Oxidative stress mediates the conversion of endothelial cells into myofibroblasts via a TGF-b1 and TGF-b2-dependent pathway

Laboratory Investigation

Volumn 94, Issue 10, 2014, Pages 1068-1082

  Montorfano, Ignacio ^a   Becerra, Alvaro ^a   Cerro, Roberto ^a   Echeverría, César ^a,b   Sáez, Elizabeth ^a   Morales, María Gabriela ^a   Fernández, Ricardo ^a   Cabello Verrugio, Claudio ^a   Simon, Felipe ^a,c  

^a UNIVERSIDAD ANDRÉS BELLO   (Chile)

^b UNIVERSIDAD BERNARDO O'HIGGINS   (Chile)

^c Facultad de Medicina Universidad Andrés Bello   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; RNA; SMAD3 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; BIOLOGICAL MARKER; NFKB1 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; SCLEROPROTEIN; SMAD3 PROTEIN, HUMAN; TGF-BETA TYPE I RECEPTOR; TGFB1 PROTEIN, HUMAN; TGFB2 PROTEIN, HUMAN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ARTICLE; CELL TRANSFORMATION; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; EXTRACELLULAR MATRIX; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; INFLAMMATORY DISEASE; MYOFIBROBLAST; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; UMBILICAL VEIN ENDOTHELIAL CELL; WESTERN BLOTTING; CELL CULTURE; EPITHELIAL MESENCHYMAL TRANSITION; METABOLISM; PHYSIOLOGY; SECRETION (PROCESS);

BIOLOGICAL MARKERS; CELLS, CULTURED; ENDOTHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; EXTRACELLULAR MATRIX PROTEINS; HUMANS; HYDROGEN PEROXIDE; MYOFIBROBLASTS; NF-KAPPA B P50 SUBUNIT; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2;

EID: 84919774473     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2014.100     Document Type: Article

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