Sex-dependent regulation of hepatic CYP3A by growth hormone: Roles of HNF6, C/EBPα, and RXRα

Biochemical Pharmacology

Volumn 93, Issue 1, 2015, Pages 92-103

  Li, Jie ^a   Wan, Yu ^a   Na, Shufang ^a   Liu, Xiaochan ^a   Dong, Guicheng ^b   Yang, Zheqiong ^a   Yang, Jing ^a   Yue, Jiang ^a  

^a WUHAN UNIVERSITY   (China)

^b INNER MONGOLIA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Drug metabolism; Nuclear receptor; Sexually dimorphism; Transcription factor

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; CYTOCHROME P450 3A; CYTOCHROME P450 3A2; CYTOCHROME P450 3A4; GROWTH HORMONE RECEPTOR; HEPATOCYTE NUCLEAR FACTOR 6; RETINOID X RECEPTOR ALPHA; CCAAT ENHANCER BINDING PROTEIN; CEBPA PROTEIN, MOUSE; CYP3A PROTEIN, MOUSE; CYTOCHROME P450; GROWTH HORMONE; ONECUT1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GROWTH HORMONE RELEASE; HEPG2 CELL LINE; HUMAN; HYPOPHYSECTOMY; KNOCKOUT MOUSE; LIVER; MALE; MOUSE; NONHUMAN; ORCHIECTOMY; PROTEIN EXPRESSION; PROTEIN INTERACTION; RAT; REGULATORY MECHANISM; ANIMAL; PHYSIOLOGY; SECRETION (PROCESS); SEXUAL DEVELOPMENT; WISTAR RAT;

ANIMALS; CCAAT-ENHANCER-BINDING PROTEINS; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GROWTH HORMONE; HEP G2 CELLS; HEPATOCYTE NUCLEAR FACTOR 6; HUMANS; LIVER; MALE; MICE; MICE, KNOCKOUT; RATS; RATS, WISTAR; RETINOID X RECEPTOR ALPHA; SEX CHARACTERISTICS;

EID: 84919778172     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2014.10.010     Document Type: Article

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