Hyperglycemia-induced GLP-1R downregulation causes RPE cell apoptosis

International Journal of Biochemistry and Cell Biology

Volumn 59, Issue , 2015, Pages 41-51

  Kim, Dong Il ^a   Park, Min Jung ^a   Choi, Joo Hee ^a   Lim, Seul Ki ^b   Choi, Hak Jong ^b   Park, Soo Hyun ^b  

^a Chonnam National University   (South Korea)

^b World Institute of Kimchi an Annex of Korea Food Research Institute   (South Korea)

Author keywords

Diabetic retinopathy; Endoplasmic reticulum stress; Glucagon like peptide 1 receptor; P53; Reactive oxygen species

Indexed keywords

EXENDIN 4; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; PEROXIREDOXIN 1; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; GLUCAGON RECEPTOR; GLUCAGON-LIKE PEPTIDE-1 RECEPTOR; GLUCOSE; PEPTIDE; PROTEIN BAX; STREPTOZOCIN; VENOM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DIABETIC RETINOPATHY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HYPERGLYCEMIA; INTRACELLULAR SIGNALING; MALE; NONHUMAN; OXIDATIVE STRESS; PROMOTER REGION; RAT; RECEPTOR DOWN REGULATION; RETINA PIGMENT CELL; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; ANIMAL; BIOLOGICAL MODEL; CELL CULTURE; CELL LINE; DOWN REGULATION; DRUG EFFECTS; GENETICS; INTRACELLULAR SPACE; METABOLISM; PATHOLOGY; PIGMENT EPITHELIUM; SIGNAL TRANSDUCTION;

RATTUS;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL LINE; CELLS, CULTURED; DOWN-REGULATION; ENDOPLASMIC RETICULUM STRESS; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; GLUCOSE; HUMANS; HYPERGLYCEMIA; INTRACELLULAR SPACE; MODELS, BIOLOGICAL; PEPTIDES; PROMOTER REGIONS, GENETIC; RATS; REACTIVE OXYGEN SPECIES; RECEPTORS, GLUCAGON; RETINAL PIGMENT EPITHELIUM; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STREPTOZOCIN; TUMOR SUPPRESSOR PROTEIN P53; VENOMS;

EID: 84919777801     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2014.11.018     Document Type: Article

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