Hepatocyte nuclear factor 6 activates the transcription of CYP3A4 in hepatocyte-like cells differentiated from human induced pluripotent stem cells

Drug Metabolism and Pharmacokinetics

Volumn 28, Issue 3, 2013, Pages 250-259

  Sasaki, Takamitsu ^a   Takahashi, Shogo ^a   Numata, Yoshihiro ^a   Narita, Masayo ^a   Tanaka, Yutaka ^a   Kumagai, Takeshi ^a   Kondo, Yuki ^b   Matsunaga, Tamihide ^b   Ohmori, Shigeru ^c,d   Nagata, Kiyoshi ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^b NAGOYA CITY UNIVERSITY   (Japan)

^c SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d SHINSHU UNIVERSITY HOSPITAL   (Japan)

Author keywords

CYP3A4; Differentiation; Hepatocytes; HNF6; Induced pluripotent stem cells; Liverenriched transcription factors

Indexed keywords

CYTOCHROME P450 3A4; HEPATOCYTE NUCLEAR FACTOR 6; MESSENGER RNA;

AFP GENE; ALB GENE; ARTICLE; CELL DIFFERENTIATION; CELL STRAIN HEPG2; CONTROLLED STUDY; CYP1A1 GENE; CYP1A2 GENE; CYP2C19 GENE; CYP2C9 GENE; CYP2D6 GENE; CYP3A4 GENE; CYP3A7 GENE; CYP7A1 GENE; FETUS; FETUS CELL; GAPDH GENE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HNF6 GENE; HUMAN; HUMAN CELL; LIVER CELL; PLURIPOTENT STEM CELL; PROTEIN FUNCTION; TRANSCRIPTION INITIATION;

EID: 84879406020     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-12-RG-132     Document Type: Article

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