Regulation of autophagy by high glucose in human retinal pigment epithelium

Cellular Physiology and Biochemistry

Volumn 33, Issue 1, 2014, Pages 107-116

  Yao, Jin ^a   Tao, Zhi Fu ^a   Li, Chao Peng ^a   Li, Xiu Miao ^a   Cao, Guo Fan ^a   Jiang, Qin ^a   Yan, Biao ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Autophagy; ER stress; High glucose; ROS

Indexed keywords

GLUCOSE; LC3 PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MOLECULAR MARKER; PROTEIN P62; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CELL PROTEIN; RAPAMYCIN; BIOLOGICAL MARKER; TARGET OF RAPAMYCIN KINASE;

ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL VACUOLE; CELL VIABILITY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MTT ASSAY; OXIDATIVE STRESS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; CELL DAMAGE; CELL DEATH; CELL SURVIVAL; ENDOPLASMIC RETICULUM; GLUCOSE INTAKE; LYSOSOME; PROTEIN AGGREGATION; CYTOLOGY; DRUG EFFECTS; METABOLISM; RETINAL PIGMENT EPITHELIUM; ULTRASTRUCTURE;

AUTOPHAGY; BIOMARKERS; ENDOPLASMIC RETICULUM STRESS; GLUCOSE; HUMANS; REACTIVE OXYGEN SPECIES; RETINAL PIGMENT EPITHELIUM; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84893204216     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000356654     Document Type: Article

References (28)

1. Glick D, Barth S, Macleod KF: Autophagy: cellular and molecular mechanisms. J Pathol 2010;221:3-12.
2. Klionsky DJ, Emr SD: Autophagy as a regulated pathway of cellular degradation. Science 2000;290:1717-1721.
3. Komatsu M, Waguri S, Ueno T, Iwata J, Murata S, Tanida I, Ezaki J, Mizushima N, Ohsumi Y, Uchiyama Y, Kominami E, Tanaka K, Chiba T: Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J Cell Biol 2005;169:425-434.
4. Nixon RA: Autophagy in neurodegenerative disease: Friend, foe or turncoat? Trends Neurosci 2006;29:528-535.
5. Tannous P, Zhu H, Johnstone JL, Shelton JM, Rajasekaran NS, Benjamin IJ, Nguyen L, Gerard RD, Levine B, Rothermel BA: Autophagy is an adaptive response in desmin-related cardiomyopathy. Proc Natl Acad Sci USA 2008;105:9745-9750.
6. Yang Z, Klionsky DJ: Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 2010;22:124-131.
7. He F, Xia X, Wu XF, Yu XQ, Huang FX: Diabetic retinopathy in predicting diabetic nephropathy in patients with type 2 diabetes and renal disease: a meta-analysis. Diabetologia 2013;56:457-466.
8. Hammes HP, Feng Y, Pfister F, Brownlee M: Diabetic retinopathy: targeting vasoregression. Diabetes 2011;60:9-16.
9. Du M, Wu M, Fu D, Yang S, Chen J, Wilson K, Lyons TJ: Effects of modified LDL and HDL on retinal pigment epithelial cells: a role in diabetic retinopathy? Diabetologia 2013;56:2318-2328.
10. Xu HZ, Song Z, Fu S, Zhu M, Le YZ: RPE barrier breakdown in diabetic retinopathy: seeing is believing. J Ocul Biol Dislnfor 2011;4:83-92.
11. Ablonczy Z, Dahrouj M, Tang PH, Liu Y, Sambamurti K, Marmorstein AD, Crosson CE: Human retinal pigment epithelium cells as functional models for the RPE in vivo. Invest Ophthalmol Vis Sci 2011;52:8614-8620.
12. Pitocco D, Tesauro M, Alessandro R, Ghirlanda G, Cardillo C: Oxidative stress in diabetes: implications for vascular and other complications. Int J Mol Sci 2013;14:21525-21550.
13. Jaganjac M, Tirosh 0, Cohen G, Sasson S, Zarkovic N: Reactive aldehydes-second messengers of free radicals in diabetes mellitus. Free Radic Res 2013;l:S39-48.
14. Rosenfeldt MT, Ryan KM: The multiple roles of autophagy in cancer. Carcinogenesis 2011;32:955-963.
15. Mizushima N, Yoshimori X Levine B: Methods in mammalian autophagy research. Cell 2010;140:313-326.
16. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, et al.: Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012;8:445-544.
17. Jung CH, Ro SH, Cao J, Otto NM, Kim DH: mTOR regulation of autophagy. FEBS Lett 2010;584:1287-1295.
18. Scherz-Shouval R, Elazar Z: Regulati on of autophagy by ROS: physiology and pathology. Trends Biochem Sci 2011;36:30-38.
19. Orsi A, Fioriti L, Chiesa R, Sitia R: Conditions of endoplasmic reticulum stress favor the accumulation of cytosolic prion protein. J Biol Chem 2006;281:30431-30438.
20. Simo R, Villarroel M, Corraliza L, Hernandez C, Garcia-Ramirez M: The retinal pigment epithelium: something more than a constituent of the blood-retinal barrier-implications for the pathogenesis of diabetic retinopathy. J Biomed Biotechnol 2010;190724. doi: 10.1155/2010/190724.
21. Shintani X Klionsky DJ: Autophagy in health and disease: a double-edged sword. Science 2004;306:990-995.
22. Ma X Zhu J, Chen X, Zha D, Singhal PC, Ding G: High glucose induces autophagy in podocytes. Exp Cell Res 2013;319:779-789.
23. Jung HS, Chung KW, Won Kim J, Kim J, Komatsu M, Tanaka K, Nguyen YH, Kang TM, Yoon KH, Kim JW, Jeong YT, Han MS, Lee MK, Kim KW, Shin J, Lee MS: Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metab 2008;8:318-324.
24. Kobayashi S, Xu X, Chen K, Liang Q: Suppression of autophagy is protective in high glucose-induced cardiomyocyte injury. Autophagy 2012;84:577-592.
25. Sauer H, Wartenberg M, Hescheler J: Reactive o xygen species as intracellular messengers during cell growth and differentiation. Cell Physiol Biochem 2001;11:173-186.
26. Rutkowski DT, Kaufman RJ: A trip to the ER: coping with stress. Trends Cell Biol 2004;14:20-28.
27. Rosenbluth JM, Pietenpol JA: mTOR regulates autophagy-associated genes downstream of p73. Autophagy 2009;5:114-116.
28. Kim J, Kundu M, Viollet B, Guan KL: AMPK and mTOR regulate autophagy through direct phosphorylation of Ulkl. Nat Cell Biol 2011;13:132-141.