Hyperglycaemia Exacerbates Choroidal Neovascularisation in Mice via the Oxidative Stress-Induced Activation of STAT3 Signalling in RPE Cells

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Li, Xia ^a   Cai, Yan ^a   Wang, Yu Sheng ^a   Shi, Yuan Yuan ^a   Hou, Wei ^a   Xu, Chun Sheng ^a   Wang, Hai Yan ^a   Ye, Zi ^a   Yao, Li Bo ^b   Zhang, Jian ^b  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; ACETOACETIC ACID; ACETYLCYSTEINE; ANTIOXIDANT; DICHLOROFLUORESCEIN; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; REACTIVE OXYGEN METABOLITE; STAT3 PROTEIN; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE SEVERITY; DNA DAMAGE; ENZYME LINKED IMMUNOSORBENT ASSAY; EYE FUNDUS; HYPERGLYCEMIA; IMMUNOFLUORESCENCE; IN VITRO STUDY; LASER COAGULATION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PIGMENT EPITHELIUM; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES; SUBRETINAL NEOVASCULARIZATION; WESTERN BLOTTING;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; CHOROID; CHOROIDAL NEOVASCULARIZATION; DIABETES MELLITUS, EXPERIMENTAL; DNA DAMAGE; EPITHELIAL CELLS; GENE EXPRESSION; HYPERGLYCEMIA; LIGHT COAGULATION; MICE; OXIDATIVE STRESS; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; RETINA; RETINAL PIGMENT EPITHELIUM; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; STREPTOZOCIN; TYRPHOSTINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84867669761     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047600     Document Type: Article

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