) EMBO J. , vol.19 , pp. 4783
    • Macian, F.1    Garcia-Rodriguez, C.2    Rao, A.3
  • 34
    • 0030585703 scopus 로고    scopus 로고
    • Extracellular matrix components of the mouse thymus microenvironment. V. Interferon-γ modulates thymic epithelial cell/thymocyte interactions via extracellular matrix ligands and receptors
    • Lagrota-Candido, J. M., D. M. Villa-Verde, F. H. Vanderlei, Jr., and W. Savino. 1996. Extracellular matrix components of the mouse thymus microenvironment. V. Interferon-γ modulates thymic epithelial cell/thymocyte interactions via extracellular matrix ligands and receptors. Cell. Immunol. 170:235.
    • (1996) Cell. Immunol. , vol.170 , pp. 235
    • Lagrota-Candido, J.M.1    Villa-Verde, D.M.2    Vanderlei Jr., F.H.3    Savino, W.4
  • 35
    • 0033593884 scopus 로고    scopus 로고
    • Effects of cytokines from thymocytes and thymic stromal cells on chicken intrathymic T cell development
    • Mukamoto, M., H. Kodama, and T. Baba. 1999. Effects of cytokines from thymocytes and thymic stromal cells on chicken intrathymic T cell development. Vet. Immunol. Immunopathol. 67:223.
    • (1999) Vet. Immunol. Immunopathol. , vol.67 , pp. 223
    • Mukamoto, M.1    Kodama, H.2    Baba, T.3
  • 36
    • 0023601776 scopus 로고
    • Interferon-γ is produced by activated immature mouse thymocytes and inhibits the interleukin 4-induced proliferation of immature thymocytes
    • Ransom, J., M. Fischer, T. Mosmann, T. Yokota, D. DeLuca, J. Schumacher, and A. Zlotnik. 1987. Interferon-γ is produced by activated immature mouse thymocytes and inhibits the interleukin 4-induced proliferation of immature thymocytes. J. Immunol. 139:4102.
    • (1987) J. Immunol. , vol.139 , pp. 4102
    • Ransom, J.1    Fischer, M.2    Mosmann, T.3    Yokota, T.4    DeLuca, D.5    Schumacher, J.6    Zlotnik, A.7
  • 37
    • 0037220526 scopus 로고    scopus 로고
    • Recognition of a specific self-peptide: Self-MHC class II complex is critical for positive selection of thymocytes expressing the D10 TCR
    • Dao, T., J. M. Blander, and D. B. Sant'Angelo. 2003. Recognition of a specific self-peptide: self-MHC class II complex is critical for positive selection of thymocytes expressing the D10 TCR. J. Immunol. 170:48.
    • (2003) J. Immunol. , vol.170 , pp. 48
    • Dao, T.1    Blander, J.M.2    Sant'Angelo, D.B.3
  • 38
    • 0037818713 scopus 로고    scopus 로고
    • Impaired thymic negative selection causes autoimmune graft-versus-host disease
    • Teshima, T., P. Reddy, C. Liu, D. Williams, K. R. Cooke, and J. L. Ferrara. 2003. Impaired thymic negative selection causes autoimmune graft-versus-host disease. Blood 102:429.
    • (2003) Blood , vol.102 , pp. 429
    • Teshima, T.1    Reddy, P.2    Liu, C.3    Williams, D.4    Cooke, K.R.5    Ferrara, J.L.6
  • 40
    • 0029051162 scopus 로고
    • Cytokine production and requirements during T-cell development
    • Zlotnik, A., and T. A. Moore. 1995. Cytokine production and requirements during T-cell development. Curr. Opin. Immunol. 7:206.
    • (1995) Curr. Opin. Immunol. , vol.7 , pp. 206
    • Zlotnik, A.1    Moore, T.A.2
  • 41
  • 42
    • 0037260543 scopus 로고    scopus 로고
    • Differential requirements for JAK2 and TYK2 in T cell proliferation and IFN-γ production induced by IL-12 alone or together with IL-18
    • Sugimoto, N., M. Nakahira, H. J. Ahn, M. Micallef, T. Hamaoka, M. Kurimoto, and H. Fujiwara. 2003. Differential requirements for JAK2 and TYK2 in T cell proliferation and IFN-γ production induced by IL-12 alone or together with IL-18. Eur. J. Immunol. 33:243.
    • (2003) Eur. J. Immunol. , vol.33 , pp. 243
    • Sugimoto, N.1    Nakahira, M.2    Ahn, H.J.3    Micallef, M.4    Hamaoka, T.5    Kurimoto, M.6    Fujiwara, H.7
  • 45
    • 0032412441 scopus 로고    scopus 로고
    • Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
    • Agarwal, S., and A. Rao. 1998. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity 9:765.
    • (1998) Immunity , vol.9 , pp. 765
    • Agarwal, S.1    Rao, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.